Article
Pediatrics
Alicia K. Yee, Leon S. Siriwardhana, Gillian M. Nixon, Lisa M. Walter, Flora Y. Wong, Rosemary S. C. Horne
Summary: The study aimed to investigate the amount of time spent in periodic breathing and its consequences in infants born preterm before and after hospital discharge. The results showed no significant changes in the percentage of sleep time spent in periodic breathing between different time points. Infants who had a high percentage of periodic breathing at 32-36 weeks of gestational age also had a high percentage at 36-40 weeks and 6 months of corrected age.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Silvia Martini, Marek Czosnyka, Peter Smielewski, Marica Iommi, Silvia Galletti, Francesca Vitali, Vittoria Paoletti, Federica Camela, Topun Austin, Luigi Corvaglia
Summary: This study found that dopamine treatment, low blood pressure, haemodynamically significant patent ductus arteriosus (hsPDA), and high CRIB-II score are associated with impaired cerebrovascular reactivity in preterm infants during the transitional period. This has potential implications for the development of intraventricular haemorrhage (IVH).
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Daniel Pfurtscheller, Christina H. Wolfsberger, Nina Hoeller, Bernhard Schwaberger, Lukas Mileder, Nariae Baik-Schneditz, Berndt Urlesberger, Gerhard Pichler
Summary: This study assessed the association between blood pressure, cerebral-regional-oxygen-saturation (crSO2), and cerebral-fractional-tissue-oxygen-extraction (cFTOE) in preterm neonates during immediate transition after birth, with and without respiratory support. The results showed a positive correlation between crSO2 and blood pressure, as well as a negative correlation between cFTOE and blood pressure in compromised neonates with respiratory support. These findings suggest an impaired cerebral autoregulation in preterm neonates with respiratory support.
FRONTIERS IN PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Shannon Gunawardana, Fahad M. S. Arattu Thodika, Vadivelam Murthy, Prashanth Bhat, Emma E. E. Williams, Theodore Dassios, Anthony D. D. Milner, Anne Greenough
Summary: This study aimed to investigate the association between low end-tidal carbon dioxide (ETCO2) levels, low oxygen saturation (SpO2), and high expiratory tidal volumes (VTE) during early resuscitation and adverse outcomes in prematurely born infants. Analysis of respiratory recordings in 60 infants showed that lower ETCO2 levels were associated with an increased risk of intracerebral hemorrhage (ICH) and death, while lower SpO2 levels were associated with an increased risk of death.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Physiology
Pietro Ciliberti, Danilo Cardim, Alberto Giardina, Matjaz Groznik, Lorenzo Ball, Martina Giovannini, Denise Battaglini, Erta Beqiri, Basil Matta, Peter Smielewski, Marek Czosnyka, Paolo Pelosi, Chiara Robba
Summary: This study aims to assess the effects of hyperoxygenation and hyperoxemia on cerebral autoregulation in acute brain injured patients. The results suggest that short-term hyperoxygenation does not critically affect cerebral autoregulation.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Filipe Goncalves Costa, Naser Hakimi, Frank Van Bel
Summary: Abnormal patterns of cerebral perfusion/oxygenation are associated with neuronal damage. NIR-spectroscopy is a noninvasive bedside tool to monitor brain oxygenation and perfusion. Early assessment of brain oxygenation patterns in preterm neonates and term infants can help decide treatment plans, and further technical advances in NIRS will be discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
George M. Hoffman, John P. Scott, Eckehard A. Stuth
Summary: Neonates undergoing the Norwood procedure are at higher risk of brain, kidney, and intestinal ischemic injury, shock, and death. Monitoring cerebral and renal circulations with near infrared spectroscopy can provide rational physiologic targets for treatment.
FRONTIERS IN PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Ourania Kaltsogianni, Sara Zaidi, Ravindra Bhat, Anne Greenough, Theodore Dassios
Summary: This study investigated the disparities in hypoxia and oxidative stress between Black and White preterm infants. The results showed no significant differences in arterial oxygen saturation (SaO2) and carboxyhaemoglobin (COHb) levels between the two groups. Lower saturation levels were associated with higher maximum COHb levels, regardless of racial background.
EARLY HUMAN DEVELOPMENT
(2023)
Review
Pediatrics
Daniel Pfurtscheller, Nariae Baik-Schneditz, Bernhard Schwaberger, Berndt Urlesberger, Gerhard Pichler
Summary: This qualitative systematic review aimed to investigate the combination of blood pressure monitoring and cerebral tissue oxygenation monitoring in neonates during the first week after birth, focusing on cerebral autoregulation. Thirty-one studies focused on preterm neonates, while five included both preterm and term neonates. The results showed that integrating blood pressure monitoring with cerebral tissue oxygenation measurements has the potential to improve treatment decisions and optimize neurodevelopmental outcomes in high-risk neonates.
Review
Chemistry, Analytical
Maria Roldan, Panayiotis A. Kyriacou
Summary: Traumatic brain injury (TBI) occurs when sudden trauma causes damage to the brain, with secondary injuries potentially affecting cerebral oxygenation and autoregulation. Near-infrared spectroscopy (NIRS) is a potential noninvasive monitoring technique for assessing TBI early, based on chromophore absorption of infrared light.
Article
Obstetrics & Gynecology
Nadja Bednarczuk, Emma E. Williams, Anne Greenough, Theodore Dassios
Summary: Higher COHb levels in prematurely born infants were associated with the development of BPD and IVH, but not with the duration of ventilation, BPD severity, or survival to discharge.
EARLY HUMAN DEVELOPMENT
(2022)
Article
Clinical Neurology
Chiara Robba, Antonio Messina, Denise Battaglini, Lorenzo Ball, Iole Brunetti, Matteo Bassetti, Daniele R. Giacobbe, Antonio Vena, Nicolo' Patroniti, Maurizio Cecconi, Basil F. Matta, Xiuyun Liu, Patricia R. M. Rocco, Marek Czosnyka, Paolo Pelosi
Summary: This study observed the effects of PLR test, FC, and NE on cerebral autoregulation in severe COVID-19 patients, finding that PLR test had a negative impact on CA. Individualized strategies to assess both hemodynamic and cerebral needs are necessary for patients at high risk of neurological complications.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pediatrics
Valerie Y. Chock, Emily Smith, Sylvia Tan, M. Bethany Ball, Abhik Das, Susan R. Hintz, Haresh Kirpalani, Edward F. Bell, Lina F. Chalak, Waldemar A. Carlo, C. Michael Cotten, John A. Widness, Kathleen A. Kennedy, Robin K. Ohls, Ruth B. Seabrook, Ravi M. Patel, Abbot R. Laptook, Toni Mancini, Gregory M. Sokol, Michele C. Walsh, Bradley A. Yoder, Brenda B. Poindexter, Sanjay Chawla, Carl T. D'Angio, Rosemary D. Higgins, Krisa P. Van Meurs
Summary: This study aimed to analyze the changes in cerebral and mesenteric oxygen saturation in extremely low birth weight (ELBW) infants and explore their relationship with perinatal variables. The results showed that the oxygen saturation of the brain and gut decreased while oxygen extraction increased over the first week after birth. The increase in oxygen extraction was greater in the brain compared to the gut in infants with lower gestational age, lower birth weight, and 5-minute Apgar score ≤ 5. Infants managed with a lower hemoglobin transfusion threshold and receiving ≥ 2 transfusions in the first week had the lowest cerebral saturation and highest cerebral oxygen extraction.
PEDIATRIC RESEARCH
(2022)
Article
Medicine, General & Internal
Yuki Kishihara, Hideto Yasuda, Masahiro Kashiura, Naoshige Harada, Takashi Moriya
Summary: This study evaluated the correlation between mean arterial pressure (MAP) and cerebral regional oxygen saturation (rSO(2)) during resuscitation to determine if rSO(2) can be used as an indicator of the quality of chest compressions. The results showed a mild but statistically significant association between rSO(2) and MAP, suggesting that rSO(2) could be a non-invasive and simple method to assess the quality of chest compressions during resuscitation.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Martin Parnov Reichhardt, Marcel Messing, Sture Andersson, Kaija-Leena Kolho, Seppo Meri
Summary: The first three months of a baby's life show changes in SALSA levels, with premature infants having lower levels during the same period. This suggests that prematurity may impact the development of the infant intestinal immune system. Changes in SALSA in early life may have an effect on the early establishment of the human microbiome.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Letter
Pediatrics
Laure Dombrecht, Kim Beernaert, Kenneth Chambaere, Filip Cools, Linde Goossens, Gunnar Naulaers, Joachim Cohen, Luc Deliens
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Anesthesiology
Dries Hendrikx, Sophie A. Costerus, Katrin Zahn, Alba Perez-Ortiz, Alexander Caicedo Dorado, Sabine Van Huffel, Jurgen de Graaff, Rene Wijnen, Lucas Wessel, Dick Tibboel, Gunnar Naulaers
Summary: This study aimed to investigate neonatal pathophysiology and cerebral blood flow regulation peri-operatively using neurocardiovascular graphs. Different peri-operative management strategies had varying effects on the neurovascular coupling in neonates undergoing surgery.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2022)
Article
Clinical Neurology
Tim Hermans, Liesbeth Thewissen, Marc Gewillig, Bjorn Cools, Katrien Jansen, Kirubin Pillay, Maarten De Vos, Sabine Van Huffel, Gunnar Naulaers, Anneleen Dereymaeker
Summary: The study investigates the functional brain maturation and sleep-wake physiology in neonates with Congenital Heart Disease (CHD) and finds delayed Functional Brain Age (FBA) and altered sleep organization preoperatively. However, FBA and sleep organization normalize postoperatively.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2022)
Article
Medicine, General & Internal
Isabelle Dehaene, Caroline Van Holsbeke, Kristien Roelens, Noortje Nvh van Oostrum, Katrien Nulens, Koenraad Smets, Marie-Rose Van Hoestenberghe, Gunnar Naulaers, Roland Devlieger
Summary: The impact of COVID-19 and its mitigation measures on preterm birth incidence is still unclear and varies across countries. In three Belgian tertiary care hospitals, there were no differences in preterm birth rates between 2019 and 2020.
ACTA CLINICA BELGICA
(2023)
Review
Pediatrics
Eva Maes, Filip Cools, Anneleen Dereymaeker, Katrien Jansen, Gunnar Naulaers, Liesbeth Thewissen
Summary: This systematic review and meta-analysis investigated the effect of body position on rScO2 in preterm infants during the first 2 weeks after birth. The results showed that the prone position led to significantly higher rScO2 in the second week after birth compared to the supine position, but no difference was observed in extremely preterm and preterm infants.
Article
Clinical Neurology
Astrid van den Brande, Bieke Bollen, Bart Boets, Gunnar Naulaers, Els Ortibus
Summary: This study aims to investigate the executive function and its relationship with gestational age, sex, maternal education, and neurodevelopmental outcome in preterm children. Three tasks were used to assess executive function. The results show that lower gestational age and maternal education are associated with lower executive function scores, while better cognitive and motor function and lower autism risk are related to higher executive function scores. There is no relationship between sex and executive function.
Article
Multidisciplinary Sciences
Tim Hermans, Katherine Carkeek, Anneleen Dereymaeker, Katrien Jansen, Gunnar Naulaers, Sabine Van Huffel, Maarten De Vos
Summary: In neonates with hypoxic ischemic encephalopathy, the use of wavelet coherence between EEG power and rSO2 is a promising method for assessing neurovascular coupling. However, fluctuations in SpO2 limit the reliability of previous methods. To address this issue, partial wavelet coherence is proposed to eliminate the influence of SpO2. Furthermore, the study investigates the additional value of novel NVC biomarkers compared to traditional EEG and NIRS biomarkers for identifying brain injury.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Tim Hermans, Laura Smets, Katrien Lemmens, Anneleen Dereymaeker, Katrien Jansen, Gunnar Naulaers, Filippo Zappasodi, Sabine Van Huffel, Silvia Comani, Maarten De Vos
Summary: This paper proposes a semi-supervised deep learning approach for artefact detection in neonatal EEG. The proposed method outperforms existing state-of-the-art models and achieves good performance on two separate datasets. The results demonstrate the effectiveness of the semi-supervised multi-task training strategy and the relevance of artefact detection for automated EEG analysis.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Lyssa de Vries, Steffie Amelynck, Paer Nystroem, Lotte van Esch, Thijs Van Lierde, Petra Warreyn, Herbert Roeyers, Ilse Noens, Gunnar Naulaers, Bart Boets, Jean Steyaert, TIARA Team
Summary: This study aimed to investigate the developmental trajectories of the autonomic nervous system (ANS) in infants, with or without increased likelihood for atypical ANS development. The pupillary light reflex (PLR) was used as an index and eye-tracking was employed to capture the PLR in 216 infants. The results revealed an increase in PLR parameters with age, as well as group differences in baseline pupil diameter and latency to constriction.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Medicine, General & Internal
Mathias L. Hansen, Adelina Pellicer, Simon Hyttel-Srensen, Ebru Ergenekon, Tomasz Szczapa, Cornelia Hagmann, Gunnar Naulaers, Jonathan Mintzer, Monica Fumagalli, Gabriel Dimitriou, Eugene Dempsey, Jakub Tkaczyk, Guoqiang Cheng, Siv Fredly, Anne M. Heuchan, Gerhard Pichler, Hans Fuchs, Saudamini Nesargi, Gitte H. Hahn, Salvador Piris-Borregas, Jan Sirc, Miguel Alsina-Casanova, Martin Stocker, Hilal Ozkan, Kosmas Sarafidis, Andrew O. Hopper, Tanja Karen, Beata Rzepecka-Weglarz, Serife S. Oguz, Luis Arruza, Asli C. Memisoglu, Ruth del Rio Florentino, Mariana Baserga, Pierre Maton, Anita C. Truttmann, Isabel de las Cuevas, Peter Agergaard, Pamela Zafra, Lars Bender, Ryszard Lauterbach, Chantal Lecart, Julie de Buyst, Afif El-Khuffash, Anna Curley, Olalla O. Vaccarello, Jan Miletin, Evangelia Papathoma, Zachary Vesoulis, Giovanni Vento, Luc Cornette, Laura S. Lopez, Beril Yasa, Anja Klamer, Massimo Agosti, Olivier Baud, Emmanuele Mastretta, Merih Cetinkaya, Karen McCall, Shujuan Zeng, Eleftheria Hatzidaki, Agata Bargiel, Sylwia Marciniak, Xiaoyan Gao, Lin Huijia, Lina Chalak, Ling Yang, Shashidhar A. Rao, Xin Xu, Begona L. Gonzalez, Maria Wilinska, Zhaoqing Yin, Iwona Sadowska-Krawczenko, Itziar Serrano-Vinuales, Barbara Krolak-Olejnik, Marta M. Ybarra, Catalina Morales-Betancourt, Peter Korcek, Marta Teresa-Palacio, Fabio Mosca, Anja Hergenhan, Nilgun Koksal, Konstantia Tsoni, Munaf M. Kadri, Claudia Knoepfli, Elzbieta Rafinska-Wazny, Mustafa S. Akin, Tone Nordvik, Zhang Peng, Sinem G. Kersin, Liesbeth Thewissen, Ana Alarcon, David Healy, Berndt Urlesberger, Muenevver Bas, Jana Baumgartner, Eleni Skylogianni, Veronika Karadyova, Eva Valverde, Elena Bergon-Sendin, Jachym Kucera, Silvia Pisoni, Le Wang, Anne Smits, Rebeca Sanchez-Salmador, Marie I. Rasmussen, Markus H. Olsen, Aksel K. Jensen, Christian Gluud, Janus C. Jakobsen, Gorm Greisen
Summary: A multicenter, randomized trial found that treatment guided by cerebral oximetry monitoring for the first 72 hours after birth did not reduce the risk of death or severe brain injury at 36 weeks' postmenstrual age in extremely preterm infants.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Pediatrics
Minoo Ashoori, John M. O'Toole, Ken D. O'Halloran, Gunnar Naulaers, Liesbeth Thewissen, Jan Miletin, Po-Yin Cheung, Afif EL-Khuffash, David Van Laere, Zbynek Stranak, Eugene M. Dempsey, Fiona B. McDonald
Summary: This study aimed to test the potential utility of applying machine learning methods to detect brain injury in extremely preterm infants using regional cerebral (rcSO(2)) and peripheral oxygen saturation (SpO(2)) signals. The analysis of a subset of infants in a clinical trial showed that data-driven desaturation (PRD) in rcSO(2) could better predict brain injury compared to a threshold-based approach.
Article
Clinical Neurology
Nathalie De Beukelaer, Ines Vandekerckhove, Geert Molenberghs, Gunnar Naulaers, Liesbeth Thewissen, Domiziana Costamagna, Anja Van Campenhout, Kaat Desloovere, Els Ortibus
Summary: This study found that muscle growth is already affected in infants with spastic cerebral palsy. Muscle size growth further reduces with decreasing functional levels, regardless of the brain lesion. Early monitoring and intervention for muscle growth is necessary.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Pediatrics
Aurelie Pascal, Nele de Bruyn, Gunnar Naulaers, Els Ortibus, Britta Hanssen, Ann Oostra, Kris de Coen, Michel Sonnaert, Eva Cloet, Alexandra Casaer, James D'Haese, Sabine Laroche, An Jonckheere, Katleen Plaskie, Christine van Mol, Els Bruneel, Marie-Rose van Hoestenberghe, Bieke Samijn, Paul Govaert, Christine Van den Broeck
Summary: This study investigated the incidence of intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL) in relation to gestational age, as well as the impact on mortality and neurodevelopmental outcomes in very preterm/very low birthweight infants. The results showed that both the prevalence and severity of IVH/PVL decreased significantly as gestational age advanced. More than 75% of infants with low grades of IVH/PVL had normal motor and cognitive outcomes at 2 years of age. High-grade PVL/IVH has become less common and is associated with adverse outcomes.
JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, Research & Experimental
Marie Isabel Rasmussen, Mathias Luhr Hansen, Adelina Pellicer, Christian Gluud, Eugene Dempsey, Jonathan Mintzer, Simon Hyttel-Sorensen, Anne Marie Heuchan, Cornelia Hagmann, Ebru Ergenekon, Gabriel Dimitriou, Gerhard Pichler, Gunnar Naulaers, Guoqiang Cheng, Jakub Tkaczyk, Hans Fuchs, Monica Fumagalli, Saudamini Nesargi, Siv Fredly, Tomasz Szczapa, Anne Mette Plomgaard, Bo Molholm Hansen, Janus Christian Jakobsen, Gorm Greisen
Summary: The SafeBoosC-III follow-up study aims to assess mortality, neurodevelopmental disability, or any harm in trial participants at 2 years of corrected age. The lack of funding for trial-specific assessment local costs is a challenge that needs to be addressed.
Proceedings Paper
Medicine, Research & Experimental
Tim Hermans, Katherine Carkeek, Anneleen Dereymaeker, Katrien Jansen, Gunnar Naulaers, Sabine Van Huffel, Maarten De Vos
Summary: Brain monitoring is crucial in assessing the severity of HIE and identifying neonates at risk of adverse neurodevelopmental outcome. This study explores the use of wavelet coherence as a biomarker for NVC and proposes average real coherence as a potential indicator. The results suggest that wavelet coherence between EEG bandpower and rSO(2) can provide valuable information about HIE severity in neonates with peripartal asphyxia.
OXYGEN TRANSPORT TO TISSUE XLIII
(2022)
