Article
Oncology
Raquel Davila Fajardo, Rhoikos Furtwaengler, Martine van Grotel, Harm van Tinteren, Claudia Pasqualini, Kathy Pritchard-Jones, Reem Al-Saadi, Beatriz de Camargo, Gema L. Ramirez Villar, Norbert Graf, Xavier Muracciole, Patrick Melchior, Daniel Saunders, Christian Rube, Marry M. van den Heuvel-eibrink, Geert O. Janssens, Arnauld C. Verschuur
Summary: This study aims to explore the outcomes of metastatic patients with completely necrotic local stage III Wilms tumours, in relation to the application of postoperative radiotherapy. The results indicated excellent 5-year event-free survival and overall survival rates in this patient category, suggesting that abdominal irradiation may not be necessary in first-line treatment for these patients.
Review
Oncology
Janna A. Hol, Rosalyn Jewell, Tanzina Chowdhury, Catriona Duncan, Kayo Nakata, Takaharu Oue, Marion Gauthier-Villars, Annemieke S. Littooij, Yasuhiko Kaneko, Norbert Graf, Franck Bourdeaut, Marry M. van den Heuvel-Eibrink, Kathy Pritchard-Jones, Eamonn R. Maher, Christian P. Kratz, Marjolijn C. J. Jongmans
Summary: The updated Wilms tumour surveillance guidelines have been released for clinical geneticists, pediatricians, pediatric oncologists, and radiologists caring for children at risk of WT. These guidelines stress the importance of registering all patients with cancer predisposition syndromes in order to improve future tumor risk estimation and surveillance programs.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Surgery
Wei Wu, Yibo Wu, Weijue Xu, Jiangbin Liu, Zhibao Lv
Summary: This study is the first to report on the incidence of teratoid Wilms tumor (TWT) among Chinese children. The results suggest that a combination of surgery and chemotherapy may be appropriate for the treatment of WT patients, although prognostic outcomes vary among patients with different stages of the disease. TWT tumor density may be lower than classical WT tumor density. Further research on the biological characteristics of TWT and relevant therapeutic markers is needed to guide the development of personalized treatments for this rare cancer type.
FRONTIERS IN SURGERY
(2022)
Review
Oncology
Juri Fuchs, Anastasia Murtha-Lemekhova, Markus Kessler, Patrick Guenther, Katrin Hoffmann
Summary: This systematic review explores the role of liver resection in the treatment of Wilms' tumor liver metastases (WTLM). The results suggest that liver resection may improve survival rates of WTLM patients, particularly those with persistent disease after neoadjuvant chemotherapy or metachronous liver metastases. However, due to the limited number of studies and potential bias, further research is needed to provide more definitive evidence on the optimal treatment for WTLM.
Review
Cell Biology
Gordan M. Vujanic, Ellen D'Hooghe, Christian Vokuhl, Paola Collini
Summary: ICCR develops datasets for histopathological reporting of various cancer types, but international reporting guidelines for Wilms' tumors have not been established yet. Different treatment approaches result in varied assessment methods and classification criteria followed by countries worldwide.
Article
Oncology
Prakriti Roy, Sophie E. van Peer, Rana Dandis, Catriona Duncan, Joaquim Caetano de Aguirre-Neto, Arnauld Verschuur, Beatriz de Camargo, Henrike E. Karim-Kos, Luna Boschetti, Filippo Spreafico, Gema L. Ramirez-Villar, Norbert Graf, Harm van Tinteren, Kathy Pritchard-Jones, Marry M. van den Heuvel-Eibrink
Summary: The COVID-19 pandemic had a brief impact on the characteristics of paediatric renal tumour patients, leading to a decrease in newly diagnosed cases, an increase in disease severity, and larger tumour volumes. However, there were no delays in patient referral or treatment initiation.
Article
Oncology
Abdelhafeez H. Abdelhafeez, Tea Reljic, Ambuj Kumar, Tahmina Banu, Sharon Cox, Andrew M. Davidoff, Ahmed Elgendy, Khalil Ghandour, J. Ted Gerstle, Jonathan Karpelowsky, Sue C. Kaste, Nahla Kechiche, Natia Esiashvili, Abdulrasheed Nasir, Amon Ngongola, Jin Marollano, Amabelle A. Moreno, Arlene Muzira, Jeannette Parkes, Lily J. Saldana, Jaime Shalkow, Gordan M. Vujanic, Thelma Velasquez, Kokila Lakhoo, Sheena Mukkada, Simone Abib
Summary: This study provides resource-sensitive recommendations for the surgical management of Wilms tumor. The recommendations include expediting treatment initiation, performing surgery in high-volume settings, optimizing preoperative planning with cross-sectional imaging, and more.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Gordan M. Vujanic, Ellen D'Hooghe, Norbert Graf, Christian Vokuhl, Reem Al-Saadi, Tanzina Chowdhury, Kathy Pritchard-Jones, Rhoikos Furtwangler
Summary: The study aimed to evaluate if a subset of Wilms' tumors showing an excellent response to preoperative chemotherapy had comparable survival rates as completely necrotic tumors, and to establish a cut-off point of chemotherapy-induced changes. It was found that patients with Wilms' tumors showing high levels of chemotherapy-induced changes had similar excellent event-free survival and overall survival rates as patients with completely necrotic tumors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Michael V. Ortiz, Christa Koenig, Amy E. Armstrong, Jesper Brok, Beatriz de Camargo, Annelies M. C. Mavinkurve-Groothuis, Thelma B. Velasquez Herrera, Rajkumar Venkatramani, Andrew D. Woods, Jeffrey S. Dome, Filippo Spreafico
Summary: Outcomes for most Wilms tumor patients are positive, but there are subgroups with a survival rate of around 50% or lower. This article discusses the historical and current approach to the classification and treatment of high-risk Wilms tumors, including those with specific histology, relapsed patients, and those in socioeconomic disadvantaged areas. As conventional therapies are insufficient, further investigation is needed to identify active agents.
PEDIATRIC BLOOD & CANCER
(2023)
Review
Oncology
Michael V. Ortiz, Christa Koenig, Amy E. Armstrong, Jesper Brok, Beatriz de Camargo, Annelies M. C. Mavinkurve-Groothuis, Thelma B. Velasquez Herrera, Rajkumar Venkatramani, Andrew D. Woods, Jeffrey S. Dome, Filippo Spreafico
Summary: Outcomes for the majority of Wilms tumor patients are excellent, but there are still subgroups with a lower survival rate. This review discusses the historical and current approach to the classification and treatment of high-risk Wilms tumors, including specific criteria for high-risk patients. Inadequate conventional therapies highlight the urgency for advancements in laboratory and early-phase clinical investigations to identify effective agents.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Pediatrics
Henry Drysdale, David Fawkner-Corbett, Zubrina Solomon, Olivia Cundy, Jerome Loveland, Jenni Perrin, Rosemary Lane, Neil Price, Lofty-John Chukwuemeka Anyanwu, Shaun Wilson, Kokila Lakhoo
Summary: This study compares the management and outcomes of bilateral Wilms' tumours between low-income centres and high-income centres, revealing significantly higher ten-year survival in high-income centres. This difference may be due to patient factors such as late disease diagnosis in low-income centres.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Daniel C. Aronson
Summary: This commentary discusses a manuscript titled "Bilateral Wilms' Tumour: An International Comparison of Treatments and Outcomes" by Drysdale H, Fawkner-Corbett D, Solomon Z, et al. The authors extensively compare and analyze treatments and outcomes in an international context.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Veterinary Sciences
Powell T. Slinkard, Susan E. Lana, Chad B. Frank, Lynn R. Griffin
Summary: This case report describes the aggressive nature of a canine spinal nephroblastoma despite multimodal therapy, which includes surgery, radiation therapy, and chemotherapy.
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
(2022)
Review
Oncology
Akzhol Karim, Kundyz Shaikhyzada, Nazgul Abulkhanova, Akzhunis Altyn, Bakytkali Ibraimov, Dair Nurgaliyev, Dimitri Poddighe
Summary: Wilms tumor (WT) is a rare form of cancer that typically affects children and is usually confined to the kidneys. Extra-renal Wilms tumor (ERWT) is even rarer and develops in other areas of the body, such as the retroperitoneum and inguinal regions, and occasionally at the level of the spinal cord. Our research emphasizes the importance of timely diagnosis and treatment and, possibly, standardized medical approach, in order to improve the outcome of these very rare pediatric malignancies, whose clinical management is even more problematic in developing countries.
Article
Oncology
Gordan M. Vujanic, Norbert Graf, Ellen D'Hooghe, Tanzina Chowdhury, Christian Vokuhl, Reem Al-Saadi, Kathy Pritchard-Jones, Patrick Melchior, Rhoikos Furtwaengler
Summary: This study retrospectively analyzed the outcomes in patients with stage III Wilms' tumor due to positive resection margins (RM). The results showed that patients without viable tumor had better local-relapse-free survival (RFS) and event-free survival (EFS) compared to patients with viable tumor.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Obstetrics & Gynecology
Zdeslav Benzon, Ivana Kuzmic Prusac, Sandra Zekic Tomas, Marko Vulic, Luka Vulic, Sandra Benzon, Vedran Stefanovic
Summary: The study compared the immunohistochemical expression of IL-6 in placental membranes of late preterm delivery in women with histologically proven chorioamnionitis with and without PPROM. Despite the clinical presentation, chorioamnionitis did not impact the immunohistochemical expression of IL-6 in the placental membranes of women with late preterm delivery.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Environmental Sciences
Matea Dolic, Vesna Anticevic, Kresimir Dolic, Zenon Pogorelic
Summary: This study aims to determine the main variables associated with nurses' sickness absence and improve the prediction of sickness absence based on pandemic-related experiences. It also examines the differences between COVID-19 and non-COVID-19 nurses in terms of post-traumatic stress disorder symptoms, personality traits, coping strategies, and professional stressors. The results show that it is possible to predict the probability of nurses using sickness absence based on their pandemic professional experience, personality traits, and coping strategies.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Zenon Pogorelic, Sachit Anand, Tomislav Zuvela, Apoorv Singh, Zvonimir Krizanac, Nellai Krishnan
Summary: During the COVID-19 pandemic, there is a significantly higher incidence of complicated appendicitis in children compared to the pre-pandemic period. Additionally, a significantly higher proportion of children are managed via non-operative management during the pandemic.
Article
Pediatrics
Miro Jukic, Ivona Biuk, Zenon Pogorelic
Summary: This study investigated and evaluated the use of unplanned return to the operating room (uROR) as a quality indicator in pediatric surgery. The study found that the incidence of uROR was low in pediatric surgery, but it was associated with emergency surgeries, male gender, and higher ASA scores in elective surgeries.
Article
Pediatrics
Ana Nevescanin Biliskov, Danijela Gulam, Marija Zaja, Zenon Pogorelic
Summary: The study aimed to investigate the effect of TIVA with ketofol and ketofol with lidocaine on recovery in children. The findings showed that the lidoketofol group had significantly shorter extubation time, anesthesia duration, and length of stay in the PACU compared to the ketofol group. Additionally, the lidoketofol group had lower fentanyl and propofol consumption.
Review
Pediatrics
Sachit Anand, Zenon Pogorelic, Apoorv Singh, Carlos Martin Llorente Munoz, Nellai Krishnan, Anjan Kumar Dhua, Prabudh Goel, Minu Bajpai
Summary: This meta-analysis compared the incidence of macroscopic and microscopic glove perforations during minimally invasive surgeries (MIS) and open surgeries (OS). The results showed no significant difference in the incidence of macroscopic glove perforations between MIS and OS, but the incidence of microscopic perforations was significantly higher in OS compared to MIS.
Review
Surgery
Sachit Anand, Miro Jukic, Nellai Krishnan, Zenon Pogorelic
Summary: The study found that the use of barbed suture (BS) in minimally invasive pyeloplasty can significantly reduce operative time. While the BS group had a higher incidence of redo-pyeloplasty, there was no significant difference in postoperative complications and the need for redo-pyeloplasty between the two treatment groups.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2022)
Review
Medicine, General & Internal
Sachit Anand, Nellai Krishnan, Miro Jukic, Zvonimir Krizanac, Carlos Martin Llorente Munoz, Zenon Pogorelic
Summary: The red blood cell distribution width (RDW) has been investigated as a potential biomarker for acute appendicitis (AA), but there is currently no evidence to support its utility in diagnostic testing for AA.
Article
Pediatrics
Zenon Pogorelic, Viktor Vegan, Miro Jukic, Carlos Martin Llorente Munoz, Dubravko Furlan
Summary: This study analyzed the outcomes and complications of elastic stable intramedullary nailing (ESIN) for tibial fractures in children. The results showed that ESIN is a highly effective treatment with low complication rates.
Article
Obstetrics & Gynecology
Andrea Dagelic, Vedran Stefanovic, Jasminka Resic Karara, Ivana Kuzmic Prusac, Damir Roje, Indira Kosovic, Sandra Zekic Tomas
Summary: The study aims to determine the morphological characteristics of placentas from COVID-19 positive mothers in relation to the trimester of infection onset and low weight molecular heparin (LMWH) treatment. The findings suggest that the onset of COVID-19 infection and LMWH usage are associated with fetal vascular malperfusion and perivillous fibrin deposition in the placenta.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Pediatrics
Zenon Pogorelic, Tin Cohadzic
Summary: This is a case report of a 14-year-old male who developed acute appendicitis due to a swallowed tooth. The main symptoms were acute abdominal pain and vomiting. The diagnosis was confirmed by abdominal ultrasound and emergency laparoscopic appendectomy was successfully performed. The importance of this case lies in emphasizing the need for a thorough history in pediatric patients presenting to the emergency department with suspected acute appendicitis to rule out any precipitating events.
Article
Green & Sustainable Science & Technology
Matea Dolic, Vesna Anticevic, Kresimir Dolic, Zenon Pogorelic
Summary: The purpose of this study was to determine the influence of occupational stressors and personality traits on post-traumatic stress symptoms in nurses during the COVID-19 pandemic. Results showed that personality traits, work stressors, and direct exposure to COVID-19 patients were significant risk factors for post-traumatic stress symptoms. The use of protective equipment did not change the impact of pandemic-related stressors on the amount of trauma experienced.
Article
Pediatrics
Zenon Pogorelic, Ivana Jankovic Marendic, Tin Cohadzic, Miro Jukic
Summary: The aim of this study was to evaluate the clinical outcomes and complication rate of laparoscopic appendectomy in children operated on during the daytime versus nighttime. The results showed no significant difference in complication rates and treatment outcomes between daytime and nighttime surgeries.
Article
Pediatrics
Miro Jukic, Petra Nizeteo, Jakov Matas, Zenon Pogorelic
Summary: This study aimed to determine the negative appendectomy rates and analyze the demographic and clinical data of patients with negative histopathology reports. The findings showed a negative appendectomy rate of 12.4%, with higher rates in female children, especially those aged 10 to 15 years. Female children also had significantly lower BMI values compared to male children. Increasing the use of auxiliary diagnostic methods, such as computed tomography, may help reduce the pediatric negative appendectomy rate.
Review
Medicine, General & Internal
Apoorv Singh, Zenon Pogorelic, Aniket Agrawal, Carlos Martin Llorente Munoz, Deepika Kainth, Ajay Verma, Bibekanand Jindal, Sandeep Agarwala, Sachit Anand
Summary: This study evaluated the role of serum ischemia-modified albumin (IMA) in diagnosing and prognosticating acute appendicitis. The results showed that IMA levels were significantly elevated in patients with acute appendicitis and higher in patients with complicated appendicitis compared to non-complicated appendicitis. However, the methodological quality of the available studies was limited, indicating a need for further well-designed and adequately powered studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
