Review
Biochemistry & Molecular Biology
Sandra Diaz del Moral, Maha Benaouicha, Ramon Munoz-Chapuli, Rita Carmona
Summary: The translation introduces the importance of insulin and insulin-like growth factors during embryonic development and their role in cardiac development and cardiomyocyte proliferation. The study also discusses the clinical potential of utilizing the IGF signaling pathway for adult cardiac repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Patryk Leczycki, Maciej Banach, Marek Maciejewski, Agata Bielecka-Dabrowa
Summary: In recent decades, there has been a significant increase in the number of adults with congenital heart diseases (ACHD), necessitating thorough evaluation of their current condition. There is currently a lack of universal parameters or scales to easily assess the deterioration of ACHD patients' condition, emphasizing the need to identify widely available, cost-effective, and user-friendly factors. Studies have shown potential prognostic factors including echocardiography and magnetic resonance imaging, cardiopulmonary exercise testing, and biomarkers. However, further research is needed to create a specific assessment panel for patients with specific congenital heart diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Margarita Brida, Daniel Lovric, Massimo Griselli, Fernando Riesgo Gil, Michael A. Gatzoulis
Summary: Heart failure is the leading cause of morbidity and mortality in adult patients with congenital heart disease. The nature of the underlying congenital heart disease affects the timing and severity of heart failure, and ongoing management is necessary. Drug therapy has some effect on left ventricle failure, but there is currently a lack of data on drug therapy for right ventricle and Fontan circulation failure. Cardiac resynchronization therapy is considered as a treatment option, while mechanical circulatory support and transplantation are last resorts in highly selected patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Eugene S. J. Tan, Siew-Pang Chan, Yeunhyang C. Choi, Chris J. Pemberton, Richard Troughton, Katrina Poppe, Mayanna Lund, Gerry Devlin, Robert N. Doughty, A. Mark Richards
Summary: The regional handling of IGFBP-7 in CHF is distinct from other biomarkers. IGFBP-7 is associated with adverse outcomes and demonstrates a strong prognostic performance in predicting the prognosis of CHF.
JACC-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Jeremy P. Moore, Ariane Marelli, Luke J. Burchill, Henry Chubb, S. Lucy Roche, Ari M. Cedars, Paul Khairy, Ali N. Zaidi, Jan Janousek, David S. Crossland, Robert H. Pass, Jeffrey P. Jacobs, Jonathan N. Menachem, David S. Frankel, Sabine Ernst, Jim T. Vehmeijer, Mitchell Cohen
Summary: Heart failure and arrhythmia are the most important cardiovascular diseases among adults with congenital heart disease, and they often overlap and interact with each other. It is crucial for clinical management to recognize these interactions and have access to the available pharmacologic and interventional resources.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Endocrinology & Metabolism
Olivia R. Ghosh-Swaby, Amy C. Reichelt, Paul A. S. Sheppard, Jeffrey Davies, Timothy J. Bussey, Lisa M. Saksida
Summary: This article discusses the role of metabolic hormones in neural plasticity and cognition, as well as the relationship between metabolic hormones and metabolic syndromes such as obesity and diabetes. Adjusting metabolic hormone levels can restore metabolic homeostasis and enhance cognitive function.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiayang Lin, Linjie Yang, Junlin Huang, Yating Liu, Xuzhen Lei, Ruxin Chen, Bingyan Xu, Chensihan Huang, Weijuan Dou, Xueyun Wei, Deying Liu, Peizhen Zhang, Yan Huang, Zhimin Ma, Huijie Zhang
Summary: This study found that both low and high levels of circulating IGF-1 are associated with increased risk of cardiovascular disease in the general population. The results highlight the importance of monitoring IGF-1 status on cardiovascular health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Steffen Blum, Stefanie Aeschbacher, Pascal Meyre, Michael Kuhne, Nicolas Rodondi, Jurg H. Beer, Peter Ammann, Giorgio Moschovitis, Leo H. Bonati, Manuel R. Blum, Peter Kastner, Fiona Baguley, Christian Sticherling, Stefan Osswald, David Conen
Summary: In AF patients, higher levels of IGFBP-7 were strongly associated with CHF hospitalization, and the prognostic information provided by IGFBP-7 was additive to that of NT-proBNP.
Review
Medicine, Research & Experimental
Fei Song, Xiao-Xia Zhou, Yu Hu, Gang Li, Yan Wang
Summary: The IGF system plays multiple roles in disease development by regulating cell proliferation and differentiation. IGFBPs can bind to IGFs and perform different functions, possibly having broader functions through IGF-independent mechanisms.
ADVANCES IN THERAPY
(2021)
Article
Physiology
Kaitlin E. Burch, Kelly McCracken, Daniel J. Buck, Randall L. Davis, Dusti K. Sloan, Kathleen S. Curtis
Summary: Research suggests that weight gain after ovariectomy is associated with selective changes in metabolic hormone signaling in the CNS, including alterations in insulin and leptin receptors in different brain areas, potentially impacting weight regulation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Martin A. Daniels, Pamela Fischer-Posovszky, Michael Boschmann, Reiner Jumpertz-von Schwartzenberg, Timo D. Mueller, Leontine Sandforth, Sabine Frank-Podlech, Sonja Huelskaemper, Andreas Peter, Martin Wabitsch, Jens Jordan, Andreas L. Birkenfeld
Summary: This study investigated the effect of ANP on the levels of the anorexigenic adipokine leptin in healthy humans. The results showed that ANP infusion led to a significant decrease in plasma leptin levels and an increase in free fatty acids, indicating enhanced lipolysis. Additionally, ANP was found to suppress leptin release in human SGBS adipocytes.
FRONTIERS IN ENDOCRINOLOGY
(2023)