4.7 Article

Ambulatory ECMO as a Bridge to Lung Transplant in a Previously Well Pediatric Patient With ARDS

Journal

PEDIATRICS
Volume 134, Issue 2, Pages E583-E585

Publisher

AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2013-3435

Keywords

extracorporeal membrane oxygenation; lung transplant; rehabilitation; acute respiratory distress syndrome; acute lung injury; air leak; pneumothorax; ambulation; physical therapy; respiratory failure; pediatric

Categories

Ask authors/readers for more resources

Extracorporeal membrane oxygenation (ECMO) is increasingly implemented in patients with end-stage pulmonary disease as a bridge to lung transplant. Several centers have instituted an approach that involves physical rehabilitation and ambulation for patients supported with ECMO. Recent reports describe the successful use of ambulatory ECMO in patients with chronic respiratory illnesses being bridged to lung transplant. We describe the first case of a previously healthy pediatric patient with acute respiratory failure successfully supported with ambulatory ECMO as a bridge to lung transplant after an unsuccessful bridge to recovery. Although there are challenges associated with awake and ambulatory ECMO in children, this strategy represents an exciting breakthrough and a potential paradigm shift in ECMO management for pediatric acute respiratory failure.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Biotechnology & Applied Microbiology

Development of a novel intravascular oxygenator catheter: Oxygen mass transfer properties across nonporous hollow fiber membranes

Stewart Farling, Tobias L. Straube, Travis P. Vesel, Nick Bottenus, Bruce Klitzman, Ira M. Cheifetz, Marc A. Deshusses

Summary: The study demonstrates the technical feasibility of providing oxygen to blood through nonporous hollow fiber membranes using hyperbaric oxygen. Oxygen transfer rate is related to oxygen pressure and bulk liquid mixing.

BIOTECHNOLOGY AND BIOENGINEERING (2021)

Article Critical Care Medicine

High-Frequency Jet Ventilation in Pediatric Acute Respiratory Failure

Andrew G. Miller, Kaitlyn E. Haynes, Rachel M. Gates, Karan R. Kumar, Ira M. Cheifetz, Alexandre T. Rotta

Summary: High-frequency jet ventilation (HFJV) is associated with improved ventilation in pediatric critical care patients, but does not significantly impact oxygenation. Patients with higher Pediatric Index of Mortality 2 scores, immunocompromised status, and lower airway resistance have a higher risk of mortality.

RESPIRATORY CARE (2021)

Article Engineering, Biomedical

Veno-Venous Extracorporeal Membrane Oxygenation for Children With Cancer or Hematopoietic Cell Transplant: A Ten Center Cohort

Brian C. Bridges, Todd J. Kilbaugh, Ryan P. Barbaro, Melania M. Bembea, Ranjit S. Chima, Renee M. Potera, Elizabeth A. Rosner, Hitesh S. Sandhu, James E. Slaven, Keiko M. Tarquinio, Ira M. Cheifetz, Courtney M. Rowan, Matthew L. Friedman

Summary: This study compared outcomes of children aged 14 days to 18 years in the US with cancer or HCT who received V-V ECMO support from 2011 to 2016. Children with oncology or HCT had higher ICU mortality, mortality on ECMO, and conversion rate to V-A ECMO compared to other children receiving V-V ECMO support.

ASAIO JOURNAL (2021)

Article Critical Care Medicine

Adherence to Lung-Protective Ventilation Principles in Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study*

Anoopindar K. Bhalla, Margaret J. Klein, Guillaume Emeriaud, Yolanda M. Lopez-Fernandez, Natalie Napolitano, Analia Fernandez, Awni M. Al-Subu, Rainer Gedeit, Steven L. Shein, Ryan Nofziger, Deyin Doreen Hsing, George Briassoulis, Stavroula Ilia, Florent Baudin, Byron Enrique Pineres-Olave, Ledys Maria Izquierdo, John C. Lin, Ira M. Cheifetz, Martin C. J. Kneyber, Lincoln Smith, Robinder G. Khemani, Christopher J. L. Newth

Summary: The study described mechanical ventilation management in pediatric acute respiratory distress syndrome and found that nonadherence to lung-protective ventilation principles is common, potentially impacting outcomes. Modifiable factors exist that may improve adherence.

CRITICAL CARE MEDICINE (2021)

Article Critical Care Medicine

Early Neuromuscular Blockade in Moderate-to-Severe Pediatric Acute Respiratory Distress Syndrome

Michelle W. Rudolph, Martin C. J. Kneyber, Lisa A. Asaro, Ira M. Cheifetz, David Wypij, Martha A. Q. Curley

Summary: This study aims to evaluate the use of neuromuscular blocking agents in pediatric acute respiratory distress syndrome (PARDS). It was found that early NMBA use was associated with a longer duration of mechanical ventilation (MV), but not with mortality or long-term cognitive and functional impairment.

CRITICAL CARE MEDICINE (2022)

Article Pediatrics

Respiratory Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference

Nadir Yehya, Robinder G. Khemani, Simon Erickson, Lincoln S. Smith, Courtney M. Rowan, Philippe Jouvet, Doug F. Willson, Ira M. Cheifetz, Shan Ward, Neal J. Thomas

Summary: This study aimed to develop an operational and evidence-based definition of respiratory dysfunction for critically ill children through a comprehensive literature review.

PEDIATRICS (2022)

Article Pediatrics

Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary

Melania M. Bembea, Michael Agus, Ayse Akcan-Arikan, Peta Alexander, Rajit Basu, Tellen D. Bennett, Desmond Bohn, Leonardo R. Brandao, Ann-Marie Brown, Joseph A. Carcillo, Paul Checchia, Jill Cholette, Ira M. Cheifetz, Timothy Cornell, Allan Doctor, Michelle Eckerle, Simon Erickson, Reid W. D. Farris, E. Vincent S. Faustino, Julie C. Fitzgerald, Dana Y. Fuhrman, John S. Giuliano, Kristin Guilliams, Michael Gaies, Stephen M. Gorga, Mark Hall, Sheila J. Hanson, Mary Hartman, Amanda B. Hassinger, Sharon Y. Irving, Howard Jeffries, Philippe Jouvet, Sujatha Kannan, Oliver Karam, Robinder G. Khemani, Niranjan Kissoon, Jacques Lacroix, Peter Laussen, Francis Leclerc, Jan Hau Lee, Stephane Leteurtre, Katie Lobner, Patrick J. McKiernan, Kusum Menon, Paul Monagle, Jennifer A. Muszynski, Folafoluwa Odetola, Robert Parker, Nazima Pathan, Richard W. Pierce, Jose Pineda, Jose M. Prince, Karen A. Robinson, Courtney M. Rowan, Lindsay M. Ryerson, L. Nelson Sanchez-Pinto, Luregn J. Schlapbach, David T. Selewski, Lara S. Shekerdemian, Dennis Simon, Lincoln S. Smith, James E. Squires, Robert H. Squires, Scott M. Sutherland, Yves Ouellette, Michael C. Spaeder, Vijay Srinivasan, Marie E. Steiner, Robert C. Tasker, Ravi Thiagarajan, Neal Thomas, Pierre Tissieres, Chani Traube, Marisa Tucci, Katri Typpo, Mark S. Wainwright, Shan L. Ward, R. Scott Watson, Scott Weiss, Jane Whitney, Doug Willson, James L. Wynn, Nadir Yehya, Jerry J. Zimmerman

Summary: The prior criteria for organ dysfunction in critically ill children were based on expert opinion. This study summarized data characterizing single and multiple organ dysfunction and derived contemporary criteria for pediatric organ dysfunction through systematic reviews of the literature. A total of 43 criteria for pediatric organ dysfunction were established, providing a foundation for researchers to identify and study organ dysfunction in critically ill children.

PEDIATRICS (2022)

Article Critical Care Medicine

Trends in Time to Extubation for Pediatric Postoperative Cardiac Patients and Its Correlation With Changes in Clinical Outcomes: A Virtual PICU Database Study*

Rebecca Epstein, Shelley J. Ohliger, Ira M. Cheifetz, Sindhoosha Malay, Steven L. Shein

Summary: This study retrospectively analyzed the trends in early extubation after cardiac surgery in children and evaluated the outcomes of centers that practiced early extubation more frequently. The study found that although the overall early extubation rates did not change significantly, centers with higher rates had more ICU-free time and lower reintubation rates in univariable analysis. However, after adjusting for other factors, the early extubation rates were not associated with improved outcomes.

PEDIATRIC CRITICAL CARE MEDICINE (2022)

Article Critical Care Medicine

Flexible Bronchoscopy in Pediatric Venovenous Extracorporeal Membrane Oxygenation

Elizabeth A. Rosner, Jessica L. Parker, Caryn Vandenberg, Brian C. Bridges, Todd J. Kilbaugh, Melania M. Bembea, Ranjit S. Chima, Renee M. Potera, Hitesh S. Sandhu, Ryan P. Barbaro, Keiko M. Tarquinio, Ira M. Cheifetz, Matthew L. Friedman

Summary: This study assessed the clinical course of pediatric patients with ARDS who underwent flexible bronchoscopy (FB) while on venovenous extracorporeal membrane oxygenation (VV-ECMO). The results showed that FB can be performed with a low incidence of complications on patients receiving VV-ECMO. Early FB may be beneficial for the efficacy of VV-ECMO and is associated with shorter ICU length of stay.

RESPIRATORY CARE (2022)

Review Critical Care Medicine

Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts

Tobias L. Straube, Stewart Farling, Marc A. Deshusses, Bruce Klitzman, Ira M. Cheifetz, Travis P. Vesel

Summary: Acute respiratory failure is a common reason for ICU admission, but there are limited treatment options beyond invasive ventilation. Development of intravascular respiratory assist catheters for gas exchange has had limited success.

RESPIRATORY CARE (2022)

Editorial Material Critical Care Medicine

Electrical Impedance Tomography in Mechanically Ventilated Children: Will It Impact Clinical Care?

John T. Gallagher, Kevin L. Ives, Ira M. Cheifetz

RESPIRATORY CARE (2022)

Review Respiratory System

High flow nasal cannula in the pediatric intensive care unit

Jason A. Clayton, Katherine N. Slain, Steven L. Shein, Ira M. Cheifetz

Summary: The use of high flow nasal cannula (HFNC) in pediatric intensive care units (PICUs) has become widespread, but there is a lack of studies evaluating its safety and efficacy. This scoping review examines the application and mechanisms of HFNC in critically ill children. Current research is limited to small observational studies, and there is a need for more robust studies to evaluate patient-centered outcomes.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2022)

Review Cardiac & Cardiovascular Systems

Current evidence for pharmacologic therapy following stage 1 palliation for single ventricle congenital heart disease

Meredith C. G. Broberg, Ira M. Cheifetz, Sarah T. Plummer

Summary: Infants with single ventricle congenital heart disease are prone to complications between stage 1 and stage 2 of treatment. This article discusses the medical management during this interstage period, focusing on angiotensin converting enzyme inhibitors, digoxin, and other commonly used medications. The lack of evidence and the complexity of the condition highlight the importance of careful evaluation and consideration of the risks and benefits of each medication.

EXPERT REVIEW OF CARDIOVASCULAR THERAPY (2022)

Editorial Material Critical Care Medicine

Pediatric Acute Lung Injury and Sepsis Investigators (PALISI): Evolution of an Investigator-Initiated Research Network

Adrienne G. Randolph, Melania M. Bembea, Ira M. Cheifetz, Martha A. Q. Curley, Heidi R. Flori, Robinder G. Khemani, Sapna R. Kudchadkar, Akira Nishisaki, R. Scott Watson, Marisa Tucci, Jacques Lacroix, Ann E. Thompson, Neal J. Thomas

Summary: The PALISI Network, established over 20 years ago, aims to optimize the care of critically ill infants and children through research. The network is funded by subscriptions from members and has evolved to include investigators from over 90 pediatric intensive care units in the US and Canada. The research focus of the network has expanded beyond sepsis and acute lung injury to encompass various aspects of pediatric critical care.

PEDIATRIC CRITICAL CARE MEDICINE (2022)

Proceedings Paper Engineering, Biomedical

Ultrasonic bubble detection and tracking using spatial coherence and motion modeling

Nick Bottenus, Tobias Straube, Stewart Farling, Travis Vesel, Bruce Klitzman, Marc A. Deshusses, Ira M. Cheifetz

Summary: This study introduces a newly developed intravascular oxygenator catheter capable of delivering oxygen directly to the bloodstream of patients, using ultrasound imaging and image processing technology to address the issue of bubble formation during oxygenation. Experimental results show that there was no significant increase in bubble counts after 30 minutes of oxygenation using the device.

MEDICAL IMAGING 2021: ULTRASONIC IMAGING AND TOMOGRAPHY (2021)

No Data Available