Article
Radiology, Nuclear Medicine & Medical Imaging
Harvey A. Ziessman, Mathurika Jeyasingam, Ahsan U. Khan, Zsuzsanna McMahan, Pankaj J. Pasricha
Summary: This study found that most patients had dysmotility in different regions of the esophagogastrointestinal tract. There was a poor correlation between the results of the water-only study and water with the solid meal study. Patient symptoms were often not predictive of scintigraphic findings.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Chen Xu, Jiying Cong, Tingting Liu, Chenmeng Jiao, Mingsen Li, Yongjun Yu, Zhao Zhang, Shiwu Zhang, Yuwei Li
Summary: This study utilized high-resolution colonic manometry to evaluate the colonic motility in patients with slow transit constipation (STC). The study found that STC patients had lower occurrence rate and times of high amplitude propagated contraction (HAPC) compared to healthy controls (HCs). The characteristics of HAPC contraction, including length, amplitude, area under the curve (AUC) of pressure wave, and duration, were reduced in STC patients. The study also classified STC patients into four types based on HRCM characteristics and provided treatment recommendations.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Samuel Tanner, Ahson Chaudhry, Navneet Goraya, Rohan Badlani, Asad Jehangir, Dariush Shahsavari, Zubair Malik, Henry P. Parkman
Summary: In patients with chronic constipation, about 22% have dyssynergic defecation (DD), about 55% have slow transit constipation (STC), and 13% have both DD and STC. There were no specific symptoms differentiating STC from DD, but patients with STC and DD reported more severe constipation symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jeng-Jung Chen, R. N. Kitzia Colliard, Samuel Nurko, Leonel Rodriguez
Summary: Melanosis coli is associated with the use of sennosides, but it does not affect colonic motility or increase the need for surgery in pediatric functional constipation.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xingyang Wan, Qian Zhou, Huaxian Chen, Zhen Li, Mianling Mo, Zhimin Liu, Heng Zhang, Zhuojie He, Guozhong Xiao, Yihui Zheng, Hongcheng Lin, Donglin Ren
Summary: This study found that treatment with AS-IV improved symptoms in STC mice and affected changes in gut microbiota and metabolites, with correlations found between specific gut microbes and fecal metabolites such as 3-BrY. It was suggested that 3-BrY may reduce caspase-dependent apoptosis of ECs and protect cell survival by inhibiting the activation of the p38 MAPK and ERK signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Wen-jing Gong, Rong Li, Qiao-qiong Dai, Peng Yu
Summary: The study found that METTL3, DGCR8, miR-30b-5p, and m6A methylation levels were significantly increased in tissues from patients with slow transit constipation (STC) and in glutamic acid-induced interstitial cells (ICCs). Inhibiting METTL3 and miR-30b-5p can reduce cell death in ICCs, while overexpression of miR-30b-5p can reverse the protective effect of METTL3 knockdown on cells.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Yuanming Huang, Yanan Guo, Xianping Li, Yuchun Xiao, Zhihuan Wang, Liqiong Song, Zhihong Ren
Summary: This study evaluated the impact of Lactiplantibacillus plantarum GUANKE (GUANKE) on diphenoxylate-induced slow transit constipation in a mouse model. GUANKE alleviated constipation symptoms by regulating intestinal factors, neurotransmitters, hormones, and specific bacterial taxa.
Article
Medicine, General & Internal
Hongliang Tian, Chen Ye, Bo Yang, Jiaqu Cui, Zhijun Zheng, Chunyan Wu, Shailan Zhou, Xiaoqiong Lv, Nan Qin, Huanlong Qin, Ning Li, Qiyi Chen
Summary: In this study, the researchers found significant differences in the intestinal microbiome of patients with slow transit constipation (STC) compared to healthy individuals. The differences were observed at the phylum, genus, and species level. The study also identified potential biomarkers and pathways associated with STC. These findings suggest that alterations in the microbiome and microbial-derived metabolites may contribute to the development of constipation, providing potential targets for the development of microbial drugs.
FRONTIERS IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Yuanzhe Zhang, Shengnan Jian, Yuchuan Li
Summary: This study explored the role and mechanism of Benzoylmesaconine (BAC) in the treatment of slow transit constipation (STC). The results showed that BAC improved the symptoms of STC and improved the composition of intestinal microflora associated with STC.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Plant Sciences
Yong Wen, Yu Zhan, Shiyu Tang, Fang Liu, Rong Wu, Pengfei Kong, Qian Li, Xuegui Tang
Summary: This study explores the analgesic effect and mechanism of a traditional Chinese medicine compound Zuotong Capsule on cancer pain. The results demonstrate that this compound can significantly alleviate the severity of cancer pain by inhibiting the release of inflammatory factors and regulating the levels of neurotransmitters. These findings provide a theoretical basis for further research and application of traditional Chinese medicine compounds.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
LiangFeng Wang, Fei Wu, YanLong Hong, Lan Shen, LiJie Zhao, Xiao Lin
Summary: Traditional Chinese medicine (TCM) shows good clinical efficacy in treating slow transit constipation (STC) with multiple mechanisms, focusing on balancing yin and yang, qi and blood, and liver qi. Single Chinese herbs and active ingredients also exhibit promising efficacy in STC treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yongxiang Jiang, Hao Kong, Tingmin Chang, Tao Bai, Xuelian Xiang, Xiaohao Zhang, Xiaoping Xie, Lili Zhang, Chaoxian Zhang, Xiaohua Hou, Rong Lin
Summary: The traditional radiopaque markers protocol for colonic transit time is not suitable for Chinese patients due to their rapid colonic motility. This study found that a modified protocol tailored for Chinese individuals with rapid colon movement showed high diagnostic accuracy and sensitivity in diagnosing constipation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
George Triadafilopoulos, Megan Lee, Leila Neshatian
Summary: This study assessed the relative utility of the London classification in the decision-making of patients with chronic constipation (CC) by comparing wireless motility capsule (WMC) and high-resolution anorectal manometry (HR-ARM) results. It was found that anorectal dysfunction had a high prevalence in patients with slow colonic transit time (CTT) regardless of the classification criteria. Therefore, the specificity and utility of WMC and HR-ARM in assessing patients with CC need further investigation.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Sanne J. Verkuijl, Monika Trzpis, Paul M. A. Broens
Summary: This study found that there may be a neural pathway in the anal canal that leads to rectal contraction to assist defaecation. Anal anaesthesia significantly decreased rectal contraction and the electrosensitivity of the anal canal was negatively correlated with maximum rectal contraction.
COLORECTAL DISEASE
(2022)
Article
Chemistry, Applied
Xiaoli Bai, Yi He, Bingyan Quan, Ting Xia, Xianglong Zhang, Yongqi Wang, Yu Zheng, Min Wang
Summary: This study investigated the physicochemical properties and structure of tea insoluble dietary fiber (T-IDF), and found that T-IDF exhibits excellent physical and chemical properties. Consumption of T-IDF significantly promoted defecation and enhanced the production of short chain fatty acids.
Article
Surgery
Paul Kruger, Warwick J. Teague, Rija Khanal, John M. Hutson, Sebastian K. King
ANZ JOURNAL OF SURGERY
(2019)
Article
Surgery
Paul Kruger, Warwick J. Teague, Rija Khanal, John M. Hutson, Sebastian K. King
ANZ JOURNAL OF SURGERY
(2019)
Letter
Pediatrics
John M. Hutson
PEDIATRIC SURGERY INTERNATIONAL
(2019)
Letter
Pediatrics
John Hutson
PEDIATRIC SURGERY INTERNATIONAL
(2020)
Review
Pediatrics
J. M. Hutson, M. C. Hynes, I. Kearsey, Y. I. Yik, D. M. Veysey, C. F. Tudball, T. M. Cain, S. K. King, B. R. Southwell
PEDIATRIC SURGERY INTERNATIONAL
(2020)
Article
Pediatrics
Norman Ling, Misel Trajanovska, Andrew Griffith, Tracey Phan, Susan Gibb, Sharon Goldfeld, Sebastian K. King
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2020)
Review
Medicine, Research & Experimental
Bridget R. Southwell
Article
Pediatrics
Alice C. Burnett, Julia K. Gunn-Charlton, Stephanie Malarbi, Esther Hutchinson, Tiong Yang Tan, Warwick J. Teague, Sebastian K. King, Rod W. Hunt
Summary: Children with OA showed varying cognitive, language, and executive functioning, with some displaying lower than expected intellectual development. At 5 years, they exhibited age-appropriate language and self-regulation, but reduced attention. By 8 years, the OA group had lower sustained attention, divided attention, and mathematics skills, but typical memory and literacy. Parents consistently reported increased working memory difficulties, and other executive functioning and behavioral symptoms were transiently observed. Findings did not consistently differ according to clinical characteristics.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Sharman P. Tan Tanny, Sebastian K. King, Assia Comella, Alisa Hawley, Jo-Anne Brooks, Rod W. Hunt, Bryn Jones, Warwick J. Teague
Summary: Preoperative echocardiography is routinely used in neonates with esophageal atresia to identify those with congenital cardiac disease that may impact anesthesia and surgical decisions. Selective strategies can reduce the number of echocardiograms performed, improving timeliness of care and resource utilization without compromising patient safety.
PEDIATRIC SURGERY INTERNATIONAL
(2021)
Review
Gastroenterology & Hepatology
Hannah M. E. Evans-Barns, Justina Swannjo, Misel Trajanovska, Mark Safe, John M. Hutson, Warwick J. Teague, Phil G. Dinning, Sebastian K. King
Summary: This systematic review evaluated the evidence regarding colonic manometry in children with Hirschsprung disease (HD) following surgical repair. The study highlighted limitations in the current literature, including variable methodologies, heterogeneous cohorts, and a lack of high-resolution manometry. Further research is needed to better understand colonic dysmotility in this population.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Gastroenterology & Hepatology
Hannah M. E. Evans-Barns, Justina B. Swannjo, Misel Trajanovska, Mark Safe, John M. Hutson, Phil G. Dinning, Sebastian K. King
Summary: The systematic review focused on post-operative anorectal manometry in children with Hirschsprung disease, revealing a lack of high-quality evidence and consistency in reported outcomes. Standardization of protocols, cohort reporting, and outcome assessments are essential for future research in this area.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Anesthesiology
Geoff Frawley, Luis Ignacio Cortinez, Brian J. Anderson, Andrew Bjorksten, Sebastian King
Summary: This study aimed to measure the total plasma concentrations of levobupivacaine in infants after repeat caudal anesthesia and to establish a pharmacokinetic model to predict plasma concentrations after repeat caudal anesthesia in neonates, infants, and children. The results showed that repeat caudal levobupivacaine at 2.5 mg/kg, 3 hours after an initial dose, did not exceed the concentration associated with systemic local anesthetic toxicity. However, in some simulated neonates, repeat caudal anesthesia breached the lower concentration limit associated with toxicity at both 3 and 4 hours after the initial caudal.
PEDIATRIC ANESTHESIA
(2022)
Article
Pediatrics
Isabel C. Hageman, Hendrik J. J. van der Steeg, Ekkehart Jenetzky, Misel Trajanovska, Sebastian K. King, Ivo de Blaauw, ARM Net Consortium
Summary: The quality of the Anorectal Malformation Network (ARM-Net) registry was assessed, and it was found that while the collected data are valuable, they are susceptible to error and user variability. Continuous evaluations are needed to maintain relevant and high-quality data and achieve long-term sustainability.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Health Care Sciences & Services
Fern Ee Caryn Koo, Man Ching Esther Chan, Sebastian K. King, Misel Trajanovska
Summary: The study aims to determine whether the health-related quality of life (HRQoL) of children with Hirschsprung disease (HD) differs from healthy pediatric populations, and explore the relationship between HRQoL of HD children and psychosocial outcomes of parents. A cross-sectional survey was conducted on parents of 48 Australian children treated for HD, and it was found that while postoperative HRQoL of HD children was comparable to healthy controls, their psychosocial quality of life was significantly poorer. The study highlights the need for long-term follow-up care for HD patients and their families.
QUALITY OF LIFE RESEARCH
(2023)
Article
Surgery
Hemal Kodikara, Sebastian K. King, Elizabeth McLeod
SURGICAL CASE REPORTS
(2020)