Editorial Material
Critical Care Medicine
Brendan Burke, William Tierney, Rachel Georgopoulos, Samir Q. Latifi, Hemant S. Agarwal
Summary: Involvement of the upper airway in the systemic lupus erythematosus (SLE) disease process is uncommon, but can lead to severe complications such as acute tracheal necrosis. Prompt airway evaluation and treatment are crucial for the recovery of SLE patients with rare upper airway involvement.
Article
Pediatrics
Wei Quan, Jingnan An, Gang Li, Guanghui Qian, Meifang Jin, Chenxi Feng, Si Li, Xiaozhong Li, Yunyun Xu, Xiaohan Hu
Summary: This study identified significantly elevated levels of IL-2, IL-10, and IL-21 in cSLE patients compared to healthy controls, with a positive correlation to disease activity. This suggests potential new approaches for regulating T lymphocyte subsets in cSLE diagnosis.
Article
Pediatrics
Pondtip Jongvilaikasem, Pornpimol Rianthavorn
Summary: Patients with childhood-onset systemic lupus erythematosus are at risk of becoming short adults, with independent risk factors including male sex, short stature at diagnosis, low body weight at final height, and cumulative corticosteroid dose. Adequate nutrition and corticosteroid minimization should be emphasized in patients at high risk for short final height.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Chemistry, Medicinal
Noel Zahr, Saik Urien, Christian Funck-Brentano, Helene Vantomme, Nicolas Garcelon, Isabelle Melki, Margaux Boistault, Olivia Boyer, Brigitte Bader-Meunier
Summary: This study investigated the pharmacokinetics of hydroxychloroquine (HCQ) in pediatric patients with systemic lupus erythematosus (SLE). The results showed that HCQ blood concentration was associated with disease activity and could serve as a significant predictor of disease status.
Review
Immunology
Lu Pan, Jinxiang Liu, Congcong Liu, Lishuang Guo, Marilynn Punaro, Sirui Yang
Summary: Childhood-onset systemic lupus erythematosus (cSLE) is a challenging autoimmune disease that requires aggressive treatment due to its genetic background and prevalent elevated type I Interferon expression. High dose oral glucocorticoid (GC) is the standard treatment for moderate to severe cSLE, although its side effects and toxicities cannot be ignored. Recent studies have shown that GC pulse therapy can quickly achieve disease remission and reduce GC-related side effects. This article reviews the characteristics and manifestations of cSLE, and summarizes the evidence on GC therapy, particularly GC pulse therapy, in cSLE.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Lingxiao Xu, Jian Zhao, Qing Sun, Xue Xu, Lei Wang, Ting Liu, Yunjuan Wu, Jingfeng Zhu, Linyu Geng, Yun Deng, Alexander Awgulewitsch, Diane L. Kamen, Jim C. Oates, Prithvi Raj, Edward K. Wakeland, R. Hal Scofield, Joel M. Guthridge, Judith A. James, Bevra H. Hahn, Deborah K. McCurdy, Fang Wang, Miaojia Zhang, Wenfeng Tan, Gary S. Gilkeson, Betty P. Tsao
Summary: This research found two novel SAT1 LOF variants through whole exome sequencing in families with multiple siblings affected by systemic lupus erythematosus (SLE), demonstrating their association with SLE. The study highlights the pathogenic role of dysregulated polyamine catabolism in lupus.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Pediatrics
Shobashenee Sritharan, Peter Sie-Teck Lau, Kamilah Manan, Anand Mohan
Summary: The presence of occult splenic abscesses in children diagnosed with childhood-onset SLE, without evidence of concomitant infection, is an unusual finding. Treatment with corticosteroids and immunosuppressive therapy resulted in rapid recovery of symptoms and complete resolution of the abscesses.
FRONTIERS IN PEDIATRICS
(2023)
Article
Rheumatology
Maya Gerstein, R. Ezequiel Borgia, Daniela Dominguez, Brian M. Feldman, Fangming Liao, Deborah M. Levy, Lawrence Ng, Mohamed Abdelhaleem, Earl D. Silverman, Linda T. Hiraki
Summary: The study aimed to differentiate macrophage activation syndrome (MAS) from active childhood-onset systemic lupus erythematosus (cSLE) and generated decision rules based on clinical and laboratory features. Recursive partitioning identified serum ferritin as the best discriminator between MAS and non-MAS patients. Validation in independent cohorts is needed to confirm the findings.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Immunology
Xiaoyue Wen, Dan Xu, Shiying Yuan, Jiancheng Zhang
Summary: This study summarized the clinical features of acute transverse myelitis (TM) secondary to systemic lupus erythematosus (SLE) through a case report and systematic review, providing a novel insight into this rare disease.
AUTOIMMUNITY REVIEWS
(2022)
Article
Rheumatology
Ana C. Ulloa, Fangming Liao, Raffaella L. Carlomagno, Talia Diaz, Daniela Dominguez, Deborah M. Levy, Lawrence Ng, Andrea M. Knight, Linda T. Hiraki
Summary: The association between schizophrenia genetic susceptibility loci and NPSLE features in multiethnic childhood-onset SLE patients was examined. The results suggested that there was no significant association between schizophrenia risk loci and NPSLE in this cohort.
JOURNAL OF RHEUMATOLOGY
(2022)
Review
Rheumatology
Resit Yildirim, Tatiana Oliveira, David Alan Isenberg
Summary: In recent years, there have been efforts to improve the prognosis and outcome in patients with autoimmune inflammatory rheumatic diseases by using treat-to-target strategy and early intervention strategies with immunosuppressive agents. However, infectious complications due to medication side effects remain a major concern. Vaccination programmes and vaccine immunity play a crucial role in patients with SLE in terms of morbidity and mortality. Although research on vaccines' efficacy and immune response in immunosuppressed patients has increased, there is still a lack of data investigating these parameters for those receiving biological agents, leading to a lack of consensus on a vaccination policy for patients with SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Mario Sestan, Nastasia Kifer, Todor Arsov, Matthew Cook, Julia Ellyard, Carola G. Vinuesa, Marija Jelusic
Summary: The pathogenesis of childhood-onset systemic lupus erythematosus (cSLE) involves genetic risk factors, epigenetic mechanisms, and environmental triggers. While cSLE is typically considered a polygenic disease, rare cases with a single gene mutation provide valuable insights into the disease mechanism and aid in targeted treatment strategies. This review aims to provide an overview of monogenic and polygenic SLE, emphasizing the implications of specific genes in disease pathogenesis. Understanding the genetic factors involved in SLE may improve our understanding of disease mechanisms, identify biomarkers, and guide appropriate therapies.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Rheumatology
Gizem Durcan, Sezgin Sahin, Zehra Koyuncu, Mehmet Yildiz, Elif Hacivelioglu, Fatih Haslak, Amra Adrovic, Kenan Barut, Aybuke Gunalp, Burak Dogangun, Ozgur Kasapcopur
Summary: The study evaluated the sleep habits of children and adolescents with SLE and compared them with healthy peers. Results showed that SLE patients had higher scores for bedtime resistance and night waking, with a slightly higher total sleep score compared to the control group. The prevalence of sleep disorders was also slightly higher in the patient group.
CLINICAL RHEUMATOLOGY
(2022)
Article
Pediatrics
Ana P. Sakamoto, Clovis A. Silva, Aline G. Islabao, Glaucia Novak, Beatriz Molinari, Paulo K. Nogueira, Rosa M. R. Pereira, Claudia Saad-Magalhaes, Gleice Clemente, Daniela P. Piotto, Nadia E. Aikawa, Ana C. Pitta, Vitor C. Trindade, Simone Appenzeller, Luciana M. Carvalho, Carlos N. Rabelo-Junior, Adriana R. Fonseca, Flavio R. Sztajnbok, Maria C. Santos, Blanca E. Bica, Evaldo G. Sena, Ana J. Moraes, Melissa M. Fraga, Teresa C. Robazzi, Paulo F. Spelling, Iloite M. Scheibel, Andre S. Cavalcanti, Erica N. Matos, Luciano J. Guimaraes, Flavia P. Santos, Licia M. H. Mota, Eloisa Bonfa, Maria T. Terreri
Summary: This study evaluated stages of chronic kidney disease (CKD) in pediatric systemic lupus erythematosus (SLE) patients and identified risk factors for CKD. The study found that hypertension, biopsy-proven proliferative nephritis, and lack of antimalarial use were associated with an increased risk of CKD in these patients.
PEDIATRIC NEPHROLOGY
(2023)
Review
Medicine, General & Internal
Swee Ping Tang, Sern Chin Lim, Thaschawee Arkachaisri
Summary: Childhood onset systemic lupus erythematosus is more common in Southeast Asian children than in the West, with a higher prevalence in females. Disease activity is initially higher but responds well to therapy. However, organ damage occurs early and continues to accumulate over time, with infections remaining the leading cause of mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Daniel Castellanos, Frances C. Travelli, Iris Reyhan, Jodie K. Votava-Smith, Anusha Ramanathan, Yaniv Bar-Cohen
Review
Rheumatology
Arunima Agarwal, Stephanie Biglarian, Sophia Lim-Stavros, Jodie K. Votava-Smith, Anusha Ramanathan
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2015)
Article
Rheumatology
Susanna Felsenstein, Andreas O. Reiff, Anusha Ramanathan
ARTHRITIS CARE & RESEARCH
(2015)
Article
Rheumatology
Anusha Ramanathan, Hemalatha Srinivasalu, Robert A. Colbert
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2013)
Article
Cell Biology
William D. Shipman, Susan Chyou, Anusha Ramanathan, Peter M. Izmirly, Sneh Sharma, Tania Pannellini, Dragos C. Dasoveanu, Xiaoping Qing, Cynthia M. Magro, Richard D. Granstein, Michelle A. Lowes, Eric G. Pamer, Daniel H. Kaplan, Jane E. Salmon, Babak J. Mehrara, James W. Young, Robert M. Clancy, Carl P. Blobel, Theresa T. Lu
SCIENCE TRANSLATIONAL MEDICINE
(2018)
Article
Infectious Diseases
Annette Langer-Gould, Jessica B. Smith, Edlin G. Gonzales, Rhina D. Castillo, Judith Garza Figueroa, Anusha Ramanathan, Bonnie H. Li, Michael K. Gould
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Pediatrics
Paul Han, Jelena Douillard, Jerry Cheng, Anusha Ramanathan, David Tieu, Timothy Degner
CASE REPORTS IN PEDIATRICS
(2020)