Article
Chemistry, Multidisciplinary
Yoonjin Park, Seoyoon Choi, Boyong Kim, Seung Gwan Lee
Summary: The study demonstrates that Cordyceps militaris extract has strong effects on modulating macrophages, dendritic cells, and T cells under inflammatory stress, promoting M2 polarization and attenuating M1 polarization. It also enhances macrophage phagocytosis and promotes differentiation of dendritic cells towards CD11b(+) and Xcr1(+) cells, as well as T-reg and natural killer T-like (NKTL) cells.
APPLIED SCIENCES-BASEL
(2021)
Article
Immunology
Yan Zhou, Yali Qiu, Wuping Bao, Lei Han, Yishu Xue, Yingying Zhang, Xue Tian, Qiang Fu, Chengjian Lv, Dongning Yin, Min Zhang
Summary: This study investigates the influence of vitamin D on patients with T2-high and T2-low asthma. The results show that asthma patients have decreased vitamin D levels, and vitamin D deficiency can exacerbate asthma symptoms. Vitamin D levels are associated with asthma severity, especially in T2-low asthma. Further research is needed to understand the mechanisms of vitamin D on different types of asthma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Hong-Bo Fan, Qian-Wang Zheng, Qing Han, Yuan Zou, Ying-Li Liu, Li-Qiong Guo, Jun-Fang Lin
Summary: A novel Cordyceps militaris immunomodulatory protein (CMIMP) was identified in this study, which was found to induce macrophages to differentiate into M1 phenotype through the TLR4-NF-kappa B pathway, increasing proinflammatory cytokine secretion. This suggests that CMIMP may be a promising functional food ingredient or medicament.
Article
Pharmacology & Pharmacy
Lien-Thuong Thi Nguyen, Thi-Han Vo, Dang-Khoa Nguyen, Minh-Chanh Nguyen, Uyen-Chi Nguyen Le
Summary: Cordyceps militaris extract has been found to promote wound healing. Its efficacy can be further improved by combining with small silica nanoparticles, resulting in faster wound closure and enhanced recovery of skin structure.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hong-Bo Fan, Yuan Zou, Qing Han, Qian-Wang Zheng, Ying-Li Liu, Li-Qiong Guo, Jun-Fang Lin
Summary: CMIMP significantly enhanced the phagocytic ability of immune cells and increased bactericidal activity through increasing F-actin expression and cell size in a TLR4-NF-kappa B pathway dependent way.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Chunwei Jiao, Huijia Liang, Li Liu, Shunxian Li, Jiaming Chen, Yizhen Xie
Summary: CME significantly alleviated the inflammatory progression of GA and ameliorated the onset of GA. The underlying mechanism may be related to triggering the cytokine-cytokine receptor interaction signaling pathway to inhibit the activation of the inflammasome and regulate the immune system. And it regulates the inflammatory response induced by MSU crystals through the genes CCL7, CSF2RB, and IL-1 beta.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Man Zhang, Suhui Xing, Cuncun Fu, Fan Fang, Jun Liu, Juan Kan, Chunlu Qian, Qingqing Chai, Changhai Jin
Summary: The effects of four drying methods on the taste profile and flavor characteristic of Cordyceps militaris were studied. The MW-HAD method resulted in the highest levels of umami taste compounds, while the VFD method retained the most aroma compounds.
Article
Agriculture, Multidisciplinary
Shishi Huang, Yuan Zou, Hongbiao Tang, Jingyu Zhuang, Zhiwei Ye, Tao Wei, Junfang Lin, Qianwang Zheng
Summary: This study found that Cordyceps militaris polysaccharides (CMP) can significantly reduce obesity induced by a high-fat diet, improve hyperlipidemia and insulin resistance, and alleviate systemic inflammation. Additionally, CMP can regulate obesity-induced gut dysbiosis by restoring the diversity of gut microbiota and increasing the abundance of short-chain fatty acid-producing bacteria. This study highlights the potential of CMP as a prebiotic agent to protect obese individuals from metabolic disorders and gut dysbiosis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Immunology
Tongqian Wu, Lan Ma, Xiaoqian Jin, Jingjing He, Ke Chen, Dingshan Zhang, Rui Yuan, Jun Yang, Qin Zhong, Haiyan Zhou, Zou Xiang, Yu Fang
Summary: The study demonstrated that S100A4 plays a critical role in regulating mast cell activation and allergic responses. S100A4(-/-) mice showed reduced symptoms in allergic models, indicating that S100A4 is required for mast cell activation and may be involved in the regulation of allergic diseases through this mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xinxing Zhang, Yu Ma, Yanyu He, Wenjing Gu, Yongdong Yan, Wei Ji, Li Huang, Yuqing Wang, Chuangli Hao, Gang Li, Zhengrong Chen
Summary: The overexpression of Foxp2 gene can attenuate allergic asthma by inhibiting Th9 cell differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Tatsuya Kato, Konomi Nishimura, Ahmad Suparmin, Kazuho Ikeo, Enoch Y. Park
Summary: The study showed that Cordyceps militaris produces cordycepin which enhances its pathogenicity towards silkworm larvae, impacting the expression of certain genes in the silkworm larvae.
Article
Immunology
Cancan Zhang, Huisha Xu, Keilah G. Netto, Leon A. Sokulsky, Yiyan Miao, Zhongyuan Mo, Yan Meng, Yingying Du, Chengyong Wu, Liyou Han, Lirong Zhang, Chi Liu, Guojun Zhang, Fuguang Li, Ming Yang
Summary: In this study, the therapeutic potential of GGsTop, a γ-glutamyl transferase inhibitor, on acute asthma exacerbations was investigated using a murine model. The results showed that GGsTop significantly attenuated hallmark features of asthma exacerbation, including airway hyperresponsiveness, mucus hypersecretion, collagen deposition, and expression of inflammatory cytokines. Furthermore, GGsTop restored the level of glutathione and inhibited the activation of the LPS/NFκB signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Shan Lin, Wen-Kuang Hsu, Ming-Shiun Tsai, Tai-Hao Hsu, Tso-Ching Lin, Hong-Lin Su, Sue-Hong Wang, Dazhi Jin
Summary: Cordyceps militaris fermentation products, especially extracellular polysaccharides (EPS), exhibit strong androgen-like activities that can promote male reproductive development in mice.
SCIENTIFIC REPORTS
(2022)
Article
Integrative & Complementary Medicine
Rong Zheng, Weijie Zhang, Jufang Song, Yifei Zhong, Rong Zhu
Summary: The study found that cordycepin produced by Cordyceps militaris can alleviate oxidative stress and inflammation in diabetic nephropathy by regulating the expression of the miR-193b-5p/MCL-1 axis.
Article
Allergy
Hui-Hsien Pan, Jiunn-Liang Ko, Chia-Ta Wu, Hai-Lun Sun, Yeak-Wun Quek, Min-Sho Ku, Ko-Huang Lue
Summary: The study demonstrated that the OVA/CFA sensitization model successfully induced neutrophilic asthma and airway inflammation, while FIP-fve improved airway features and significantly reduced neutrophil infiltration.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
