Article
Reproductive Biology
Victoria de Brun, Juan J. Loor, Hugo Naya, Andrea Grana-Baumgartner, Mario Vailati-Riboni, Omar Bulgari, Khuram Shahzad, Jose Alfonso Abecia, Cecilia Sosa, Ana Meikle
Summary: Transcriptomics and bioinformatics were used to study the impact of undernutrition and pregnancy on uterine immune system and remodeling. Results showed that pregnancy altered gene expression, particularly immune system and uterine remodeling genes, while undernutrition attenuated these effects.
Article
Cell Biology
Livia Budziarek Eslabao, Gabriela Farias Gubert, Lucas Cafferati Beltrame, Isis M. A. Mello, Oscar Bruna-Romero, Carlos R. Zarate-Blades
Summary: Childhood malnutrition affects gut microbiota, and the use of SXT prophylaxis treatment may result in dysbiosis and functional metabolic consequences.
Article
Veterinary Sciences
Weihao Chen, Xinyu Gu, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Shanhe Wang, Wei Sun
Summary: This study used RNA-seq technology to analyze the expression of miRNAs and circRNAs in sheep mammary gland during different lactation periods and identified potential miRNAs and circRNAs related to sheep mammary gland development through bioinformatics analysis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Feifan Wu, Luoyang Ding, Jiasheng Wang, Qiaoqing Chen, Asmita Thapa, Jianyu Mao, Mengzhi Wang
Summary: This study investigated the effects of temperament on rumen fermentation and microbial composition in Hu ram lambs. The results showed differences in rumen fermentation parameters and microbial composition between calm and nervous lambs. The calm lambs exhibited higher energy utilization efficiency, which could be explained by differences in the rumen microbiota and metabolism.
FERMENTATION-BASEL
(2023)
Article
Agriculture, Dairy & Animal Science
Maria Peterson, Mary Gauvin, Sambhu Pillai, Amanda Jones, Katelyn McFadden, Katelynn Cameron, Sarah Reed, Steven Zinn, Kristen Govoni
Summary: Maternal under- and over-nutrition during gestation were found to alter offspring pancreas structure, causing reductions in islet size and number. The changes in DNA methylation patterns were diet-specific and sex-dependent, indicating a potential mechanism for the effects of fetal programming on pancreas development.
Article
Agriculture, Dairy & Animal Science
Weibing Lv, Xiu Liu, Yuzhu Sha, Hao Shi, Hong Wei, Yuzhu Luo, Jiqing Wang, Shaobin Li, Jiang Hu, Xinyu Guo, Xiaoning Pu
Summary: The Qinghai-Tibet Plateau presents unique challenges to the survival of livestock due to its high altitude, low oxygen levels, and imbalances in forage supply. Through adjusting amino acid and energy metabolism pathways, as well as balancing the rumen core microbiota, Tibetan sheep are able to better adapt to the harsh environment. The rumen fermentation characteristics and microbiota of Tibetan sheep vary in different months, highlighting the importance of metabolic pathways in energy utilization and adaptation.
Article
Public, Environmental & Occupational Health
Mark H. Oliver, Frank H. Bloomfield, Amita Bansal, Hui Hui Phua, Eric B. Thorstensen, Jane E. Harding, Anne L. Jaquiery
Summary: Maternal periconceptional undernutrition affects fetal pancreatic maturation and glucose tolerance in offspring, with reduced insulin secretion and increased glucose area under the curve in adult sheep. These lasting effects indicate a significant impact of maternal periconceptional nutrition on offspring metabolic homeostasis.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Agriculture, Dairy & Animal Science
Nidhi Rawat, Manoj Kumar Singh, Tushar Sharma, Preeti Vats, D. Nagoorvali, Prabhat Palta, Manmohan Singh Chauhan, Radhey Sham Manik
Summary: The study suggests that providing stem cell culture conditions at a specific time during reprogramming can help generate iPSCs with greater efficiency, and reprogramming is accompanied by time-dependent events.
ANIMAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Feng Wang, Chaolai Man, Xiaoqiu Wang, Jack Odle, Christian Maltecca, Xi Lin
Summary: Maternal undernutrition during pregnancy can lead to severe fetal impairments, but the exact mechanisms are not fully understood. This study investigated the potential impacts of restricted nutrition on metabolic pathways in fetal pigs. The results revealed differential expression of mRNA and miRNA, as well as alterations in metabolic and signaling pathways. These findings provide valuable insights into the negative effects of maternal malnutrition on hepatic metabolism in full-term fetal pigs via miRNA-mRNA interactions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Ophelie Teteau, Philippe Liere, Antoine Pianos, Alice Desmarchais, Olivier Lasserre, Pascal Papillier, Claire Vignault, Marie-Emilie Lebachelier de la Riviere, Virginie Maillard, Aurelien Binet, Svetlana Uzbekova, Marie Saint-Dizier, Sebastien Elis
Summary: This study assessed the effects of chronic exposure to BPS, a potential endocrine disruptor, on steroid hormones in the ovaries, oviducts, and plasma of ewes. The results showed that BPS had adverse effects on the steroid hormones in these reproductive organs, with differential effects observed in different diet groups and metabolic statuses.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Serkan Sayiner, Isfendiyar Darbaz, Osman Ergene, Selim Aslan
Summary: This study aimed to monitor the alterations in antioxidant enzyme activities and metabolic profile parameters in dairy cows during different reproductive stages. Results showed a relationship between blood antioxidant enzymes and metabolic parameters at different periods.
Article
Reproductive Biology
M. Moradi, Y. Chashnidel, A. Abdollahi, A. Teimouri Yansari, B. Khazari, M. Mansouryar
Summary: This study aimed to investigate the effect of moderate over-nutrition of energy and protein on prepartal insulin resistance, metabolic status, and performance of ewes. The results showed that moderately over-fed ewes with extra protein and energy had improved insulin sensitivity and milk production, as well as better metabolic status around parturition.
Article
Environmental Sciences
Alice Desmarchais, Ophelie Teteau, Nathalie Kasal-Hoc, Juliette Cognie, Olivier Lasserre, Pascal Papillier, Marlene Lacroix, Claire Vignault, Peggy Jarrier-Gaillard, Virginie Maillard, Aurelien Binet, Maria-Teresa Pellicer-Rubio, Sandrine Freret, Sebastien Elis
Summary: Our study suggests that diet does not affect follicle population and embryo production in adult ewes, but may impact corpus luteum quality and progesterone secretion. Chronic low BPS exposure does not affect follicular population and oocyte competence, but the interaction between diet and dose may modulate the effects on embryo production. Further research is needed to assess the reproductive health risks of BPS exposure for the general public.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Endocrinology & Metabolism
Kuan-Yu Lin, Yu-Ting Kuo, Mei-Fang Cheng, Pei-Lung Chen, Hsiu-Po Wang, Tsu-Yao Cheng, Chia-Hsuin Chang, Hsiang-Fong Kao, Shih-Hung Yang, Hung-Yuan Li, Chia-Hung Lin, Yuh-Tsyr Chou, An-Ko Chung, Wan-Chen Wu, Jin-Ying Lu, Chih-Yuan Wang, Wen-Hui Hsih, Chen-Yu Wen, Wei-Shiung Yang, Shyang-Rong Shih
Summary: Recent studies suggest that the clinical characteristics and biological behavior of pituitary tumors in patients with MEN1 may be less aggressive than previously reported. Increased imaging of the pituitary as recommended by screening guidelines identifies more tumors potentially at an earlier stage. However, it is unknown if these tumors have different clinical characteristics in different MEN1 mutations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Angelos Dimas, Anastasia Politi, Alexandra Bargiota, Theodoros Panoskaltsis, Nikolaos F. Vlahos, Georgios Valsamakis
Summary: Fetal exposure to adverse environmental factors during intrauterine life can affect the development and future metabolic health of the offspring. Maternal bone turnover is implicated in fetal growth and neonatal body composition and metabolic wellbeing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Mariana Muelbert, Laura Galante, Tanith Alexander, Jane E. Harding, Chris Pook, Frank H. Bloomfield
Summary: This study found that sensory-active volatile fatty acids are major contributors to the smell of preterm breastmilk and are influenced by the lactation stage and maternal characteristics. The concentration of medium-chain fatty acids was higher in colostrum compared to transitional breastmilk, and this concentration was associated with socioeconomic status, gestational diabetes, and ethnicity. Longitudinal analysis showed that fatty acids increased with advancing lactation.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Sophie L. St Clair, Jane E. Harding, Justin M. O'Sullivan, Gregory D. Gamble, Jane M. Alsweiler, Tommi Vatanen, H. P. O. D. Study Group
Summary: This study aimed to investigate the effect of dextrose gel on the neonatal gut microbiome, showing no impact on the microbiome. Mode of birth, type of milk fed, hospital of birth, and ethnicity were associated with differences in the neonatal microbiome.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Aakash B. Rajay, Jane E. Harding
Summary: There is wide variation in guideline recommendations for the management of neonatal hypoglycaemia across New Zealand and Australian neonatal units, including differences in diagnostic thresholds, monitoring methods, and treatment protocols.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Article
Multidisciplinary Sciences
Olivia J. Hofer, Jane E. Harding, Thach Tran, Caroline A. Crowther
Summary: This study aimed to determine whether there were differences in maternal, infant, and childhood health outcomes between the use of dexamethasone or betamethasone as a repeat antenatal corticosteroid for women at risk of preterm birth after an initial course. The results showed that there were no significant differences in health outcomes between the two groups.
Review
Nutrition & Dietetics
Luling Lin, Greg D. Gamble, Caroline A. Crowther, Frank H. Bloomfield, Massimo Agosti, Stephanie A. Atkinson, Augusto Biasini, Nicholas D. Embleton, Fernando Lamy Filho, Christoph Fusch, Maria L. Gianni, Hayriye Goezde Kanmaz Kutman, Winston Koo, Ita Litmanovitz, Colin Morgan, Kanya Mukhopadhyay, Erica Neri, Jean-Charles Picaud, Niels Rochow, Paola Roggero, Kenneth Stroemmen, Maw J. Tan, Francesco M. Tandoi, Claire L. Wood, Gitte Zachariassen, Jane E. Harding
Summary: Neonatal nutritional supplements may improve early growth for infants born small, but the effects on long-term growth are uncertain and may vary by sex. These supplements can increase length and bone mineral content in infancy, but do not affect BMI in childhood. Supplementation can enhance height z-score in male toddlers, but not in females.
Article
Pediatrics
Deborah L. Harris, Greg D. Gamble, Jane E. Harding
Summary: Treatment of neonatal hypoglycaemia with dextrose gel does not increase the rate of neurosensory impairment, but further assessment of visual processing and growth may be warranted.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Obstetrics & Gynecology
Esther Calje, Joy Marriott, Charlotte Oyston, Lesley Dixon, Frank Bloomfield, Katie Groom
Summary: This study reports the incidence of postpartum anaemia in three district health board regions in New Zealand and describes the current management of moderate to severe postpartum anaemia, including differences among different ethnicities.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Clinical Neurology
Ryan Jim San Diego, Nike Franke, Jane Elizabeth Harding, Trecia Ann Wouldes
Summary: Executive function is an important neurocognitive process for self-regulation of behavior and acquisition of social and cognitive competencies. While there are valid measures for adult and adolescent executive function, there is a lack of valid measures for preschool children. This study evaluated the cross-cultural validity and reliability of the Behavior Rating Inventory of Executive Function Preschool Version (BRIEF-P) in New Zealand Maori and European parents of children with neonatal hypoglycemia. The results showed that the BRIEF-P is a highly reliable and valid instrument.
CHILD NEUROPSYCHOLOGY
(2023)
Article
Pediatrics
Anthony G. B. Walters, Luling Lin, Caroline A. Crowther, Greg D. Gamble, Stuart R. Dalziel, Jane E. Harding
Summary: The objective of this study was to present the complete results of the first randomized trial of antenatal corticosteroids conducted 50 years ago using modern analysis and reporting methods. The results showed that antenatal betamethasone administered to women at risk of preterm birth between 24 and less than 37 weeks of gestation significantly reduces the incidence of respiratory distress syndrome, with greater efficacy in male infants than female infants. Doubling the dose of betamethasone does not provide additional benefit.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Sophie L. St Clair, Darren W. T. Dai, Deborah L. Harris, Gregory D. Gamble, Christopher J. D. McKinlay, Samson Nivins, Rajesh K. Shah, Benjamin Thompson, Jane E. Harding
Summary: In the treatment of neonatal hypoglycaemia, dextrose gel is safe and effective, but at 9-10 years old, children in the dextrose gel group had slightly lower visual perception abilities compared to the placebo group.
Review
Medicine, Research & Experimental
Robyn W. May, Gonzalo Maso D. Talou, Alys R. Clark, Jonathan P. Mynard, Joseph J. Smolich, Pablo J. Blanco, Lucas O. Mueller, Thomas L. Gentles, Frank H. Bloomfield, Soroush Safaei
Summary: Computational modeling is widely used in the study of cardiovascular hemodynamics for medical research and improving the diagnosis and treatment of cardiovascular diseases. Most existing cardiovascular models focus on the adult circulatory system, but the perinatal period is unique as cardiovascular physiology undergoes significant changes. This review discusses computational models of the cardiovascular system in early life, their applications, and proposes a roadmap for developing an open-source model spanning fetal, perinatal, and postnatal periods.
WIRES MECHANISMS OF DISEASE
(2023)
Review
Nutrition & Dietetics
Meiliana Meiliana, Tanith Alexander, Frank H. Bloomfield, Barbara E. Cormack, Jane E. Harding, Orla Walsh, Luling Lin
Summary: There is currently a lack of high-quality and consistent nutrition guidelines for preterm infants, which leads to substantial variation in practice.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Ophthalmology
Mukhit Kulmaganbetov, Myra Leung, Jane M. Alsweiler, Joanna Black, Frank H. Bloomfield, Greg D. Gamble, Jane E. Harding, Yannan Jiang, Tanya Poppe, Anna C. Tottman, Trecia A. Wouldes, Benjamin Thompson
Summary: This study aimed to assess the effect of increased protein intake on ophthalmic and visual development in school-age children born very preterm. The results showed that there were subtle and complex associations between early neonatal nutrition and visual development at school age.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Pediatrics
Nike Franke, Trecia Ann Wouldes, Gavin Thomas Lumsden Brown, Kim Ward, Jenny Rogers, Jane E. Harding
Summary: This study explores the views of young adults on their participation in medical research during childhood, specifically focusing on the acceptability of consent and their priorities regarding health, development, and well-being as potential trial outcomes. The findings indicate that participants were comfortable with their parents giving consent on their behalf, but highlighted the challenges of obtaining autonomous child assent. They generally expressed satisfaction with the outcomes investigated in the follow-up studies, while also suggesting additional outcomes of interest such as mental health and learning disabilities.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Review
Pediatrics
Eamon P. G. Walsh, Jane M. Alsweiler, Julena Ardern, Sara M. Hanning, Jane E. Harding, Christopher J. D. McKinlay
Summary: There is insufficient evidence to support the efficacy and safety of glucagon for the treatment of neonatal hypoglycemia. Current evidence suggests that glucagon may increase blood glucose levels, but recurrent hypoglycemia is common. High-quality randomized controlled trials are needed to determine the role of glucagon in managing neonatal hypoglycemia.