Journal
PEDIATRIC TRANSPLANTATION
Volume 15, Issue 3, Pages 306-313Publisher
WILEY
DOI: 10.1111/j.1399-3046.2010.01465.x
Keywords
Epstein-Barr virus; renal transplant; PCR; T lymphocytes; post-transplant lymphoproliferative
Categories
Funding
- Grants-in-Aid for Scientific Research [22591182, 23591573] Funding Source: KAKEN
Ask authors/readers for more resources
High viral load carriage of EBV is one of the risks for PTLD in transplant recipients. We reviewed retrospectively in pediatric renal transplant recipients with EBV seronegative. EBV loads in peripheral blood and EBV-CTLs were measured every 1-3 months in 13 patients after grafting. Immunosuppressants were reduced when the patients were considered to have persistent high EBV loads (> 1000 copies/mu gDNA for over six months). All showed primary EBV infection: six with asymptomatic persistent high EBV loads (group A) and seven with neither EBV-associated symptoms nor persistent high EBV loads (group B). No patient developed PTLD in either group. Chronic rejection occurred in one patient in group A after immunosuppressants' reduction. There was no difference in renal dysfunction rates between the two groups. The maximum and increase rates in EBV loads were significantly higher in group A. The CTLs' percentage was significantly lower in group A when EBV loads first rose above 100 copies/mu g DNA. This study suggests the possibility that EBV loads and CTLs' monitoring may be useful for avoidance of PTLD, as patients with asymptomatic persistent high EBV loads had higher EBV loads and lower percentages of CTLs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available