Article
Multidisciplinary Sciences
Ruonan Zhang, Xiaofeng Li, Jie Zhang, Yanjun Li, Yuan Wang, Yuhang Song, Feifei Ren, Huiyu Yi, Xiaojuan Deng, Yangjin Zhong, Yang Cao, Michael R. Strand, Xiao-Qiang Yu, Wanying Yang
Summary: Toll/Toll-like receptors play different roles in mammals and insects, with insects primarily activating the Toll pathway through binding Spatzle cytokines rather than directly recognizing pathogen-associated molecular patterns.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Lianghui Zhan, Jingru Zheng, Jianbiao Meng, Danting Fu, Lisha Pang, Chunlian Ji
Summary: This study found that TLR4 deficiency can reduce inflammatory responses and apoptosis, improve intestinal damage, regulate intestinal flora, and alleviate LPS-induced intestinal barrier dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Teng Guan, Ying Guo, Chengren Li, Ting Zhou, Qiang Yu, Chaoxian Yang, Guohui Zhang, Jiming Kong
Summary: Neurodegeneration can benefit from ischemic preconditioning, but it has a deleterious effect on oligodendrocyte precursor cells (OPCs). The study identifies BNIP3 as a key protein involved in OPCs loss after preconditioning, and inhibition of BNIP3 can prevent OPCs loss and preserve white matter integrity, thus improving ischemic tolerance.
Article
Pharmacology & Pharmacy
Ludmila Filaretova, Olga Komkova, Maria Sudalina, Natalia Yarushkina
Summary: Remote ischemic preconditioning (RIPC) has been shown to protect various organs from ischemia-reperfusion injury, with glucocorticoids potentially playing a role in this protective effect. Studies demonstrated that RIPC reduced gastric erosion area in rats, and the involvement of glucocorticoids was confirmed through experiments with glucocorticoid inhibitors and receptor antagonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ioanna Tsioti, Beatrice L. Steiner, Pascal Escher, Martin S. Zinkernagel, Peter M. Benz, Despina Kokona
Summary: Clustering of microglia around the vasculature was observed after systemic administration of lipopolysaccharides (LPS) in the retina and brain of mice. This study investigated the effect of systemic LPS in the pigmented mouse retina and the involvement of endothelial TLR4 in LPS-induced retinal microglia activation. The results showed that activation of microglia, infiltration of monocyte-derived macrophages, impaired ribbon synapse organization, and retinal dysfunction were observed after LPS exposure, and these effects were dependent on endothelial TLR4.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Wei Zhang, Eun-Koung An, Juyoung Hwang, Jun-O Jin
Summary: The study found that LPS can directly stimulate pDCs via the TLR4/MD2 pathway and promote the activation of pDCs and cDCs. cDCs may contribute to the enhancement of IFN-alpha production in pDCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Patricia G. G. Valles, Andrea Fernanda Gil Lorenzo, Rodrigo D. D. Garcia, Valeria Cacciamani, Maria Eugenia Benardon, Valeria Victoria Costantino
Summary: Acute kidney injury (AKI) is a common and devastating condition with no effective pharmacological treatment. Toll-like receptor 4 (TLR4) and its ligands play a crucial role in the pathogenesis of AKI by mediating inflammatory responses. Excessive activation of TLR4 can lead to chronic inflammation. This review discusses the role of TLR4 in ischemic/reperfusion-induced AKI and sepsis-associated AKI, as well as its potential signaling patterns in kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Rafael Torosyan, Shengping Huang, Prashant Bommi, Ratnakar Tiwari, Si Young An, Michael Schonfeld, Ganeshkumar Rajendran, Matthew A. Kavanaugh, Benjamin Gibbs, Agnieszka D. Truax, Samuel Bohney, M. Wade Calcutt, Evan W. Kerr, Roberta Leonardi, Peng Gao, Navdeep S. Chandel, Pinelopi P. Kapitsinou
Summary: The study found that hypoxic preconditioning and PHD inhibition increase serum kynurenine levels, protecting the kidney from damage. The IDO1-kynurenine axis plays a critical role in mediating hypoxic preconditioning.
Article
Immunology
Huanyu Jiang, Yubiao Zhang, Geliang Hu, Xiaobin Shang, Jianghua Ming, Ming Deng, Yaming Li, Yonggang Ma, Shiqing Liu, Yan Zhou
Summary: The study reveals the important role of surfactant protein D (SP-D) in regulating inflammation and immune response in osteoarthritis (OA). SP-D exhibits chondroprotective properties by downregulating inflammation-related genes, suppressing cytokine production, and reducing infiltration of inflammatory cells. The binding of SP-D to the TLR4/MD-2 complex further inhibits TLR4-mediated signaling activation. These findings suggest that SP-D has a beneficial effect in attenuating inflammation and preserving cartilage integrity in OA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Neurosciences
He Li, Yin Luo, Peng Liu, Pei Liu, Weilong Hua, Yongxin Zhang, Lei Zhang, Zifu Li, Pengfei Xing, Yongwei Zhang, Bo Hong, Pengfei Yang, Jianmin Liu
Summary: The study demonstrated that cerebral ischemic preconditioning can ameliorate cerebral ischemia/reperfusion injury by releasing exosomes containing miR-451a.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Su Woong Jung, Jung-Woo Seo, Seon Hwa Park, Yang Gyun Kim, Ju-Young Moon, Sangdun Choi, Sang-Ho Lee
Summary: TIP1 demonstrated significant protective effects in a mouse model of renal IRI, reducing plasma creatinine levels, alleviating tubular injury, inhibiting inflammatory cytokine expression, decreasing apoptosis and oxidative stress levels, and reducing cell infiltration, suggesting potential benefits in attenuating kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rui Teixeira da Silva, Ivo F. Machado, Joao S. Teodoro, Arnau Panisello-Rosello, Joan Rosello-Catafau, Anabela P. Rolo, Carlos M. Palmeira
Summary: PEG35 preconditioning effectively ameliorates hepatic hypoxia/reoxygenation injury through the enhancement of autophagy and mitochondrial quality control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ritesh Kumar Srivastav, Tarique Mahmood Ansari, Mahesh Prasad, Vishal Kumar Vishwakarma, Prabhat Kumar Upadhyay, Farogh Ahsan, Arshiya Shamim
Summary: The experiment demonstrated that DDZ enhances the cardioprotective effects of IPC, reducing cardiac damage in OCZ-challenged rat hearts, decreasing infarct size and oxidative stress, and improving mitochondrial function.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yu Chen, Xiao Xiao Wang, Corrie H. C. Ng, Sai Wah Tsao, Wai Keung Leung
Summary: Transcripts and proteins of TLR1/2/4/5/6, NOD1/2 and NLRP1/2 were expressed in human periodontal tissue in health and disease, with NOD2 possibly considered as a key damage-associated molecular pattern sensor on periodontal resident cells.
APPLIED SCIENCES-BASEL
(2021)