Journal
PEPTIDES
Volume 30, Issue 11, Pages 2076-2080Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2009.05.004
Keywords
Melanin-concentrating hormone; MCHR1; MCHR2; Neuropeptide; Immune system; Lymphocyte; Cytokine; Inflammation
Funding
- Leon Fredericq Foundation
- Fonds Speciaux pour la Recherche
- University of Liege
- FRS-FNRS
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To date, melanin-concentrating hormone (MCH) has been generally considered as peptide acting almost exclusively in the central nervous system. In the present paper, we revise the experimental evidence, demonstrating that MCH and its receptors are expressed by cells of the immune system and directly influence the response of these cells in some circumstances. This therefore supports the idea that, as with other peptides, MCH could be considered as a modulator of the immune system. Moreover, we suggest that this could have important implications in several immune-mediated disorders and affirm that there is a clear need for further investigation. (c) 2009 Elsevier Inc. All rights reserved.
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