Journal
PEPTIDES
Volume 30, Issue 2, Pages 439-444Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2008.10.002
Keywords
Obestatin; Ghrelin; Obesity; Diabetes
Funding
- National Natural Science Foundation of China [30800375, 30572190, 30700380]
- Major State Basic Research Development Program of the People's Republic of China [2006CB503807]
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The high prevalence of obesity and diabetes will lead to higher rates of morbidity and mortality. It is well known that ghrelin plays a potential role in obesity and diabetes. Obestatin, a novel 23 amino acid amidated peptide encoded by the same gene that encodes ghrelin, was initially reported to have opposite actions to ghrelin in the regulation of food intake, emptying of the stomach and body weight. Recent work suggests that obestatin also regulate p-cell survival and insulin secretion. The ghrelin-obestatin system is, therefore, a promising target for the developing of new drugs for the treatment of obesity and diabetes. This review summarizes the interrelationship between obestatin, obesity and diabetes. (C) 2008 Elsevier Inc. All rights reserved.
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