Article
Gastroenterology & Hepatology
Xiu-Cai Fang, Wen-Juan Fan, Douglas D. Drossman, Shao-Mei Han, Mei-Yun Ke
Summary: This study compared bowel symptoms and psychosocial features in IBS patients diagnosed with Rome III criteria with abdominal discomfort, abdominal pain, and pain & discomfort. The results showed that IBS patients with abdominal discomfort have similar bowel symptoms and psychosocial features to those with abdominal pain.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Pediatrics
Robyn Rexwinkel, Arine M. Vlieger, Miguel Saps, Merit M. Tabbers, Marc A. Benninga
Summary: Disorders of the gut-brain interaction have a negative impact on quality of life and socio-economic burden. The understanding and guidelines for the treatment of functional abdominal pain disorders in children are lacking, making their management challenging. It is important to make an accurate diagnosis of irritable bowel syndrome or functional abdominal pain-not otherwise specified in children with chronic abdominal pain to prevent unnecessary referrals and costs.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Pr. Benoit Coffin, Henri Duboc
Summary: Persistent abdominal pain is a challenging condition often misdiagnosed as functional disorders. This article provides an update on less well-known causes of abdominal pain and their diagnosis and management.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pediatrics
Elvira Ingrid Levy, Charlotte De Geyter, Abdelhalim Ouald Chaib, Berthold Albert Aman, Badriul Hegar, Yvan Vandenplas
Summary: There are limited randomized controlled trials on managing pediatric IBS, with most intervention trials targeting changes to the gastrointestinal microbiome. Heterogeneity in study designs and outcomes make it difficult to formulate recommendations. Insufficient evidence exists to recommend therapeutic interventions in pediatric IBS, despite the association with dysbiosis. More prospective trials are needed.
Review
Pharmacology & Pharmacy
Michael Camilleri, Saam Dilmaghani
Summary: This narrative review provides an update on current approaches for the treatment of pain, global symptoms, or relief in irritable bowel syndrome (IBS). The review evaluates medications, dietary interventions, fecal microbial transplantation (FMT), electrical approaches, and behavioral therapies. The evidence suggests only modest benefit in global IBS symptoms and pain relief. A future approach involving validated biomarkers could individualize treatment and improve outcomes.
PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Cong Dai, Yu-Hong Huang, Min Jiang
Summary: This article is connected to the papers of Marasco et al. To access these papers, visit and
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Iam van Thiel, W. J. de Jonge, R. M. van den Wijngaard
Summary: Although the gut microbiota consists of bacteria, viruses, and fungi, most studies on the microbiota-gut-brain axis in IBS have primarily focused on bacteria due to their higher presence. However, recent research on the intestinal mycobiome in inflammatory bowel disease suggests that the low numbers of fungi and viruses may still have relevance. This review discusses the current IBS mycobiome data and how these findings could relate to previous observations in IBS, as well as identifies questions for future research.
Review
Gastroenterology & Hepatology
Vivek C. Goodoory, Mais Khasawneh, Christopher J. Black, Eamonn M. M. Quigley, Paul Moayyedi, Alexander C. Ford
Summary: This article conducted a meta-analysis to study the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). The study found that certain combinations of probiotics or strains may be beneficial for IBS, but the certainty of the evidence was low.
Article
Nutrition & Dietetics
Wojciech Roczniak, Agnieszka Szymlak, Bogdan Mazur, Agata Chobot, Malgorzata Stojewska, Joanna Oswiecimska
Summary: This study assessed the nutritional status and serum concentrations of adipokines in children with irritable bowel syndrome (IBS) and healthy controls. The results showed significant differences in serum chemerin and omentin-1 concentrations between IBS patients and healthy children. These adipokines could be used as IBS biomarkers as they demonstrate good specificity and moderate sensitivity.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Letter
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This article is connected to Marasco et al papers. To view these articles, visit and...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
David Deutsch, Michel Bouchoucha, Julien Uzan, Jean-Jacques Raynaud, Jean-Marc Sabate, Robert Benamouzig
Summary: The severity of abdominal pain is associated with bloating severity in patients with functional bowel disorders, with differences in associations based on gender and specific phenotype. In female patients, severity of abdominal pain is negatively associated with age and positively associated with depression, constipation severity, and diarrhea severity. In male patients, severity of abdominal pain is associated with state anxiety, constipation severity, and diarrhea severity.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Medicine, General & Internal
Mustafa Abdul Karim, Nadeen Al-Baz, Peter M. Haddad, Shuja M. Reagu, Majid Alabdulla
Summary: This case study suggests that buspirone is effective in treating refractory IBS. Further research is needed to evaluate the role of buspirone in IBS management.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This meta-analysis aimed to estimate the incidence of post-COVID-19 functional dyspepsia (FD) and irritable bowel syndrome (IBS). The analysis found that COVID-19 survivors are at a higher risk of developing IBS compared to controls, while data for FD are inconclusive.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Isabelle Mack, Juliane Schwille-Kiuntke, Nazar Mazurak, Beate Niesler, Kurt Zimmermann, Hubert Moennikes, Paul Enck
Summary: This study investigated the effectiveness of a nonviable probiotic lysate (BL) in the treatment of IBS and found that BL was not effective for all IBS subtypes, but may offer a treatment option for IBS-D which needs further verification through adequately powered drug trials.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Olga P. Nyssen, Dino Vaira, Bojan Tepes, Limas Kupcinskas, Dmitry Bordin, Angeles Perez-Aisa, Antonio Gasbarrini, Manuel Castro-Fernandez, Luis Bujanda, Ana Garre, Alfredo Lucendo, Liudmila Vologzhanina, Natasa B. Jurecic, Luis Rodrigo-Saez, Jose M. Huguet, Irina Voynovan, Jorge Perez-Lasala, Pilar Mata Romero, Miroslav Vujasinovic, Rustam Abdulkhakov, Jesus Barrio, Luis Fernandez-Salazar, Francis Megraud, Colm O'Morain, Javier P. Gisbert
Summary: Based on the European Registry on Helicobacter pylori management, this study evaluated common mistakes in the eradication of H. pylori infection. Results showed that some European gastroenterologists made common mistakes in the management, such as using ineffective treatment, prescribing short-term therapy, and using low doses of medications. These errors led to suboptimal treatment outcomes. Although clinical practice is slowly adapting to current recommendations, there is still a delay in adopting updated guidelines.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Letter
Gastroenterology & Hepatology
M. Reyes Busta Nistal, Lourdes del Olmo Martinez, Benito Velayos Jimenez, Luis Fernandez Salazar, Miguel Dura Gil
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Letter
Gastroenterology & Hepatology
M. Reyes Busta Nistal, Noelia Alcaide Suarez, Luis Fernandez Salazar, Daniel Corrales Cruz
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Letter
Gastroenterology & Hepatology
M. Reyes Busta Nistal, M. Concepcion Garcia Sanchez, Natalia Mora Cuadrado, Miguel Dura Gil, Luis Fernandez Salazar
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Article
Gastroenterology & Hepatology
Olga P. Nyssen, Dino Vaira, Angeles Perez Aisa, Luis Rodrigo, Manuel Castro-Fernandez, Laimas Jonaitis, Bojan Tepes, Liudmila Vologzhanina, Maria Caldas, Angel Lanas, Alfredo J. Lucendo, Luis Bujanda, Juan Ortuno, Jesus Barrio, Jose M. Huguet, Irina Voynovan, Jorge Perez Lasala, Aiman Silkanovna Sarsenbaeva, Luis Fernandez-Salazar, Javier Molina-Infante, Natasa Brglez Jurecic, Miguel Areia, Antonio Gasbarrini, Juozas Kupcinskas, Dmitry Bordin, Ricardo Marcos-Pinto, Frode Lerang, Marcis Leja, Gyorgy M. Buzas, Yaron Niv, Theodore Rokkas, Perminder Phull, Sinead Smith, Oleg Shvets, Marino Venerito, Vladimir Milivojevic, Ilkay Simsek, Vincent Lamy, Peter Bytzer, Lyudmila Boyanova, Lumir Kunovsky, Christoph Beglinger, Michael Doulberis, Wojciech Marlicz, Adrian Goldis, Ante Tonkic, Lisette Capelle, Ignasi Puig, Francis Megraud, Colm O' Morain, Javier P. Gisbert
Summary: The study evaluated the effectiveness and safety of second-line empiric treatment for H pylori infection by European gastroenterologists. For patients who failed previous eradication treatment attempts, treatment regimens including quinolone triple therapies and levofloxacin-bismuth quadruple therapy showed optimal eradication rates.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Javier P. Gisbert, Javier Alcedo, Javier Amador, Luis Bujanda, Xavier Calvet, Manuel Castro-Fernandez, Luis Fernandez-Salazar, Emili Gene, Angel Lanas, Alfredo J. Lucendo, Javier Molina-Infante, Olga P. Nyssen, A. Perez-Aisa, Ignasi Puig
Summary: Helicobacter pylori infection is common in the Spanish population and is the main cause of chronic gastritis, peptic ulcer, and gastric cancer. Recently, experts in Spain developed recommendations for eradication therapy, with quadruple therapies being recommended as first-line treatments.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Editorial Material
Gastroenterology & Hepatology
Luis Fernandez-Salazar, Julio Valle-Munoz
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2022)
Article
Medicine, General & Internal
Ana Gutierrez, Pedro Zapater, Elena Ricart, Maria Gonzalez-Vivo, Jordi Gordillo, David Olivares, Isabel Vera, Miriam Manosa, Javier P. Gisbert, Mariam Aguas, Eugenia Sanchez-Rodriguez, Maia Bosca-Watts, Viviana Laredo, Blau Camps, Ignacio Marin-Jimenez, Yamile Zabana, Maria Dolores Martin-Arranz, Roser Munoz, Merce Navarro, Eva Sierra, Lucia Madero, Milagros Vela, Jose Lazaro Perez-Calle, Empar Sainz, Xavier Calvet, Lara Arias, Victor Morales, Fernando Bermejo, Luis Fernandez-Salazar, Manuel Van Domselaar, Luisa De Castro, Cristina Rodriguez, Carmen Munoz-Villafranca, Rufo Lorente, Montserrat Rivero, Eva Iglesias, Belen Herreros, David Busquets, Joan Riera, Maria Pilar Martinez-Montiel, Marta Roldon, Oscar Roncero, Esther Hinojosa, Monica Sierra, Jesus Barrio, Ruth De Francisco, Jose Huguet, Olga Merino, Daniel Carpio, Daniel Ginard, Fernando Munoz, Marta Piqueras, Pedro Almela, Federico Argueelles-Arias, Guillermo Alcain, Luis Bujanda, Noemi Mancenido, Alfredo J. Lucendo, Pilar Varela, Iago Rodriguez-Lago, Laura Ramos, Laura Sempere, Eva Sese, Manuel Barreiro-de Acosta, Eugeni Domenech, Ruben Frances
Summary: Compared with native-born patients, first-generation-immigrant IBD patients in Spain show differences in disease onset age, extraintestinal manifestations, and biologics usage.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Luis Fernandez-Salazar, Ana Campillo, Luis Rodrigo, Angeles Perez-Aisa, Jesus M. Gonzalez-Santiago, Xavier Segarra Ortega, Maja Denkovski, Natasa Brglez Jurecic, Luis Bujanda, Blas Jose Gomez Rodriguez, Juan Ortuno, Sotirios Georgopoulos, Laimas Jonaitis, Ignasi Puig, Olga P. Nyssen, Francis Megraud, Colm O'Morain, Javier P. Gisbert
Summary: This study evaluated the decisions and outcomes of H. pylori management by European gastroenterologists through an international multicenter observational registry. The findings suggest that high-dose dual therapy (HDDT) is not a good option for first-line or rescue treatment of H. pylori in Europe, even with the addition of bismuth.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Elena Resina, Maria G. Donday, Samuel J. Martinez-Dominguez, Emilio Jose Laserna-Mendieta, Angel Lanas, Alfredo J. Lucendo, Marta Sanchez-Luengo, Noelia Alcaide, Luis Fernandez-Salazar, Luisa De La Pena-Negro, Luis Bujanda, Marta Gomez-Ruiz De Arbulo, Javier Alcedo, Angeles Perez-Aisa, Raul Rodriguez, Sandra Hermida, Yanire Brenes, Olga P. Nyssen, Javier P. Gisbert
Summary: This study assessed the accuracy of a new SAT, the LIAISON(R) Meridian H. pylori SA, compared to the gold standard UBT. The results showed that the new SAT had good accuracy for the diagnosis of H. pylori infection, and PCR testing further improved its accuracy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Garcia-Alvarado, J. Barrio, M. Sierra-Ausin, L. Arias, L. Fernandez-Salazar, A. Fuentes Coronel, L. Arias Garcia, F. J. Garcia-Alonso, M. Garcia-Prada, J. Legido, J. G. Sanchez-Hernandez, F. Munoz
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Garcia-Alvarado, J. Barrio, M. Sierra-Ausin, L. Arias, L. Fernandez-Salazar, A. Fuentes Coronel, L. Arias Garcia, F. J. Garcia-Alonso, M. Garcia-Prada, J. Legido, J. G. Sanchez-Hernandez, F. Munoz
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
R. M. Saiz Chumillas, L. Alba, Y. Gonzalez-Lama, B. Velayos, P. Suarez, C. Maroto-Martin, A. Nunez, L. Hernandez, L. Relea, L. Fernandez-Salazar, M. Sierra-Ausin, J. Barrio, F. Munoz, L. Arias, B. Sicilia
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Baldan-Martin, M. Azkargorta, I. Iloro, L. Ortega Moreno, L. Aldars Garcia, I. Soleto Fernandez, C. Ramirez, S. Riestra, M. Rivero, A. Gutierrez, I. Rodriguez-Lago, L. Fernandez-Salazar, D. Ceballos, J. M. Benitez, M. Aguas, I. Baston-Rey, F. Bermejo, M. J. Casanova, R. Llorente, Y. Ber, V. Royo, M. Esteve, F. Elortza, M. Chaparro, J. P. Gisbert
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
D. Bernardo, E. Arribas-Rodriguez, C. G. De Castro, A. Fiz-Lopez, A. De Prado, L. Fernandez-Salazar, J. Barrio, S. Izquierdo, J. Garcia-Alonso, B. De Andres, J. M. Garcia-Abril, A. Romero, J. Sanchez-Gonzalez, J. A. Garrote, E. Arranz
JOURNAL OF CROHNS & COLITIS
(2022)