Article
Acoustics
Qiuyang Li, Kaixiu Yang, Yongjiao Ji, Hongrui Liu, Xiang Fei, Yan Zhang, Jingbo Li, Yukun Luo
Summary: This study assessed the incidence of adverse events (AEs) in a large cohort of patients who underwent contrast-enhanced ultrasound (CEUS) with Lumason/SonoVue. The study found a low incidence of AEs, most of which were mild and had a short duration.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Judy H. Squires, M. Beth McCarville
Summary: The utilization of CEUS in children is rapidly expanding, offering several advantages such as dynamic evaluation of vascular structures and lack of ionizing radiation. UCAs used intravenously in children have been shown to have excellent safety profiles, with potential off-label applications expanding diagnostic possibilities. CEUS is commonly used for focal liver lesion evaluation, and has potential alternative applications like evaluation of blunt abdominal trauma in hemodynamically stable children. Additional potential applications in various organs require further study.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Pediatrics
Susan J. Back, Patricia T. Acharya, Richard D. Bellah, Harris L. Cohen, Kassa Darge, Annamaria Deganello, Zoltan Harkanyi, Damjana Kljucevsek, Aikaterini Ntoulia, Harriet J. Paltiel, Maciej Piskunowicz
Summary: The pediatric applications of CEUS for kidneys and adrenal glands are expanding, with a focus on evaluating ischemic disorders, tumor differentiation, cystic lesions, pyelonephritis, and trauma. The use of CEUS in children remains off-label for intravenous administration of US contrast agents but shows potential for clinical utilization by extrapolating adult kidney evaluation knowledge to the pediatric context.
PEDIATRIC RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yijie Qiu, Zhihua Wu, Yanling Chen, Jinghan Liao, Qi Zhang, Quan Wang, Yi Duan, Ke Gong, Sheng Chen, Liting Wang, Peili Fan, Yourong Duan, Wenping Wang, Yi Dong
Summary: This study introduces a nano ultrasound contrast agent (ATO/PFH NPs@Au-cRGD) that integrates diagnosis and treatment for efficient ultrasound imaging and liver cancer therapy. The nanodrug delivery system promotes the release of tumor-associated antigens, enhances the synergistic effects of ATO and photothermal therapy, and activates the antitumor immune response. Additionally, when combined with anti-PD-L1 immunotherapy, the system inhibits tumor metastasis and establishes long-term immunological memory.
Article
Pediatrics
Ryne A. Didier, David M. Biko, Misun Hwang, Sunil Unnikrishnan, Magdalena M. Wozniak, Gibran T. Yusuf, Anush Sridharan
Summary: The use of ultrasound contrast agent in radiology is expanding beyond traditional applications, with emerging techniques such as 3-D and 4-D contrast-enhanced ultrasound imaging showing potential in improving accuracy in voiding urosonography and assisting in tumor resection. There is also active research and early clinical translation in targeted US molecular imaging. Additionally, a new exciting development involves the use of UCA for localized drug delivery and release in the treatment of aggressive brain tumors.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Cheng Fang, Sudha A. Anupindi, Susan J. Back, Doris Franke, Thomas G. Green, Zoltan Harkanyi, Jorg Jungert, Jeannie K. Kwon, Harriet J. Paltiel, Judy H. Squires, Vassil N. Zefov, M. Beth McCarville
Summary: Contrast-enhanced ultrasound (CEUS) is increasingly used in children for characterization and follow-up of liver lesions. It involves intravenous administration of ultrasound contrast agents for real-time observation of enhancement patterns, often providing definite diagnosis and avoiding the need for further imaging or procedures. The recent approval of Lumason for pediatric liver CEUS applications has contributed to the widespread use of CEUS.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Maciej Piskunowicz, Susan J. Back, Kassa Darge, Paul D. Humphries, Joerg Juengert, Damjana Kljucevsek, Norbert Lorenz, Hans-Joachim Mentzel, Judy H. Squires, Dean Y. Huang
Summary: CEUS is currently limited to liver and heart imaging in pediatric and adult populations, but has great potential for imaging small organs like the thyroid gland, lymph nodes, testes, ovaries, and uterus. While studies in adults have shown the utility of CEUS for evaluating these small organs, there is still untapped potential for its application in children based on adult literature.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Doris Franke, Reza J. Daugherty, Damjana Kljucevsek, Aikaterini Ntoulia, Vasileios Rafailidis, Marcelo S. Takahashi, Alvaro Torres, Bernarda Viteri, Frank M. Volberg
Summary: Ultrasound, especially contrast-enhanced ultrasound (CEUS), plays a crucial role in evaluating liver and kidney transplants by assessing organ status, vascular patency, and potential complications, aiding in prompt and accurate diagnosis for management decisions. It is particularly useful for detecting vascular complications, parenchymal abnormalities, and excluding underlying causes for organ dysfunction suspected of transplant rejection.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Harriet J. Paltiel, Richard A. Barth, Costanza Bruno, Aaron E. Chen, Annamaria Deganello, Zoltan Harkanyi, M. Katherine Henry, Damjana Kljucevsek, Susan J. Back
Summary: Trauma is a major cause of morbidity and mortality in children, with rapid identification of organ injury being crucial for successful treatment. Contrast-enhanced ultrasound (CEUS) is a beneficial alternative to contrast-enhanced CT in evaluating blunt abdominal trauma in children, particularly in reducing radiation exposure. CEUS is effective in diagnosing solid organ injuries and detecting abnormalities that may not be visible on conventional ultrasound.
PEDIATRIC RADIOLOGY
(2021)
Review
Pediatrics
Aikaterini Ntoulia, Sudha A. Anupindi, Susan J. Back, Ryne A. Didier, Misun Hwang, Ann M. Johnson, M. Beth McCarville, Frederica Papadopoulou, Maciej Piskunowicz, Maria E. Sellars, Kassa Darge
Summary: Research has shown that adverse reactions in pediatric CEUS use are mainly non-serious, with a very small number of children experiencing allergic reactions. In studies involving intravenous CEUS, the rate of serious adverse events is low, while the rate of non-serious adverse events is slightly higher. Adverse events caused by the use of UCA in the bladder are mostly related to bladder catheters rather than the UCA itself.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Aikaterini Ntoulia, Carol E. Barnewolt, Andrea S. Doria, Victor M. Ho-Fung, Norbert Lorenz, Hans-Joachim Mentzel, Susan J. Back
Summary: The use of CEUS in musculoskeletal applications has expanded in both adults and children, with various applications such as detecting inflammatory joint diseases, imaging muscle and tendon perfusion, evaluating malignant potential of soft-tissue masses, and aiding in the diagnosis and treatment of pediatric hip diseases. Quantitative CEUS measurements of blood flow imaging parameters are crucial for monitoring treatment outcomes.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Doris Franke, Sudha A. Anupindi, Carol E. Barnewolt, Thomas G. Green, Mary-Louise C. Greer, Zoltan Harkanyi, Norbert Lorenz, M. Beth McCarville, Hans-Joachim Mentzel, Aikaterini Ntoulia, Judy H. Squires
Summary: This manuscript provides an overview of the applications of contrast-enhanced ultrasound (CEUS) for normal variants and diseases affecting the spleen, gallbladder, and pancreas in children. It highlights how CEUS can serve in the diagnosis and follow-up for such diseases in children with specific examination techniques and presentation of main imaging findings in various benign and malignant lesions. The limitations of CEUS for these organs are also acknowledged.
PEDIATRIC RADIOLOGY
(2021)
Article
Acoustics
Aswin Gnanaskandan, Chao-Tsung Hsiao, Georges Chahine
Summary: This study numerically investigates the impact of the viscoelastic shell properties of ultrasound contrast agents on heat deposition in bubble enhanced high intensity focused ultrasound (HIFU). Three different shell models are considered and their effects on heat deposition are analyzed. The importance of modeling shell elasticity is discussed through comparisons between Newtonian and non-Newtonian shell models, and a parametric study varying shell properties is conducted to examine the roles of shell viscosity and elasticity in affecting heat deposition.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Acoustics
Sean Mcgrath, Yu-Jack Shen, Masato Aragaki, Yamato Motooka, Takamasa Koga, Alexander Gregor, Nicholas Bernards, Emmanuel Cherin, Christine E. M. Demore, Kazuhiro Yasufuku, Naomi Matsuura
Summary: This study assessed the imaging ability of CE-EBUS in vitro and in vivo and found that CE-EBUS can produce contrast imaging comparable to commercial pre-clinical and clinical ultrasound systems. CE-EBUS has the potential for clinical characterization of mediastinal lymph nodes in lung cancer patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pankaj Gupta, Pratyaksha Rana, Yashi Marodia, Jayanta Samanta, Vishal Sharma, Saroj K. Sinha, Harjeet Singh, Vikas Gupta, Thakur Deen Yadav, Radhika Sreenivasan, Kim Vaiphei, Arvind Rajwanshi, Rakesh Kochhar, Manavjit Sandhu
Summary: Contrast-enhanced ultrasound (CEUS) plays an important role in the evaluation of solid pancreatic head lesions (SPHL) and can be used to differentiate pancreatic ductal adenocarcinoma (PDAC) from non-PDAC lesions.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Lynn Million, Andrea Hayes-Jordan, Yueh-Yun Chi, Sarah S. Donaldson, Suzanne Wolden, Carol Morris, Stephanie Terezakis, Fran Laurie, Karen Morano, T. J. Fitzgerald, Torunn I. Yock, David A. Rodeberg, James R. Anderson, Rose Anne Speights, Jennifer O. Black, Cheryl Coffin, Mary Beth McCarville, Simon C. Kao, Douglas S. Hawkins, Sheri L. Spunt, R. Lor Randall
Summary: The ARST0332 trial for pediatric and young adults with NRSTS utilized risk-based treatment to achieve high local control rates, particularly after R0 resection. Most patients were able to undergo delayed R0/R1 resection after neoadjuvant therapy, leading to improved survival outcomes.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Sara A. Mansfield, M. Beth McCarville, John T. Lucas, Matthew J. Krasin, Sara M. Federico, Victor M. Santana, Wayne L. Furman, Andrew M. Davidoff
Summary: The study showed that neoadjuvant chemotherapy can reduce the number of IDRFs in patients with high-risk neuroblastoma, and the number of IDRFs present after chemotherapy is positively correlated with the extent of tumor resection.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Howard M. Katzenstein, Marcio H. Malogolowkin, Mark D. Krailo, Jin Piao, Alexander J. Towbin, M. Beth McCarville, Gregory M. Tiao, Stephen P. Dunn, Max R. Langham, Eugene D. McGahren, Milton J. Finegold, Sarangarajan Ranganathan, Christopher B. Weldon, Patrick A. Thompson, Angela D. Trobaugh-Lotrario, Allison F. O'Neill, Wayne L. Furman, Nadia Chung, Jessica Randazzo, Carlos Rodriguez-Galindo, Rebecka L. Meyers
Summary: The study showed that adding doxorubicin to the previous standard regimen of C5V is feasible, tolerable, and effective, suggesting that the new regimen C5VD may be suitable for future clinical trials.
Article
Oncology
Wayne L. Furman, Beth McCarville, Barry L. Shulkin, Andrew Davidoff, Matthew Krasin, Chia-Wei Hsu, Haitao Pan, Jianrong Wu, Rachel Brennan, Michael W. Bishop, Sara Helmig, Elizabeth Stewart, Fariba Navid, Brandon Triplett, Victor Santana, Teresa Santiago, Jacquelyn A. Hank, Stephen D. Gillies, Alice Yu, Paul M. Sondel, Wing H. Leung, Alberto Pappo, Sara M. Federico
Summary: Combining hu14.18K322A with chemotherapy improves early response and outcomes in high-risk neuroblastoma. This treatment is well-tolerated and reduces tumor volume in most patients, leading to improved end-of-induction response rates and encouraging 3-year event-free survival.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Pediatrics
Heather Campbell, Jennifer Check, Karl C. K. Kuban, Alan Leviton, Robert M. Joseph, Jean A. Frazier, Laurie M. Douglass, Kyle Roell, Elizabeth N. Allred, Lynn Ansley Fordham, Stephen R. Hooper, Hernan Jara, Nigel Paneth, Irina Mokrova, Hongyu Ru, Hudson P. Santos, Rebecca C. Fry, T. Michael O'Shea
Summary: The study found that neonatal cranial ultrasound abnormalities in extremely preterm infants at birth, especially those indicative of WMD, are associated with neurodevelopmental impairments at 10 years of age, with the strongest associations found in children with cerebral palsy.
JOURNAL OF PEDIATRICS
(2021)
Article
Surgery
Andrew M. Fleming, Caitlyn Duffy, Jessica Gartrell, M. Beth McCarville, Max R. Langham, Robert E. Ruiz, Teresa Santiago, Andrew J. Murphy
Summary: Giant focal nodular hyperplasia (GFNH) is rare in children and presents complex considerations for diagnosis and management. Pathognomonic radiographic findings can be absent in this population and the nuances of pathological examination are critical.
JOURNAL OF SURGICAL CASE REPORTS
(2022)
Article
Oncology
Kevin B. Cederberg, Ramesh S. Iyer, Apeksha Chaturvedi, M. B. McCarville, Janice D. McDaniel, Jesse K. Sandberg, Amer Shammas, Susan E. Sharp, Helen R. Nadel
Summary: This paper provides consensus-based recommendations for imaging in children with osteosarcoma and Ewing sarcoma at diagnosis, during therapy, and after therapy.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Kyle J. Morgan, Andrew Dudas, Wayne L. Furman, M. Beth McCarville, Barry L. Shulkin, Zhaohua Lu, Himani Darji, Doralina L. Anghelescu
Summary: This study examined the association between opioid consumption and tumor response in children with neuroblastoma. The results showed that there was no significant correlation between opioid use and tumor volume or burden.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Michael Richard Acord, Erika Pace, Alexander El-Ali, Apeksha Chaturvedi, Ramesh S. Iyer, Oscar M. Navarro, Neeta Pandit-Taskar, Ashishkumar K. Parikh, Ann Schechter, Raja Shaikh, M. Beth McCarville
Summary: This manuscript provides consensus-based imaging recommendations for patients with a soft tissue tumor of the extremity at different stages.
PEDIATRIC BLOOD & CANCER
(2023)
Meeting Abstract
Hematology
Ayobami Olanrewaju, Zachary Abramson, Jane S. Hankins, Clifford Takemoto, M. Beth McCarville, Andrew M. Heitzer, Guolian Kang, Victoria Okhomina, Winfred C. Wang
Letter
Oncology
Zhongbo Hu, Trisha K. Paul, Yen-Chun Liu, Mary E. McCarville, Melissa Hines, Gabriela Gheorghe, Patrick K. Campbell
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Abdelhafeez H. H. Abdelhafeez, Suraj Sarvode Mothi, Luca Pio, Motomi Mori, Teresa C. C. Santiago, M. Beth McCarville, Sue C. C. Kaste, Alberto S. S. Pappo, Lindsay J. J. Talbot, Andrew J. J. Murphy, Andrew M. M. Davidoff
Summary: ICG-guided identification of pulmonary nodules is not feasible for all pediatric solid tumors. However, it may be useful for localizing most metastatic hepatic tumors and high-grade sarcomas in children.
PEDIATRIC BLOOD & CANCER
(2023)
Editorial Material
Oncology
E. R. Tang, A. L. Alazraki, P. G. Thacker, M. B. McCarville, A. J. Towbin
Summary: Pediatric cancer imaging requires experienced radiologists due to its rarity. The Children's Oncology Group Diagnostic Imaging Committee and the Society for Pediatric Radiology Oncology Committee, composed of experts in pediatric cancer imaging, have recently created a series of 23 White Papers as evidence-based imaging recommendations and protocols. This manuscript describes the methods employed in authoring the White Paper series.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Pediatrics
Paul G. Thacker, Adina L. Alazraki, M. Beth McCarville, Elizabeth R. R. Tang, Alexander J. Towbin
PEDIATRIC RADIOLOGY
(2023)
Meeting Abstract
Oncology
Michael W. Bishop, Yimei Li, Rachel Christine Brennan, Sara Michele Federico, Elizabeth Stewart, Mark Edward Hatley, Sara Helmig, John Thomas Lucas, Christopher L. Tinkle, Andrew M. Davidoff, Mary B. McCarville, Karen H. Albritton, Daniel J. Indelicato, Alberto S. Pappo, Matthew J. Krasin
JOURNAL OF CLINICAL ONCOLOGY
(2022)