Article
Obstetrics & Gynecology
Raheleh Faramarzi, Azadeh Darabi, Maryam Emadzadeh, Gholamali Maamouri, Reyhane Rezvani
Summary: This retrospective cohort study aimed to evaluate neurodevelopmental outcomes of preterm infants in the NICU. By recalling the mentioned infants in 2021, the study assessed the neurodevelopmental outcomes using the Bayley Scales of Infant and Toddler Development, and found that prolonged hospital stays and longer duration of oxygen therapy were associated with developmental impairments in different domains.
EARLY HUMAN DEVELOPMENT
(2023)
Article
Medicine, Research & Experimental
Friederike Beker, Ian P. Hughes, Sue Jacobs, Helen G. Liley, Samudragupta Bora, Gabrielle Simcock, Peter G. Davis
Summary: The TASTE trial investigated the effects of smell and taste of milk with tube feeding on the growth of preterm infants. This follow-up study aims to assess the 2-year neurodevelopmental and growth outcomes of preterm infants exposed to the smell and taste of milk. The results showed higher head circumference and length z-scores in the intervention group at 36 weeks postmenstrual age.
Article
Nutrition & Dietetics
Erandi Hewawasam, Carmel T. Collins, Beverly S. Muhlhausler, Lisa N. Yelland, Lisa G. Smithers, John Colombo, Maria Makrides, Andrew J. McPhee, Jacqueline F. Gould
Summary: This study found that DHA supplementation in infants born preterm did not improve attention at 18 months' corrected age.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Pediatrics
Hanne Lademann, Anna Janning, Josephyn Mueller, Luisa Neumann, Dirk Olbertz, Jan Daebritz
Summary: This study investigates the combined influence of common risk factors and developmental care on the long-term outcome of preterm infants. It found that bronchopulmonary dysplasia and exclusive formula feeding were associated with a higher risk of developmental deficits in terms of mental, psychomotor development, and body length. National guidelines for developmental care did not fully prevent these outcomes. Future research may explore tailored measures based on individual risk factors.
Article
Medicine, General & Internal
Elisabeth C. McGowan, Julie A. Hofheimer, T. Michael O'Shea, Howard Kilbride, Brian S. Carter, Jennifer Check, Jennifer Helderman, Charles R. Neal, Steve Pastyrnak, Lynne M. Smith, Marie Camerota, Lynne M. Dansereau, Sheri A. Della Grotta, Barry M. Lester
Summary: This study found that high-risk neonatal neurobehavioral patterns at NICU discharge were associated with adverse cognitive, motor, and behavioral outcomes at 2 years.
Article
Orthopedics
Haluk Tekerlek, Bilge Nur Yardimci-Lokmanoglu, Deniz Inal-Ince, Ugur Ozcelik, Akmer Mutlu
Summary: Infants with cystic fibrosis (CF) may have delayed cognitive, language, and motor development. It is important to assess their developmental functioning as early as possible and consider age-specific early intervention programs when necessary.
Article
Pediatrics
Linlin Li, Zhenghong Li, Weilin Wan, Ji Li, Yu Zhang, Changyan Wang, Lin Wang
Summary: The study found that a combination of online and face-to-face follow-up during the COVID-19 epidemic can effectively alleviate the anxiety of parents of preterm infants and achieve a similar first-time follow-up rate as in 2019. Most parents were satisfied with online follow-up, but some still believed that it could not completely replace face-to-face follow-up.
FRONTIERS IN PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Miheret Yitayew, Nayef Chahin, Salem Rustom, Leroy R. Thacker, Karen D. Hendricks-Munoz
Summary: A study compared the performance of two growth-assessment tools, Fenton and Intergrowth-21st, in classifying size at birth, identifying growth failure, and predicting neurodevelopment in preterm infants. The results showed high agreement between the tools in identifying small for gestational age, but moderate agreement in classifying postnatal growth failure at discharge. Growth failure was less prevalent using IG-21st, and weight-based growth failure was significantly associated with poor neurodevelopmental outcomes at 12 and 24 months.
Article
Pediatrics
Tiina Saarinen, Milla Ylijoki, Liisa Lehtonen, Petriina Munck, Suvi Stolt, Helena Lapinleimu, Paivi Rautava, Leena Haataja, Sirkku Setanen, Marika Leppanen, Mira Huhtala, Katriina Saarinen, Linda Gronroos, Riikka Korja, PIPARI Study Grp
Summary: This paper introduces a web-based follow-up tool ePIPARI for preterm infants, aiming to investigate its feasibility and effectiveness in identifying children and parents in need of clinical interventions. ePIPARI includes 8 assessment points to evaluate the health, growth, eating and feeding, neurodevelopment, and parental well-being of infants. A study is conducted to compare web-based follow-up with ePIPARI to clinical follow-up for parents of preterm infants born before 34 weeks of gestation during 2019-2022.
Article
Biochemistry & Molecular Biology
Anna Janning, Hanne Lademann, Dirk Olbertz
Summary: This retrospective cohort study highlights the importance of early diagnosis of developmental delays using the MFED tool. Risk factors such as intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia are significantly associated with developmental delay. However, post-discharge developmental care therapies do not seem to have a clear beneficial effect on infant development.
Article
Obstetrics & Gynecology
Charles E. Green, Jon E. Tyson, Roy J. Heyne, Susan R. Hintz, Betty R. Vohr, Carla M. Bann, Abhik Das, Edward F. Bell, Sana Boral Debsareea, Emily Stephens, Marie G. Gantz, Carolyn M. Petrie Huitema, Karen J. Johnson, Kristi L. Watterberg, Ricardo Mosquera, Myriam Peralta-Carcelen, Deanne E. Wilson-Costello, Tarah T. Colaizy, Nathalie L. Maitre, Stephanie L. Merhar, Ira Adams-Chapman, Janell Fuller, Michelle E. Hartley-McAndrew, William F. Malcolm, Sarah Winter, Andrea F. Duncan, Gary J. Myer, Stephen D. Kicklighter, Myra H. Wyckoff, Sara B. DeMauro, Anna Maria Hibbs, Barbara J. Stoll, Waldemar A. Carlo, Krisa P. Van Meurs, Matthew A. Rysavy, Ravi M. Patel, Pablo J. Sanchez, Abbot R. Laptook, C. Michael Cotten, Carl T. D'Angio, Michele C. Walsh
Summary: The use of Bayley III norm-based thresholds may underestimate the impairment rates of extremely preterm infants. Assessing these rates relative to healthy term infants born in the same hospital may be a better approach.
JOURNAL OF PERINATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Oskar Komisarek, Roksana Malak, Jacek Kwiatkowski, Katarzyna Wiechec, Tomasz Szczapa, Joanna Kasperkowicz, Maja Matthews-Kozanecka, Teresa Matthews-Brzozowska, Malgorzata Wojcik, Wlodzimierz Samborski, Ewa Mojs
Summary: This study used surface electromyography to analyze the involvement of muscles in sucking and swallowing in premature infants and studied their relationship with gestational age, birth weight, and umbilical blood pH. The results showed that premature infants with younger gestational age had higher suprahyoid muscle tension, and there was a positive correlation between pH value and suprahyoid muscles. Therefore, sEMG may be a useful diagnostic tool in evaluating the masticatory system of premature infants.
Article
Nutrition & Dietetics
Robert D. D. Roghair, Tarah T. T. Colaizy, Baiba Steinbrekera, Reka A. Vass, Erica Hsu, Daniel Dagle, Trassanee Chatmethakul
Summary: Leptin deficiency in preterm infants is associated with adverse cardiovascular and neurodevelopmental outcomes. Supplementation of leptin can improve developmental assessment scores, particularly in males. Further research is needed to investigate the effects of neonatal leptin supplementation on long-term outcomes in preterm infants.
Review
Nutrition & Dietetics
Kendell R. German, Sandra E. Juul
Summary: Iron plays a critical role in brain development, with deficiencies potentially leading to permanent alterations in brain structure and function. Children with perinatal iron deficiency may experience delayed nerve conduction speeds, disrupted sleep patterns, motor deficits, and other issues.
Article
Medicine, General & Internal
Lisa Szatkowski, Don Sharkey, Helen Budge, Shalini Ojha
Summary: This study aimed to investigate the impact of opioids use during mechanical ventilation on infants born at <32 weeks' gestational age. The findings suggest that the use of opioids is associated with an increased risk of preterm brain injury in preterm infants.
Article
Endocrinology & Metabolism
Rolf H. H. Groenwold, Jelle J. Goeman, Saskia Le Cessie, Olaf M. Dekkers
Summary: In medical research, the testing of multiple hypotheses raises the risk of false-positive conclusions. Methods to mitigate this risk are discussed.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Jiao Luo, Fleur L. Meulmeester, Leon G. Martens, Nadia Ashrafi, Renee de Mutsert, Dennis O. Mook-Kanamori, Frits R. Rosendaal, Ko Willems van Dijk, Saskia le Cessie, Kevin Mills, Raymond Noordam, Diana van Heemst
Summary: A study on middle-aged individuals found that urinary oxidized metabolites were associated with glucose homeostasis, while blood alpha-TOH was not. This suggests that estimates of the conversion of alpha-TOH in urine may be more informative in relation to insulin resistance.
CLINICAL NUTRITION
(2021)
Article
Immunology
Anna M. Eikenboom, Saskia Le Cessie, Ingeborg Waernbaum, Rolf H. H. Groenwold, Mark G. J. de Boer
Summary: Propensity score methods are increasingly used in infectious disease medicine to study the effectiveness of antimicrobial therapy. However, the quality and reporting of these methods need improvement.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Hematology
Floris J. Kranenburg, Sesmu M. Arbous, Camila Caram-Deelder, Hein Putter, Saskia le Cessie, Johanna G. van der Bom
Summary: This study retrospectively analyzed the effect of red blood cell transfusion on organ functioning in nonbleeding critically ill patients, and found that the average effect of transfusion on next-day organ function was negligible for patients with hemoglobin concentrations between 6 and 9 g/dL. This suggests caution in clinical decision-making regarding transfusion for nonbleeding critically ill patients.
Review
Medicine, General & Internal
Kim van Bentem, Marie-Louise Van der Hoorn, Jan van Lith, Saskia le Cessie, Eileen Lashley
Summary: This study aims to conduct a DONOR IPD meta-analysis to determine the risk of developing hypertensive complications in oocyte donation (OD) pregnancy. The analysis will adjust for confounders, perform subgroup analysis, and externally validate a prediction model for the development of pre-eclampsia (PE) in OD pregnancy.
Article
Multidisciplinary Sciences
Alan J. Waring, Julian P. Whitelegge, Shantanu K. Sharma, Larry M. Gordon, Frans J. Walther
Summary: The three-dimensional structure of the synthetic lung Surfactant Protein B Peptide Super Mini-B was determined using mass spectrometry and isotope enhanced Fourier-transform infrared (FTIR) spectroscopy. Analysis confirmed the correct folding and disulfide pairing using oxidative structure-promoting solvent systems. The residue-specific analysis indicated well-defined alpha-helical sequences in the N-terminal and C-terminal domains. Molecular dynamics simulation further refined the structure and revealed a helical hairpin structure resembling critical elements of the predicted full-length Surfactant Protein B structure.
Article
Cardiac & Cardiovascular Systems
Jiao Luo, Raymond Noordam, J. Wouter Jukema, Ko Willems van Dijk, Sara Hagg, Felix Grassmann, Saskia le Cessie, Diana van Heemst
Summary: This study investigates the associations between leukocyte mitochondrial DNA abundance and coronary artery disease (CAD) and heart failure (HF), and utilizes Mendelian randomization for causal inference. The findings suggest that lower leukocyte mitochondrial DNA abundance is causally associated with higher CAD risk, but not with heart failure.
CARDIOVASCULAR RESEARCH
(2023)
Article
Transplantation
Robin Lengton, Esmee M. van der Willik, Esther N. M. de Rooij, Yvette Meuleman, Saskia Le Cessie, Wieneke M. Michels, Marc Hemmelder, Friedo W. Dekker, Ellen K. Hoogeveen
Summary: This study investigated the association between residual estimated glomerular filtration rate (eGFR), dialysis adequacy, or serum phosphate level and chronic kidney disease-associated pruritus (CKD-aP) in incident dialysis patients. The results showed that higher residual eGFR and lower serum phosphate level, but not the dialysis dose, were related to a lower burden of CKD-aP in dialysis patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Public, Environmental & Occupational Health
Jungyeon Choi, Olaf M. Dekkers, Saskia le Cessie
Summary: Ill-defined research questions can cause problems in epidemiological studies where measurements are subject to fluctuations due to events like medication use. Failing to specify how medication use should be handled during analysis can lead to arbitrary decisions and a disconnect between the intended question and analysis, resulting in different or meaningless interpretations of effects. This study discusses the formulation of well-defined research questions when medication use is involved, distinguishing between scenarios where exposure or outcome is affected by medication use and addressing methodological considerations under each question.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Mathematical & Computational Biology
Doranne Thomassen, Ewout Steyerberg, Saskia le Cessie
Summary: In clinical practice, it is crucial to determine the absolute risk reduction of treatment for individual patients. However, logistic regression in trials with binary outcomes provides estimates of treatment effects in terms of log odds differences. In this study, we propose a new Bayesian regression model for binary outcomes on the additive risk scale, allowing for direct estimation of treatment effects on the linear scale of clinical interest. Comparisons were made with a previously proposed additive risk model and backtransforming predictions from a logistic model. Results showed that modelling untransformed risk can yield significantly different treatment effect estimates, particularly for small sample sizes or extreme predicted risks close to 0% or 100%. Our proposed model proved to be more sensitive in detecting all information in the data in a network meta-analysis.
STATISTICS IN MEDICINE
(2023)
Article
Medical Laboratory Technology
Tirsa T. van Duijl, Esther N. M. de Rooij, Maxim M. Treep, Marte E. Koelemaij, Fred P. H. T. M. Romijn, Ellen K. Hoogeveen, L. Renee Ruhaak, Saskia le Cessie, Johan W. de Fijter, Christa M. Cobbaert
Summary: This study explored the potential of emerging and conventional urinary kidney injury biomarkers in different populations using LC-MS/MS analysis. The results showed that kidney injury biomarkers were increased in kidney transplant recipients with ischemia-reperfusion injury. NGAL and B2M showed the strongest response.
CLINICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Alan J. Waring, Grace C. -L. Jung, Shantanu K. Sharma, Frans J. Walther
Summary: Lung surfactant prevents lung collapse and is involved in innate immunity. Synthetic lung surfactant has shown clinical efficacy in surfactant-deficient premature infants and critically ill patients with acute respiratory distress syndrome (ARDS). COVID-19 pneumonia can cause loss and dysfunction of lung surfactant, which can be relieved by treatment with an exogenous lung surfactant. Synthetic lung surfactant peptide mimics can act as competitive inhibitors of the binding of viral receptor-binding domain (RBD) to the cellular receptor angiotensin-converting enzyme 2 (ACE2).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Leon G. Martens, Daan van Hamersveld, Saskia le Cessie, Ko Willems van Dijk, Diana van Heemst, Raymond Noordam
Summary: Low socioeconomic status (SES) is associated with increased cardiovascular risk factors and coronary artery disease (CAD) risk. This study found that SES can modify the association between classical cardiovascular risk factors and CAD in European-ancestry participants. Furthermore, the risk for CAD attributable to increased body mass index (BMI) is not the same across different SES groups.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Bart J. J. Velders, J. W. Taco Boltje, Michiel D. Vriesendorp, Robert J. M. Klautz, Saskia Le Cessie, Rolf H. H. Groenwold
Summary: This study systematically evaluated the quality of conduct and reporting of confounding adjustment methods in observational studies on cardiothoracic interventions. The findings showed insufficient reporting of these methods, making it difficult to assess the quality. Proper application of confounding adjustment methods is crucial for causal inference on optimal treatment strategies in clinical practice.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Friso M. Rijnberg, Luca C. van't Hul, Mark G. Hazekamp, Pieter J. van den Boogaard, Joe F. Juffermans, Hildo J. Lamb, Covadonga Terol Espinosa de Los Monteros, Lucia J. M. Kroft, Sasa Kenjeres, Saskia le Cessie, Monique R. M. Jongbloed, Jos J. M. Westenberg, Arno A. W. Roest, Jolanda J. Wentzel
Summary: This study investigated the relationship between conduit size and haemodynamics in adolescent Fontan patients. The results showed that most patients had relatively undersized conduits, leading to suboptimal haemodynamics.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
