Journal
TRENDS IN NEUROSCIENCES
Volume 38, Issue 11, Pages 701-711Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2015.08.012
Keywords
-
Categories
Funding
- FEDER (QREN), through Programa Mais Centro [CENTRO-07-ST24-FEDER-002002, CENTRO-07-ST24-FEDER-002006]
- Programa Operacional Factores de Competitividade (COMPETE)
- National funds via Fundacao para a Ciencia e a Tecnologia (FCT) [UID/NEU/04539/2013, PTDC/SAU-FCF/099082/2008, SFRH/BD/73004/2010]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/73004/2010, PTDC/SAU-FCF/099082/2008] Funding Source: FCT
Ask authors/readers for more resources
Accumulating evidence suggests that neuropeptide Y (NPY) has a role in aging and lifespan determination. In this review, we critically discuss age-related changes in NPY levels in the brain, together with recent findings concerning the contribution of NPY to, and impact on, six hallmarks of aging, specifically: loss of proteostasis, stem cell exhaustion, altered intercellular communication, deregulated nutrient sensing, cellular senescence, and mitochondria! dysfunction. Understanding how NPY contributes to, and counteracts, these hallmarks of aging will open new avenues of research on limiting damage related to aging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
