Article
Emergency Medicine
Sejin Heo, Kyeongman Jeon, Boram Park, Ryoung-Eun Ko, Taerim Kim, Sung Yeon Hwang, Hee Yoon, Tae Gun Shin, Won Chul Cha, Se Uk Lee
Summary: This study investigated the characteristics and outcomes of chemotherapy-induced FN patients returning to the ED. It found that shock index, thrombocytopenia, and lactic acid level were associated with an increased risk of a return visit to the ED, while being transferred from other hospitals was associated with a decreased risk.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Oncology
Mario A. Melgar, Maysam R. Homsi, Brooke Happ, Yin Su, Li Tang, Miriam L. Gonzalez, Miguela A. Caniza
Summary: The management of febrile neutropenia in pediatric oncology centers in Latin America shows adherence to standard guidelines but also variability in care practices. Further evaluation of care resources and practices is needed to prioritize interventions based on findings. Professional networks can aid in discussions and consensus building for febrile neutropenia management in Latin America.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Pediatrics
Serdar Nepesov, Yontem Yaman, Murat Elli, Nihan Bayram, Kursat Ozdilli, Akif Ayaz, Sema Anak
Summary: This study retrospectively analyzed the clinical characteristics of 36 patients with chronic neutropenia and found differences in neutrophil counts among patients. It was observed that a majority of patients showed normalization of neutrophil counts.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Oncology
Ahuva Averin, Amanda Silvia, Lois Lamerato, Kathryn Richert-Boe, Manpreet Kaur, Devi Sundaresan, Neel Shah, Mark Hatfield, Tatiana Lawrence, Gary H. Lyman, Derek Weycker
Summary: This retrospective study revealed that the majority of metastatic cancer patients receiving chemotherapy, particularly those at higher risk for febrile neutropenia (FN), did not receive recommended G-CSF prophylaxis, leading to notably high FN incidence. It is crucial to carefully identify and manage patients with elevated FN risk to ensure appropriate use of supportive care.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Jiyoung Keum, Hee Seung Lee, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Seungmin Bang
Summary: This study aimed to investigate the association between UGT1A1 polymorphisms and FOLFIRINOX-induced neutropenia. The results showed that female sex, ECOG PS = 1, UGT1A1 IM, and UGT1A1 PM were independent risk factors for FN. It is recommended to screen UGT1A1 before chemotherapy.
Article
Emergency Medicine
Nicholas Pettit, Daniel Boadu, Jason J. Bischof
Summary: A retrospective chart review of 203 patients with FN confirmed the low prevalence of FN among 13 EDs, but poor guideline compliance for low-risk patients. All patients were admitted, and nearly all received IV fluids and IV antibiotics, indicating an opportunity for improving ED care of cancer patients by reducing unnecessary hospitalizations.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Gabrielle M. Haeusler, Alexandra L. Garnham, Connie Sn Li-Wai-Suen, Julia E. Clark, Franz E. Babl, Zoe Allaway, Monica A. Slavin, Francoise Mechinaud, Gordon K. Smyth, Bob Phillips, Karin A. Thursky, Marc Pellegrini, Marcel Doerflinger
Summary: This study investigated the transcriptome of peripheral blood mononuclear cells (PBMCs) in children with cancer and febrile neutropenia (FN) to identify potential predictors of serious infection. The study found global differences in gene expression associated with specific immune responses in children with FN and documented infection, compared to episodes without documented infection. These differences may inform monitoring and aid in defining adequate treatment for different infectious aetiologies in children with cancer.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Article
Oncology
Sophie Peltekian, Shellyza Sajwani, Xiang Wang, Salmaan Kanji
Summary: The purpose of this study was to determine the incidence of febrile neutropenia (FN) and neutropenia in patients with castrate-resistant metastatic prostate cancer (mCRPC) receiving docetaxel and to identify predictors for FN. The results showed that the incidence of FN and neutropenia in patients receiving docetaxel for mCRPC was 25% and 33% respectively. Age and multiple comorbidities were identified as risk factors for FN.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Oncology
Zhigang Zhang, Xiao Cao, Qi Wang, Qiuyu Yang, Mingyao Sun, Long Ge, Jinhui Tian
Summary: This study evaluated the quality of clinical practice guidelines for cancer pain and identified limitations in knowledge. The findings showed that the methodological quality of these guidelines fluctuated widely, and the reporting rates in some domains were very low.
FRONTIERS IN ONCOLOGY
(2022)
Article
Microbiology
Maria Bachlitzanaki, George Aletras, Eirini Bachlitzanaki, Ippokratis Messaritakis, Stergos Koukias, Asimina Koulouridi, Emmanouil Bachlitzanakis, Eleni Kaloeidi, Elena Vakonaki, Emmanouil Kontopodis, Nikolaos Androulakis, Georgios Chamilos, Dimitrios Mavroudis, Petros Ioannou, Diamantis Kofteridis
Summary: Febrile neutropenia is a common and serious complication in cancer patients, and this study aimed to investigate the epidemiological and microbiological characteristics of hospitalized patients with solid tumors and neutropenia, as well as factors influencing patient outcomes.
Article
Immunology
Ryoji Kobayashi, Satoru Matsushima, Daiki Hori, Hirozumi Sano, Daisuke Suzuki, Kenji Kishimoto, Kunihiko Kobayashi
Summary: In pediatric patients, risk factors for recurrent fever after discontinuation of antibiotics in a neutropenic state include incomplete remission of original disease, high white blood cell count, neutrophil count, and C reactive protein levels at start of antibiotics. Additionally, lower neutrophil count at discontinuation of antibiotics and other factors were also identified as risk factors.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Review
Gastroenterology & Hepatology
Kenji Nakagawa, Masayuki Sho, Mitsuhiro Fujishiro, Naomi Kakushima, Takahiro Horimatsu, Ken-ichi Okada, Mikitaka Iguchi, Toshio Uraoka, Motohiko Kato, Yorimasa Yamamoto, Toru Aoyama, Takahiro Akahori, Hidetoshi Eguchi, Shingo Kanaji, Kengo Kanetaka, Shinji Kuroda, Yuichi Nagakawa, Souya Nunobe, Ryota Higuchi, Tsutomu Fujii, Hiroharu Yamashita, Suguru Yamada, Yukiya Narita, Yoshitaka Honma, Kei Muro, Tetsuo Ushiku, Yasuo Ejima, Hiroki Yamaue, Yasuhiro Kodera
Summary: Duodenal cancer has no established treatment guidelines in Japan, so we developed guidelines based on clinical practice and patient needs. Draft recommendations were made through literature search and systematic review, and decisions were made according to actual clinical practice. It is important to consult with patients, their families, treating physicians, and other medical staff when deciding how to handle each case.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Infectious Diseases
Pedro Puerta-Alcalde, Juan Ambrosioni, Mariana Chumbita, Marta Hernandez-Meneses, Nicole Garcia-Pouton, Celia Cardozo, Estela Moreno-Garcia, Francesc Marco, Josep Mensa, Montserrat Rovira, Jordi Esteve, Jose A. Martinez, Felipe Garcia, Josep Mallolas, Alex Soriano, Jose M. Miro, Carolina Garcia-Vidal
Summary: This study compared the clinical characteristics and outcomes of bloodstream infections in cancer patients with febrile neutropenia with and without HIV infection, revealing that HIV infection affects the epidemiology and clinical presentation of patients, leading to higher mortality. However, HIV infection itself was not associated with mortality.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Oncology
D. Rossini, A. Boccaccino, A. Sbrana, F. Daniel, B. Borelli, A. Raimondi, D. Santini, V Conca, G. Tomasello, S. Caponnetto, F. Marmorino, A. Zaniboni, A. Buonadonna, G. Masi, S. Lonardi, F. Pietrantonio, A. Falcone, A. Antonuzzo, C. Cremolini
Summary: The studies analyzed the incidence and dynamics of neutropenia and febrile neutropenia in metastatic colorectal cancer patients receiving FOLFOXIRI/ bevacizumab, revealing a higher risk compared to other treatments, with older females being more susceptible to neutropenia.
Article
Medicine, General & Internal
Arom Choi, Incheol Park, Hye Sun Lee, Jinseok Chung, Min Joung Kim, Yoo Seok Park
Summary: This study developed a novel prognostic nomogram using qSOFA score and mean platelet volume to predict 28-day mortality and serious medical complications in cancer patients with febrile neutropenia. The nomogram showed good discrimination and provides rapid patient evaluation, especially applicable in the emergency department.
ANNALS OF MEDICINE
(2022)
Article
Oncology
Somsak Prasongtanakij, Usanarat Anurathapan, Thitinee Vanichapol, Bunyada Jittorntrum, Korakot Atjanasuppat, Pongpak Pongpitcha, Samart Pakakasama, Duantida Songdej, Nongnuch Sirachainan, Karan Paisooksantivatana, Suparerk Borwaornpinyo, Borje S. Andersson, Suradej Hongeng
Summary: This study aimed to design and manufacture CD19 CAR-modified T cells for clinical use in Thailand and investigate the impact of different spacer lengths on cytotoxic potential. The results showed that all CD19 CAR T cell constructs exhibited similar levels of cytotoxicity, and the intermediate length spacer construct was selected for clinical application due to its higher transduction efficiency and slower initial proliferation.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Koollawat Chupradit, Wannisa Khamaikawin, Supachai Sakkhachornphop, Chaniporn Puaninta, Bruce E. Torbett, Suparerk Borwornpinyo, Suradej Hongeng, Methichit Wattanapanitch, Chatchai Tayapiwatana
Summary: The study demonstrates the efficacy and safety of using 2LTRZFP in human CD34(+) HSPCs for gene therapy in HIV-1-infected individuals. The 2LTRZFPmCherry-transduced macrophages showed normal function and phenotype, and exhibited resistance to HIV-1 integration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Franco Locatelli, Alexis A. Thompson, Janet L. Kwiatkowski, John B. Porter, Adrian J. Thrasher, Suradej Hongeng, Martin G. Sauer, Isabelle Thuret, Ashutosh Lal, Mattia Algeri, Jennifer Schneiderman, Timothy S. Olson, Ben Carpenter, Persis J. Amrolia, Usanarat Anurathapan, Axel Schambach, Christian Chabannon, Manfred Schmidt, Ivan Labik, Heidi Elliot, Ruiting Guo, Mohammed Asmal, Richard A. Colvin, Mark C. Walters
Summary: The study demonstrates that betibeglogene autotemcel therapy can achieve transfusion independence in patients with transfusion-dependent beta-thalassemia, with good safety profile and stable results, suitable for most patients with non-beta(0)/beta(0) genotype.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Pediatrics
Weerapong Chaya, Usanarat Anurathapan, Sasivimol Rattanasiri, Chonnamet Techasaensiri, Samart Pakakasama, Nopporn Apiwattanakul
Summary: Thalassemic patients undergoing HSCT had a lower incidence of IBI compared to patients with other underlying diseases, with catheter-related blood stream infection being the major type of IBI in these patients. Having thalassemia as an underlying disease was the only factor associated with lower IBI in pediatric post-HSCT patients.
PEDIATRIC TRANSPLANTATION
(2022)
Article
Pharmacology & Pharmacy
Ai-Hoc Nguyen, Mohitosh Biswas, Apichaya Puangpetch, Santirhat Prommas, Samart Pakakasama, Usanarat Anurathapan, Jiratha Rachanakul, Rattanaporn Sukprasong, Nutthan Nuntharadtanaphong, Nutcha Jongjitsook, Suradej Hongeng, Chonlaphat Sukasem
Summary: This study found a significant association between the polymorphism of GSTA1 and variations in the pharmacokinetic properties of busulfan treatment in pediatric Asian patients. Patients carrying the GSTA1*B variant showed a significant impact on the PK of busulfan, with a notable augmentation in AUC.
Article
Cell & Tissue Engineering
Tanapat Pornsukjantra, Kitsada Kangboonruang, Pirut Tong-Ngam, Thipwimol Tim-Aroon, Duangrurdee Wattanasirichaigoon, Usanarat Anurathapan, Suradej Hongeng, Alisa Tubsuwan, Kanit Bhukhai, Nithi Asavapanumas
Summary: In this study, a human induced pluripotent stem cell line for Gaucher disease was established, providing a valuable tool for further investigations.
STEM CELL RESEARCH
(2022)
Article
Virology
Natali Ludowyke, Worakorn Phumiphanjarphak, Nopporn Apiwattanakul, Suwimon Manopwisedjaroen, Samart Pakakasama, Insee Sensorn, Ekawat Pasomsub, Wasun Chantratita, Suradej Hongeng, Pakorn Aiewsakun, Arunee Thitithanyanont
Summary: In this study, it was found that 21.4% of pediatric patients undergoing hematopoietic stem cell transplant were infected with HPgV-1 virus, with two cases belonging to genotype 2 and one case belonging to genotype 3. The study highlights the importance of screening HSCT patients and donors to reduce the risk of HPgV-1 transmission.
Article
Oncology
Jirawan Panachan, Napat Rojsirikulchai, Nutkridta Pongsakul, Ladawan Khowawisetsut, Pongpak Pongphitcha, Teerapong Siriboonpiputtana, Takol Chareonsirisuthigul, Pitichai Phornsarayuth, Nisakorn Klinkulab, Natini Jinawath, Wararat Chiangjong, Usanarat Anurathapan, Kovit Pattanapanyasat, Suradej Hongeng, Somchai Chutipongtanate
Summary: This study aimed to establish a less invasive method to detect the MYCN status in pediatric neuroblastoma (NB) based on the content of MYCN mRNA in extracellular vesicles (EVs). The study successfully detected MYCN mRNA in microvesicles (MVs) of MYCN-amplified NB cells. The feasibility of the EV-based method was demonstrated using simulated samples and clinical specimens, showing promising results.
Article
Immunology
Songpon Getsuwan, Pornthep Tanpowpong, Suradej Hongeng, Usanarat Anurathapan, Samart Pakakasama, Suporn Treepongkaruna
Summary: This article describes a case of an adolescent male who underwent bone marrow transplantation and developed chronic graft-versus-host disease (GVHD) mimicking eosinophilic gastrointestinal disorders (EGIDs). The patient was initially diagnosed with eosinophilic gastroenteritis and received corticosteroids, but later developed recurrent symptoms and persistent hypereosinophilia. Ultimately, the patient was diagnosed with chronic GVHD and treatment with ruxolitinib resulted in significant clinical improvement.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Hematology
Supavich Tannumsaeung, Usanarat Anurathapan, Samart Pakakasama, Pongpak Pongpitcha, Duantida Songdej, Nongnuch Sirachainan, Borje S. Andersson, Suradej Hongeng
Summary: This study reviewed the clinical outcomes data of 43 patients undergoing allo-HSCT and compared the effectiveness and tolerability of thiotepa-based and TBI-based conditioning regimens. The results showed no difference in engraftment and overall survival rates between the two regimens.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Review
Oncology
Praewa Suthapot, Wararat Chiangjong, Parunya Chaiyawat, Pongsakorn Choochuen, Dumnoensun Pruksakorn, Surasak Sangkhathat, Suradej Hongeng, Usanarat Anurathapan, Somchai Chutipongtanate
Summary: Genomic aberrations detection has provided valuable information for precise treatment strategies in cancer. However, the development of pediatric precision oncology is challenging due to limited samples and target genetic aberrations.
Article
Virology
Songpon Getsuwan, Nopporn Apiwattanakul, Chatmanee Lertudomphonwanit, Suradej Hongeng, Sophida Boonsathorn, Wiparat Manuyakorn, Pornthep Tanpowpong, Usanarat Anurathapan, Kanchana Tangnararatchakit, Suporn Treepongkaruna
Summary: This study aimed to investigate CMV-specific T cell immune reconstitution among pediatric LT recipients. The results showed that despite intense immunosuppressive therapy, CMV-specific T cell immune reconstitution occurred in pediatric patients post-LT, which could confer protection against CMV reactivation.
Review
Biochemistry & Molecular Biology
Usanarat Anurathapan, Samart Pakakasama, Duantida Songdej, Pongpak Pongphitcha, Ampaiwan Chuansumrit, Borje S. Andersson, Suradej Hongeng
Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for thalassemia and a program consisting of pharmacologic pre transplant immune suppression phase (PTIS) and other treatment strategies has been shown to improve the success rate of the transplantation in this study.