Article
Multidisciplinary Sciences
Cameron Bieganek, Constantin Aliferis, Sisi Ma
Summary: Clinical trials often face the challenge of poor recruitment, resulting in wasted resources. This study utilized a large dataset and machine learning methods to successfully predict the recruitment rate of clinical trials. The findings revealed that study design has a significant impact on recruitment, providing valuable insights for decision-making in clinical trials.
Article
Oncology
Subha Perni, Beverly Moy, Ryan D. Nipp
Summary: The study found disparities in phase 1 versus phase 2/3 trial enrollment, with Black, Hispanic/Latino, and male patients being less likely to enroll in phase 1 trials compared to White patients. The findings suggest a need for targeted interventions to improve access to and education about phase 1 trials for Black and Hispanic/Latino patients.
Article
Clinical Neurology
Suzanne E. Schindler, Yan Li, Melody Li, Alyssa Despotis, Ethan Park, Liberty Vittert, Barton H. Hamilton, Kyle B. Womack, Benjamin Saef, David M. Holtzman, John C. Morris, Randall J. Bateman, Mahendra R. Gupta
Summary: This study developed a web-based application to model the time and financial cost of screening for Alzheimer's disease (AD) clinical trials. The results showed that incorporating an AD blood test into the screening process can reduce the time and financial cost of trial enrollment, and improvements in test accuracy have only minor impact on savings.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Elizabeth J. Siembida, Holli A. Loomans-Kropp, Irene Tami-Maury, David R. Freyer, Lillian Sung, Howland E. Crosswell, Brad H. Pollock, Michael E. Roth
Summary: This study examines the patterns of barriers and facilitators between high- and low-enrolling community-based clinics for AYA patients with cancer. High-enrolling clinics face more barriers downstream in the enrollment process, such as physician gatekeeping, while low-enrolling clinics struggle with earlier steps in the CCT enrollment process, such as identifying eligible trials. These findings highlight the need for multi-level, tailored interventions to improve AYA enrollment in the community setting.
Article
Oncology
Mariam F. Eskander, Lindsay Gil, Eliza W. Beal, Yaming Li, Ahmad Hamad, Bridget Oppong, Samilia Obeng-Gyasi, Allan Tsung
Summary: The study found that age, race, insurance, and geography are barriers to clinical trial enrollment for pancreatic cancer patients. Despite an overall increase in enrollment, Black patients and patients on Medicaid remain underrepresented. Social determinants of health are still associated with clinical trial enrollment after adjusting for cancer-specific factors, suggesting the need for targeted interventions.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Pediatrics
Elliott Mark Weiss, Katherine F. Guttmann, Aleksandra E. Olszewski, Brooke E. Magnus, Sijia Li, Scott Y. H. Kim, Anita R. Shah, Sandra E. Juul, Yvonne W. Wu, Kaashif A. Ahmad, Ellen Bendel-Stenzel, Natalia A. Isaza, Andrea L. Lampland, Amit M. Mathur, Rakesh Rao, David Riley, David G. Russell, Zeynep N. Salih, Carrie B. Torr, Joern-Hendrik Weitkamp, Uchenna E. Anani, Taeun Chang, Juanita Dudley, John Flibotte, Erin M. Havrilla, Alexandra C. O'Kane, Krystle Perez, Brenda J. Stanley, Seema K. Shah, Benjamin S. Wilfond
Summary: The study revealed that the parental experience of recruitment varied by enrollment status. Parents who declined to enroll preferred to be approached by clinical team members rather than research team members, while enrolled parents more frequently reported positive initial impressions. Many parents in both groups made their decision early in the recruitment process.
JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Stephen M. Bart, John J. Farley, Shukal Bala, Thushi Amini, Edward Cox
Summary: As drug development becomes more globalized, geographical recruitment trends for recent antibacterial clinical trials vary by indication, but demographic characteristics and microbiology are broadly similar across regions, alleviating concerns about generalizability due to shifting enrollment trends.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Computer Science, Information Systems
Miao Qi, Amar K. K. Das, Kristin P. P. Bennett
Summary: Randomized clinical trials are widely considered as the most reliable form of evidence for treatment efficacy. However, if the trial population is not representative of the intended patients, the results may not be applicable in clinical practice. To address this issue, we propose a goal-programming approach to design equitable enrollment plans that consider measurable goals. Our model successfully generates enrollment plans that achieve sample representativeness and minimum cost, and it can also detect and adjust deviations during the enrollment process. Furthermore, by selecting appropriate sites, our model can demonstrate the possibility of enrolling a nationally representative study population even with geographic constraints.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Hematology
Lori Muffly, Jun Yin, Sawyer Jacobson, Anna Wall, Elisa Quiroz, Anjali S. Advani, Selina M. Luger, Martin S. Tallman, Mark R. Litzow, Matthew C. Foster, Harry P. Erba, Frederick R. Appelbaum, Richard A. Larson, Theresa H. M. Keegan, Wendy Stock
Summary: Hispanic patients treated on CALGB 10403 performed similarly to NHWs and better than population estimates, with higher rates of protocol completion. However, there was a geographical misalignment between trial sites and disease epidemiology, possibly explaining the lower-than-expected enrollment of Hispanic AYA ALL patients.
Article
Multidisciplinary Sciences
Josue Chirinos, Isabella M. Turco, Raffaele F. Di Fenza, Stefano Gianni, Grant Larson, Joseph Swingle, Oluwaseun Akeju, Lorenzo Berra
Summary: The COVID-19 pandemic has had a significant impact on non-COVID-19 clinical research, but little is known about how patients have responded to clinical trial recruitment during this time. This study investigated the effect of the pandemic on patient consent rates for non-COVID-19 clinical trials, finding a significant decrease in consent rates during the pandemic.
Review
Oncology
Mitchell S. von Itzstein, Melanie Hullings, Helen Mayo, M. Shaalan Beg, Erin L. Williams, David E. Gerber
Summary: The use of information technology platforms in cancer clinical trials has increased efficiencies in site selection, patient recruitment, and patient screening, but more studies are needed to fully understand its impact in oncologic settings. The complexity and individualized nature of oncologic clinical care and trial protocols may limit the applicability of experience from other fields using this technology. Further research is required to determine how these services can address ongoing challenges in cancer clinical research.
Article
Health Care Sciences & Services
Jessica A. Cao, Sagar B. Patel, Calvin W. Wong, David Garcia, Jose Munoz, Cassandra Cone, Deneva Zamora, Mary Reagan, Tieu V. Nguyen, Will Pearce, Richard H. Fish, David M. Brown, Varun Chaudhary, Charles C. Wykoff, Kenneth C. Fan
Summary: This study examines the impact of historical marginalization on the enrollment process of clinical trials for retinal diseases. It suggests that factors such as age, gender, race, ethnicity, preferred language, and socioeconomic status may affect patient participation in these trials.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Kaitlyn F. Melnick, Patricia Miller, Ethan Carmichael, Kyle McGrath, Ashley Ghiaseddin, David D. Tran, Maryam Rahman
Summary: Participation in a clinical trial is associated with improved survival in patients with GBM, regardless of treatment arm.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Joseph M. Unger, Melissa Beauchemin, Dawn L. Hershman
Summary: Adolescent and young adult (AYA) cancer patients have not experienced the same survival improvements as pediatric or older adult patients, potentially due to lower participation in clinical trials. This study found that AYA patients were well represented in SWOG trials, with a more racially/ethnically diverse population compared to older patients, but less diversity compared to the US AYA cancer population.
Article
Surgery
Vina Y. Chhaya, C. Chase Binion, Shanen M. Mulles, Paige A. Tannhauser, Daniel Z. Aziz, James D. Greenwood, Mark H. Barlek, Jessica R. Rouan, Thomas G. Wyatt, Melina R. Kibbe
Summary: This study aims to explore whether female enrollment in clinical trials published in high-impact journals from 2015 to 2019 is correlated with the gender of first and/or senior authors. The results show that more females were enrolled when both first and senior authors were female. However, the proportion of female enrollment decreased when the first and senior authors were male. Additionally, female enrollment was influenced by factors such as funding source, phase, trial type, and geographic location.
ANNALS OF VASCULAR SURGERY
(2023)
