Article
Clinical Neurology
Jose-Miguel Yamal, Imoigele P. Aisiku, H. Julia Hannay, Frances A. Brito, Claudia S. Robertson
Summary: This study suggests that Disability Rating Scale (DRS) collected during the weeks 1 to 4 after severe traumatic brain injury (TBI) may be predictors of favorable 6-month outcome. The results indicate that this early marker could be useful for guiding clinical decision making and adaptive clinical trials.
Article
Neurosciences
Claire Vallat-Azouvi, Marie Swaenepoel, Alexis Ruet, Eleonore Bayen, Idir Ghout, Gaelle Nelson, Pascale Pradat-Diehl, Layide Meaude, Philippe Aegerter, James Charanton, Claire Jourdan, Philippe Azouvi
Summary: In a long-term study of patients with severe traumatic brain injury, cognitive testing and questionnaires were significantly correlated with functional outcome measures, while life satisfaction was only related to patient-rated questionnaires.
Article
Clinical Neurology
Jan Stubberud, Ruth Hypher, Anne E. Brandt, Torun G. Finnanger, Eva Skovlund, Stein Andersson, Kari Risnes, Torstein B. Ro
Summary: This study aimed to identify factors associated with impairments in functional school outcomes in children with pediatric acquired brain injury (pABI), with a specific focus on the significance of fatigue. The results showed that fatigue, IQ, global functioning, behavioral problems, and sex were potential predictors for functional school outcomes. Fatigue emerged as the strongest potential predictor for parent-reported and self-reported quality of life in school. The study suggests that personalized accommodations tailored to the child's specific function and symptoms, such as fatigue, are recommended for reintroduction to school after pABI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medical Laboratory Technology
Yun Xie, Zhidong Guo, Fanghui Chen, Chen Xiao, Jianping Xu, Dezhi Bo
Summary: The study found that serum netrin-1 concentrations in TBI patients are closely related to prognosis, and may serve as a potential biomarker for predicting outcomes in TBI patients.
CLINICA CHIMICA ACTA
(2021)
Article
Clinical Neurology
Brian E. Powers, Son T. Ton, Robert G. Farrer, Suhani Chaudhary, Russ P. Nockels, Gwendolyn L. Kartje, Shih-Yen Tsai
Summary: This study suggests that anti-Nogo-A antibody treatment may improve functional recovery by promoting axonal growth and neuronal plasticity in individuals with traumatic brain injury. The experiments conducted on rats showed significant improvement in motor deficits after receiving the treatment, indicating the potential efficacy of anti-Nogo-A Ab therapy for patients with TBI.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Rehabilitation
Sara Neumane, Hugo Camara-Costa, Leila Francillette, Melanie Araujo, Hanna Toure, Dominique Brugel, Anne Laurent-Vannier, Linda Ewing-Cobbs, Philippe Meyer, Georges Dellatolas, Laurence Watier, Mathilde Chevignard
Summary: A study followed 45 children with severe TBI for 24 months, finding that functional impairments were mainly related to socio-emotional, cognitive and physical impairments, and the severity of initial TBI was the main prognostic factor associated with functional status.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Rehabilitation
Sinikka Tarvonen-Schroder, Mari Koivisto
Summary: This study compares the functioning of patients with traumatic brain injury measured using the World Health Organization Disability Assessment Schedule (WHODAS-12) completed by patients and proxies with assessments made by professionals. The study found that disability increased with the severity of traumatic brain injury, as measured by different assessment tools. Proxies rated functioning as more impaired than patients, but there was still a strong correlation between patient and proxy assessments.
JOURNAL OF REHABILITATION MEDICINE
(2023)
Article
Rehabilitation
Sara Neumane, Hugo Camara-Costa, Leila Francillette, Hanna Toure, Dominique Brugel, Anne Laurent-Vannier, Philippe Meyer, Laurence Watier, Georges Dellatolas, Mathilde Chevignard
Summary: This study described the functional outcomes of childhood severe TBI at 1 and 7 years post-injury and found that functional impairment at 1 year post-injury was the best predictor of long-term disability at 7 years.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Medicine, Research & Experimental
Orli Thau-Zuchman, Linda Svendsen, Simon C. Dyall, Ursula Paredes-Esquivel, Molly Rhodes, John Priestley, Rene G. Feichtinger, Barbara Kofler, Susanne Lotstra, J. Martin Verkuyl, Robert J. Hageman, Laus M. Broersen, Nick van Wijk, Jose P. Silva, Jordi L. Tremoleda, Adina T. Michael-Titus
Summary: The new ketogenic diet (KD) with a ratio of 2:1 of fat to carbohydrate plus protein showed neuroprotective potential in adult traumatic brain injury (TBI). It significantly improved sensorimotor deficits and spatial memory, reduced lesion size, inflammation, oxidation, and oligodendrocyte loss. The new formulation demonstrated therapeutic potential in adult TBI by enhancing the mTOR pathway and histone modifications.
Article
Neurosciences
Mecca B. A. R. Islam, Booker T. Davis IV, Mary J. Kando, Qinwen Mao, Daniele Procissi, Craig Weiss, Steven J. Schwulst
Summary: The study found that young adult mice showed more severe neuropathology and greater loss of white matter connectivity after TBI compared to aged mice. Differential functional outcomes were also observed in anxiety response, learning, and memory between young adult and aged mice after TBI.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Critical Care Medicine
Peter Ferrazzano, Benjamin Yeske, Jeanette Mumford, Gregory Kirk, Erin D. Bigler, Katherine Bowen, Nicole O'Brien, Bedda Rosario, Sue R. Beers, Paul Rathouz, Michael J. Bell, Andrew L. Alexander
Summary: Adolescent traumatic brain injury is a significant public health issue, with neuroimaging being a primary diagnostic tool. This study aimed to identify imaging biomarkers for long-term neurocognitive outcomes after severe adolescent TBI, finding associations between VBR and corpus callosum cross-sectional area with overall functional and neurocognitive outcomes.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Rehabilitation
Marie-Julie Potvin, Pauline Brayet, Veronique Paradis, Charles Overbeek, Erik Therrien, Laurie-Anne Dion, Francis Bernard, Nadia Gosselin, Isabelle Rouleau, Olivier Boucher, Jean-Francois Giguere
Summary: The study aimed to predict long-term functional outcomes in traumatic brain injury patients using the new test EXACT and found that EXACT, in some cases, may predict functional outcomes more accurately than PTA, suggesting it could be a promising tool for future TBI recovery research.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Neurosciences
Jing Wang, Yujiao Lu, Christopher Carr, Krishnan M. Dhandapani, Darrell W. Brann
Summary: This study found that long-term (months) after traumatic brain injury (TBI), there is a significant presence of proinflammatory senescent cells in the brain. The administration of senolytic drugs can improve long-term functional outcomes by reducing inflammation and neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Nada Andelic, Cecilie Roe, Olli Tenovuo, Philippe Azouvi, Helen Dawes, Marek Majdan, Jukka Ranta, Emilie I. Howe, Eveline J. A. Wiegers, Cathrine Tverdal, Ida Borgen, Marit V. Forslund, Ingerid Kleffelgaard, Hilde M. Dahl, Louis Jacob, Melanie Cogne, Juan Lu, Nicole von Steinbuechel, Marina Zeldovich
Summary: This study aimed to assess rehabilitation needs and services for individuals with moderate-to-severe disability after traumatic brain injury. The study found that severity of brain injury, physical and cognitive impairments increased the likelihood of receiving rehabilitation, while psychological problems decreased it.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Valeria Pingue, Valentina Boetto, Anna Bassetto, Maruska Nava, Antonio Nardone, Chiara Mele
Summary: This study retrospectively evaluated the impact of decompressive craniectomy on functional outcomes, mortality, and the occurrence of seizures in patients with traumatic brain injury (TBI). The results showed that decompressive craniectomy was not significantly associated with poor functional outcomes or mortality, but it was associated with the occurrence of seizures.