Journal
PEDIATRIC RESEARCH
Volume 65, Issue 2, Pages 215-220Publisher
NATURE PUBLISHING GROUP
DOI: 10.1203/PDR.0b013e31818d6850
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- Fapesp
- Finep
- CNPq
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Intrauterine growth restriction (IUGR) is associated with metabolic disorders in adulthood. In rats. an early adverse environment alters food preferences in adult life. We investigated whether IUGR is associated with spontaneous macronutrient preferences in humans. Two thousand sixty-three participants from a Brazilian birth cohort were evaluated at 24 y of age using a food frequency questionnaire, physical examination, anthropometric measurements. and biochemical assays (glucose, insulin. cholesterol, and triglycerides). IUGR was defined by the birth weight ratio (BWR birth weight/mean weight for gestational age). Individuals were classified as non growth restricted (BWR >= 0.85), moderately growth restricted (0.85 > BWR >= 0.75). and severely growth restricted (BWR < 0.75). Severe IUGR women consumed a greater carbohydrate to protein ratio. even after controlling for social variables. There was a continuous association between growth restriction and later carbohydrate to protein ratio consumption in women. Women from both IUGR groups had a larger waist to hip ratio (WHR). The prevalence of metabolic syndrome was comparable between the groups. IUGR women preferred carbohydrates to protein in their regular diet, suggesting that spontaneous food choices may precede the appearance and contribute to the risk for metabolic diseases in this group. (Pediatr Res 65: 215-220, 2009)
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