Review
Rheumatology
Hema Chaplin, Lewis Carpenter, Anni Raz, Elena Nikiphorou, Heidi Lempp, Sam Norton
Summary: The study identified that refractory disease in RA and polyJIA is defined mainly as resistance to multiple drugs with different mechanisms of action and persistence of symptoms and high disease activity. It is concluded that there is a need for a clear unified definition to aid study comparisons and appropriate identification of patients.
Article
Immunology
Karen Yu, Luna Dillemans, Mieke Gouwy, Helena Bessa, Mieke Metzemaekers, Erik Martens, Patrick Matthys, Xavier Bossuyt, Patrick Verschueren, Carine Wouters, Lien De Somer, Paul Proost
Summary: In this study, a fluorescent in vitro assay was improved to characterize endogenous PAD activity in complex samples. The results showed similar levels of PAD activity in synovial fluids of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) patients, while citrullination was limited in joints of patients with gout or Lyme's disease. Interestingly, a higher level of extracellular citrullination was only found in blood of anti-CCP-positive RA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Zuzana Parackova, Irena Zentsova, Hana Malcova, Dita Cebecauerova, Anna Sediva, Rudolf Horvath
Summary: This study found that posttranslational modifications (PTMs) of proteins and dysregulated generation of neutrophil extracellular traps (NETs) contribute to the pathogenesis of juvenile idiopathic arthritis (JIA) by inducing the generation of autoantibodies. These findings suggest that regulating inflammation using immune therapy may help prevent the development of autoimmune responses.
FRONTIERS IN MEDICINE
(2022)
Review
Biology
Sydney Moore McIntosh, Christian Kerut, Payton P. Hollenshead, Dorothy H. Askins, Kasra Mansourian, Zachary R. Palowsky, Varsha Allampalli, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye
Summary: Psoriatic arthritis is a chronic autoimmune condition with unique cutaneous manifestations. Tumor necrosis factor inhibitors, such as golimumab, have become a hallmark treatment option. Multiple studies have shown the efficacy of golimumab in both juvenile and adult-onset psoriatic arthritis.
Article
Immunology
Jie Zheng, Yong Wang, Jun Hu
Summary: This study explores the shared gene signatures and potential molecular mechanisms of polyarticular juvenile idiopathic arthritis (pJIA) and autoimmune uveitis (AU) through data analysis and functional enrichment analysis. Neutrophil degranulation may be considered a shared pathogenic mechanism, and the roles of ARID1A gene and hsa-miR-146a are worthy of further study. Additionally, periodic inspection of kidney function is also important.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Renu Singh, Vijay D. Ivaturi, Justin Penzenstadler, Tao Liu, Jianmeng Chen, Anshu Marathe, Ping Ji, Rachel Glaser, Nikolay Nikolov, Chandrahas Sahajwalla
Summary: This study aimed to compare the extrapolation of efficacy between pJIA and RA, with findings indicating that in the majority of cases, pJIA response was similar or higher compared to RA trials.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Rheumatology
Nicolino Ruperto, Hermine Brunner, Athimalaipet Ramanan, Gerd Horneff, Ruben Cuttica, Michael Henrickson, Jordi Anton, Alina Lucica Boteanu, Inmaculada Calvo Penades, Kirsten Minden, Heinrike Schmeling, Markus Hufnagel, Jennifer E. Weiss, Manuela Pardeo, Kabita Nanda, Johannes Roth, Nadina Rubio-Perez, Joy C. Hsu, Sunethra Wimalasundera, Chris Wells, Kamal Bharucha, Wendy Douglass, Min Bao, Navita L. Mallalieu, Alberto Martini, Daniel Lovell, Fabrizio De Benedetti
Summary: The study found that the dosing regimens of s.c. tocilizumab in systemic JIA and polyarticular JIA are similar to i.v. tocilizumab with good efficacy. Additionally, the subcutaneous administration route is more convenient and suitable for at-home use.
Article
Rheumatology
Nicolino Ruperto, Hermine Brunner, Cesar Pacheco-Tena, Ingrid Louw, Gabriel Vega-Cornejo, Alberto J. Spindler, Daniel J. Kingsbury, Heinrike Schmeling, Arturo Borzutzky, Ruben Cuttica, C. J. Inman, Victor Malievskiy, Christiaan Scott, Vladimir Keltsev, Maria Teresa Terreri, Diego Oscar Viola, Ricardo M. Xavier, Taciana A. Pedrosa Fernandes, Maria Del Rocio Maldonado Velazquez, Michael Henrickson, Michael B. Clark, Karen A. Bensley, Xiaoming Li, Kim Hung Lo, Jocelyn H. Leu, Chyi-Hung Hsu, Elizabeth C. Hsia, Zhenhua Xu, Alberto Martini, Daniel J. Lovell
Summary: Intravenous golimumab was effective, showed consistent pharmacokinetics, and was relatively safe in pediatric patients with polyarticular-course JIA. Treatment led to significant JIA ACR response rates at 28 and 52 weeks, with steady PK exposure maintained. However, the presence of antibodies in some patients and rare serious infections were noted as potential issues.
Article
Pediatrics
Lili Ye, Yingying Jin, Hua Huang, Fei Ding, Xuemei Xu, Chenxi Liu, Shengfang Bao, Jing Wu, Yanliang Jin
Summary: This study explored the role of DKK-1 and SOST in the pathogenesis of JIA. It was found that plasma levels of DKK-1 were significantly higher in JIA patients, especially in those with HLA-B27 positivity. After treatment, DKK-1 levels decreased significantly. However, there was no significant change in SOST levels among different JIA subtypes, before and after treatment, and healthy controls.
PEDIATRIC RESEARCH
(2023)
Article
Rheumatology
Alice Combier, Camelia Frantz, Julien Wipff, Romain Bazeli, Muriel Elhai, Antoine Feydy, Pierre Quartier, Gertrude Touanga Ngoti, Marion Thomas, Chantal Deslandre, Jerome Avouac, Yannick Allanore
Summary: This study aimed to determine whether anti-citrullinated peptide antibodies (ACPA) could be of value to assess structural damage in polyarticular juvenile idiopathic arthritis (pJIA) persisting in adulthood. Retrospectively including pJIA patients with available ACPA, rheumatoid factor (RF), and X-ray data, it was found that ACPA positivity was significantly associated with RF positivity and correlated with structural damage.
Review
Cell Biology
Brianna Hurysz, Nunzio Bottini
Summary: Rheumatoid arthritis (RA) is a common autoimmune disease associated with dysregulation of proteoglycans. Modulating the function and signaling of proteoglycans, as well as targeting citrullinated aggrecan with tolerizing agents, may provide a potential approach to improve current RA therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Pediatrics
Johannes Dirks, Jonas Fischer, Gabriele Haase, Annette Holl-Wieden, Christine Hofmann, Hermann Girschick, Henner Morbach
Summary: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases with almost half of the patients showing antinuclear antibodies (ANAs), indicating B cell dysregulation as a potential pathomechanism. This study aimed to characterize potential differences in B cell differentiation in ANA+ JIA patients, finding higher frequencies of transitional and switched-memory B cells in peripheral blood (PB) and a different distribution of B cell subsets in synovial fluid (SF) between ANA- and ANA+ patients.
FRONTIERS IN PEDIATRICS
(2021)
Review
Medicine, General & Internal
Jiaxi Liu, Jinfang Gao, Zewen Wu, Liangyu Mi, Na Li, Yajing Wang, Xinyue Peng, Ke Xu, Fengping Wu, Liyun Zhang
Summary: ACPAs are autoantibodies commonly found in patients with RA, with most of the mechanisms of formation and bone destruction well-understood. Despite advances in clinical applications and targeted therapies related to ACPAs, the presence of different subtypes poses a limitation.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
B. Schiappapietra, C. Bava, S. Rosina, A. Pistorio, F. Mongelli, S. Pederzoli, S. Verazza, S. Lanni, V Muratore, S. Davi, S. Dalpra, G. C. Varnier, M. Bertamino, C. Suffia, G. Bracciolini, G. Giancane, A. Consolaro, A. Ravelli
Summary: The number of affected joints and the CRP level in the first 6 months were identified as the strongest predictors of polyarticular extension in children with oligoarticular-onset JIA.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Health Care Sciences & Services
Amelia J. Garner, Reza Saatchi, Oliver Ward, Daniel P. Hawley
Summary: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children, requiring prompt and accurate diagnosis due to its potential for chronic damage and functional disability. Recent studies have demonstrated the potential value of novel tools and techniques in assessing and monitoring JIA, but additional research is needed to confirm their clinical utility.