Article
Medicine, General & Internal
Justyna Kikut, Malgorzata Mokrzycka, Arleta Drozd, Urszula Grzybowska-Chlebowczyk, Maciej Zietek, Malgorzata Szczuko
Summary: The study compared the concentrations of proinflammatory mediators of arachidonic acid (ARA) and linoleic acid (LA) in patients with CD and UC, and identified differences in inflammation levels between the two diseases. Active CD patients had higher concentrations of 15S-HETE than active UC patients, and levels of TXB2, LTB4, and 9S-HODE were higher in active CD compared to inactive CD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Amy Yu, Sonia Friedman, Ashwin N. Ananthakrishnan
Summary: This study analyzed patients with pregnancy-onset IBD, and found that they were more likely to develop ulcerative colitis and had a higher risk of disease-related hospitalizations.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Medicine, General & Internal
Hsu-Heng Yen, Tsui-Chun Hsu, Mei-Wen Chen, Pei-Yuan Su, Yang-Yuan Chen
Summary: In this study, the clinical features of IBD patients in Taiwan were reviewed, with UC being the predominant type and CD patients requiring more frequent biologic therapy. Subsequent research indicated a trend of decreased bowel resection for IBD patients since 2015.
Review
Immunology
Niranjani Venkateswaran, Scott Weisnniller, Kofi Clarke
Summary: Indeterminate colitis (IC) is a type of inflammatory bowel disease that can be difficult to differentiate from ulcerative colitis (UC) or Crohn's disease (CD) in the early stages, but most patients will ultimately be diagnosed with one of the two diseases after a period of observation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Jeongseok Kim, Hyuk Yoon, Nayoung Kim, Kang-Moon Lee, Sung-Ae Jung, Chang Hwan Choi, Eun Soo Kim, Yunho Jung, Chang Soo Eun, Tae Oh Kim, Sang-Bum Kang, You Sun Kim, Geom-Seog Seo, Chang Kyun Lee, Jong Pil Im, Soo Jung Park, Dong Il Park, Byong Duk Ye
Summary: The study demonstrated the effectiveness and safety of VDZ induction therapy among Korean patients with CD or UC for whom anti-tumor necrosis factor therapy failed. Early clinical response was associated with clinical remission after VDZ induction therapy.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Craig Haifer, Laurence Don Wai Luu, Sudarshan Paramsothy, Thomas J. Borody, Rupert W. Leong, Nadeem O. Kaakoush
Summary: This study characterized the differences in gut microbiota between two FMT donors and found that donor microbiota stability and species evenness were associated with therapeutic efficacy in UC. These findings have important implications for improving FMT donor selection.
Article
Gastroenterology & Hepatology
David T. Rubin, Charles Sninsky, Britta Siegmund, Miquel Sans, Ailsa Hart, Brian Bressler, Yoram Bouhnik, Alessandro Armuzzi, Anita Afzali
Summary: Patients and physicians with inflammatory bowel diseases generally share the same treatment goals and communication patterns, but differ in definitions of remission, expectations for treatment efficacy, and concerns about corticosteroid use.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Filippos Koutroumpakis, Anna Evans Phillips, Dhiraj Yadav, Jorge D. Machicado, Maaz Ahsan, Claudia Ramos Rivers, Xiaoqing Tan, Marc Schwartz, Siobhan Proksell, Elyse Johnston, Jeffrey Dueker, Jana G. Hashash, Arthur Barrie, Janet Harrison, Michael A. Dunn, Liza Konnikova, Douglas J. Hartman, Hasieb Din, Dmitriy Babichenko, Gong Tang, David G. Binion
Summary: The study identified that IgG4 subclass deficiency is common in patients with IBD and associated with markers of disease severity. Treatment with intravenous Ig replacement therapy was beneficial in patients with IgG4-deficient severe IBD. Further research is needed to understand the mechanistic role of IgG4 deficiency in this subset of severe IBD patients.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Immunology
Masaya Yokoyama, Motoko Y. Kimura, Toshihiro Ito, Koji Hayashizaki, Yukihiro Endo, Yangsong Wang, Ryoji Yagi, Tomoo Nakagawa, Naoya Kato, Hisahiro Matsubara, Toshinori Nakayama
Summary: This study found that Myl9/12 were highly expressed in patients with inflammatory bowel disease and mice with DSS-induced colitis. Administration of anti-Myl9/12 Ab alleviated inflammation and prolonged survival, indicating Myl9/12 may be a new therapeutic target for patients with IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
C. R. H. Hedin, E. Sonkoly, M. Eberhardson, M. Stahle
Summary: Psoriasis and inflammatory bowel disease (IBD) are immune-mediated diseases with higher prevalence in northern Europe. Changes in gut microbiota play a key role in IBD pathogenesis, while genetic susceptibility has a greater impact on psoriasis.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Medicine, General & Internal
Ugo Grossi, Gaetano Gallo, Gian Luca Di Tanna, Umberto Bracale, Mattia Ballo, Elisa Galasso, Andrea Kazemi Nava, Martino Zucchella, Francesco Cinetto, Marcello Rattazzi, Carla Felice, Giacomo Zanus
Summary: The safety and effectiveness of surgical treatment for hemorrhoidal disease in patients with inflammatory bowel disease (IBD) is currently poorly supported by evidence. However, cautious surgical management of non-responsive CD patients with inactive disease is still recommended, though further studies are needed to assess the potential benefits of non-excisional techniques in this population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Jacob R. Sweeney, Carl Crawford, Rhonda K. Yantiss
Summary: Patients with inflammatory bowel disease (IBD) are at increased risk for Clostridioides difficile infection, although clinically important infections can be difficult to recognise. This study found that patients with C. difficile infection have symptoms and endoscopic findings that are indistinguishable from active IBD.
Article
Immunology
Wasuwit Wanchaitanawong, Nithi Thinrungroj, Siriporn C. Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Summary: Inflammatory bowel disease (IBD) is a group of intestinal disorders with increasing global incidence. Despite existing treatments not being effective for all patients, metformin has shown significant benefits for IBD and could be a promising therapeutic option.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yiftach Barash, Eyal Klang, Noam Tau, Shomron Ben-Horin, Hussein Mahajna, Asaf Levartovsky, Naila Arebi, Shelly Soffer, Uri Kopylov
Summary: The study found a steady increase in the number of publications related to inflammatory bowel disease over the past 25 years. While the United States leads in total publication count, Denmark, Sweden, and Israel stand out in terms of per capita publications. Medical therapeutics is the most popular topic, with a rising focus on imaging and monitoring research.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Immunology
Valeria Dipasquale, Claudio Romano
Summary: Inflammatory bowel diseases (IBDs) are influenced by both genetic and environmental factors, with the environment affecting susceptibility and genetic background modulating disease course and phenotype. Understanding gene-environment interactions will contribute to personalized patient management.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Valeria Dipasquale, Madeleine Aumar, Delphine Ley, Matthieu Antoine, Claudio Romano, Frederic Gottrand
Summary: This review aims to report on the latest hot topics and new directions in tube-feeding strategies for children with neurological disability.
Article
Rheumatology
Joeri W. van Straalen, Lianne Kearsley-Fleet, Jens Klotsche, Sytze de Roock, Kirsten Minden, Arnd Heiligenhaus, Kimme L. Hyrich, Joke H. de Boer, Lovro Lamot, Alma N. Olivieri, Romina Gallizzi, Elzbieta Smolewska, Enrique Faugier, Serena Pastore, Philip J. Hashkes, Cristina N. Herrera, Wolfgang Emminger, Rita Consolini, Nico M. Wulffraat, Nicolino Ruperto, Joost F. Swart
Summary: This study aimed to develop and externally validate a prediction model for new-onset chronic uveitis in children with juvenile idiopathic arthritis (JIA). Data from the international Pharmachild registry were used to develop a multivariable Cox proportional hazards model. The model was subsequently validated and recalibrated in two inception cohorts. The results showed that the model had acceptable performance and could be used for risk estimation in clinical practice.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Valeria Dipasquale, Francesca Lagana, Serena Arrigo, Giuseppe Trimarchi, Carmelo Romeo, Giuseppe Navarra, Girolamo Mattioli, Paolo Gandullia, Claudio Romano
Summary: This study reports the outcomes of an enhanced recovery after surgery (ERAS) protocol in pediatric inflammatory bowel disease (IBD) surgery. Implementation of the ERAS protocol resulted in a significantly lower postoperative complication rate and earlier first defecation in children with IBD. However, there was no significant difference in the length of hospital stay between the ERAS group and the non-ERAS group. Further pediatric studies are needed to validate these findings and support the application of ERAS in children with IBD.
Article
Gastroenterology & Hepatology
Valeria Dipasquale, Giuseppe Cicala, Francesca Lagana, Paola Cutroneo, Giuseppe Trimarchi, Edoardo Spina, Claudio Romano
Summary: This study analyzed the characteristics of PPI-related ADRs and found that most PPI-related ADRs are non-serious. Omeprazole and combination therapy appear to be associated with ADR seriousness.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Pediatrics
Valeria Dipasquale, Lisa Palermo, Andrea Barbalace, Giampaolo Tumminello, Claudio Romano
Summary: This study aimed to evaluate the efficacy of melatonin combined with Lactobacillus Rhamnosus GG in the treatment of pediatric patients with functional abdominal pain disorders. The results showed that melatonin combined with Lactobacillus Rhamnosus GG can be considered as a therapeutic option for these conditions in children.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Pediatrics
Roberta Caorsi, Antonella Insalaco, Francesca Bovis, Giorgia Martini, Marco Cattalini, Marcello Chinali, Alessandro Rimini, Chiara Longo, Silvia Federici, Camilla Celani, Giovanni Filocamo, Rita Consolini, Maria Cristina Maggio, Gloria Fadanelli, Francesco Licciardi, Micol Romano, Barbara Lia Teruzzi, Andrea Taddio, Angela Miniaci, Francesco La Torre, Alessandro De Fanti, Giulio Cavalli, Barbara Bigucci, Romina Gallizzi, Matteo Chinello, Massimo Imazio, Antonio Brucato, Rolando Cimaz, Fabrizio De Benedetti, Marco Gattorno
Summary: This study analyzed the treatment of pediatric patients with recurrent pericarditis using anti-IL-1 therapy. The study found that most patients received inadequate first-line treatment and only a few achieved drug-free remission. The effectiveness of anakinra was supported, but the different response rates to anakinra and canakinumab may suggest a role of IL-1 alpha in the pathogenesis of recurrent pericarditis.
JOURNAL OF PEDIATRICS
(2023)
Correction
Rheumatology
Marta Bustaffa, Isabelle Kone-Paut, Seza Ozen, Gayane Amaryan, Efimia Papadopoulou-Alataki, Romina Gallizzi, Maria Carrabba, Yonatan Butbul Aviel, Luca Cantarini, Maria Alessio, Jordi Anton, Laura Obici, Faysal Gok, Ezgi Deniz Batu, Estefania Moreno, Paul Brogan, Maria Trachana, Gabriele Simonini, Donato Rigante, Yosef Uziel, Antonella Insalaco, Maria Cristina Maggio, Nicolino Ruperto, Marco Gattorno, Rossi Semerano
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Review
Gastroenterology & Hepatology
Paolo Lionetti, Eytan Wine, Rinat Ran Ressler, Gerard J. Minor, Giles Major, Boutaina Zemrani, Frederic Gottrand, Claudio Romano
Summary: Children who require enteral nutrition often experience gastrointestinal symptoms. Fiber-containing enteral formulas can improve bowel function, promote healthy gut microbiota growth, and improve immune homeostasis. However, there is a lack of guidance in clinical practice.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Pediatrics
Adele Civino, Federico Diomeda, Luca Giordano, Maria Beatrice Damasio, Sandra Perrone, Romina Gallizzi, Angelo Ravelli, Prisco Piscitelli, Maria Cristina Maggio
Summary: Intra- and juxta-articular osteoid osteomas are rare and can mimic inflammatory monoarthritis. The diagnostic delay can be long, and misdiagnosis is common, especially in unusual sites. Knowledge of the atypical presentations and pitfalls is crucial for accurate diagnosis.
Article
Nutrition & Dietetics
Valeria Dipasquale, Ugo Cucinotta, Angela Alibrandi, Francesca Lagana, Vincenzo Ramistella, Claudio Romano
Summary: Tube feeding is an important treatment for children with neurological disabilities, improving their nutrition and feeding disorders. This study evaluated the outcomes of tube feeding in these children, showing improvements in weight, symptoms, and complications.
Review
Health Care Sciences & Services
Ugo Cucinotta, Claudio Romano, Valeria Dipasquale
Summary: Avoidant/Restrictive food intake disorder (ARFID) is a feeding disorder characterized by persistent difficulty eating, such as limited choices of preferred foods and negative emotions related to eating. It can have serious physical and mental health consequences, but is often underrecognized and undertreated. Treatment usually involves a multidisciplinary approach, but there are gaps in the therapeutic approach due to a lack of trials and standardized guidelines.
Article
Immunology
Valeria Dipasquale, Angela Alibrandi, Salvatore Pellegrino, Vincenzo Ramistella, Claudio Romano
Summary: This study investigated predictors for IFX-BioS trough levels (TLs) in pediatric inflammatory bowel disease (IBD) and found that age, dose/kg, gender, and hemoglobin were positively correlated with TLs.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Claudio Romano, Paolo Lionetti, Maria Immacolata Spagnuolo, Sergio Amarri, Antonella Diamanti, Elvira Verduci, Antonella Lezo, Gatti Simona
Summary: The benefits of bolus feeding for children receiving home enteral feeding (HEN) are supported by new evidence. However, current home methods have limitations, especially for mobile or restless patients. Therefore, innovative delivery methods have been introduced to provide more flexible and efficient feeding options.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
M. Petrisano, S. Sestito, L. Castaldo, S. Ferraro, M. Miraglia Del Giudice, S. Leonardi, M. D. Ceravolo, C. Cuppari, A. Salpietro, R. Gallizzi, L. Pensabene, D. Concolino
Summary: Inborn errors of metabolism (IEM) can manifest as emergencies during acute metabolic decompensation, necessitating specific treatments to prevent morbidity and mortality. Metabolic imbalance is often triggered by diet or concurrent illnesses, with nonspecific symptoms that increase the risk of missed diagnosis. The principle of acute management is to halt further decompensation and ensure adequate metabolic requirements are met.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
