Article
Clinical Neurology
Elisabeth Bloch-Salisbury, Lauren McKenna, Emma Boland, Donald Chin
Summary: Premature infants often face disruptions in sleep due to adverse noise in the neonatal intensive care unit. This study found that a hearing protection device called DREAMIES may help improve sleep in premature infants by reducing noise levels.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Pediatrics
Christine Manich Bech Baggesgaard, Anja Poulsen, Kia Hee Schultz Dungu, Lotte Jensen, Hanna Rahimi, Lise Aunsholt, Stine Lund
Summary: This study investigated the timeliness of childhood vaccinations in preterm infants in Denmark and identified factors influencing delayed vaccination. The results showed that most preterm infants received the first vaccination on time, but the timeliness decreased with subsequent vaccinations. Therefore, efforts should be made to educate healthcare personnel and parents to ensure timely vaccination.
Article
Pediatrics
Jonathan Wen Yi Ong, Lucy Everitt, Jodie Hiscutt, Catherine Griffiths, Alison McEvoy, Kevin Colin William Goss, Mark John Johnson, Hazel J. Evans
Summary: This retrospective cohort study aimed to describe the background characteristics, comorbidities, characteristics at the initiation of ventilation, and outcomes of ex-preterm infants with severe bronchopulmonary dysplasia established on long-term ventilation. The results showed that noninvasive ventilation is a feasible option, while tracheostomy invasive ventilation requires longer hospital stays.
PEDIATRIC PULMONOLOGY
(2022)
Article
Dermatology
Zeyao Shi, Xiaowen Li
Summary: This study compares the predictive ability and reliability of two pressure injury assessment tools, the Neonatal/Infant (N/I) Braden Q and Braden QD scale, in neonates. The results show that both scales are valid and reliable in predicting the risk of pressure injury in the neonatal intensive care unit (NICU), but the N/I Braden Q scale is better at distinguishing patients at risk and not at risk than the Braden QD scale.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Infectious Diseases
Marcus Wing Choy Loe, Kee Thai Yeo
Summary: This study aimed to describe the patterns of early-life surface colonization with multidrug resistant organisms (MDROs) among newborns in the neonatal intensive care unit (NICU). The study found that MDROs accounted for a certain proportion of gram-negative bacteria in this setting.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Ophthalmology
Sylvia M. F. Mayer, Larissa K. G. Mazarollo, Cristina Okamoto, Luciane Moreira, Luisa M. Hopker
Summary: This study evaluated patients in two neonatal intensive care units in Parana/Brazil and identified risk factors for the development of retinopathy of prematurity. The results suggest that early neonatal care and transportation of premature infants may influence the occurrence and prognosis of the disease.
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA
(2022)
Article
Hematology
Victoria Robinson, Meredith A. Achey, Uttara P. Nag, Christopher R. Reed, Kristy S. Pahl, Rachel G. Greenberg, Reese H. Clark, Elisabeth T. Tracy
Summary: Thrombosis in neonatal intensive care unit (NICU) patients is associated with prematurity, low birth weight, sepsis, and invasive procedures. The majority of infants diagnosed with thrombosis do not receive anticoagulation, but those who do have higher disease rates. Thrombosis in infants is linked to higher mortality and longer hospital stays.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Pediatrics
Tim J. van Hasselt, Kirstin Webster, Chris Gale, Elizabeth S. Draper, Sarah E. Seaton
Summary: This study conducted a systematic review to compare the proportion of preterm-born and term-born children admitted to a pediatric intensive care unit (PICU) for respiratory syncytial virus (RSV) and/or bronchiolitis, and their outcomes in PICU. The study found that preterm-born children had a higher risk of requiring invasive ventilation in PICU compared to term-born children, but there was no significant increase in the risk of mortality within PICU for preterm-born children.
Review
Pediatrics
Paula Rodriguez Gonzalez, Veronica Perez-Cabezas, Gema Chamorro-Moriana, Carmen Ruiz Molinero, Ana Maria Vazquez-Casares, Gloria Gonzalez-Medina
Summary: Oral sensorimotor stimulation shows significant benefits in helping preterm infants achieve independent oral feeding, promoting the maturation of sucking patterns, transitioning to full feeding, improving motor function, and reducing the length of hospital stay.
Article
Pediatrics
Yi Dai, Li Zhu, Yequn Zhou, Chao Chen, Shulian Zhang
Summary: This study found an increasing trend in the incidence of retinopathy of prematurity among extremely preterm infants in a large neonatal care unit in China over the past 10 years. The increased survival rate and use of high-target oxygen saturation in the later period may partly explain this trend. Further investigations are needed to improve care practices and reduce the incidence of severe retinopathy of prematurity.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Marina Caballero-Bellon, Anna Alonso-Saladrigues, Sara Bobillo-Perez, Anna Faura, Laura Arques, Cristina Rivera, Albert Catala, Jose Luis Dapena, Susana Rives, Iolanda Jordan
Summary: CAR-T-cell CD19 therapy is an effective treatment for relapsed/refractory B-cell acute lymphoblastic leukemia. However, it can lead to life-threatening toxicities that often require admission to the PICU. This study aims to describe the clinical characteristics, treatment, and outcome of these patients. The results showed that the main reason for PICU admission after CAR-T therapy was cytokine release syndrome, and supportive treatment was effective in managing and improving survival. Some patients may experience a fulminant course with CAR-T-associated hemophagocytic lymphohistiocytosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Sophia Wang, Anthony J. Perkins, Rosalyn Chi, Brandon A. Yates, Sikandar H. Khan, Sujuan Gao, Malaz Boustani, Babar A. Khan
Summary: A secondary data analysis of ICU patients revealed that stroke and depression were identified as risk factors for post-ICU dementia, highlighting the need for interventions targeting these factors to reduce dementia incidence.
ALZHEIMERS & DEMENTIA
(2023)
Article
Nutrition & Dietetics
Melissa K. Blake, Ruixuan Ma, Erika Viana Cardenas, Parisa Varanloo, Yaray Agosto, Carolina Velasquez, Katheryn A. Espina, Joanne Palenzuela, Sarah E. Messiah, Ruby A. Natale
Summary: This study investigated the association between age at solid food initiation and obesity prevalence in preschool-aged children, taking into account disability status, ethnicity, gestational age, and birth weight. The findings revealed no significant difference in obesity prevalence based on age at solid food introduction. Children with disabilities and preterm births had significantly lower odds of being obese, while Hispanic children and those with higher birth weights were more likely to be obese.
Article
Pediatrics
Hongyu Chen, Le Dong
Summary: This study investigated the effect of family integrated care on the prognosis of hospitalized preterm infants. The results showed that family integrated care could shorten the duration of nasogastric tube retention, increase the rate of exclusive breastfeeding and weight gain, and have a positive effect on parents.
Article
Pediatrics
Fanny E. M. Goth, Birgitte J. Schmidt, Kent Green, Andreas K. Jensen, Lone Agertoft, Inger M. Jorgensen
Summary: The study found an age-specific association between neonatal fractional exhaled nitric oxide and respiratory symptoms in moderately premature infants. The risk of troublesome respiratory symptoms was associated with postnatal factors in premature infants and prenatal factors in mature infants.
PEDIATRIC PULMONOLOGY
(2021)
Article
Pediatrics
Jane E. Brumbaugh, Edward F. Bell, Shawn C. Hirsch, Emma G. Crenshaw, Sara B. DeMauro, Ira S. Adams-Chapman, Jean R. Lowe, Girija Natarajan, Myra H. Wyckoff, Betty R. Vohr, Tarah T. Colaizy, Heidi M. Harmon, Kristi L. Watterberg, Susan R. Hintz
Summary: This study found that children with mild retinopathy of prematurity (ROP) who did not receive intervention did not have adverse neurodevelopmental outcomes at 2 years' corrected age compared to children without ROP, but had an increased incidence of strabismus. This study addresses a gap in the literature regarding the relationship between milder forms of ROP that regress without intervention and neurodevelopment and vision outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Jean Lowe, Janell F. Fuller, Allison G. Dempsey, Barbara Do, Carla M. Bann, Abhik Das, Kathryn E. Gustafson, Betty R. Vohr, Susan R. Hintz, Kristi L. Watterberg
Summary: This study found that a blunted cortisol awakening response is associated with memory and attention problems in preterm children. This has implications for stress reactivity and learning problems in preterm children.
PEDIATRIC RESEARCH
(2023)
Review
Obstetrics & Gynecology
Jennifer Canvasser, Ravi Mangal Patel, Erin Pryor, Linseigh Green, Susan R. Hintz, Maureen Fagan, James D. Harrison
Summary: Necrotizing enterocolitis (NEC) is a devastating intestinal disease that primarily affects pre-mature infants. Limited research has evaluated the impact of NEC on long-term complications and quality of life in children older than two years. This study provides insight into the lived experience of NEC survivors and parents of children affected by NEC, revealing the long-term physical, mental, and social impacts of the disease on their quality of life.
SEMINARS IN PERINATOLOGY
(2023)
Letter
Medicine, General & Internal
Yair J. J. Blumenfeld, Susan R. R. Hintz, Natali Aziz, Richard A. A. Barth, Jacquelyn M. M. Spano, Yasser Y. Y. El-Sayed, Carlos Milla
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Susan R. Hintz, Raye-Ann deRegnier, Betty R. Vohr
CLINICS IN PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Richard J. Shaw, Angelica Moreyra, Stephanie Simon, Emily Wharton, LaTrice L. Dowtin, Erin Armer, Lindsey Wallace Goldman, Tonyanna Borkovi, Eric Neri, Booil Jo, Susan Hintz, Krisa Van Meurs, Sarah M. Horwitz
Summary: This study compared group-based intervention and individual therapy in reducing symptoms of posttraumatic stress, depression, and anxiety in parents of premature infants. The individual intervention showed greater improvement in trauma symptoms, although both conditions showed clinically significant improvement. In-person treatment was found to be superior to telehealth treatment, although the difference was not significant.
EARLY HUMAN DEVELOPMENT
(2023)
Article
Pediatrics
Jane E. Brumbaugh, Betty R. Vohr, Edward F. Bell, Carla M. Bann, Colm P. Travers, Elisabeth C. Mcgowan, Heidi M. Harmon, Waldemar A. Carlo, Andrea F. Duncan, Susan R. Hintz
Summary: This study aims to analyze the relationship between social determinants of health (SDOH) and outcomes for extremely preterm infants. The results showed that infants born to mothers with public/no insurance had older postmenstrual age (PMA) at discharge and were more likely to be readmitted. Children exposed to multiple risk-associated SDOH at birth had higher rates of neurodevelopmental impairment (NDI) and death postdischarge compared to those not exposed.
JOURNAL OF PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Katsuaki Kojima, Chunyan Liu, Shelley Ehrlich, Beth M. Kline-Fath, Shipra Jain, Nehal A. Parikh
Summary: This study aims to investigate the association between surgery under general anesthesia and brain abnormalities and neurodevelopmental outcomes in very preterm infants. The results showed that infants who underwent surgery had worse MRI abnormalities, but there was no association with developmental outcomes after propensity score matching.
JOURNAL OF PERINATOLOGY
(2023)
Article
Developmental Biology
Tatiana M. Lanzieri, Tianyao Lu, Mihoko V. Bennett, Susan R. Hintz, David E. Sugerman, Sheila C. Dollard, Megan H. Pesch, Maria A. L. Jocson, Henry C. Lee
Summary: This study investigated the demographics and outcomes of infants with cytomegalovirus (CMV) infection in California neonatal intensive care units (NICUs) from 2010 to 2021. The results showed that among infants with CMV, 94% were discharged home alive, 86% were referred to a high-risk infant follow-up (HRIF) program, and 65% had at least one visit. Furthermore, it was found that infants born to mothers under 20 years of age had the highest CMV reporting rates, and those born to Hispanic mothers accounted for 49% of all infected infants but had the highest loss of follow-up.
BIRTH DEFECTS RESEARCH
(2023)
Article
Medicine, General & Internal
Samuel J. Gentle, Matthew A. Rysavy, Lei Li, Matthew M. Laughon, Ravim. Patel, Erik A. Jensen, Susan Hintz, Namasivayam Ambalavanan, Waldemar A. Carlo, Kristi Watterberg
Summary: In extremely preterm infants, the use of hydrocortisone does not reduce the risk of bronchopulmonary dysplasia or death, nor does it increase the risk of neurodevelopmental impairment or death.
Article
Obstetrics & Gynecology
Michael W. Varner, Elizabeth A. Thom, C. Michael Cotten, Susan R. Hintz, Grier P. Page, Dwight J. Rouse, Brian M. Mercer, Maged M. Costantine, Yoram Sorokin, John M. Thorp Jr, Susan M. Ramin, Marshall W. Carpenter, Mary J. O'Sullivan, Alan M. Peaceman, George R. Saade, Donald J. Dudley, Steve N. Caritis
Summary: This study found genetic variants associated with adverse neurodevelopmental outcomes in extremely low birth weight infants, including a variant in the SERPINE1 gene that is associated with cerebral palsy or death.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Charles E. Green, Jon E. Tyson, Roy J. Heyne, Susan R. Hintz, Betty R. Vohr, Carla M. Bann, Abhik Das, Edward F. Bell, Sana Boral Debsareea, Emily Stephens, Marie G. Gantz, Carolyn M. Petrie Huitema, Karen J. Johnson, Kristi L. Watterberg, Ricardo Mosquera, Myriam Peralta-Carcelen, Deanne E. Wilson-Costello, Tarah T. Colaizy, Nathalie L. Maitre, Stephanie L. Merhar, Ira Adams-Chapman, Janell Fuller, Michelle E. Hartley-McAndrew, William F. Malcolm, Sarah Winter, Andrea F. Duncan, Gary J. Myer, Stephen D. Kicklighter, Myra H. Wyckoff, Sara B. DeMauro, Anna Maria Hibbs, Barbara J. Stoll, Waldemar A. Carlo, Krisa P. Van Meurs, Matthew A. Rysavy, Ravi M. Patel, Pablo J. Sanchez, Abbot R. Laptook, C. Michael Cotten, Carl T. D'Angio, Michele C. Walsh
Summary: The use of Bayley III norm-based thresholds may underestimate the impairment rates of extremely preterm infants. Assessing these rates relative to healthy term infants born in the same hospital may be a better approach.
JOURNAL OF PERINATOLOGY
(2023)
Article
Medicine, General & Internal
Valerie Y. Chock, Haresh Kirpalani, Edward F. Bell, Sylvia Tan, Susan R. Hintz, M. Bethany Ball, Emily Smith, Abhik Das, Yvonne C. Loggins, Beena G. Sood, Lina F. Chalak, Myra H. Wyckoff, Stephen D. Kicklighter, Kathleen A. Kennedy, Ravi M. Patel, Waldemar A. Carlo, Karen J. Johnson, Kristi L. Watterberg, Pablo J. Sanchez, Abbot R. Laptook, Ruth B. Seabrook, C. Michael Cotten, Toni Mancini, Gregory M. Sokol, Robin K. Ohls, Anna Maria Hibbs, Brenda B. Poindexter, Anne Marie Reynolds, Sara B. DeMauro, Sanjay Chawla, Mariana Baserga, Michele C. Walsh, Rosemary D. Higgins, Krisa P. Van Meurs
Summary: This study investigates the effects of red blood cell transfusion on cerebral and mesenteric tissue saturation in preterm infants and explores the association with degree of anemia and death or neurodevelopmental impairment. The results show an increase in tissue saturation after transfusion, and lower pretransfusion cerebral saturation may be associated with adverse outcomes.
Meeting Abstract
Obstetrics & Gynecology
Sivan Farladansky Gershnabel, Praveen Jayapal, Max Zalcman, Richard A. Barth, Erika Rubesova, Susan Hintz, Jiaqi Zhang, Stephanie A. Leonard, Yasser Y. El-Sayed, Yair J. Blumenfeld
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Pediatrics
Jean Lowe, Carla M. Bann, Allison G. Dempsey, Janell Fuller, H. Gerry Taylor, Kathryn E. Gustafson, Victoria E. Watson, Betty R. Vohr, Abhik Das, Seetha Shankaran, Kimberly Yolton, M. Bethany Ball, Susan R. Hintz
Summary: The study found that the Bayley-III cognitive and language scores are correlated with later IQ, but may not accurately predict developmental delay in school-aged children or misclassify those who are not delayed. The Bayley-III can be a useful tool in identifying extremely preterm infants who may be at risk for cognitive difficulties.
JOURNAL OF PEDIATRICS
(2023)