Article
Multidisciplinary Sciences
Timothy Howarth, Helmi Ben Saad, Ara J. Perez, Charmain B. Atos, Elisha White, Subash S. Heraganahally
Summary: This study identified significant differences in DLCO and TLC parameters between Indigenous Australians compared to Australian Caucasians, highlighting the need for establishing appropriate norms for Indigenous Australians.
Review
Respiratory System
Yingmeng Ni, Youchao Yu, Ranran Dai, Guochao Shi
Summary: DLCO % predicted is significantly lower in COPD patients with more severe airflow limitation, more symptoms, and higher exacerbation risk. It is also associated with exacerbation patients, non-survivors, emphysema dominant phenotype, and pulmonary hypertension in COPD patients. The current meta-analysis suggests that DLCO % predicted may be an important measurement for evaluating COPD patients in terms of severity, exacerbation risk, mortality, emphysema domination, and presence of pulmonary hypertension.
CHRONIC RESPIRATORY DISEASE
(2021)
Article
Multidisciplinary Sciences
Katerina Byanova, Jessica Fitzpatrick, Amanda K. Jan, Maggie McGing, Marlena Hartman-Filson, Carly Farr, Michelle Zhang, Kendall Gardner, Jake Branchini, Robert Kerruish, Sharvari Bhide, Aryana W. Bates, Jenny J. Hsieh, Rebecca A. Abelman, Peter Hunt, Richard Wang, Kristina Crothers, Laurence Huang
Summary: An isolated reduction in the diffusing capacity for carbon monoxide (DLco) is associated with increased respiratory symptom burden in people living with HIV, and this association becomes stronger as the DLco worsens, indicating that impaired gas exchange has a significant negative impact on the quality of life in this population.
Article
Respiratory System
Apama Balasubramanian, Nirupama Putcha, Neil R. MacIntyre, Robert L. Jensen, Gregory Kinney, William W. Stlinger, Craig P. Hersh, Russell P. Bowler, Richard Casaburi, MeiLan K. Han, Janos Porszasz, R. Graham Barr, Elizabeth Regan, Barry J. Make, Nadia N. Hansel, Robert A. Wise, Meredith C. McCormack
Summary: DLCO is a potential predictor of mortality in COPD patients, independent of BODE index and CT evidence. For every 10% decrease in DLCO percent predicted, mortality increases by 28%. Adding DLCO to BODE improves the predictive accuracy of the model for COPD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Rheumatology
Erwan Le Tallec, Corentin Bourg, Guillaume Bouzille, Nicolas Belhomme, Estelle Le Pabic, Stephanie Guillot, Catherine Droitcourt, Antoinette Perlat, Stephane Jouneau, Erwan Donal, Alain Lescoat
Summary: DLCO alteration is associated with disease damage in SLE, potentially related to SLE vasculopathy, and has prognostic value for death or intensive care unit admission in SLE.
Article
Respiratory System
Aaron B. Holley, Thomas Carbone, Arthur W. Holtzclaw, Nikhil A. Huprikar, Rory Wagner, Michael J. Morris
Summary: This study aimed to investigate the effects of body mass index (BMI) on measures of lung function. The results showed that BMI was significantly associated with KCO and VA, but not with DLCO. These findings have implications for the sensitivity in detecting gas-exchange abnormalities.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Public, Environmental & Occupational Health
Sonia Qureshi, Nosheen Nasir, Naveed Rashid, Naveed Ahmed, Zoya Haq, Farah Qamar
Summary: This study in Pakistan aims to determine the long-term impact on lung function capacity in patients who have survived moderate or severe COVID-19 disease. The research will involve respiratory function tests at 3- and 6-month intervals, as well as echocardiograms to check for pulmonary hypertension. The findings will provide valuable insights into the disease's effects on vital functions and inform rehabilitative strategies.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Pediatrics
Pritish Mondal, Vishal Midya, Arshjot Khokhar, Shyama Sathianathan, Erick Forno
Summary: This study identified pulmonary function test estimates associated with abnormal diffusing capacity in children with Sickle Cell Disease (C-SCD) using machine learning algorithms and linear mixed-effect models. The results showed that DLCO was associated with PFT estimates representing restrictive lung disease, airflow obstruction, and inflammation in C-SCD patients, highlighting the clinical relevance of prediction models.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, Research & Experimental
Yuer Li, Rui Zhang, Hu Shan, Wenhua Shi, Xiaoli Feng, Haijuan Chen, Xia Yang, Yali Li, Jie Zhang, Ming Zhang
Summary: The ratio of FVC to D-LCO can identify PH in patients with COPD and predict their prognosis.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Oncology
Jee Seon Kim, Eun Ji Kim, Jong Geol Jang, Kyung Soo Hong, June Hong Ahn
Summary: This study compared the clinical characteristics of extensive disease small-cell lung cancer (ED-SCLC) patients with or without moderately impaired diffusion capacity for carbon monoxide (DLco) and investigated the factors associated with survival. The study found that DLco < 60%, number of metastases, and < 4 cycles of first-line chemotherapy were associated with poor survival outcomes in ED-SCLC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Respiratory System
Megan L. Neely, Anne S. Hellkamp, Shaun Bender, Jamie L. Todd, Timothy Liesching, Tracy R. Luckhardt, Justin M. Oldham, Rishi Raj, Eric S. White, Scott M. Palmer
Summary: This study evaluated the trajectories of lung function decline in patients with IPF and found that IPF is characterized by a progressive decline in lung function. Male, white, patients with a family history of ILD, oxygen users, and those using antifibrotic therapy had a greater decline in lung function.
RESPIRATORY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
S. Beyhan Sagmen, A. Fidan
Summary: This study investigated pulmonary function parameters in patients with and without pulmonary hypertension and explored the roles of forced vital capacity (FVC)/diffusing capacity of the lungs for carbon monoxide (DLCO) and FVC/DLCO/alveolar volume (VA) values in COPD patients with pulmonary hypertension. The results suggest that FVC/DLCO and FVC/DLCO/VA ratios can be important predictors of increased pulmonary artery pressure in COPD patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Respiratory System
Kathrin Kahnert, Lilli Maria Lempert, Juergen Behr, Laura Elsner, Toki Bolt, Amanda Tufman, Diego Kauffmann-Guerrero
Summary: This study found that lung function testing results are associated with prognosis in SCLC patients. Hyperinflation and reduced diffusing capacity were correlated with poorer outcomes. Therefore, body plethysmography and measurement of diffusing capacity should be included in the pre-therapeutic assessment of SCLC patients.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Review
Environmental Sciences
Paola Di Filippo, Giulia Dodi, Francesca Ciarelli, Sabrina Di Pillo, Francesco Chiarelli, Marina Attanasi
Summary: The clinical, functional, and structural pattern of chronic lung disease of prematurity has changed significantly in recent years, with premature birth potentially increasing the risk of lung function impairment in late childhood. Therefore, it is necessary for physicians to better recognize and identify at-risk individuals through CT imaging and lung function evaluation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Respiratory System
Luigi Ventura, Letizia Gnetti, Gianluca Milanese, Maurizio Rossi, Ludovica Leo, Sara Cattadori, Mario Silva, Alessandro Leonetti, Roberta Minari, Luca Musini, Pensato Nicole, Federico Illica Magrini, Giovanni Bocchialini, Enrico Maria Silini, Marcello Tiseo, Nicola Sverzellati, Paolo Carbognani
Summary: This study aimed to evaluate the potential relationship between the diffusing capacity of the lung for carbon monoxide (DLCO) and the aggressiveness of lung adenocarcinoma (ADC). The results showed that DLCOlow was associated with smoking status, low FEV1, micropapillary and solid ADC, tumour grade 3, high tumour lymphoid infiltrate and presence of tumour desmoplasia. DLCO was also found to be significantly related to overall survival (OS). Overall, this study suggests a potential connection between DLCO and the aggressiveness of lung ADC.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Letter
Pediatrics
Rhea Urs, Benjamin Stoecklin, J. Jane Pillow, Benjamin Hartmann, Graham L. Hall, Shannon J. Simpson
PEDIATRIC RESEARCH
(2022)
Article
Critical Care Medicine
Nirav R. Bhakta, David A. Kaminsky, Christian Bime, Neeta Thakur, Graham L. Hall, Meredith C. McCormack, Sanja Stanojevic
Summary: The practice of using race or ethnicity in medicine to explain differences between individuals is being questioned due to its potential contribution to biased medical care, research, and perpetuation of health disparities and structural racism. This article focuses on the interpretation of pulmonary function test (PFT) results and highlights the need to examine the perspectives of practicing pulmonologists and physiologists. It discusses the limitations of current PFT measurement and interpretation practices and proposes changes in interpretation strategies and future research to address health disparities.
Review
Pediatrics
Dimpalben Patel, Graham L. Hall, David Broadhurst, Anne Smith, Andre Schultz, Rachel E. Foong
Summary: Asthma, the most common chronic lung disease in childhood, has been a challenge to predict accurately using conventional statistical models. Machine learning offers a potential solution to improve prediction accuracy. However, only a few studies have utilized machine learning for childhood asthma prediction.
PAEDIATRIC RESPIRATORY REVIEWS
(2022)
Article
Respiratory System
Sanja Stanojevic, David A. Kaminsky, Martin R. Miller, Bruce Thompson, Andrea Aliverti, Igor Barjaktarevic, Brendan G. Cooper, Bruce Culver, Eric Derom, Graham L. Hall, Teal S. Hallstrand, Joerg D. Leuppi, Neil MacIntyre, Meredith McCormack, Margaret Rosenfeld, Erik R. Swenson
Summary: This article emphasizes the importance of accurately interpreting pulmonary function test results and updates the new standards and strategies for interpreting pulmonary function tests. It is necessary to combine clinical expertise and biological variability for interpretation to ensure an accurate understanding of individual pulmonary function measurements.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Phillip Pattie, Sarath Ranganathan, Joanne Harrison, Suzanna Vidmar, Graham L. Hall, Rachel E. Foong, Alana Harper, Kathryn Ramsey, Danielle Wurzel
Summary: The relationship between health-related quality-of-life (HRQOL) and lung function and structure in early school-aged children with cystic fibrosis (CF) is weak. These findings are important for determining study endpoints in clinical trials.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Respiratory System
David A. Kaminsky, Shannon J. Simpson, Kenneth Berger, Peter Calverley, Pedro L. de Melo, Ronald Dandurand, Raffaele L. Dellaca, Claude S. Farah, Ramon Farre, Graham L. Hall, Iulia Ioan, Charles G. Irvin, David W. Kaczka, Gregory G. King, Hajime Kurosawa, Enrico Lombardi, Geoffrey N. Maksym, Francois Marchal, Ellie Oostveen, Beno W. Oppenheimer, Paul D. Robinson, Maarten van den Berge, Cindy Thamrin
Summary: The publication of technical standards for respiratory oscillometry has a significant impact on the medical field. Oscillometry has wide applications in airway resistance, bronchodilator responsiveness, medical therapy, and has unique advantages in specific situations. Despite the great potential as a clinical tool, more clinical evidence is needed to support its routine use in diagnosing and monitoring respiratory diseases.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Respiratory System
Don B. Sanders, Ashley R. Deschamp, Joseph E. Hatch, James E. Slaven, Netsanet Gebregziabher, Mariette Kemner-van de Corput, Harm A. W. M. Tiddens, Tim Rosenow, Gregory A. Storch, Graham L. Hall, Stephen M. Stick, Sarath Ranganathan, Thomas W. Ferkol, Stephanie D. Davis
Summary: This study aimed to investigate the association between respiratory viruses and structural lung disease on chest CT in infants with cystic fibrosis (CF). The results showed that infants with CF had minimal structural lung disease, and no association was found between respiratory viruses and CT abnormalities. However, wheezing and frequency of cough were associated with early structural changes.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Letter
Respiratory System
Anne-Christianne Kentgens, Philipp Latzin, Pinelopi Anagnostopoulou, Renee Jensen, Mirjam Stahl, Alana Harper, Sophie Yammine, Rachel E. Foong, Graham L. Hall, Florian Singer, Sanja Stanojevic, Marcus A. Mall, Felix Ratjen, Kathryn A. Ramsey
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Obstetrics & Gynecology
Laura A. Wijs, Dorota A. Doherty, Jeffrey A. Keelan, Blagica Penova-Veselinovic, Peter Burton, John L. Yovich, Graham L. Hall, Peter D. Sly, Patrick G. Holt, Roger J. Hart
Summary: Adolescents conceived with assisted reproductive technologies (ART) show no difference in asthma prevalence compared to those conceived without, but have slightly altered lung function, increased rates of allergic rhinoconjunctivitis, food allergies, and positive skin prick testing.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Clinical Neurology
Aysha Stroobach, Andrew C. Wilson, Jenny Lam, Graham L. Hall, Adelaide Withers, Jenny Downs
Summary: This study aims to explore the barriers and enablers to the participation of children and adolescents with neuromuscular disorders and their parents. The findings suggest that meaningful participation is related to personal factors such as the child's sense of self, preferences, and competence. Factors such as adaptive equipment and activity modification, social relationships, inclusion, accessibility, social attitudes, and policies can either enable or hinder participation.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Respiratory System
Rachel E. Foong, Peter Franklin, Francesca Sanna, Graham L. Hall, Peter D. Sly, Eric B. Thorstensen, Dorota A. Doherty, Jeffrey A. Keelan, Roger J. Hart
Summary: This study investigated the effects of prenatal exposure to phthalates and bisphenol A (BPA) on asthma, allergy, and lung function outcomes from childhood to adulthood. The results showed that prenatal BPA exposure was associated with an increased likelihood of persistent asthma in males, while prenatal phthalate exposure was associated with an increased likelihood of adult asthma in males. However, lung function was not adversely affected by prenatal exposure to these chemicals.
Article
Pediatrics
Zoe Freislich, Benjamin Stoecklin, Naomi Hemy, J. Jane Pillow, Graham L. L. Hall, Andrew C. C. Wilson, Shannon J. J. Simpson
Summary: Preterm infants continue to have attenuated ventilatory response to hypoxia at 12-15 months corrected postnatal age, especially in males. Predictive factors affect the magnitude of the blunted ventilatory response.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Myrtha E. Reyna, Ruixue Dai, Maxwell M. Tran, Vanessa Breton, Maria Medeleanu, Wendy Y. W. Lou, Rachel E. Foong, Melanie Emmerson, Christoffer Dharma, Kozeta Miliku, Diana L. Lefebvre, Elinor Simons, Meghan B. Azad, Moira Chan-Yeung, Allan B. Becker, Piush J. Mandhane, Stuart E. Turvey, Graham L. Hall, Theo J. Moraes, Malcolm R. Sears, Padmaja Subbarao
Summary: Despite advances in asthma therapeutics, the burden of asthma is still highest in preschool children. This study developed and evaluated a symptom-based screening tool to detect preschool children at high risk of asthma and persistent wheeze symptoms. The tool, called CHART, showed good predictive accuracy and could be easily incorporated into primary care settings.
Article
Genetics & Heredity
Nick Shrine, Abril G. Izquierdo, Jing Chen, Richard Packer, Robert J. Hall, Anna L. Guyatt, Chiara Batini, Rebecca J. Thompson, Chandan Pavuluri, Vidhi Malik, Brian D. Hobbs, Matthew Moll, Wonji Kim, Ruth Tal-Singer, Per Bakke, Katherine A. Fawcett, Catherine John, Kayesha Coley, Noemi Nicole Piga, Alfred Pozarickij, Kuang Lin, Iona Y. Millwood, Zhengming Chen, Liming Li, Sara R. A. Wijnant, Lies Lahousse, Guy Brusselle, Andre G. Uitterlinden, Ani Manichaikul, Elizabeth C. Oelsner, Stephen S. Rich, R. Graham Barr, Shona M. Kerr, Veronique Vitart, Michael R. Brown, Matthias Wielscher, Medea Imboden, Ayoung Jeong, Traci M. Bartz, Sina A. Gharib, Claudia Flexeder, Stefan Karrasch, Christian Gieger, Annette Peters, Beate Stubbe, Xiaowei Hu, Victor E. Ortega, Deborah A. Meyers, Eugene R. Bleecker, Stacey B. Gabriel, Namrata Gupta, Albert Vernon Smith, Jian'an Luan, Jing-Hua Zhao, Ailin F. Hansen, Arnulf Langhammer, Cristen Willer, Laxmi Bhatta, David Porteous, Blair H. Smith, Archie Campbell, Tamar Sofer, Jiwon Lee, Martha L. Daviglus, Bing Yu, Elise Lim, Hanfei Xu, George T. O'Connor, Gaurav Thareja, Omar M. E. Albagha, Said I. Ismail, Wadha Al-Muftah, Radja Badji, Hamdi Mbarek, Dima Darwish, Tasnim Fadl, Heba Yasin, Maryem Ennaifar, Rania Abdellatif, Fatima Alkuwari, Muhammad Alvi, Yasser Al-Sarraj, Chadi Saad, Asmaa Althani, Eleni Fethnou, Fatima Qafoud, Eiman Alkhayat, Nahla Afifi, Sara Tomei, Wei Liu, Stephan Lorenz, Najeeb Syed, Hakeem Almabrazi, Fazulur Rehaman Vempalli, Ramzi Temanni, Tariq Abu Saqri, Mohammedhusen Khatib, Mehshad Hamza, Tariq Abu Zaid, Ahmed El Khouly, Tushar Pathare, Shafeeq Poolat, Rashid Al-Ali, Souhaila Al-Khodor, Mashael Alshafai, Ramin Badii, Lotfi Chouchane, Xavier Estivill, Khalid Fakhro, Younes Mokrab, Jithesh Puthen, Zohreh Tatari, Karsten Suhre, Raquel Granell, Tariq O. Faquih, Pieter S. Hiemstra, Annelies M. Slats, Benjamin H. Mullin, Jennie Hui, Alan James, John Beilby, Karina Patasova, Pirro Hysi, Jukka T. Koskela, Annah B. Wyss, Jianping Jin, Sinjini Sikdar, Mikyeong Lee, Sebastian May-Wilson, Nicola Pirastu, Katherine A. Kentistou, Peter K. Joshi, Paul R. H. J. Timmers, Alexander T. Williams, Robert C. Free, Xueyang Wang, John L. Morrison, Frank D. Gilliland, Zhanghua Chen, Carol A. Wang, Rachel E. Foong, Sarah E. Harris, Adele Taylor, Paul Redmond, James P. Cook, Anubha Mahajan, Lars Lind, Teemu Palviainen, Terho Lehtimaki, Olli T. Raitakari, Jaakko Kaprio, Taina Rantanen, Kirsi H. Pietilainen, Simon R. Cox, Craig E. Pennell, Graham L. Hall, W. James Gauderman, Chris Brightling, James F. Wilson, Tuula Vasankari, Tarja Laitinen, Veikko Salomaa, Dennis O. Mook-Kanamori, Nicholas J. Timpson, Eleftheria Zeggini, Josee Dupuis, Caroline Hayward, Ben Brumpton, Claudia Langenberg, Stefan Weiss, Georg Homuth, Carsten Oliver Schmidt, Nicole Probst-Hensch, Marjo-Riitta Jarvelin, Alanna C. Morrison, Ozren Polasek, Igor Rudan, Joo-Hyeon Lee, Ian Sayers, Emma L. Rawlins, Frank Dudbridge, Edwin K. Silverman, David P. Strachan, Robin G. Walters, Andrew P. Morris, Stephanie J. London, Michael H. Cho, Louise Wain, Ian P. Hall, Martin Tobin
Summary: Through a large-scale multi-ancestry genome-wide association meta-analysis, 1020 independent association signals implicating 559 genes related to COPD were identified. These genes were enriched in 29 pathways. Variants showed heterogeneity across ancestries, age and smoking groups, and the genetic risk score was strongly associated with COPD across ancestry groups. New potential causal variants, genes, proteins and pathways were highlighted, including those targeted by existing drugs. These findings contribute to a better understanding of lung function and COPD mechanisms and have implications for functional genomics experiments and future COPD therapies.
Article
Respiratory System
Francesca Sanna, Francesca Locatelli, Peter D. Sly, Elisha White, David Blake, Jane Heyworth, Graham L. Hall, Rachel E. Foong
Summary: This study aims to identify early-life risk factors and their impact on lung function trajectories. The findings suggest that asthma, maternal smoking, and early-life exposure to PM2.5Absorbance are risk factors for low lung function trajectories.
