Article
Nutrition & Dietetics
Chiara Biagetti, Alessio Correani, Rita D'Ascenzo, Enrica Ferretti, Cecilia Proietti, Luca Antognoli, Ilaria Giretti, Adriana Pompilio, Paola Cogo, Virgilio P. Carnielli
Summary: In a large cohort of preterm infants receiving routine PN, the use of fish oil containing LE did not lead to better neurodevelopment outcomes compared to standard LE, despite some infants already receiving fish oil-enriched lipid emulsions. Large randomized controlled trials are needed to clarify the impact of fish oil containing LE on neurodevelopment in preterm infants.
CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Samir Ahmed, Jacqueline K. Innes, Philip C. Calder
Summary: A systematic review was conducted to assess the effects of different IVLEs in adult patients requiring HPN. Alternative IVLEs may be beneficial for patients, but more and larger RCTs are needed to determine superiority of one formulation over another.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Christoph Binder, Hannah Schned, Nicholas Longford, Eva Schwindt, Margarita Thanhaeuser, Alexandra Thajer, Katharina Goeral, Matteo Tardelli, David Berry, Lukas Wisgrill, David Seki, Angelika Berger, Katrin Klebermass-Schrehof, Andreas Repa, Vito Giordano
Summary: The study compared the impact of using S-LE and SMOF-LE on neuronal conduction in preterm infants, finding no significant difference in N2 and P2 values between the two groups, but a possible better treatment effect in the SMOF-LE group with a trend towards shorter latency.
Article
Nutrition & Dietetics
Marcia S. Antunes, Dan L. Waitzberg, Alweyd Tesser, Felipe A. Gutierres, Erika M. Tamanaha, Ronaldo Oliveira, Geni Sampaio, Elizabeth A. Torres, Priscilla C. Garla, Phillip C. Calder, Raquel S. Torrinhas
Summary: This study evaluated the dynamics of polyunsaturated fatty acid (PUFA) concentrations in different body pools after the infusion of fish oil-containing lipid emulsion (FOLE) in rats undergoing surgery. The results showed that PUFA concentrations changed in all pools immediately after FOLE infusion, resulting in a higher omega-3 to omega-6 ratio, but these changes decreased over time, suggesting early clearance of omega-3 PUFA after FOLE infusion.
Article
Nutrition & Dietetics
Josep M. Llop Talaveron, Ana Suarez-Lledo Grande, Elisabet Leiva Badosa, Jordi Bas Minguet, Joan Climent Marti, Elisabet Poyatos Canton, Maria B. Badia Tahull
Summary: This study investigates the association between inflammatory markers and liver function biomarker (LFB) alterations in patients treated with parenteral nutrition (PN) containing phytosterols (PS). The results show that increases in gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT) are associated with inflammatory markers.
FRONTIERS IN NUTRITION
(2023)
Article
Biology
Sylwia Osowska, Marek Kunecki, Jacek Sobocki, Joanna Tokarczyk, Krystyna Majewska, Magdalena Burkacka, Marek Radkowski, Magdalena Makarewicz-Wujec, Helena L. Fisk, Sultan Mashnafi, Sabine Baumgartner, Jogchum Plat, Philip C. Calder
Summary: This study investigates the effect of different levels of phytosterols in lipid emulsions (LEs) used in parenteral nutrition (PN) on liver function markers and inflammation in adult home PN patients. The findings suggest that long-chain omega-3 fatty acids can mitigate the adverse effects of phytosterols on liver function.
Article
Nutrition & Dietetics
Nayima M. Clermont-Dejean, Katherine J. P. Schwenger, Ennaliza Salazar, Flavia Faganello Colombo, Zihang Lu, Wendy Lou, Leah Gramlich, Scott Whittaker, David Armstrong, Brian Jurewitsch, Maitreyi Raman, Donald R. Duerksen, James D. McHattie, Sanjay Murthy, Johane P. Allard
Summary: This 2-year prospective cohort study found that patients receiving MO lipid emulsion for HPN had a higher risk of hospitalization compared to those receiving SO ILE. Further evaluation through large randomized controlled trials is needed to assess the long-term effects of using MO lipid emulsion in HPN patients.
CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Lorenzo Pradelli, Konstantin Mayer, Stanislaw Klek, Martin D. Rosenthal, Massimiliano Povero, Axel R. Heller, Maurizio Muscaritoli
Summary: This study conducted a network meta-analysis to compare the effects of different types of intravenous lipid emulsions (ILEs) on clinical outcomes in adult patients. The results showed that fish oil (FO)-ILEs had the most significant clinical benefits, reducing the risk of infection and sepsis, and shortening the length of hospital stay.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
I-Lun Chen, Chih-Hsing Hung, Hsin-Chun Huang
Summary: This study found that lipid emulsions containing fish oil can improve the neurodevelopmental outcomes of premature infants, especially at ages two and five, with significant reductions in the prevalence of diseases such as ADHD and ASD.
Article
Medicine, Research & Experimental
Yi-Ling Wang, Lih-Ju Chen, Lon-Yen Tsao, Hsiao-Neng Chen, Cheng-Han Lee, Chien-Chou Hsiao
Summary: In premature infants, the use of fish oil-based lipid emulsions is associated with a lower incidence of PN-associated cholestasis compared to soybean oil-based lipid emulsions. The duration to full feeding days is shorter, and complications like severe retinopathy of prematurity and bronchopulmonary dysplasia are significantly reduced in the fish oil-based lipid emulsion group.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Review
Pediatrics
Ting-Ting Zou, Jin-Rong Li, Yu Zhu, Chao-Min Wan, Qiong Liao
Summary: Fish oil-containing lipid emulsions can significantly reduce the occurrence of PNAC in VLBW infants, especially for patients with parenteral nutrition duration exceeding 14 days and extremely low birth weight infants.
WORLD JOURNAL OF PEDIATRICS
(2022)
Article
Pharmacology & Pharmacy
Aleksandra Gostynska, Joanna Starkowska, Paulina Sobierajska, Anna Jelinska, Maciej Stawny
Summary: The study evaluated the physicochemical stability of pediatric three-in-one parenteral nutrition (PN) admixtures using Aminoplasmal Paed-based formulations. Different variations of PN admixtures were tested for stability over seven days, showing minimal changes in pH, osmolality, and zeta potential. The research concluded that the selected PN admixtures had appropriate quality for central venous administration in pediatric patients, with stable composition and homogeneity observed throughout the storage period.
Article
Nutrition & Dietetics
Ulrika Sjoebom, Mats X. Andersson, Aldina Pivodic, Anna -My Lund, Mireille Vanpee, Ingrid Hansen-Pupp, David Ley, Dirk Wackernagel, Karin Savman, Lois E. H. Smith, Chatarina Lofqvist, Ann Hellstrom, Anders K. Nilsson
Summary: This study focused on the risk of deficits in long-chain polyunsaturated fatty acids (LCPUFAs) in preterm infants, which may lead to morbidities and hinder neurodevelopment. By analyzing the serum fatty acid profiles of preterm infants and the impact of enteral and parenteral lipid sources, the study found that enteral supplementation of fatty acids can increase the target fatty acids without significant impact on other fatty acids, while parenteral lipid administration can result in decreased levels of AA and DHA relative to other fatty acids. The study also observed differences in fatty acid patterns when expressed in relative or absolute units.
CLINICAL NUTRITION
(2023)
Review
Critical Care Medicine
Krista Haines, Braylee Grisel, Laura Gorenshtein, Paul E. Wischmeyer
Summary: Recently, there has been interest in switching patients to nonsoybean-based intravenous lipid emulsion (ILE) formulas for parental nutrition (PN) due to adverse outcomes related to high Omega-6 content in soybean oil (SO) ILE's. This review summarizes recent literature on improved clinical outcomes with new Omega-6 lipid-sparing ILE's in PN management.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Nutrition & Dietetics
Nigel Navaratnarajah, Gabrielle Girard, Guilherme Sant'Anna, Helene Langlois, Ana Maria Sant'Anna
Summary: This study compared the levels of conjugated bilirubin (CB) at the end of intravenous lipid emulsion (ILE) administration in infants receiving prolonged parenteral nutrition. The results showed that infants treated with SMOFlipid had significantly lower CB levels, suggesting a protective role of this type of emulsion in this high-risk population.
CLINICAL NUTRITION ESPEN
(2022)
Article
Engineering, Biomedical
Gianluca Fontana, Joshua Gershlak, Michal Adamski, Jae-Sung Lee, Shion Matsumoto, Hau D. Le, Bernard Binder, John Wirth, Glenn Gaudette, William L. Murphy
ADVANCED HEALTHCARE MATERIALS
(2017)
Article
Multidisciplinary Sciences
Michel Adamski, Gianluca Fontana, Joshua R. Gershlak, Glenn R. Gaudette, Hau D. Le, William L. Murphy
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Gastroenterology & Hepatology
Brian T. Kalish, Hau D. Le, Jonathan M. Fitzgerald, Samantha Wang, Kyle Seamon, Kathleen M. Gura, Karsten Gronert, Mark Puder
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2013)
Article
Gastroenterology & Hepatology
Vincent E. de Meijer, Deanna Y. Sverdlov, Hau D. Le, Yury Popov, Mark Puder
HEPATOLOGY RESEARCH
(2012)
Article
Nutrition & Dietetics
Hau D. Le, Jonathan A. Meisel, Vincent E. de Meijer, Erica M. Fallon, Kathleen M. Gura, Vania Nose, Bruce R. Bistrian, Mark Puder
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2012)
Article
Nutrition & Dietetics
Vincent E. de Meijer, Brian T. Kalish, Jonathan A. Meisel, Hau D. Le, Mark Puder
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2013)
Article
Surgery
Deepika Nehra, Amy H. Pan, Hau D. Le, Erica M. Fallon, Sarah J. Carlson, Brian T. Kalish, Mark Puder
JOURNAL OF SURGICAL RESEARCH
(2014)
Article
Endocrinology & Metabolism
Pei-Ra Ling, Alpin Malkan, Hau D. Le, Mark Puder, Bruce R. Bistrian
METABOLISM-CLINICAL AND EXPERIMENTAL
(2012)
Article
Endocrinology & Metabolism
Hau D. Le, Erica M. Fallon, Brian T. Kalish, Vincent E. de Meijer, Jonathan A. Meisel, Kathleen M. Gura, Vania Nose, Amy H. Pan, Bruce R. Bistrian, Mark Puder
METABOLISM-CLINICAL AND EXPERIMENTAL
(2013)
Article
Pediatrics
Carmen M. Barnes, Daniela Prox, Emily A. Christison-Lagay, Hau D. Le, Sarah Short, Flavia Cassiola, Dipak Panigrahy, Deviney Chaponis, Catherine Butterfield, Deepika Nehra, Erica M. Fallon, Mark Kieran, Judah Folkman, Mark Puder
PEDIATRIC RESEARCH
(2012)
Article
Multidisciplinary Sciences
Brian T. Kalish, Hau D. Le, Kathleen M. Gura, Bruce R. Bistrian, Mark Puder
Article
Multidisciplinary Sciences
Dipak Panigrahy, Brian T. Kalish, Sui Huang, Diane R. Bielenberg, Hau D. Le, Jun Yang, Matthew L. Edin, Craig R. Lee, Ofra Benny, Dayna K. Mudge, Catherine E. Butterfield, Akiko Mammoto, Tadanori Mammoto, Bora Inceoglu, Roger L. Jenkins, Mary A. Simpson, Tomoshige Akino, Fred B. Lih, Kenneth B. Tomer, Donald E. Ingber, Bruce D. Hammock, John R. Falck, Vijaya L. Manthati, Arja Kaipainen, Patricia A. D'Amore, Mark Puder, Darryl C. Zeldin, Mark W. Kieran
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Oncology
Richard E. Overman, Tanvi T. Kartal, Aaron J. Cunningham, Elizabeth A. Fialkowski, Bindi J. Naik-Mathuria, Sanjeev A. Vasudevan, Marcus M. Malek, Ranjeet Kalsi, Hau D. Le, Linda Cherney Stafford, Timothy B. Lautz, Benjamin T. Many, Rachel E. Jones, Andreana Butter, Jacob Davidson, Andrew Williams, Roshni Dasgupta, Jana Lewis, Misty Troutt, Jennifer H. Aldrink, Sara A. Mansfield, Dave R. Lal, Jerry Xiao, Rebecka L. Meyers, Scott S. Short, Erika A. Newman
PEDIATRIC BLOOD & CANCER
(2020)
Article
Cardiac & Cardiovascular Systems
Keon Young Park, Kevin C. Janek, Joshua L. Hermsen, Petros V. Anagnostopoulos, Hau D. Le
Summary: This study presented a rare case of concurrent CSL and ARSA in an infant, highlighting the importance of a multidisciplinary approach in managing symptomatic patients efficiently.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Article
Pediatrics
Gwyneth A. Sullivan, Audra J. Reiter, Charesa Smith, Richard D. Glick, David E. Skarda, Hau D. Le, Kenneth W. Gow, Barrie S. Rich, Mehul V. Raval
Summary: This study investigated the perceptions and involvement of pediatric surgeons in environmental stewardship efforts in the operating room. The results showed that while most surgeons considered environmental stewardship important, less than 10% were currently involved in initiatives at their institutions. The most common climate-smart actions were the use of reusable materials and equipment, as well as the reprocessing of medical devices. Common barriers included financial constraints and staff resistance to change. Regional differences were observed in the adoption of energy efficiency strategies.
JOURNAL OF PEDIATRIC SURGERY
(2023)