Article
Immunology
Inna G. Ovsyannikova, Iana H. Haralambieva, Daniel J. Schaid, Nathaniel D. Warner, Gregory A. Poland, Richard B. Kennedy
Summary: This study identified that SNPs in the SIGLEC5/SIGLEC14 genes play a significant role in cellular and inflammatory immune responses to mumps vaccination, providing insights for further research on the functional roles of SIGLEC genes in regulating immunity induced by mumps vaccine.
Article
Multidisciplinary Sciences
Brock Kingstad-Bakke, Woojong Lee, Shaswath S. Chandrasekar, David J. Gasper, Cristhian Salas-Quinchucua, Thomas Cleven, Jeremy A. Sullivan, Adel Talaat, Jorge E. Osorio, M. Suresh
Summary: The study found that mucosal or parenteral immunization effectively controlled the virus and protected the lungs from damage with or without neutralizing antibodies. The protection provided by mucosal memory CD8 T cells was largely redundant in the presence of neutralizing antibodies, but unhelped mucosal memory CD8 T cells provided no protection against the homologous SARS-CoV-2 without CD4 T cells and neutralizing antibodies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Josien Lanfermeijer, Marieke M. Nuehn, Maarten E. Emmelot, Martien C. M. Poelen, Cecile A. C. M. van Els, Jose A. M. Borghans, Debbie van Baarle, Patricia Kaaijk, Jelle de Wit
Summary: Decrease in MuV-specific humoral response after vaccination may contribute to recent mumps outbreaks, but CD8(+) T cells could play a key role in the immune response against MuV. The frequency of MuV-specific CD8(+) T cells in the blood declines within 9 months post-infection, although the TCR beta analysis reveals a stable MuV-specific T-cell repertoire over time.
Article
Immunology
Huy Quang Quach, Jun Chen, Jonathon M. Monroe, Tamar Ratishvili, Nathaniel D. Warner, Diane E. Grill, Iana H. Haralambieva, Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy
Summary: This study found that a third dose of measles-mumps-rubella vaccine (MMR) enhances humoral immune responses specific to measles, but not cellular immune responses. These findings support the administration of MMR3 to seronegative or high-risk individuals.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Microbiology
Xiaoli Hao, Fan Zhang, Yi Yang, Shaobin Shang
Summary: Cellular immune responses play critical roles in controlling avian viral diseases, but have been neglected due to limited reagents and methods. However, with the development of more immunological reagents and methods, evaluating cellular immunity in birds has become feasible. Future efforts should focus on improving analytical methods to enhance the studies of avian cellular immunity.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Natalia Syrimi, Flora Sourri, Maria-Christina Giannakopoulou, Dimitrios Karamanis, Asterios Pantousas, Persefoni Georgota, Eleni Rokka, Zoe Vladeni, Euaggelia Tsiantoula, Evangelia Soukara, Nikoletta Lavda, Dimitrios Gkaragkanis, Aikaterini Zisaki, Panagiotis Vakalidis, Vasiliki Goula, Evdokia Loupou, Leonidas Palaiodimos, Dimitrios Hatzigeorgiou
Summary: In this study, the trajectory of humoral and cellular immunity after nine months of primary vaccination with the BNT162b2 mRNA vaccine among 189 healthcare workers was investigated. Correlations between immunity parameters and common variables and comorbidities were also examined. The study found a significant drop in antibodies over time, with age and smoking status affecting the rise of antibodies. T-cell activation was not demonstrated in more than half of the participants at nine months. Female gender and antibody levels at four months predicted the detection of cellular immunity at nine months post-vaccination. This study contributes to our understanding of the immune response to the BNT162b2 mRNA vaccine and its associated factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Laura Massarenti, Christian Enevold, Dres Damgaard, Niels Odum, Peter Garred, Morten Frisch, Miriam A. Shelef, Soren Jacobsen, Claus Henrik Nielsen
Summary: This study found an association between PADI4 gene polymorphisms and ACPA-positive RA, particularly in HLA-DRB1*04-positive individuals, and independently with ACPA-negative RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Veterinary Sciences
Sk Mohiuddin Choudhury, XuSheng Ma, Wen Dang, YuanYuan Li, HaiXue Zheng
Summary: Vaccines are crucial in preventing and stopping infectious diseases in livestock. Utilizing specific antigens to induce immunity is the fundamental concept of vaccination. Novel vaccines such as subunit vaccines and recombinant vaccines are gaining scientific and public attention as potential replacements to traditional vaccines.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Oncology
Jing Wen, Lan Wang, Jie Ren, Emiko Kranz, Shilin Chen, Di Wu, Toshio Kanazawa, Irvin Chen, Yunfeng Lu, Masakazu Kamata
Summary: A humanized NSG(-Hc1) mouse model was developed with a corrected Hc gene mutation to support complement-dependent cytotoxicity, demonstrating its effectiveness in evaluating the efficacy of anticancer drugs. Nanoencapsulated rituximab showed enhanced antilymphoma activity in this humanized mouse model.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Microbiology
Rossella Talotta
Summary: After the worldwide COVID-19 vaccination campaign, an increase in cases of autoimmune diseases occurring after vaccination has been reported. In this study, an analysis was conducted to investigate the presence of protein epitopes encoded by the BNT-162b2 mRNA vaccine, which could potentially induce autoimmunity in susceptible individuals. The analysis revealed the presence of immunogenic epitopes, some of which may be associated with immunological diseases. However, further experimental studies are needed to confirm this hypothesis.
Article
Immunology
Patricia Kaaijk, Alienke J. Wijmenga-Monsuur, Hinke I. ten Hulscher, Jeroen Kerkhof, Gaby Smits, Mioara Alina Nicolaie, Marianne A. van Houten, Rob S. van Binnendijk
Summary: This follow-up study investigated the antibody levels of mumps, measles, and rubella in young adults who received a third dose of the MMR vaccine. The results showed that the antibody levels remained elevated even 3 years after vaccination, with the strongest increase observed in individuals with low mumps antibody levels before vaccination. The study suggested that a third dose of MMR vaccine could provide additional protection during mumps outbreaks.
Article
Immunology
Marguerite M. Riggenbach, Iana H. Haralambieva, Inna G. Ovsyannikova, Daniel J. Schaid, Gregory A. Poland, Richard B. Kennedy
Summary: This study found that females have higher neutralizing antibody titers after receiving two doses of MMR vaccine, while males have higher secretion levels of certain cytokines.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Augusta Horvath, Lisa Rogers, Georgios Pollakis, Olga Baranov, Nora Pieroth, Sarah Joseph, Mkunde Chachage, Asli Heitzer, Lucas Maganga, Frank Msafiri, Agricola Joachim, Edna Viegas, Leigh-Anne Eller, Hannah Kibuuka, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Jittima Dhitavat, Nakorn Premsri, Sarah Fidler, Robin J. J. Shattock, Merlin Lee Robb, Jonathan Weber, Sheena McCormack, Patricia Jane Munseri, Eligius Lyamuya, Charlotta Nilsson, Arne Kroidl, Michael Hoelscher, Ralf Wagner, Christof Geldmacher, Kathrin Held
Summary: Immunogens and vaccination regimens can impact the recognition of immune-epitopes, with the potential to steer responses towards or away from vulnerable viral epitopes. This study examined HIV vaccine trials and found that the induction of V3-specific antibodies did not inhibit the targeting of other linear epitopes. Strong V3 targeting was associated with a stronger overall immune response and recognition of more antigenic regions, while V2 targeting was specific to certain immunogens. These findings suggest that the induction of antibodies against V3 and other vulnerable regions may not be mutually exclusive.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Juanjuan Yang, Qian Wang, Shuqun Zhang, Zongfang Li, Wei Jiang
Summary: The immune cells in the peripheral blood of frontline medical workers changed significantly 10 days after struggling with COVID-19, but returned to normal after 10 months. These changes may be related to psychological stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Henning Jacobsen, Sabra L. Klein
Summary: The ongoing COVID-19 pandemic has highlighted the sex-specific differences in immunity and outcomes following SARS-CoV-2 infection, with evidence suggesting a male bias in disease severity mediated by differential immune responses. While males are more susceptible to most viral infections, females possess immunological features that make them vulnerable to distinct immune-related disease outcomes. Sex chromosome complement, related genes, and sex steroids all play crucial roles in mediating these sex differences in immunity to viral infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Correction
Biochemistry & Molecular Biology
Eileen O. Dareng, Jonathan P. Tyrer, Daniel R. Barnes, Michelle R. Jones, Xin Yang, Katja K. H. Aben, Muriel A. Adank, Simona Agata, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Gerasimos Aravantinos, Banu K. Arun, Annelie Augustinsson, Judith Balmana, Elisa V. Bandera, Rosa B. Barkardottir, Daniel Barrowdale, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Marina Bermisheva, Marcus Q. Bernardini, Line Bjorge, Amanda Black, Natalia V. Bogdanova, Bernardo Bonanni, Ake Borg, James D. Brenton, Agnieszka Budzilowska, Ralf Butzow, Saundra S. Buys, Hui Cai, Maria A. Caligo, Ian Campbell, Rikki Cannioto, Hayley Cassingham, Jenny Chang-Claude, Stephen J. Chanock, Kexin Chen, Yoke-Eng Chiew, Wendy K. Chung, Kathleen B. M. Claes, Sarah Colonna, Linda S. Cook, Fergus J. Couch, Mary B. Daly, Fanny Dao, Eleanor Davies, Miguel de la Hoya, Robin de Putter, Joe Dennis, Allison DePersia, Peter Devilee, Orland Diez, Yuan Chun Ding, Jennifer A. Doherty, Susan M. Domchek, Thilo Dork, Andreas du Bois, Matthias Durst, Diana M. Eccles, Heather A. Eliassen, Christoph Engel, Gareth D. Evans, Peter A. Fasching, James M. Flanagan, Renee T. Fortner, Eva Machackova, Eitan Friedman, Patricia A. Ganz, Judy Garber, Francesca Gensini, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Marc T. Goodman, Mark H. Greene, Jacek Gronwald, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Ute Hamann, Thomas V. O. Hansen, Holly R. Harris, Mikael Hartman, Florian Heitz, Michelle A. T. Hildebrandt, Estrid Hogdall, Claus K. Hogdall, John L. Hopper, Ruea-Yea Huang, Chad Huff, Peter J. Hulick, David G. Huntsman, Evgeny N. Imyanitov, Claudine Isaacs, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Allan Jensen, Oskar Th. Johannsson, Esther M. John, Michael E. Jones, Daehee Kang, Beth Y. Karlan, Anthony Karnezis, Linda E. Kelemen, Elza Khusnutdinova, Lambertus A. Kiemeney, Byoung-Gie Kim, Susanne K. Kjaer, Ian Komenaka, Jolanta Kupryjanczyk, Allison W. Kurian, Ava Kwong, Diether Lambrechts, Melissa C. Larson, Conxi Lazaro, Nhu D. Le, Goska Leslie, Jenny Lester, Fabienne Lesueur, Douglas A. Levine, Lian Li, Jingmei Li, Jennifer T. Loud, Karen H. Lu, Jan Lubinski, Phuong L. Mai, Siranoush Manoukian, Jeffrey R. Marks, Rayna Kim Matsuno, Keitaro Matsuo, Taymaa May, Lesley McGuffog, John R. McLaughlin, Iain A. McNeish, Noura Mebirouk, Usha Menon, Austin Miller, Roger L. Milne, Albina Minlikeeva, Francesmary Modugno, Marco Montagna, Kirsten B. Moysich, Elizabeth Munro, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Joanne Ngeow Yuen Yie, Henriette Roed Nielsen, Finn C. Nielsen, Liene Nikitina-Zake, Kunle Odunsi, Kenneth Offit, Edith Olah, Siel Olbrecht, Olufunmilayo I. Olopade, Sara H. Olson, Hakan Olsson, Ana Osorio, Laura Papi, Sue K. Park, Michael T. Parsons, Harsha Pathak, Inge Sokilde Pedersen, Ana Peixoto, Tanja Pejovic, Pedro Perez-Segura, Jennifer B. Permuth, Beth Peshkin, Paolo Peterlongo, Anna Piskorz, Darya Prokofyeva, Paolo Radice, Johanna Rantala, Marjorie J. Riggan, Harvey A. Risch, Cristina Rodriguez-Antona, Eric Ross, Mary Anne Rossing, Ingo Runnebaum, Dale P. Sandler, Marta Santamarina, Penny Soucy, Rita K. Schmutzler, V. Wendy Setiawan, Kang Shan, Weiva Sieh, Jacques Simard, Christian F. Singer, Anna P. Sokolenko, Honglin Song, Melissa C. Southey, Helen Steed, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Anthony J. Swerdlow, Yen Yen Tan, Manuel R. Teixeira, Soo Hwang Teo, Kathryn L. Terry, Mary Beth Terry, Mads Thomassen, Pamela J. Thompson, Liv Cecilie Vestrheim Thomsen, Darcy L. Thull, Marc Tischkowitz, Linda Titus, Amanda E. Toland, Diana Torres, Britton Trabert, Ruth Travis, Nadine Tung, Shelley S. Tworoger, Ellen Valen, Anne M. van Altena, Annemieke H. van der Hout, Els Van Nieuwenhuysen, Elizabeth J. van Rensburg, Ana Vega, Digna Velez Edwards, Robert A. Vierkant, Frances Wang, Barbara Wappenschmidt, Penelope M. Webb, Clarice R. Weinberg, Jeffrey N. Weitzel, Nicolas Wentzensen, Emily White, Alice S. Whittemore, Stacey J. Winham, Alicja Wolk, Yin-Ling Woo, Anna H. Wu, Li Yan, Drakoulis Yannoukakos, Katia M. Zavaglia, Wei Zheng, Argyrios Ziogas, Kristin K. Zorn, Zdenek Kleibl, Douglas Easton, Kate Lawrenson, Anna DeFazio, Thomas A. Sellers, Susan J. Ramus, Celeste L. Pearce, Alvaro N. Monteiro, Julie M. Cunningham, Ellen L. Goode, Joellen M. Schildkraut, Andrew Berchuck, Georgia Chenevix-Trench, Simon A. Gayther, Antonis C. Antoniou, Paul D. P. Pharoah
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Lingxin Zhang, Vivekananda Sarangi, Duan Liu, Ming-Fen Ho, Angela R. Grassi, Lixuan Wei, Irene Moon, Robert A. Vierkant, Nicholas B. Larson, Konstantinos N. Lazaridis, Arjun P. Athreya, Liewei Wang, Richard Weinshilboum
Summary: This study investigated the potential impact of nsSNPs in the ACE2 and TMPRSS2 genes on SARS-CoV-2 infectivity using deep mutational scanning. The results suggest that these nsSNPs may influence the transmission of the virus.
HUMAN MOLECULAR GENETICS
(2022)
Article
Oncology
Paulina S. Marell, Robert A. Vierkant, Janet E. Olson, Joerg Herrmann, Nicole Larson, Nathan K. LeBrasseur, Stacy D. D'Andre, Andrea L. Cheville, Toure Barksdale, Charles L. Loprinzi, Fergus Couch, Kathryn J. Ruddy
Summary: This study identifies characteristics associated with an increased likelihood of meeting physical activity guidelines among breast cancer survivors, including younger age, longer time after diagnosis, absence of recurrence, absence of metastatic disease, absence of bilateral mastectomy, and lower BMI.
Article
Oncology
Ashley Weir, Eun-Young Kang, Nicola S. Meagher, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Aleksandra Gentry-Maharaj, Andy Ryan, Naveena Singh, Martin Widschwendter, Jennifer Alsop, Michael S. Anglesio, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Jessica Boros, Alison H. Brand, James D. Brenton, Angela Brooks-Wilson, Michael E. Carney, Julie M. Cunningham, Kara L. Cushing-Haugen, Cezary Cybulski, Esther Elishaev, Ramona Erber, Sian Fereday, Anna Fischer, Luis Paz-Ares, Javier Gayarre, Blake C. Gilks, Marcel Grube, Paul R. Harnett, Holly R. Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y. Hernandez, Sabine Heublein, Yajue Huang, Tomasz Huzarski, Anna Jakubowska, Mercedes Jimenez-Linan, Catherine J. Kennedy, Felix K. F. Kommoss, Jennifer M. Koziak, Bernhard Kraemer, Nhu D. Le, Jaime Lesnock, Jenny Lester, Jan Lubinski, Janusz Menkiszak, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Robles-Diaz, Matthias Ruebner, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Helen Steed, Aline Talhouk, Sarah E. Taylor, Nadia Traficante, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Javier Benitez, Andrew Berchuck, David D. Bowtell, Francisco J. Candido dos Reis, Linda S. Cook, Anna DeFazio, Jennifer A. Doherty, Peter A. Fasching, Maria J. Garcia, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, David G. Huntsman, Beth Y. Karlan, Stefan Kommoss, Francesmary Modugno, Joellen M. Schildkraut, Hans-Peter Sinn, Annette Staebler, Linda E. Kelemen, Caroline E. Ford, Usha Menon, Paul D. P. Pharoah, Martin Koebel, Susan J. Ramus, D. Bowtell, A. DeFazio, N. Traficante, S. Fereday, A. Brand, P. Harnett, R. Sharma
Summary: Recently, a study found a positive correlation between protein expression of FOXJ1 and the 5-year survival rate of patients with tubo-ovarian high-grade serous carcinoma (HGSC). However, protein expression of GMNN was not significantly associated with patient survival. This study provides preliminary evidence for the prognostic value of FOXJ1 in HGSC and validates the prior mRNA-based prognostic association through immunohistochemistry.
BRITISH JOURNAL OF CANCER
(2023)
Article
Dentistry, Oral Surgery & Medicine
Dane C. McMillan, Kale B. McMillan, Sarah Kay Youny Lee, Robert A. Vierkant, Thomas J. Salinas, Kyle Ettinger, Kevin Arce
Summary: The purpose of this study was to evaluate the recurrence rate in patients with malignant oral disease undergoing immediate implant placement and microvascular free flap surgery, compare the timing of implant placement and the time to oral rehabilitation, and investigate the association between implant placement timing and tumor recurrence. The results showed a recurrence rate of 12.5% in patients with malignant oral cancer undergoing microvascular reconstruction, implants, and an oral prosthesis. Delayed implant placement significantly delayed the completion of oral rehabilitation compared to immediate implant placement, but there was no significant difference in the recurrence rate between the immediate and delayed implant groups.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Surgery
Ahmet Vahibe, Matthew J. Aizpuru, Michael G. Sarr, Manpreet S. Mundi, Robert A. Vierkant, Travis McKenzie, Barham K. Abu Dayyeh, Omar M. Ghanem
Summary: This study retrospectively reviewed the medical records of severely malnourished patients who underwent revisional bariatric surgery at our institution from 2008 to 2020. The results showed that revisional surgery can effectively reduce the need for nutritional support, and postoperative complications are increased but not prohibitive.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Article
Surgery
Pearl Ma, Ahmet Vahibe, Travis McKenzie, Maria D. Hurtado Andrade, Robert A. Vierkant, Kelvin Higa, Michael Kendrick, Omar M. Ghanem
Summary: The study aimed to assess whether metabolic and bariatric surgery (MBS) reduces the use of immunosuppressant agents in patients with rheumatic diseases (RD). The results showed that a significant proportion of patients stopped using prednisone and/or reduced the use of immunosuppressant agents during the follow-up period. The findings of this study indicate that MBS may have a positive impact on the treatment and disease management of patients with rheumatic diseases.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Oncology
Eun-Young Kang, Ashley Weir, Nicola S. Meagher, Kyo Farrington, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Adelyn Bolithon, Gordana Popovic, Betty Leung, Katrina Tang, Neil Lambie, Joshua Millstein, Jennifer Alsop, Michael S. Anglesio, Beyhan Ataseven, Ellen Barlow, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Hans Boesmueller, Jessica Boros, Alison H. Brand, Angela Brooks-Wilson, Sara Y. Brucker, Michael E. Carney, Yovanni Casablanca, Alicia Cazorla-Jimenez, Paul A. Cohen, Thomas P. Conrads, Linda S. Cook, Penny Coulson, Madeleine Courtney-Brooks, Daniel W. Cramer, Philip Crowe, Julie M. Cunningham, Cezary Cybulski, Kathleen M. Darcy, Mona A. El-Bahrawy, Esther Elishaev, Ramona Erber, Rhonda Farrell, Sian Fereday, Anna Fischer, Maria J. Garcia, Simon A. Gayther, Aleksandra Gentry-Maharaj, C. Blake Gilks, Marcel Grube, Paul R. Harnett, Shariska Petersen Harrington, Philipp Harter, Arndt Hartmann, Jonathan L. Hecht, Sebastian Heikaus, Alexander Hein, Florian Heitz, Joy Hendley, Brenda Y. Hernandez, Susanna Hernando Polo, Sabine Heublein, Akira Hirasawa, Estrid Hogdall, Claus K. Hogdall, Hugo M. Horlings, David G. Huntsman, Tomasz Huzarski, Andrea Jewell, Mercedes Jimenez-Linan, Michael E. Jones, Scott H. Kaufmann, Catherine J. Kennedy, Dineo Khabele, Felix K. F. Kommoss, Roy F. P. M. Kruitwagen, Diether Lambrechts, Nhu D. Le, Marcin Lener, Jenny Lester, Yee Leung, Anna Linder, Liselore Loverix, Jan Lubinski, Rashna Madan, G. Larry Maxwell, Francesmary Modugno, Susan L. Neuhausen, Alexander Olawaiye, Siel Olbrecht, Sandra Orsulic, Jose Palacios, Celeste Leigh Pearce, Malcolm C. Pike, Carmel M. Quinn, Ganendra Raj Mohan, Cristina Rodriguez-Antona, Matthias Ruebner, Andy Ryan, Stuart G. Salfinger, Naoko Sasamoto, Joellen M. Schildkraut, Minouk J. Schoemaker, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Naveena Singh, Gabe S. Sonke, Linda Steele, Colin J. R. Stewart, Karin Sundfeldt, Anthony J. Swerdlow, Aline Talhouk, Adeline Tan, Sarah E. Taylor, Kathryn L. Terry, Aleksandra Toloczko, Nadia Traficante, Koen K. Van de Vijver, Maaike A. van der Aa, Toon Van Gorp, Els Van Nieuwenhuysen, Lilian Van-Wagensveld, Ignace Vergote, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Anna H. Wu, Javier Benitez, Andrew Berchuck, Francisco J. Candido Dos Reis, Anna DeFazio, Peter A. Fasching, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, Beth Y. Karlan, Stefan Kommoss, Usha Menon, Hans-Peter Sinn, Annette Staebler, James D. Brenton, David D. Bowtell, Paul D. P. Pharoah, Susan J. Ramus, Martin Kobel
Summary: This study validates that high-level amplification of CCNE1 is associated with shorter survival in tubo-ovarian high-grade serous carcinoma (HGSC), supporting its use as a prognostic biomarker in this disease.
Article
Oncology
Mark E. Sherman, Robert A. Vierkant, Matthew Masters, Derek C. Radisky, Stacey J. Winham, Amy C. Degnim, Celine M. Vachon, Alpa V. Patel, Lauren R. Teras
Summary: Nonsteroidal anti-inflammatory agents (NSAID) are inconsistently associated with modest reductions in breast cancer risk in the general population, but studies focusing on patients with benign breast disease (BBD) have shown a lower risk with NSAID use. As BBD includes fibroinflammatory lesions linked to elevated breast cancer risk, this study examined the association between NSAID use and breast cancer risk among patients with BBD.
CANCER PREVENTION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Ron Pery, Hallbera Gudmundsdottir, David M. Nagorney, Niv Pencovich, Rory L. Smoot, Cornelius A. Thiels, Mark J. Truty, Robert A. Vierkant, Susanne G. Warner, Michael L. Kendrick, Sean P. Cleary
Summary: This study compared the outcomes of laparoscopic liver resections (LLRs) and open liver resections (OLRs) for Gallbladder cancer (GBC) and Intrahepatic Cholangiocarcinoma (iCCA) in a high-volume center. The results showed that LLR had less blood loss and shorter length of stay compared to OLR. There were no significant differences in post-operative complications, negative margin rates, completeness of lymphadenectomy rates, and 3-year overall and disease-free survival between LLR and OLR.
Article
Surgery
Bradley A. Richards, Robert A. Vierkant, Benzon M. Dy, Trenton R. Foster, Travis J. McKenzie, Melanie L. Lyden
Summary: This study aimed to determine if intraoperative parathyroid hormone levels (IOPTH) can determine autotransplantation (ATX) candidacy. The results showed that a low parathyroid hormone after 2-4 weeks postoperatively is an indication for ATX. However, the clinical practicality of using IOPTH to determine ATX candidacy is limited.
Editorial Material
Oncology
Hallbera Gudmundsdottir, Elizabeth B. Habermann, Robert A. Vierkant, Patrick Starlinger, Cornelius A. Thiels, Susanne G. Warner, Rory L. Smoot, Mark J. Truty, Michael L. Kendrick, Thorvardur R. Halfdanarson, David M. Nagorney, Sean P. Cleary
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Chen Wang, Matthew S. Block, Julie M. Cunningham, Mark E. Sherman, Bryan M. McCauley, Sebastian M. Armasu, Robert A. Vierkant, Nadia Traficante, Aline Talhouk, Jennifer A. Doherty, Nadja Pejovic, Martin Kobel, Brooke D. Jorgensen, Dale W. Garsed, Sian Fereday, Susan J. Ramus, Dinuka Ariyaratne, Michael S. Anglesio, Martin Widschwendter, Tanja Pejovic, Jesus Gonzalez Bosquet, David D. Bowtell, Stacey J. Winham, Ellen L. Goode
Summary: This study analyzed genome-wide DNA methylation in 1,040 cases of tubo-ovarian high-grade serous carcinoma and found a methylation signature associated with shorter time to recurrence. This signature was also correlated with immune cell composition and gene expression molecular subtypes. The findings provide insights into personalized treatment strategies.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Medical Laboratory Technology
Julia R. Naso, Jackie Chan, Janani Reisenauer, Eric S. Edell, Katherine Stackhouse, Aaron O. Bungum, Robert A. Vierkant, Karlyn Pierson, Andrew Seidl, Charles D. Sturgis, Chady Meroueh, Yajue Huang, Christopher P. Hartley
Summary: The use of a remote-controlled robotic microscope improved the ease of adequacy assessment compared to non-robotic telecytology and enabled expediently rendered strongly concordant diagnoses. This study provides evidence that modern robotic telecytology is a feasible and user-friendly method for remotely and potentially intraoperatively rendering adequacy assessments and diagnoses on bronchoscopic cytology specimens.
DIAGNOSTIC CYTOPATHOLOGY
(2023)
Review
Surgery
Benjamin Clapp, Katie Marrero, John Corbett, Ishna Sharma, Karl Hage, Robert A. A. Vierkant, Travis McKenzie, Scott S. S. Davis Jr, Omar M. M. Ghanem
Summary: The study examined the relationship between operative time and complications in bariatric surgery. The results showed that longer operative time was associated with increased rates of complications, readmission, reoperation, and reintervention.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)