Review
Critical Care Medicine
Eric Lang, Hossam Abdou, Joseph Edwards, Neerav Patel, Jonathan J. Morrison
Summary: Trauma-hemorrhage is a major cause of death both before and early in hospitalization, and it also contributes to the development of organ dysfunction/failure and sepsis. Sex hormone therapy, including estradiol and its derivatives, has shown beneficial effects in animal models. Gender-based differences in mortality following trauma-hemorrhage have been observed, suggesting a role for estrogens.
Article
Environmental Sciences
Xin Wang, Ning Ding, Sioban D. Harlow, John F. Randolph Jr, Ellen B. Gold, Carol Derby, Howard M. Kravitz, Gail Greendale, Xiangmei Wu, Keita Ebisu, Joel Schwartz, Sung Kyun Park
Summary: This study investigated the association between air pollution and levels of estradiol (E2) and follicle-stimulating hormone (FSH) in women during menopause. The findings showed that increased levels of PM2.5 and NO2 were associated with significant decreases in E2 levels, while increased levels of NO2 were associated with decreases in FSH levels. This suggests that air pollutants have a detrimental impact on women's reproductive hormones.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Neurosciences
Bin Ke, Chunyu Li, Huifang Shang
Summary: The study found a link between higher levels of estradiol and a reduced risk of epilepsy, particularly in males. No association was found between testosterone or progesterone and the risk of epilepsy. These findings highlight the importance of estradiol in the development of preventive or therapeutic interventions in clinical trials.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Ke Xu, Yicheng Fu, Buzi Cao, Mingyi Zhao
Summary: This study aims to evaluate the association between sex hormones and sex hormone-binding globulin (SHBG) with bone mineral density (BMD) in adolescents. The results show differences in the association of sex hormones with BMD in boys and girls, where an appropriate increase in serum testosterone levels may be beneficial for skeletal development in girls and keeping estradiol levels below a certain level in boys may be considered.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Tina B. McKay, Shrestha Priyadarsini, Dimitrios Karamichos
Summary: This review focuses on the effects of systemic hormones, including androgens, estrogens, human growth hormone, and insulin growth factor-1, on ocular surface homeostasis, wound healing, and corneal thickness. The findings suggest that age-related changes in hormone levels should be considered as an important factor in the study of corneal health and disease.
Article
Public, Environmental & Occupational Health
Nuozhou Liu, Ying Feng, Xinyao Luo, Xue Ma, Fang Ma
Summary: This study reveals an association between a proinflammatory diet and decreased levels of SHBG in women, particularly in premenopausal women.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Shuai Yuan, Lijuan Wang, Jing Sun, Lili Yu, Xuan Zhou, Jie Yang, Yimin Zhu, Dipender Gill, Stephen Burgess, Joshua C. Denny, Susanna C. Larsson, Evropi Theodoratou, Xue Li
Summary: This study used Mendelian randomization to investigate the associations between sex hormone binding globulin (SHBG), testosterone, and estradiol levels and disease outcomes. The results suggest a causal relationship between sex hormones and several health outcomes.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Endocrinology & Metabolism
Zheng Qin, Nuozhou Liu, Ruoxi Liao, Luojia Jiang, Baihai Su
Summary: The study found a negative association between pro-inflammatory diet and testosterone and estradiol levels in male adolescents, with no significant association observed in male children. Further research is needed to confirm the causal relationship between DII and sex hormones.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Justin C. Brown, Kathleen Sturgeon, David B. Sarwer, Andrea B. Troxel, Angela M. DeMichele, Crystal S. Denlinger, Kathryn H. Schmitz
Summary: Insufficient physical activity and obesity in breast cancer survivors are linked to an increased risk of cancer recurrence and death. However, this study found that exercise alone, diet alone, or exercise plus diet did not significantly change sex steroid hormone concentrations in postmenopausal breast cancer survivors who were insufficiently physically active and had overweight or obesity at week 52.
ENDOCRINE-RELATED CANCER
(2022)
Article
Cardiac & Cardiovascular Systems
Jessie van Wezenbeek, Joanne A. Groeneveldt, Aida Llucia-Valldeperas, Cathelijne E. van Der Bruggen, Samara M. A. Jansen, A. Josien Smits, Rowan Smal, Joost W. van Leeuwen, Cris dos Remedios, Anne Keogh, Marc Humbert, Peter Dorfmuller, Olaf Mercier, Christophe Guignabert, Hans W. M. Niessen, M. Louis Handoko, J. Tim Marcus, Lilian J. Meijboom, Frank P. T. Oosterveer, Berend E. Westerhof, Annemieke C. Heijboer, Harm Jan Bogaard, Anton Vonk Noordegraaf, Marie Jose Goumans, Frances S. de Man
Summary: This study investigated the association between altered sex hormone expression and long-term right ventricular adaptation and progression of right heart failure in patients with pulmonary arterial hypertension across a wide range of ages.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Frank Z. Stanczyk, Intira Sriprasert, Roksana Karim, Juliana Hwang-Levine, Wendy J. Mack, Howard N. Hodis
Summary: Studies on age-specific reference ranges of endogenous sex steroid hormones in postmenopausal women are lacking. This study aimed to establish reference ranges for sex steroid hormones and SHBG in different age groups of healthy postmenopausal women and investigate their association with demographic characteristics. The results showed that estrogen levels remained relatively stable across different age groups, while total testosterone levels increased gradually with age. The study provides valuable insight into the profiles of sex steroid hormones and SHBG in healthy postmenopausal women of different ages.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Biochemical Research Methods
Amy Gravitte, Timothy Archibald, Allison Cobble, Benjamin Kennard, Stacy Brown
Summary: Liquid chromatography coupled with tandem mass spectrometry is a powerful tool for accurate quantification of sex steroid hormones, essential for understanding the role of these regulators in human development, fertility, and disease risk. LC-MS/MS offers advantages in specificity and sensitivity over immunoassay techniques, making it a growing method for clinically relevant quantification of sex steroid hormones.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Review
Endocrinology & Metabolism
C. Szoeke, S. J. Downie, A. F. Parker, S. Phillips
Summary: This paper discusses the role of sex hormones in the intersection of vascular disease and dementia, emphasizing interactive risk factors and the role of inflammation in the evolution of the disease, as well as the impact of estrogen-based hormone therapy on cognition over the past 45 years.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Fa-Zhan Xu, Lu-Lu Zheng, Ke-Hao Chen, Ru Wang, Dan-Dan Yi, Chao-Yu Jiang, Zhi-Jian Liu, Xian-Biao Shi, Jian-Feng Sang
Summary: This study observed the correlation between serum sex hormones and pathological features of PTC in male patients, providing further evidence for the role of sex hormones in PTC. Higher levels of serum estrogens may increase the risk of PTC, while androgens may have a protective effect. This study contributes new variables for future PTC prediction models.
Article
Endocrinology & Metabolism
Pranav Gupta, Briana C. Patterson, Lena Chu, Sarah Gold, Seth Amos, Howa Yeung, Michael Goodman, Vin Tangpricha
Summary: This study investigated the proportion and reasons for discontinuation of gender-affirming hormone therapy (GAHT) in transgender and gender diverse (TGD) individuals. The results showed that only a small percentage of participants discontinued GAHT, and the main reason was achieving desired treatment effects. This suggests that GAHT discontinuation is low when therapy follows the guidelines of the Endocrine Society.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Respiratory System
Paul D. Robinson, Renee Jensen, Ryan A. Seeto, Sanja Stanojevic, Clare Saunders, Christopher Short, Jane C. Davies, Felix Ratjen
JOURNAL OF CYSTIC FIBROSIS
(2022)
Editorial Material
Respiratory System
Lucy Mary Perrem, Paul McNally, Felix Ratjen
Editorial Material
Pediatrics
Hartmut Grasemann, Nancy McDonald, Xi Zhou Yuan, Sharon Dell, Valerie Waters, Felix Ratjen
Summary: Treating exacerbations of primary ciliary dyskinesia resulted in increased sputum NO metabolites and decreased neutrophilic inflammation. The association between the two suggests that neutrophilic inflammation contributes to airway NO deficiency in primary ciliary dyskinesia, and reducing inflammation may improve airway NO homeostasis.
JOURNAL OF PEDIATRICS
(2022)
Article
Respiratory System
Gyde Nissen, Elad Ben-Meir, Matthias Kopp, Michelle Shaw, Felix Ratjen, Hartmut Grasemann
Summary: Airway nitric oxide (NO) deficiency is a characteristic of cystic fibrosis (CF), and this study found that ivacaftor therapy significantly reduces IL-1β concentration in sputum, which is closely related to the improvement in NO metabolism, suggesting a potential interaction between transepithelial chloride conductance, IL-1β, and airway NO production.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Letter
Respiratory System
Renee Jensen, Michelle Shaw, Angel Phanthanourak, Felix Ratjen
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Respiratory System
Andrew Zikic, Felix Ratjen, Michelle Shaw, Elizabeth Tullis, Valerie Waters
Summary: Changing antibiotics during treatment for pulmonary exacerbations in cystic fibrosis patients with poor clinical response did not lead to improved lung function recovery or return to baseline.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Clinical Neurology
Roxana Azma, Adam A. Dmytriw, Asthik Biswas, Mordechai Pollak, Felix Ratjen, Afsaneh Amirabadi, Helen M. Branson, Abhaya V. Kulkarni, Peter Dirks, Prakash Muthusami
Summary: This study describes the neurovascular findings in a large cohort of children with hereditary hemorrhagic telangiectasia (HHT) and investigates the correlation between phenotype and genotype. The most commonly observed vascular malformations in these patients were developmental venous anomalies and brain arteriovenous malformations.
PEDIATRIC NEUROLOGY
(2022)
Article
Respiratory System
Lucy Perrem, Sanja Stanojevic, Melinda Solomon, Hartmut Grasemann, Neil Sweezey, Valerie Waters, Don B. Sanders, Stephanie D. Davis, Felix Ratjen
Summary: The changes in lung clearance index (LCI) have different thresholds for clinical relevance in children with cystic fibrosis (CF), and these thresholds can also be applied to healthy children.
Article
Respiratory System
Isabel Gascon Casaredi, Michelle Shaw, Valerie Waters, Ryan Seeto, Ana C. Blanchard, Felix Ratjen
Summary: This study conducted long-term follow-up observation on cystic fibrosis patients and found that antibiotic eradication therapy (AET) can improve lung function in patients with early Pseudomonas aeruginosa infection.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Editorial Material
Pediatrics
Ediane De Queiroz Andrade, Brooke Bailey, Jane C. C. Davies, Renee Jensen, Felix Ratjen, Clare J. J. Saunders, Christopher Short, Paul D. D. Robinson
PEDIATRIC PULMONOLOGY
(2023)
Review
Respiratory System
Lucy Perrem, Isaac Martin, Felix Ratjen
Summary: Pulmonary exacerbations in children with cystic fibrosis are common and even mild clinical events contribute to the progression of lung disease. Prompt diagnosis and management are necessary to preserve lung function.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Cell Biology
Tarini N. A. Gunawardena, Zoltan Bozoky, Claire Bartlett, Hong Ouyang, Paul D. W. Eckford, Theo J. Moraes, Felix Ratjen, Tanja Gonska, Christine E. Bear
Summary: In vitro studies on nasal epithelial cultures derived from cystic fibrosis patients suggest that the rescue effect of CFTR modulator drugs can be predicted through these studies. There is interest in evaluating different measuring methods for in vitro modulator responses in patient-derived nasal cultures. The fluorescence-based Fl-ACC method shows effectiveness in detecting positive responses to interventions for all genotypes and has the potential for greater sensitivity in detecting responses to pharmacological rescue strategies targeting W1282X.
Editorial Material
Respiratory System
Christine Bear, Felix Ratjen
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Pediatrics
Dvir Gatt, Michelle Shaw, Valerie Waters, Fiona Kritzinger, Melinda Solomon, Sharon Dell, Felix Ratjen
Summary: This retrospective study analyzed 52 pulmonary exacerbation events in 28 children with PCD between 2010 and 2022. The majority of lung function recovery occurred within the first week of IV therapy. Lower BMI was associated with nonresponse to treatment.
PEDIATRIC PULMONOLOGY
(2023)
Letter
Respiratory System
Elias Seidl, Johann-Christoph Licht, Wallace B. Wee, Martin Post, Felix Ratjen, Hartmut Grasemann
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)