Article
Public, Environmental & Occupational Health
Dagrun Slettebo Daltveit, Kari Klungsoyr, Anders Engeland, Anders Ekbom, Mika Gissler, Ingrid Glimelius, Tom Grotmol, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Rebecca Troisi, Tone Bjorge
Summary: This study found an association between childhood cancer and birth defects, with a stronger association observed among females. However, birth defects did not fully explain the differences in childhood cancer risk by sex, suggesting the involvement of other biological pathways.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Cari M. Kitahara, Dagrun Slettebo Daltveit, Anders Ekbom, Anders Engeland, Mika Gissler, Ingrid Glimelius, Tom Grotmol, Ylva Trolle Lagerros, Laura Madanat-Harjuoja, Tuija Mannisto, Henrik Toft Sorensen, Rebecca Troisi, Tone Bjorge
Summary: Thyroid cancer is often diagnosed at a younger age compared to other malignancies, with in-utero exposures related to maternal thyroid disorders being associated with an increased risk of thyroid cancer in offspring. The study used registry data from four Nordic countries to assess these associations and found that factors such as higher birth weight, congenital hypothyroidism, and maternal thyroid disorders were linked to a higher risk of thyroid cancer in offspring.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Roshan John Selvaratnam, Euan Morrison Wallace, Rory Wolfe, Peter John Anderson, Mary-Ann Davey
Summary: This study in Victoria, Australia found that iatrogenic delivery of infants with severe SGA due to suspected FGR was associated with poorer school outcomes compared with infants with severe SGA not suspected of having FGR. Iatrogenic delivery of infants with normal growth due to suspected FGR was not associated with poorer school outcomes compared with infants with normal growth not suspected of having FGR.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Environmental Sciences
Yu Jin, Zhiyi Li, Hang An, Yiming Pang, Kexin Li, Yali Zhang, Le Zhang, Lailai Yan, Bin Wang, Rongwei Ye, Zhiwen Li, Aiguo Ren
Summary: This study found that higher maternal blood titanium concentration in early pregnancy may increase the risk of low birth weight infants, with lipid metabolism and oxidative stress potentially playing important roles in the health effects associated with titanium exposure during pregnancy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Obstetrics & Gynecology
Hong-Jiao Liu, Peng-Cheng Liu, Jing Hua, Yan Zhao, Jia Cao
Summary: Reductions in placental weight and size are associated with decreased birth weight and increased odds of fetal growth restriction (FGR). These associations are more significant in male fetuses.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Editorial Material
Genetics & Heredity
David M. Evans, Rachel M. Freathy
Summary: This study utilized extensive pedigree data from the Icelandic population to identify genetic effects on birth weight that differ according to parental origin, and to distinguish the contributions from the maternal intrauterine environment and offspring genetics on fetal growth.
Article
Obstetrics & Gynecology
Chileshe M. Mabula-Bwalya, Megan E. Smithmyer, Humphrey Mwape, Gabriel Chipili, Madelyn Conner, Bellington Vwalika, Kristina De Paris, Jeffrey S. A. Stringer, Joan T. Price
Summary: Biomarker concentrations were similar between cases and controls. Participants with concomitant low sEng and high sFLT-1 had the highest odds of SGA, suggesting that a combination of biomarkers may be better for predicting SGA than single biomarkers.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Nutrition & Dietetics
Malgorzata Lewandowska
Summary: The study found that maternal pre-pregnancy obesity is associated with an increased risk of low birth weight, fetal growth restriction, and macrosomia in newborns. Additionally, the risk of macrosomia was three times higher for obese mothers, while the risk of low birth weight was 17 times higher, particularly in the subgroup of normal gestational weight gain. The risk profile showed that higher BMI values were associated with a higher risk of these outcomes, with specific threshold BMI values identified.
Article
Nutrition & Dietetics
Zainab Akhter, Nicola Heslehurst, Dries Ceulemans, Judith Rankin, Roger Ackroyd, Roland Devlieger
Summary: Prior bariatric surgery is a significant risk factor for delivering small for gestational age (SGA) babies, with factors such as gestational weight gain, receiving nutritional advice, and weight management playing significant roles in influencing the risk of SGA babies.
Article
Health Care Sciences & Services
Daniela-Loredana Bujorescu, Adrian Ratiu, Cosmin Citu, Florin Gorun, Oana Maria Gorun, Doru Ciprian Crisan, Alina-Ramona Cozlac, Ioana Chiorean-Cojocaru, Mihaela Tunescu, Zoran Laurentiu Popa, Roxana Folescu, Andrei Motoc
Summary: The optimal timing of delivery in cases of early onset fetal growth restriction is challenging to determine due to the opposing risks of stillbirth and prematurity. This study aimed to assess the likelihood of neonatal complications based on the time of birth, using Doppler parameters in fetuses with early onset fetal growth restriction. The findings suggest that infants delivered at the onset of umbilical arteries absent/reversed end-diastolic flow are less likely to develop intraventricular hemorrhage grades III/IV and bronchopulmonary dysplasia.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Environmental Sciences
Lei Jiang, Qinru Xiao, Jianqing Zhang, Yang Zhao, Lihua Chen, Shaoyou Lu
Summary: The potential hazards of polycyclic aromatic hydrocarbons (PAHs) on fetus development have raised widespread concerns in recent years. This study investigated the relationship between PAH concentrations in maternal serum and low birth weight (LBW) by conducting a questionnaire survey and analyzing blood samples from neonates in Shenzhen, China.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ayya Keshet, Hagai Rossman, Smadar Shilo, Shiri Barbash-Hazan, Guy Amit, Maytal Bivas-Benita, Chen Yanover, Irena Girshovitz, Pinchas Akiva, Avi Ben-Haroush, Eran Hadar, Arnon Wiznitzer, Eran Segal
Summary: This study assessed the long-term impact of cesarean delivery on childhood outcomes using a large dataset and simulated trial approach. The findings suggest that children born via cesarean delivery have an increased risk of asthma, higher body mass index, and more respiratory infections. These results were replicated in a separate UK cohort.
Article
Infectious Diseases
Chamara V. Senaratna, Piyumali K. Perera, Segarajasingam Arulkumaran, Nirupama Abeysekara, Pramodya Piyumanthi, Garun S. Hamilton, Gillian M. Nixon, Rupika S. Rajakaruna, Shyamali C. Dharmage
Summary: The study in Sri Lanka found a significant association between asthma and helminthiasis, particularly with Trichiuris trichura infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Victoria E. de Knegt, Paula L. Hedley, Jorgen K. Kanters, Ida N. Thagaard, Lone Krebs, Michael Christiansen, Ulrik Lausten-Thomsen
Summary: Leptin plays a crucial role in regulating pregnancy-related functions and its dysregulation during pregnancy can lead to pre-eclampsia and restricted fetal growth. The regulatory mechanisms involving leptin in pre-eclampsia are specific to each situation, and the dysregulation of leptin likely affects fetal growth through complex interactions with parallel pregnancy systems throughout pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Megan E. Smithmyer, Chileshe M. Mabula-Bwalya, Humphrey Mwape, Gabriel Chipili, Bridget M. Spelke, Margaret P. Kasaro, Kristina De Paris, Bellington Vwalika, Yuri V. Sebastiao, Jeffrey S. A. Stringer, Joan T. Price
Summary: Maternal HIV infection may lead to adverse birth outcomes through an imbalance in angiogenic factors like PlGF and sFLT-1 in the VEGF signaling pathway. Lower concentrations of these biomarkers were associated with adverse birth outcomes, particularly preterm birth and stillbirth, but larger studies are needed for further confirmation of these findings.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Gastroenterology & Hepatology
Rajani Sharma, Tracey G. Simon, Olof Stephansson, Elizabeth C. Verna, Jean Emond, Jonas Soderling, Bjorn Roelstraete, Hannes Hagstrom, Jonas F. Ludvigsson
Summary: This study found that women with autoimmune hepatitis (AIH) have a higher risk of preterm birth during pregnancy compared to the general population. Moreover, AIH was also associated with low birth weight, low 5-minute Apgar score, and some obstetric complications such as cesarean section and preeclampsia.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sissel Jessen Weissert, Ellen Margrethe Mikkelsen, Bjarke H. Jacobsen, Elizabeth E. Hatch, Amelia K. Wesselink, Lauren A. Wise, Kenneth J. Rothman, Henrik T. Sorensen, Anne Sofie Dam Laursen
Summary: This study found no meaningful association between consumption of organic food and fecundability in couples trying to conceive. However, slightly higher fecundability was observed among participants with less than 3 cycles of pregnancy attempt time when they consumed more organic food.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Gencer Kurt, Helene M. L. Svane, Rune Erichsen, Uffe Heide-Jorgensen, Henrik T. Sorensen, Evan S. Dellon, Elizabeth T. Jensen
Summary: This study is a nationwide and registry-based case-control study that found an association between early-life exposures and eosinophilic esophagitis (EoE). Further research is needed to elucidate the mechanisms underlying the observed associations.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Endocrinology & Metabolism
Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J. Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Levy, Brian D. Bradbury, Amy Hai Yan Chan, Manju Chandran, Cyrus Cooper, Maria de Ridder, Caroline Y. Doyon, Cecile Droz-Perroteau, Ganga Ganesan, Sirpa Hartikainen, Jenni Ilomaki, Han Eol Jeong, Douglas P. Kiel, Kiyoshi Kubota, Edward Chia-Cheng Lai, Jeff L. Lange, E. Michael Lewiecki, Julian Lin, Jiannong Liu, Joe Maskell, Mirhelen Mendes de Abreu, James O'Kelly, Nobuhiro Ooba, Alma B. Pedersen, Albert Prats-Uribe, Daniel Prieto-Alhambra, Simon Xiwen Qin, Ju-Young Shin, Henrik T. Sorensen, Kelvin Bryan Tan, Tracy Thomas, Anna-Maija Tolppanen, Katia M. C. Verhamme, Grace Hsin-Min Wang, Sawaeng Watcharathanakij, Stephen J. Wood, Ching-Lung Cheung, Ian C. K. Wong
Summary: In this international study, the researchers analyzed the incidence of hip fractures, post-fracture treatment, and all-cause mortality following hip fractures across different countries and regions. They used patient-level healthcare data from 19 countries and identified 4,115,046 hip fractures from 2005 to 2018. The study revealed variations in the global epidemiology of hip fractures and post-fracture outcomes, highlighting the need for interventions to reduce the burden of osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Behavioral Sciences
Nils Skajaa, Emil Bjerregaard Riahi, Szimonetta Komjathine Szepligeti, Erzsebet Horvath-Puho, Trine Toft Sorensen, Victor W. Henderson, Henrik Toft Sorensen
Summary: Using Danish nationwide registries, this study found that patients with type 2 diabetes and obesity had a reduced risk of ALS compared to the general population, especially among men and those aged 60 or above.
BRAIN AND BEHAVIOR
(2023)
Article
Hematology
Hanke M. G. Wiegers, Dora Kormendine Farkas, Erzsebet Horvath-Puho, Saskia Middeldorp, Nick van Es, Henrik T. Sorensen
Summary: The study aimed to estimate the incidence rate of superficial vein thrombosis (SVT) during pregnancy and the post-partum period, as well as the risk of subsequent venous thromboembolism. The results showed a low incidence rate of SVT, but a high risk of developing venous thromboembolism during the same pregnancy if SVT was diagnosed.
LANCET HAEMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Sia Kromann Nicolaisen, Lars Pedersen, Daniel R. Witte, Henrik Toft Sorensen, Reimar Wernich Thomsen
Summary: This study aimed to estimate the prevalence, incidence, mortality, and risk of progression to type 2 diabetes for individuals with HbA1c-defined prediabetes based on Danish nationwide population-based laboratory databases. The results showed that out of 100 Danish adults, 1.4 develop prediabetes each year, and they can be identified at an early stage in laboratory databases. Within five years, one in six individuals with prediabetes dies, and one in five progresses to diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Teresa Vest, Kirsi Rantanen, Liisa Verho, Karoliina Aarnio, Aino Korhonen, Anna Richardt, Daniel Strbian, Mika Gissler, Hannele Laivuori, Minna Tikkanen, Petra Ijas
Summary: Intracerebral hemorrhage during pregnancy or puerperium (pICH) is a major cause of maternal death globally, but limited epidemiological data exist on its etiology and outcomes. This study found that hypertensive disorders of pregnancy (HDPs) were the main risk factor for pICH, with high maternal mortality and a significant proportion of surviving women experiencing severe disabilities three months later. Therefore, early recognition and treatment of HDPs are crucial in preventing this serious pregnancy complication.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Zahra Roustaei, Anna Heino, Sonja Kiuru-Kuhlefelt, Joan K. Morris, Svetlana Glinianaia, Ester Garne, Maria Loane, Judith Rankin, Mika Gissler
Summary: A study in Finland found that children with major congenital anomalies are less likely to apply for further education compared to children without anomalies. However, most non-chromosomal congenital anomalies did not have a significant impact on educational achievement. Factors such as male sex, lower maternal education levels, and younger maternal age were associated with lower educational achievement in children with congenital anomalies.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Neurosciences
Kasper Bonnesen, Uffe Heide-Jorgensen, Henrik Toft Sorensen, Morten Schmidt
Summary: This study compared the discriminatory performance of the Danish comorbidity index for acute myocardial infarction (DANCAMI), the Charlson comorbidity index (CCI), the Elixhauser comorbidity index (ECI), and the CHA2DS2-VASc score in predicting ischemic stroke, cardiovascular mortality, and all-cause mortality after atrial fibrillation/flutter. The results showed that DANCAMI had similar predictive performance to CCI, ECI, and CHA2DS2-VASc for ischemic stroke and cardiovascular mortality risks. DANCAMI also had better predictive performance for all-cause mortality risk compared to the baseline and CHA2DS2-VASc.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Martin Bodtker Mortensen, Johnny Kahlert, Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Henrik Toft Sorensen, Reimar Wernich Thomsen, Michael Maeng
Summary: Newly diagnosed type 2 diabetes mellitus significantly increases the risk of cardiovascular disease in patients, especially among younger individuals. Compared to the general population, individuals with type 2 diabetes have a significantly higher 10-year risk of developing cardiovascular events, occurring at least 12 years earlier.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Pediatrics
Elizabeth T. Jensen, Helene M. Svane, Rune Erichsen, Gencer Kurt, Uffe Heide-Jorgensen, Henrik T. Sorensen, Evan S. Dellon
Summary: This population-based case-control study in Denmark found an association between maternal and infant use of antibiotics and acid suppressants and increased risk of developing EoE. The risk was highest when exposure occurred near the time of delivery. Early life exposure may be a critical period for risk and risk mitigation.
Article
Health Care Sciences & Services
Henrik Toft Sorensen, Lars Pedersen, Nick van Es, Harry R. Bueller, Erzsebet Horvath-Puho
Summary: Despite improvements in cancer treatment, venous thromboembolism is strongly associated with poor long-term survival in cancer patients.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Hematology
Helle Jorgensen, Erzsebet Horvath-Puho, Kristina Laugesen, Sigrid K. Braekkan, John-Bjarne Hansen, Henrik Toft Sorensen
Summary: This study examines the association between acute venous thromboembolism (VTE) and the risk of subsequent depression. Based on Danish nationwide registries, a population-based cohort of 64,596 individuals with incident VTE and a comparison cohort of 322,999 randomly selected individuals were established. The results show that VTE is associated with a 2.35-fold increased risk of depression compared to the comparison cohort, even after adjusting for socioeconomic status and comorbidities.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Pediatrics
Joanne Given, Joan K. Morris, Ester Garne, Elisa Ballardini, Laia Barrachina-Bonet, Clara Cavero-Carbonell, Mika Gissler, Francesca Gorini, Anna Heino, Sue Jordan, Amanda J. Neville, Anna Pierini, Ieuan Scanlon, Joachim Tan, Stine K. Urhoj, Maria Loane
Summary: This study aimed to evaluate the prescription rates of insulin/insulin analogues in children aged 0-9 years with and without major congenital anomalies. The results showed that children with chromosomal anomalies had an increased risk of developing diabetes requiring insulin therapy, while children with non-chromosomal anomalies had a similar risk to the reference group. Female children had a reduced risk, and preterm births without congenital anomalies were more likely to be prescribed insulin/insulin analogues.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)