Article
Pediatrics
Adele Civino, Francesca Bovis, Marta Ponzano, Giovanni Alighieri, Eleonora Prete, Stefania Sorrentino, Silvia Magni-Manzoni, Luciana Vinti, Micol Romano, Nicola Santoro, Giovanni Filocamo, Tamara Belotti, Francesca Santarelli, Chiara Gorio, Marco Cattalini, Giulia Stabile, Valentino Conter, Roberto Rondelli, Andrea Pession, Angelo Ravelli
Summary: The study aimed to develop and validate a weighted score, the ONCOREUM score, for differentiating cancer with arthropathy from juvenile idiopathic arthritis (JIA). Three statistical approaches were used to develop the score, and the highest area under the ROC curve was obtained by model 1, which was selected as the ONCOREUM score. The score is a powerful and easily applicable tool for early differentiation of malignancies with articular complaints from JIA.
JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Justine R. Smith, Janet M. Matthews, Diana Conrad, Anthony J. Hall, Rachael L. Niederer, Davinder Singh-Grewal, Mei-Ling Tay-Kearney, Jane M. Wells, Sophia L. Zagora, Peter J. McCluskey
Summary: The Australian and New Zealand-based uveitis-specialized ophthalmologists have developed 18 consensus statements for managing chronic anterior uveitis in children with JIA, providing regionally applicable advice for ophthalmic care.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Rheumatology
Clara Malattia, Lorenzo Chiarella, Miriam Sansone, Angela Pistorio, Claudio Lavarello, Manuela Carpaneto, Raffaele Ferri, Angelo Ravelli, Lino Nobili
Summary: This study investigates sleep quality in juvenile fibromyalgia syndrome (JFS) and its impact on the global burden of the disease. The results show that patients with JFS have longer sleep period time, increased wake after sleep onset, and lower N3 distribution index compared to healthy peers. Subjective poor sleep quality is related to widespread pain, symptom severity, depressive symptoms, fatigue, and symptom severity upon awakening. Sleep complaints are a key characteristic of JFS and have significant effects on pain and depression.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Lucy R. Wedderburn, Athimalaipet Ramanan, Adam P. Croft, Kimme L. Hyrich, Andrew Dick
Summary: Despite the availability of various treatments for childhood arthritis, many patients require long-term immune suppression and there is a lack of validated tools and biomarkers for treatment selection. Advances in molecular-based treatment targets and clinical trial designs could pave the way for more precise treatment strategies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Article
Rheumatology
Jaymin Upadhyay, Jordan Lemme, Mariesa Cay, Hanne Van Der Heijden, Diana Sibai, Benjamin Goodlett, Jeffery Lo, Kacie Hoyt, Maria Taylor, Melissa M. Hazen, Olha Halyabar, Esra Meidan, Rudy Schreiber, Margaret H. Chang, Peter A. Nigrovic, Camilo Jaimes, Lauren A. Henderson, Kirsten Ecklund, Robert P. Sundel
Summary: This study utilized neuroimaging techniques to explore the pain-related neurobiological features in JIA patients, finding associations between pain severity and physical stress, cognitive function, and changes in brain structures regulating emotional pain processing. These preliminary findings suggest potential mechanisms by which pain may be dissociated from detectable joint pathology and persist independently of inflammation or treatment status.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Review
Nutrition & Dietetics
Renata Puppin Zandonadi
Summary: Nutrition plays a crucial role in the treatment, health, and life of patients with juvenile idiopathic arthritis (JIA). Suboptimal nutrition can adversely affect the long-term outcome of JIA patients, while correct nutritional status helps with recovery and inflammation reduction.
Article
Medicine, General & Internal
Monika Ostrowska, Piotr Gietka, Malgorzata Manczak, Emil Michalski, Iwona Sudol-Szopinska
Summary: The study aimed to differentiate between hip arthritis in JIA and hip arthralgia of unknown etiology using MRI. MRI is effective in distinguishing between the two conditions, with good specificity in confirming a diagnosis of JIA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Saverio La Bella, Marta Rinaldi, Armando Di Ludovico, Giulia Di Donato, Giulio Di Donato, Vincenzo Salpietro, Francesco Chiarelli, Luciana Breda
Summary: This review evaluates the current understanding of the pathogenesis of JIA subtypes by examining the most relevant and up-to-date evidence. Despite significant improvements over the past decade, the exact cause and molecular mechanisms of JIA remain unclear. Complex interactions between genetic background and environmental factors, as well as the involvement of HLA haplotypes and non-HLA genes, contribute to the abnormal activation of immune cells and the inflammatory process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
Emil Carlsson, Michael W. Beresford, Athimalaipet Ramanan, Andrew D. Dick, Christian M. Hedrich
Summary: Early treatment and frequent screening are crucial for controlling JIA-associated uveitis, which poses a significant risk for serious complications. The identification of specific risk factors for JIA-associated uveitis is a key focus of research as our understanding of pathogenic drivers is still incomplete. Genomic, transcriptomic, and proteomic factors have been identified as potential risk factors, and therapeutic strategies are being discussed.
Article
Medicine, General & Internal
Alberto Martini, Daniel J. Lovell, Salvatore Albania, Hermine Brunner, Kimme L. Hyrich, Susan D. Thompson, Nicolino Ruperto
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory rheumatic condition of childhood, classified into seven categories. The pathogenesis of JIA involves autoimmune and autoinflammatory mechanisms, and the availability of new drugs has significantly improved treatment options.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Review
Nutrition & Dietetics
Chao-Yi Wu, Huang-Yu Yang, Shue-Fen Luo, Jing-Long Huang, Jenn-Haung Lai
Summary: Vitamin D plays an important role in bone health and immune regulation. Juvenile idiopathic arthritis is a chronic inflammatory joint disease, and vitamin D may have potential effects on its manifestations and outcomes.
Article
Rheumatology
Xinyi Meng, Xiaoyuan Hou, Ping Wang, Joseph T. Glessner, Hui-Qi Qu, Michael E. March, Sipeng Zhang, Xiaohui Qi, Chonggui Zhu, Kenny Nguyen, Xinyi Gao, Xiaoge Li, Yichuan Liu, Wentao Zhou, Shuyue Zhang, Junyi Li, Yan Sun, Jie Yang, Patrick M. A. Sleiman, Qianghua Xia, Hakon Hakonarson, Jin Li
Summary: This study identified rare coding variants in JIA patients using RNA-seq data, including some reported causal variants. These variants were partially replicated in polyarticular patients and shared common variants with genes associated with autoimmune diseases. Genes related to immune pathways were enriched for rare coding variants and differentially expressed genes.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Neurosciences
Leandra Woolnough, Ariel Pomputius, Heather K. Vincent
Summary: The systematic review highlighted significant changes in gait among children with JIA, such as slower walking speed, shortened step length, and decreased range of joint motion. Exercise and pharmaceutical interventions have the potential to ameliorate these changes.
Article
Oncology
Margarita B. Belogurova, Zoryana P. Kizyma, Miklos Garami, Monika Csoka, Michael J. Lamson, Anton Buchner, Peter Bias, Andreas Lammerich
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2017)
Article
Oncology
Marta Hegyi, Adam Arany, Agnes F. Semsei, Katalin Csordas, Oliver Eipel, Andras Gezsi, Nora Kutszegi, Monika Csoka, Judit Muller, Daniel J. Erdelyi, Peter Antal, Csaba Szalai, Gabor T. Kovacs
Article
Oncology
Tamas Farkas, Judit Muller, Daniel J. Erdelyi, Monika Csoka, Gabor T. Kovacs
PATHOLOGY & ONCOLOGY RESEARCH
(2017)
Article
Oncology
Luca Felkai, Rita Banusz, Ilona Kovalszky, Zoltan Sapi, Miklos Garami, Gergo Papp, Katalin Karaszi, Edit Varga, Monika Csoka
PATHOLOGY & ONCOLOGY RESEARCH
(2019)
Article
Rheumatology
Ilonka Orban, Tamas Constantin, Beata Derfalvi, Krisztina Sevcic, Diana Garan, Rita Kaposzta, Gyula Poor, Emese Kiss, Andrea Ponyi, Alessandro Consolaro, Francesca Bovis, Nicolino Ruperto
RHEUMATOLOGY INTERNATIONAL
(2018)
Article
Immunology
Kenneth Paris, Elie Haddad, Michael Borte, Nicholas Brodszki, Beata Derfalvi, Laszlo Marodi, Iftikhar Hussain, Amy Darter, Werner Engl, Heinz Leibl, Barbara McCoy, Leman Yel
Article
Biotechnology & Applied Microbiology
Gergely Buglyo, Zsofia Magyar, Eva Romicsne Gorbe, Rita Banusz, Monika Csoka, Tamas Micsik, Zsanett Berki, Peter Varga, Zoltan Sapi, Balint Nagy
JOURNAL OF BIOTECHNOLOGY
(2019)
Article
Multidisciplinary Sciences
Breanna K. V. Hargreaves, Sarah E. Roberts, Beata Derfalvi, Jeanette E. Boudreau
Article
Oncology
Luca Felkai, Ildiko Krencz, Dorottya Judit Kiss, Noemi Nagy, Gabor Petovari, Titanilla Danko, Tamas Micsik, Andras Khoor, Tamas Tornoczky, Zoltan Sapi, Anna Sebestyen, Monika Csoka
Article
Allergy
Roxane Labrosse, Sara Barmettler, Beata Derfalvi, Annaliesse Blincoe, Guilhem Cros, Jonathan Lacombe-Barrios, Julie Barsalou, Nancy Yang, Nora Alrumayyan, Jan Sinclair, Mei-Sing Ong, Carlos A. Camargo, Jolan Walter, Elie Haddad
Summary: The study revealed a high prevalence of hypogammaglobulinemia in children receiving rituximab treatment, with low IgG levels associated with an increased risk of serious infections. Underlying primary immunodeficiencies were relatively common in pediatric patients receiving rituximab.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Sarah M. McAlpine, Sarah E. Roberts, John J. Heath, Fabian Kasermann, Andrew C. Issekutz, Thomas B. Issekutz, Beata Derfalvi
Summary: IVIG treatment has multiple effects on NK cell subsets and CD4(+) T cells, promoting resolution of inflammation in patients with immune dysregulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Timothy K. Vander Leek, Edmond S. Chan, Lori Connors, Beata Derfalvi, Anne K. Ellis, Julia E. M. Upton, Elissa M. Abrams
Summary: This review discusses the safety concerns of COVID-19 vaccines for individuals with allergies and immunocompromised conditions, emphasizing the need for assessment by allergists. It also provides guidance on when COVID-19 vaccines should be offered to immunocompromised patients, with updates to this guidance expected as new information becomes available.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2021)
Article
Pediatrics
Beata Derfalvi, Kriszta Katinka Boros, Doloresz Szabo, Gabor Bozsaki, Aron Cseh, Gabor Rudas, Katalin Eszter Muller, Gabor Veres
Summary: This study provides new data on the prevalence of joint involvement in pediatric CD and its correlation with disease activity and quality of life. The results show that joint involvement is more prevalent in pediatric CD than previously reported and is associated with more severe disease activity and lower quality of life.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Allergy
Nora Alrumayyan, Drew Slauenwhite, Sarah M. McAlpine, Sarah Roberts, Thomas B. Issekutz, Adam M. Huber, Zaiping Liu, Beata Derfalvi
Summary: Prolidase deficiency is a multisystemic disease that can lead to immune dysregulation and metabolic defects. We report detailed case presentations of twin females with Prolidase deficiency, including their immunological characteristics and treatment modalities.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Zeinab A. El-Sayed, Irina Abramova, Juan Carlos Aldave, Waleed Al-Herz, Liliana Bezrodnik, Rachida Boukari, Ahmed Aziz Bousfiha, Caterina Cancrini, Antonio Condino-Neto, Ghassan Dbaibo, Beata Derfalvi, Figen Dogu, J. David M. Edgar, Brian Eley, Rasha Hasan El-Owaidy, Sara Elva Espinosa-Padilla, Nermeen Galal, Filomeen Haerynck, Rima Hanna-Wakim, Elham Hossny, Aydan Ikinciogullari, Ebtihal Kamal, Hirokazu Kanegane, Nadia Kechout, Yu Lung Lau, Tomohiro Morio, Viviana Moschese, Joao Farela Neves, Monia Ouederni, Roberto Paganelli, Kenneth Paris, Claudio Pignata, Alessandro Plebani, Farah Naz Qamar, Sonia Qureshi, Nita Radhakrishnan, Nima Rezaei, Nelson Rosario, John Routes, Berta Sanchez, Anna Sediva, Mikko R. J. Seppanen, Edith Gonzalez Serrano, Anna Shcherbina, Surjit Singh, Sangeetha Siniah, Guiseppe Spadaro, Mimi Tang, Ana Maria Vinet, Alla Volokha, Kathleen E. Sullivan
WORLD ALLERGY ORGANIZATION JOURNAL
(2019)