Editorial Material
Clinical Neurology
Blazo Nikolic, Nikola Ivancevic, Ana Pepic, Marijana Kovacevic, Jelena Mladenovic, Branislav Rovcanin, Janko Samardzic, Jasna Jancic
Summary: Neuroretinitis caused by Bartonella henselae infection is a rare cause of vision loss in children. Two pediatric cases with acute unilateral vision loss and optic nerve edema were diagnosed with neuroretinitis based on fundoscopic examinations. High titers of IgM and IgG antibodies to Bartonella henselae were detected, confirming the causative agent. Both patients significantly recovered after oral antibiotic treatment.
Article
Public, Environmental & Occupational Health
Radeyah Waseem, Muskan Seher, Sohiba Ghazal, Hussain Haider Shah, Ume Habiba
Summary: Cat-scratch disease (CSD) is an infectious disease that presents with fever, headache, loss of appetite, weight loss, tender lymphadenopathy, and other symptoms. It is the most common cause of infectious lymphadenitis in children, adolescents, and young adults and is usually caused by a scratch or bite from a cat. The disease course is influenced by the patient's immune status.
FRONTIERS IN PUBLIC HEALTH
(2023)
Editorial Material
Clinical Neurology
Anelia Dietmann, Eugenie Colin-Benoit, Gerd Tinkhauser, Thomas Raphael Meinel, Olivier Scheidegger
Summary: This case report presents a cat owner with neuralgic amyotrophy caused by cat scratch disease. The patient initially presented with hand swelling, followed by lymphadenopathy and fever, and subsequently developed bilateral neuralgic amyotrophy. After thorough examination and treatment, the patient showed an excellent response to intravenous immunoglobulin.
Article
Multidisciplinary Sciences
Juan Yu, Xiong-Ying Zhang, Yun-Xia Chen, Hong-Bing Cheng, Dong-Mei Li, Hua-Xiang Rao
Summary: The prevalence and molecular characteristics of Bartonella infections in small rodents in the Zhongtiao Mountain, China were investigated. The study found a high infection rate and significant genetic diversity of Bartonella in small rodents, suggesting the presence of a potential novel species in the area.
Article
Immunology
Marcos Rogerio Andre, Pradeep Neupane, Michael Lappin, Brian Herrin, Vicki Smith, Taufika Islam Williams, Leonard Collins, Hongxia Bai, Gabriel Lemes Jorge, Tiago Santana Balbuena, Julie Bradley, Ricardo G. Maggi, Edward B. Breitschwerdt
Summary: Research found that proteins with different abundances showed different responses in cat fleas to blood feeding and/or infection by Bartonella henselae, with some proteins strongly associated with infection status. These findings help understand the complex interactions between cat fleas and Bartonella henselae at the protein level.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
David W. McCormick, Sara L. Rassoulian-Barrett, Daniel R. Hoogestraat, Stephen J. Salipante, Dhruba SenGupta, Elizabeth A. Dietrich, Brad T. Cookson, Grace E. Marx, Joshua A. Lieberman
Summary: Molecular methods can effectively identify Bartonella spp. infections, including uncommon and undescribed species. These methods can be particularly useful for patients with culture-negative endocarditis or lymphadenitis.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Kenneth M. Zangwill
Summary: Bartonella species have been linked to human diseases, with modern diagnostic methods expanding our knowledge. Host immune-modulated interactions play a major role in the clinical syndromes associated with these bacteria, leading to a wide range of responses to antimicrobial therapy. Clinical management for cat scratch disease varies among clinicians due to a lack of evidence base.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Immunology
Kenneth M. Zangwill
Summary: Bartonella species, previously known to cause human diseases with restricted geographic or environmental influences, have now been linked to a broader ecological niche. Cats and various arthropods are the main reservoirs and vectors for Bartonella transmission. Clinical management for cat scratch disease varies greatly among clinicians, reflecting a lack of strong evidence-based practices.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Paulina Sepulveda-Garcia, Amir Alabi, Karla Alvarez, Lisbeth Rojas, Armin Mella, Luiz Ricardo Goncalves, Marcos Rogerio Andre, Rosangela Zacarias Machado, Ananda Muller, Gustavo Monti
Summary: The aim of this study was to estimate the occurrence of Bartonella spp. in cats and their owners in Valdivia, Chile. The study found that 20.43% of households had at least one Bartonella positive cat, but Bartonella DNA was not found in the blood samples of humans. Risk factors for Bartonella spp. presence in cats included age, neutering status, sampling location, and improper tick/flea control products.
Article
Parasitology
Thais Nascimento de Andrade Oliveira Cruz, Luiz Ricardo Goncalves, Maria Eduarda Chiaradia Furquim, Marcos Rogerio Andre, Alexandre Diaz Munhoz, Renata Santiago Alberto Carlos, Fabiana Lessa Silva
Summary: This study investigated the occurrence of Bartonella spp. in blood and claw samples from domestic cats in northeastern Brazil, and found that 20.7% of the blood samples and 23.9% of the claw samples were positive. Animals positive for Bartonella spp. showed higher platelet values in the blood samples. Young and unsterilized cats with outdoor access were more prone to infection by Bartonella spp.
Article
Parasitology
Clara Morato Dias, Renan Bressianini do Amaral, Livia Perles, Antonia Laila dos Santos Muniz, Tarik Fernandes Goncalves Rocha, Rosangela Zacarias Machado, Marcos Rogerio Andre
Summary: In this study, Bartonella henselae isolates from domestic cats' blood samples in midwestern Brazil were genotyped. The results showed that certain genotypes of B. henselae are associated with human infections. The presence of ST1 and ST5 variants of B. henselae in domestic cats suggests the possibility of coinfection with different genotypes, which have also been found in humans with bartonellosis.
Article
Medicine, General & Internal
Zoheb I. Sulaiman, Hasan Samra, Gina Askar
Summary: Cat scratch disease is a bacterial infection caused by Bartonella henselae, commonly associated with young cats and kittens. It usually presents as subacute regional lymphadenitis, predominantly in children and young adults. Although immunocompetent patients have a good prognosis, immunocompromised adults can develop life-threatening complications. The disease is transmitted from cats to humans through scratching or biting. This article presents a case of a 29-year-old immunocompetent male with inguinal lymphadenitis, highlighting the importance of early recognition and targeted treatment of Bartonella lymphadenitis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Immunology
Alicia Perez Perez, Maria Fernandez Miaja, Paula Diaz Garcia, Laura Garcia Suarez, Mercedes Rodriguez Perez, Victoria Rodriguez de la Rua, Maria Agustina Alonso Alvarez
Summary: The use of corticosteroids for persistent fever in cat scratch disease is controversial. However, in this case study, the administration of corticosteroids led to afebrile state within 24 hours for a 5-year-old boy with systemic cat scratch disease.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Microbiology
Estefania Torrejon, Gustavo Seron Sanches, Leonardo Moerbeck, Lenira Santos, Marcos Rogerio Andre, Ana Domingos, Sandra Antunes
Summary: This study investigated the occurrence of Bartonella spp. in animals, humans, and ticks in Portugal. The results showed that B. henselae and B. clarridgeiae are circulating in stray cats from Lisbon, while the sampled dogs, humans, and ticks were negative for Bartonella spp.
Article
Public, Environmental & Occupational Health
Erin Lashnits, Ricardo Maggi, Fredrik Jarskog, Julie Bradley, Edward Breitschwerdt, Flavio Frohlich
Summary: In this study, it was found that individuals with central nervous system symptoms were more likely to have Bartonella spp. DNA in their bloodstream compared to healthy volunteers. However, there was no significant difference in the severity of schizophrenia/schizoaffective disorder symptoms between individuals with and without evidence of Bartonella spp. infection.
VECTOR-BORNE AND ZOONOTIC DISEASES
(2021)
Article
Pediatrics
Matthew J. Lipshaw, Michelle Eckerle, Todd A. Florin, Eric J. Crotty, Jessi Lipscomb, Judd Jacobs, Mantosh Rattan, Richard M. Ruddy, Samir S. Shah, Lilliam Ambroggio
Article
Pediatrics
Todd A. Florin, Lilliam Ambroggio, Cole Brokamp, Yin Zhang, Mantosh Rattan, Eric Crotty, Michael A. Belsky, Sara Krueger, Thomas N. Epperson, Andrea Kachelmeyer, Richard Ruddy, Samir S. Shah
Article
Immunology
Todd A. Florin, Lilliam Ambroggio, Cole Brokamp, Yin Zhang, Eric S. Nylen, Mantosh Rattan, Eric Crotty, Michael A. Belsky, Sara Krueger, Thomas N. Epperson, Andrea Kachelmeyer, Richard M. Ruddy, Samir S. Shah
Summary: The study found that proADM levels increased with disease severity in children with CAP. ProADM was significantly associated with increased odds of developing severe outcomes, particularly in radiographic CAP.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Amy Zipursky, Nathan Kuppermann, Yaron Finkelstein, Roger Zemek, Amy C. Plint, Franz E. Babl, Stuart R. Dalziel, Stephen B. Freedman, Dale W. Steele, Ricardo M. Fernandes, Todd A. Florin, Derek Stephens, Anupam Kharbanda, Damian Roland, Mark D. Lyttle, David W. Johnson, David Schnadower, Charles G. Macias, Javier Benito, Suzanne Schuh
Letter
Immunology
Todd A. Florin, Lilliam Ambroggio, Richard Ruddy, Samir S. Shah
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
James W. Antoon, Matt Hall, Alison Herndon, David P. Johnson, Charlotte M. Brown, Whitney L. Browning, Todd A. Florin, Leigh M. Howard, Carlos G. Grijalva, Derek J. Williams
Summary: Neurologic complications are common in children hospitalized with influenza, especially among those with chronic neurologic conditions. Risk factors associated with neurologic complications include male sex, Asian race/ethnicity, and the presence of a chronic neurologic condition.
JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Sriram Ramgopal, Marie E. Heffernan, Anne Bendelow, Matthew M. Davis, Michael S. Carroll, Todd A. Florin, Elizabeth R. Alpern, Michelle L. Macy
Summary: Parents generally had a positive attitude towards computer-assisted management of children with respiratory illnesses in the emergency department (ED), but some reservations and discomfort about AI were present, especially among Black non-Hispanic and younger parents.
ACADEMIC PEDIATRICS
(2022)
Article
Health Care Sciences & Services
Todd A. Florin, Douglas Lorenz, Sriram Ramgopal, Rebecca Burns, Daniel Rainwater, Jillian Benedetti, Richard M. Ruddy, Jeffrey S. Gerber, Nathan Kuppermann
Summary: The objective of this pilot study was to evaluate the feasibility and reliability of telemedicine in evaluating children with respiratory concerns. Comparing the examination results with the local clinician, the parent, and the remote clinician, it was found that except for heart rate, all other examination findings had good agreement, indicating that telemedicine respiratory examinations are feasible and reliable for young children.
JOURNAL OF TELEMEDICINE AND TELECARE
(2022)
Article
Medicine, General & Internal
Jillian M. Cotter, Todd A. Florin, Angela Moss, Krithika Suresh, Nidhya Navanandan, Sriram Ramgopal, Samir S. Shah, Richard Ruddy, Allison Kempe, Lilliam Ambroggio
Summary: This study evaluated the association between antibiotic use and outcomes among children hospitalized with suspected community-acquired pneumonia. The results showed no significant differences in length of stay, care escalation, treatment failure, or revisits between children who received antibiotics and those who did not, after propensity analyses.
JOURNAL OF HOSPITAL MEDICINE
(2022)
Article
Medicine, General & Internal
Marie-Pier Lirette, Nathan Kuppermann, Yaron Finkelstein, Roger Zemek, Amy C. Plint, Todd Adam Florin, Franz E. Babl, Stuart Dalziel, Stephen Freedman, Damian Roland, Mark David Lyttle, David Schnadower, Dale Steele, Ricardo M. Fernandes, Derek Stephens, Anupam Kharbanda, David W. Johnson, Charles Macias, Javier Benito, Suzanne Schuh, Pediat Emergency Res Networks PERN
Summary: This study aimed to evaluate international variations in the use of evidence-based management in bronchiolitis, and found that management consistent with full EBM practices was associated with lower hospitalisation rates among infants. However, there was marked variation in full EBM delivery between different countries/regions, with Spain/Portugal having the lowest usage.
Article
Respiratory System
Sriram Ramgopal, Lilliam Ambroggio, Douglas Lorenz, Samir S. Shah, Richard M. Ruddy, Todd A. Florin
Summary: The aim of this study was to evaluate biomarkers to predict radiographic pneumonia among children with suspected lower respiratory tract infections (LRTI). The study found that incorporating CRP with clinical variables improved the performance for identifying pediatric radiographic pneumonia.
Article
Emergency Medicine
Todd A. Florin, Octavio Ramilo, Russell K. Banks, David Schnadower, Kimberly S. Quayle, Elizabeth C. Powell, Michelle L. Pickett, Lise E. Nigrovic, Rakesh Mistry, Aaron N. Leetch, Robert W. Hickey, Eric W. Glissmeyer, Peter S. Dayan, Andrea T. Cruz, Daniel M. Cohen, Amanda Bogie, Fran Balamuth, Shireen M. Atabaki, John M. VanBuren, Prashant Mahajan, Nathan Kuppermann
Summary: Radiographic pneumonias are rare in febrile infants, and viral infections are common. Pneumonia is associated with respiratory distress, but few other factors. Although ANC and PCT levels were elevated in infants with definite pneumonias, further research is needed to evaluate the role of blood biomarkers in infant pneumonias.
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Immunology
Jianling Xie, Nathan Kuppermann, Todd A. Florin, Daniel J. Tancredi, Anna L. Funk, Kelly Kim, Marina Salvadori, Adriana Yock-Corrales, Nipam P. Shah, Kristen A. Breslin, Pradip P. Chaudhari, Kelly R. Bergmann, Fahd A. Ahmad, Jasmine R. Nebhrajani, Santiago Mintegi, Iker Gangoiti, Amy C. Plint, Usha R. Avva, Michael A. Gardiner, Richard Malley, Yaron Finkelstein, Stuart R. Dalziel, Maala Bhatt, Nirupama Kannikeswaran, Kerry Caperell, Carmen Campos, Vikram J. Sabhaney, Shu-Ling Chong, Maren M. Lunoe, Alexander J. Rogers, Sarah M. Becker, Meredith L. Borland, Laura F. Sartori, Viviana Pavlicich, Pedro B. Rino, Andrea K. Morrison, Mark Neuman, Naveen Poonai, Norma-Jean E. Simon, April J. Kam, Maria Y. Kwok, Claudia R. Morris, Laura Palumbo, Lilliam Ambroggio, Nidhya Navanandan, Michelle Eckerle, Terry P. Klassen, Daniel C. Payne, Jonathan C. Cherry, Muhammad Waseem, Andrew C. Dixon, Isabel Beneyto Ferre, Stephen B. Freedman
Summary: This study assessed the association between laboratory findings and severe outcomes among children infected with SARS-CoV-2. The results showed that specific laboratory parameters were associated with severe outcomes, and these associations were stronger in children testing positive for SARS-CoV-2 compared to those testing negative.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Todd A. Florin, Joy Melnikow, Melissa Gosdin, Ryan Ciuffetelli, Jillian Benedetti, Dustin Ballard, Marianne Gausche-Hill, Matthew P. Kronman, Lisa A. Martin, Rakesh D. Mistry, Mark Neuman, Debra L. Palazzi, Sameer J. Patel, Wesley H. Self, Samir S. Shah, Sonal N. Shah, Susan Sirota, Andrea T. Cruz, Richard Ruddy, Jeffrey S. Gerber, Nathan Kuppermann
Summary: This study aimed to develop expert consensus on study outcomes for clinical trials of children with mild community-acquired pneumonia (CAP). Using the Delphi method, a multispecialty expert panel determined the importance of clinical response and treatment failure outcomes and proposed specific components for each outcome.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Article
Immunology
Todd A. Florin, Lilliam Ambroggio, Douglas Lorenz, Andrea Kachelmeyer, Richard M. Ruddy, Nathan Kuppermann, Samir S. Shah
Summary: A prediction model has been developed and validated to accurately predict disease severity in children with suspected community-acquired pneumonia (CAP). The model demonstrates excellent discrimination and outstanding calibration, which has the potential to assist clinicians in making more informed hospitalization decisions for these children.
CLINICAL INFECTIOUS DISEASES
(2021)
