Article
Oncology
Bernadette Jeremiasse, Cecilia E. J. Terwisscha van Scheltinga, Ludwig E. Smeele, Nelleke Tolboom, Marc H. W. A. Wijnen, Alida F. W. van der Steeg
Summary: The addition of ICG to (99m)technetium nanocolloid for visual detection of sentinel lymph nodes (SLNs) in pediatric patients is a feasible procedure. It showed an accurate detection rate and was helpful for visual guidance.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Marc Moncrieff, Sarah Pywell, Andrew Snelling, Matthew Gray, David Newman, Clare Beadsmoore, Davina Pawaroo, Martin Heaton
Summary: This study confirms the increased accuracy of SPECT/CT for identifying SLN metastases, which appears to have a significant therapeutic benefit, although there is an increased risk of cancellation of the SNB procedure on the day of surgery.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Franco Picciotto, Gianluca Avallone, Federico Castellengo, Martina Merli, Virginia Caliendo, Rebecca Senetta, Adriana Lesca, Desiree Deandreis, Maria Teresa Fierro, Pietro Quaglino, Simone Ribero
Summary: Sentinel lymph node biopsy is an effective staging procedure, but the current classification may result in inaccurate staging. A new surgical technique combined with SPECT-CT can better guide surgeons to improve staging accuracy for melanoma patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Analytical
Fahime Shahsavari, Mohsen Bakhshi Kashi, Saeed Farzanefar, Elisabeth Eppard, Nasim Vahidfar
Summary: Breast cancer is a deadly malignancy, and early and accurate diagnosis is crucial for long-term survival. Nuclear medicine has recently introduced a novel method for evaluating breast cancer at both early and advanced stages. This method is based on sentinel lymph node scintigraphy, which is preferable to axillary lymphadenectomy due to its lower postoperative complications. Radiocolloids have shown superior effectiveness in detecting metastatic lymph nodes. In this short review, we will introduce the important role of radiopharmaceuticals in the clinical application of breast cancer lymphoscintigraphy.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Kevin J. Donohoe, Brett J. Carroll, David K. V. Chung, Elizabeth H. Dibble, Emilia Diego, Francesco Giammarile, Frederick D. Grant, Stephen Y. Lai, Hannah Linden, Megan E. Miller, Neeta Pandit-Taskar, Nicholas E. Tawa Jr, Sergi Vidal-Sicart
Summary: Expert representatives from 11 professional societies have developed appropriate use criteria (AUC) for lymphoscintigraphy in sentinel lymph node mapping and lymphedema. The complete findings and discussions of the study group, including example clinical scenarios, have been published and are available online. The AUC document includes scenarios for scintigraphy in various cancers and lymphatic flow mapping in lymphedema, as well as considerations for pediatric cases. It aims to assist healthcare practitioners in using lymphoscintigraphy.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Oncology
Annette H. Chakera, Else la Cour Sibbesen, Mette Schoedt, Lisbet R. Holmich, Bo Zerahn, John F. Thompson
Summary: The study found that there was no significant migration of Tc99m-nanocolloid overnight in patients scheduled for surgery the day after lymphoscintigraphy. All nodes identified as sentinel nodes on day 1 imaging remained consistent on day 2 imaging. Some nodes identified on day 1 were not seen on day 2, suggesting the possibility of inadequate doses of radioisotope leading to the mistaken removal of second-tier nodes instead of true sentinel nodes. Further research is needed to explain the reported reduction in survival of patients undergoing next-day sentinel node biopsy procedures.
Article
Oncology
Michael G. Fadel, Sidra Rauf, Hesham S. Mohamed, Siraj Yusuf, Andrew J. Hayes, Kieran Power, Myles J. Smith
Summary: This study compared the performance of indocyanine green (ICG) and blue dye in detecting sentinel lymph nodes (SLNs) in cutaneous melanoma. The results showed that ICG had a higher detection rate and was equally effective in detecting pathological SLNs compared to blue dye. Therefore, ICG can be a useful adjunct to radioisotope in SLN biopsy for cutaneous melanoma.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Michael E. Johnston, Zishaan A. Farooqui, Rajaram Nagarajan, Joseph G. Pressey, Brian Turpin, Roshni Dasgupta
Summary: This study aimed to investigate the efficacy of ICG as an adjunct to SLNB in the pediatric and young adult population. The results showed that ICG was safer and more effective than blue dye, with a sensitivity of 87% and a PPV of 83% for detection of Tc-99m-hot lymph nodes, and a sensitivity of 84% and a PPV of 91% for detection of pathologically confirmed lymph nodes.
Review
Health Care Sciences & Services
Vincenzo Cuccurullo, Marco Rapa, Barbara Catalfamo, Giuseppe Lucio Cascini
Summary: With the advancements in sentinel lymph node technology, histopathological staging can be done using lymphatic mapping and selective lymphadenectomy. Structural imaging techniques like US, CT, and MR allow precise measurement of lymph node volume, which is strongly linked to cancerous involvement. While hybrid imaging has shown higher accuracy than standard imaging in visualizing the sentinel lymph node, it hasn't impacted surgical detection. Non-radiological fields such as ophthalmology and dermatology are introducing alternatives like fluorescence or opto-acoustic imaging. This paper analyzes the advantages and limitations of innovative methods in sentinel lymph node detection, including the continued importance of lymphoscintigraphy techniques.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Austin Eckhoff, Norma E. Farrow, Caitlin Silvestri, Emily Stroobant, Charles Intenzo, Margaret Leddy, Douglas S. Tyler, Adam Berger, Georgia M. Beasley
Summary: Use of TcTM in SLNB is associated with significantly shorter LS mapping time while identifying similar numbers of SLN, with similar FNR between the two agents.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Isong Assam, Simon P. Dierck, Yi Zhao, Michael Jueptner, Frank-Andre Siebert, Maaz Zuhayra, Ulf Luetzen
Summary: The handheld gamma-camera CrystalCam, based on high-resolution semiconductor detectors, was evaluated for localizing sentinel lymph nodes (SLN) using phantom and clinical studies. The results showed that CrystalCam has similar accuracy to conventional planar lymphoscintigraphy in detecting SLNs in malignant melanoma, but is inferior in detecting higher-echelon nodes compared to planar imaging.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Medicine, General & Internal
James R. Miller, Serigne N. Lo, Mehdi Nosrati, Jonathan R. Stretch, Andrew J. Spillane, Robyn P. M. Saw, Kerwin F. Shannon, Omgo E. Nieweg, Sydney Ch'ng, Kevin B. Kim, Stanley P. Leong, John F. Thompson, Richard A. Scolyer, Mohammed Kashani-Sabet
Summary: By refining eligibility guidelines, more appropriate patients can be identified to undergo useful medical procedures, improving cost-effectiveness in selecting patients with melanoma for sentinel lymph node biopsy (SLNB).
Review
Biology
Alexandra Allard-Coutu, Victoria Dobson, Erika Schmitz, Hely Shah, Carolyn Nessim
Summary: The use of immune-checkpoint inhibitors and targeted therapy has greatly impacted the adjuvant treatment of melanoma. While wide local excision remains the main treatment for primary cutaneous melanoma, the management of regional lymph nodes is evolving due to clinical trials and improved adjuvant therapy. Controversy exists regarding the use of completion lymph node dissection (CLND) after positive sentinel node biopsy (SLNB), with no reported overall survival benefit in large multicenter studies. This review examines the evolution of SLNB in cutaneous melanoma and highlights key clinical trials that have influenced current practice guidelines.
Review
Oncology
Franco Picciotto, Adriana Lesca, Luca Mastorino, Elena Califaretti, Luca Conti, Pietro Quaglino, Simone Ribero, Virginia Caliendo, Desiree Deandreis
Summary: This article investigates the occurrence of primary umbilical melanoma and introduces the use of SPECT/CT and SLNB techniques for lymph node metastasis detection. The report provides a case study of umbilical melanoma metastasizing only to an external iliac lymph node without involvement of superficial inguinal sentinel lymph nodes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Roberta Ferrari, Patrizia Boracchi, Lavinia Elena Chiti, Martina Manfredi, Chiara Giudice, Donatella De Zani, Carlotta Spediacci, Camilla Recordati, Valeria Grieco, Elisa Maria Gariboldi, Damiano Stefanello
Summary: The study found an association between the size of integumentary MCT and SLN status, with larger tumors and subcutaneous MCT more likely to have SLN metastasis, suggesting mapping and biopsy of SLN for these cases.
Article
Oncology
Kevin B. Cederberg, Ramesh S. Iyer, Apeksha Chaturvedi, M. B. McCarville, Janice D. McDaniel, Jesse K. Sandberg, Amer Shammas, Susan E. Sharp, Helen R. Nadel
Summary: This paper provides consensus-based recommendations for imaging in children with osteosarcoma and Ewing sarcoma at diagnosis, during therapy, and after therapy.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Kyle J. Morgan, Andrew Dudas, Wayne L. Furman, M. Beth McCarville, Barry L. Shulkin, Zhaohua Lu, Himani Darji, Doralina L. Anghelescu
Summary: This study examined the association between opioid consumption and tumor response in children with neuroblastoma. The results showed that there was no significant correlation between opioid use and tumor volume or burden.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Michael Richard Acord, Erika Pace, Alexander El-Ali, Apeksha Chaturvedi, Ramesh S. Iyer, Oscar M. Navarro, Neeta Pandit-Taskar, Ashishkumar K. Parikh, Ann Schechter, Raja Shaikh, M. Beth McCarville
Summary: This manuscript provides consensus-based imaging recommendations for patients with a soft tissue tumor of the extremity at different stages.
PEDIATRIC BLOOD & CANCER
(2023)
Editorial Material
Oncology
Hollie A. Lai, Susan E. Sharp, Aashim Bhatia, Kelly R. Dietz, Beth McCarville, Dhanashree Rajderkar, Sabah Servaes, Barry L. Shulkin, Sudh A. Singh, Andrew T. Trout, Pankaj Watal, Marguerite T. Parisi
Summary: This manuscript provides consensus-based imaging recommendations for diagnosing and monitoring pediatric neuroblastoma patients.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Mitchell A. Rees, Cara E. Morin, Gerald G. Behr, J. Christopher Davis, Hollie Lai, Ajaykumar C. Morani, Marguerite T. Parisi, Gaurav Saigal, Sudha Singh, Sireesha Yedururi, Alexander J. Towbin, Barry L. Shulkin
Summary: This paper provides consensus recommendations for imaging of pediatric patients with adrenal malignancies other than neuroblastoma.
PEDIATRIC BLOOD & CANCER
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Hedieh Khalatbari, Barry L. Shulkin, Marguerite T. Parisi
Summary: The most common indication for 18F-FDG PET/CT is tumor imaging, but in pediatric nuclear medicine, most coincidental findings of infectious, inflammatory, and autoimmune processes are not the main indication and it is important to interpret these findings correctly. This review focuses on recent literature on fever of unknown origin and inflammation of unknown origin in pediatrics, as well as the PET/CT imaging findings in two specific diseases with increased immune reactivity.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Editorial Material
Pediatrics
Lalit Parida
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Oncology
Samuel N. Rogers, Unni Udayasankar, Sumit Pruthi, Hollie A. Lai, Nadja Kadom, Julie Guerin, Michael Malinzak, Barry L. Shulkin, Tina Y. Poussaint, Zoltan Patay, Asim K. Bag
Summary: This paper provides consensus-based recommendations for optimized imaging of childhood spinal tumors, including diagnosis, follow-up during and after therapy, and response assessment.
PEDIATRIC BLOOD & CANCER
(2023)
Letter
Oncology
Zhongbo Hu, Trisha K. Paul, Yen-Chun Liu, Mary E. McCarville, Melissa Hines, Gabriela Gheorghe, Patrick K. Campbell
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Abdelhafeez H. H. Abdelhafeez, Suraj Sarvode Mothi, Luca Pio, Motomi Mori, Teresa C. C. Santiago, M. Beth McCarville, Sue C. C. Kaste, Alberto S. S. Pappo, Lindsay J. J. Talbot, Andrew J. J. Murphy, Andrew M. M. Davidoff
Summary: ICG-guided identification of pulmonary nodules is not feasible for all pediatric solid tumors. However, it may be useful for localizing most metastatic hepatic tumors and high-grade sarcomas in children.
PEDIATRIC BLOOD & CANCER
(2023)
Editorial Material
Oncology
E. R. Tang, A. L. Alazraki, P. G. Thacker, M. B. McCarville, A. J. Towbin
Summary: Pediatric cancer imaging requires experienced radiologists due to its rarity. The Children's Oncology Group Diagnostic Imaging Committee and the Society for Pediatric Radiology Oncology Committee, composed of experts in pediatric cancer imaging, have recently created a series of 23 White Papers as evidence-based imaging recommendations and protocols. This manuscript describes the methods employed in authoring the White Paper series.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Amy K. Erbe, Mitch B. Diccianni, Rajen Mody, Arlene Naranjo, Fan F. Zhang, Jen Birstler, KyungMann Kim, Arika S. Feils, Jung-Tung Hung, Wendy B. London, Barry L. Shulkin, Varsha Mathew, Marguerite T. Parisi, Sabah Servaes, Shahab Asgharzadeh, John M. Maris, Julie Park, Alice L. Yu, Paul M. Sondel, Rochelle Bagatell
Summary: In the Children's Oncology Group ANBL1221 trial, the presence or absence of certain killer immunoglobulin-like receptors (KIRs) and their ligands was associated with clinical outcomes in patients with high-risk neuroblastoma treated with chemoimmunotherapy. The study confirms the importance of KIR/KIR-ligand genotype in the context of this treatment regimen.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Pediatrics
Paul G. Thacker, Adina L. Alazraki, M. Beth McCarville, Elizabeth R. R. Tang, Alexander J. Towbin
PEDIATRIC RADIOLOGY
(2023)
Article
Oncology
John Thomas Lucas, Daniel Victor Wakefield, Michael Doubrovin, Yimei Li, Teresa Santiago, Sara Michele Federico, Thomas E. Merchant, Andrew M. Davidoff, Matthew J. Krasin, Barry L. Shulkin, Victor M. Santana, Wayne Lee Furman
Summary: This retrospective study aimed to identify predictors of metastatic site failure in high-risk neuroblastoma patients. The study found that improvements in systemic therapy influenced the patterns and type of metastatic site failure.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)