Review
Oncology
Bita Shahrami, Mohammad Biglari, Romina Kaveh-Ahangaran, Soroush Rad, Molouk Hadjibabaie, Mohammad Vaezi
Summary: This study re-evaluated the emetogenicity of commonly accepted chemotherapy regimens based on drug administration, drug-drug interactions, combination therapy, and delayed CINV. Revised CINV prophylaxis protocols and recommendations for hematologic malignancies and solid tumors have been presented based on the availability of prophylactic medications.
EUROPEAN JOURNAL OF CANCER CARE
(2023)
Article
Medicine, General & Internal
Tauseef Ahmad, Uzma Zarafshan, Bushra Sahar
Summary: This study compared the efficacy of Ondansetron and Domperidone in treating vomiting in children with acute gastroenteritis. The results showed that Ondansetron was more effective than Domperidone in stopping vomiting.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yao-Zhong Zhao, Yong-Zhao Dai, Ke Nie
Summary: Chemotherapy-induced nausea and vomiting significantly affects the quality of life in cancer patients. Traditional Chinese medicine has been recognized for its potential in treating these side effects, leading to increased research attention.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Yongzhao Dai, Yaozhong Zhao, Ke Nie
Summary: Gingerols, the main bioactive pungent constituents of ginger, have shown antiemetic effects against chemotherapy-induced nausea and vomiting (CINV), and their mechanisms have been explored. This review summarizes the potential targets and signaling pathways of gingerols in preventing CINV using network pharmacology.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Microbiology
Maria Antonia De Francesco, Giovanni Lorenzin, Antonella Meini, Richard Fabian Schumacher, Arnaldo Caruso
Summary: This study investigated the prevalence of human adenovirus infections in hospitalized pediatric patients, finding that HAdV was detected in 7.1% of stool samples with a high diversity of isolates. A majority of HAdV positives were in children under 5 years old, and genetic analysis revealed the presence of two HAdV species (B and C) with three types. This highlights the need for routine molecular assays with wide reactivity for rapid and accurate diagnosis.
MICROBIOLOGY SPECTRUM
(2021)
Article
Immunology
Chia-Yi Wu, Hsin Chi, Ching-Chuan Liu, Yhu-Chering Huang, Yi-Chuan Huang, Hsiao-Chuan Lin, Yu-Huai Ho, Li-Min Huang, Ching-Yi Huang, Shu-Man Shih, Fang-Tzy Wu, Jung-Jung Mu, Chao A. Hsiung
Summary: This study aimed to explore the clinical characteristics and risk factors of norovirus gastroenteritis among children in Taiwan.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Multidisciplinary Sciences
Martin Crozier, Janice Tubman, Bre-Anne Fifield, Rosa-Maria Ferraiuolo, Jenna Ritchie, Katie Zuccato, Emily Mailloux, Indrajit Sinha, Caroline Hamm, Lisa A. Porter
Summary: Dex treatment exacerbates the metastatic potential of ER- breast cancer cells, highlighting the adverse role of glucocorticoids in breast cancer biology.
Article
Immunology
Rachel M. Burke, Shuman Shih, Chao Agnes Hsiung, Catherine Yen, Baoming Jiang, Umesh D. Parashar, Jacqueline E. Tate, Fang-Tzy Wu, Yhu-Chering Huang
Summary: Although Taiwan did not include rotavirus vaccines in the national immunization schedule, the study found that the vaccines still significantly reduced pediatric hospitalization rates associated with rotavirus.
Article
Oncology
Matti Aapro, Florian Scotte, Yolanda Escobar, Luigi Celio, Richard Berman, Alessandra Franceschetti, Danielle Bell, Karin Jordan
Summary: This study reveals low adherence to antiemetic guidelines in highly emetogenic chemotherapy setting in daily clinical practice across five European countries, with only 15% of patients receiving guideline-recommended NK(1)RA-5-HT(3)RA-dexamethasone prophylaxis and 12% receiving no antiemetics. Strategies to improve adherence to guidelines are urgently needed.
Article
Oncology
Mototsugu Shimokawa, Naoki Haratake, Kazuki Takada, Gouji Toyokawa, Shinkichi Takamori, Fumitaka Mizuki, Tomoyoshi Takenaka, Toshinobu Hayashi
Summary: This study examined the incidence of delayed chemotherapy-induced nausea and vomiting in non-small cell lung cancer patients receiving carboplatin-based chemotherapy, finding that a three-antiemetic regimen controlled CINV better than a two-antiemetic regimen. It also identified individual risk factors such as female sex, younger age, and specific chemotherapy regimens, recommending additional supportive antiemetic treatment for these patients.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Kira L. R. Newman, Caitlin R. K. Wolf, Jennifer K. A. Logue, Janet A. Englund, Michael Y. Boeckh, Helen Y. Chu, Seattle Flu Study Investigators
Summary: This study investigated the incidence of gastrointestinal (GI) symptoms in patients with acute respiratory illness (ARI) in the Seattle area during the 2018-2019 winter season. The results showed that 29.4% of ARI patients had GI symptoms, and these symptoms were associated with pathogen detection, illness severity, and symptom burden. The study suggests that GI symptoms may be nonspecific rather than pathogen-mediated.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Immunology
Celeste M. Donato, Susie Roczo-Farkas, Carl D. Kirkwood, Graeme L. Barnes, Julie E. Bines
Summary: This study describes rotavirus disease and genotypic diversity in the Australian population aged ≥ 5 years. A substantial burden was identified, particularly in children 5-9 years and the elderly. Genotype distribution and diversity fluctuated annually and varied among age groups.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Christopher C. H. Yip, L. Li, Thomas K. H. Lau, Vicky T. C. Chan, Carol C. H. Kwok, Joyce J. S. Suen, Frankie K. F. Mo, Winnie Yeo
Summary: This retrospective analysis compared the efficacy of olanzapine-based and NEPA-based regimens in controlling chemotherapy-induced nausea and vomiting (CINV) in breast cancer patients receiving AC. The olanzapine group showed higher rates of no rescue therapy and no significant nausea during cycle 1 of AC. However, there were no differences in quality of life between the two groups. Multiple cycle assessment revealed higher rates of total control in the NEPA group in later cycles. These results do not support the superiority of either regimen for breast cancer patients receiving AC.
HONG KONG MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Xavier Sanchez, Gerardine Leal, Angel Padilla, Ruth Jimbo
Summary: The objective of this study was to estimate the direct medical cost per episode and the annual cost for acute diarrhea in children under five in Ambulatory Care Centers of the Ministry of Public Health of Ecuador. The study found that a high proportion of the direct medical cost of acute diarrhea in children under five in outpatient settings is due to unnecessary laboratory tests.
Article
Virology
Munazza Fatima, Dilshad A. Khan, Deeba Amraiz, Munir A. Lodhi, Eijaz Ghani, Saifullah K. Niazi, Sakhawat Ali
Summary: This study aimed to detect the genotypic distribution of predominant rotavirus strains in children suffering from acute gastroenteritis in Rawalpindi, Pakistan. The results showed that rotavirus infection was mainly found in children aged 2 and below, with the peak incidence at 6-12 months. Subtype G1P[8] was the most prevalent. These findings provide useful information for developing strategies to control and prevent diarrheal infections in children.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Pediatrics
Martin Gariepy MEng, Mona Beaunoyer, Marie-Claude Miron, Jocelyn Gravel
PAEDIATRICS & CHILD HEALTH
(2020)
Article
Emergency Medicine
Jaryd Zummer, Marie-Pier Desjardins, Jade Seguin, Michel Roy, Jocelyn Gravel
Summary: This study aimed to investigate whether the use of ultrasound by emergency physicians improves the probability of first-attempt success for lumbar puncture in children. Results showed a slightly higher success rate in the ultrasound group compared to the standard procedure group, but the difference was not statistically significant. Therefore, routine use of ultrasound for performing lumbar puncture in children is not supported.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pediatrics
Esli Osmanlliu, Antonio D'Angelo, Marie-Claude Miron, Marianne Beaudin, Nathalie Gaucher, Jocelyn Gravel
Summary: The study revealed that there is a short median delay between diagnosis and initiation of reduction for ileocolic intussusception patients at the pediatric hospital, especially among transferred patients and children with intravenous access prior to diagnosis. Complications from pneumatic reduction were infrequent.
PAEDIATRICS & CHILD HEALTH
(2021)
Article
Pediatrics
Sarah Rogers, Jocelyn Gravel, Gregory Anderson, Jesse Papenburg, Caroline Quach, Brett Burstein
Summary: The study retrospectively analyzed traumatic lumbar punctures in febrile infants <= 60 days old at two tertiary pediatric hospitals from 2006 through 2018. By using correction factors, half of the patients were safely reclassified with improved specificity in cerebrospinal fluid results. These corrections are helpful in enhancing the interpretative accuracy of traumatic lumbar puncture results.
PAEDIATRICS & CHILD HEALTH
(2021)
Article
Emergency Medicine
Aude Tonson la Tour, Marie Pier Desjardins, Jocelyn Gravel
Summary: This study showed that point-of-care ultrasound (POCUS) has very good sensitivity and specificity for intussusception in children when performed by emergency physicians with varying levels of experience.
ACADEMIC EMERGENCY MEDICINE
(2021)
Article
Emergency Medicine
Serge Gouin, Laurence Alix-Seguin, Marie Pier Desjardins, Jocelyn Gravel, Denis Lebel, Nathalie Gaucher
Summary: The use of oral sweet solutions did not statistically reduce pain scores in infants (1-3 months) undergoing nasopharyngeal aspiration.
JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pediatrics
Sarah Mousseau, Maude Poitras, Annie Lapointe, Bich Hong Nguyen, Catherine Hervouet-Zeiber, Jocelyn Gravel
Summary: The study found that there was no significant difference in diagnostic accuracy for AOM between students exposed to an e-learning module or a small-group lecture, but the majority of students preferred the e-learning modality.
PAEDIATRICS & CHILD HEALTH
(2021)
Article
Psychology, Developmental
Nicholas Chadi, Cesare Spinoso-Di Piano, Esli Osmanlliu, Jocelyn Gravel, Olivier Drouin
Summary: The study found an increase in the proportion of mental health-related emergency department visits during July-December 2020 (p < .01), with a 62% increase in eating disorder visits between 2018-2019 and 2020 (p < .01). However, there were no changes in the proportion of visits resulting in hospitalization for any of the four diagnostic categories.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Letter
Emergency Medicine
Soha Rached-d'Astous, Benoit Bailey, Christopher Marquis, Denis Lebel, Marie-Pier Desjardins, Evelyne D. Trottier
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Marie-Anne Pepin, Anne-Sophie Otis, Zoe Tremblay, Marianne Boule, Denis Lebel, Philippe Major, Anne Lortie, Elana Pinchefsky, Elsa Rossignol, Bruce Carleton, Jean-Francois Bussieres, Marie-Elaine Metras
Summary: A pragmatic mixed-methods prospective observational study found that clinicians and patients favor the implementation of pharmacogenetic testing in the field of pediatric epilepsy to improve patient care. Most participants had a positive view of these tests, particularly in terms of their receptiveness, characteristics, and integration into practice.
PERSONALIZED MEDICINE
(2022)
Letter
Emergency Medicine
Laura Simone, Roger Zemek, Damian Roland, Mark D. Lyttle, Simon Craig, Stuart R. Dalziel, Jocelyn Gravel, Yaron Finkelstein, Sarah Curtis, Stephen B. Freedman, Amy C. Plint, Suzanne Schuh
EMERGENCY MEDICINE JOURNAL
(2023)
Letter
Pediatrics
Francesca del Giorgio, Merieme Habti, Joanna Merckx, Jay S. Kaufman, Jocelyn Gravel, Nelson Piche, Esli Osmanlliu, Olivier Drouin
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Emilie Kate Landry, Julie Autmizguine, Sophie Berube, Raphael Kraus, Marie-Elaine Metras, Denis Lebel, Catherine Litalien
Summary: Despite international efforts, many drugs for children need to be compounded from adult dosage forms due to unavailability of suitable commercial formulations. A study on hospitalized children at a Canadian pediatric hospital found that compounded drugs for enteral administration (CDEA) accounted for 13% of all prescriptions and 23% of enteral administration prescriptions. Collaboration is needed to ensure availability of these drugs to Canadian children, considering that many CDEA are commercially available in other jurisdictions.
Article
Pediatrics
Francesca del Giorgio, Jocelyn Gravel, Nelson Piche, Olivier Drouin
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Critical Care Medicine
Michael Buyck, Yasaman Shayan, Jocelyn Gravel, Elizabeth A. Hunt, Adam Cheng, Arielle Levy
Summary: The study evaluated the impact of a CPR Coach on adherence to PALS guidelines during simulated paediatric cardiac arrest, showing that teams with a CPR Coach demonstrated better compliance with the PALS guidelines.
RESUSCITATION PLUS
(2021)