Article
Medicine, General & Internal
Chunjiang Wang, Yulu Zhou, Liying Song, Zhenzhen Deng, Weijin Fang
Summary: This study aimed to elucidate the clinical features of patients with valproate-induced Fanconi syndrome (FS). The results showed that these patients were typically young, severely disabled, tube-fed, and received other anticonvulsant medications. The most common symptoms included pathological fractures, unexplained fever, muscle weakness, and edema. Blood and urine tests revealed various abnormal values, which returned to normal levels after discontinuation of the drug.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Ignacio Portales-Castillo, David B. Mount, Sagar U. Nigwekar, ElaineW. Yu, Helmut G. Rennke, Shruti Gupta
Summary: Four patients with underlying malignancy developed Fanconi syndrome, characterized by renal dysfunction and electrolyte imbalances, after receiving Zoledronic acid (ZA) treatment. This case series strongly suggests ZA as a possible trigger for Fanconi syndrome.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Infectious Diseases
P. D. J. Bollen, H. A. B. Prins, A. Colbers, K. Velthoven-Graafland, B. J. A. Rijnders, T. E. M. S. De Vries-Sluijs, E. van Nood, J. Nouwen, H. Bax, M. de Mendonca Melo, A. Verbon, D. M. Burger, C. Rokx
Summary: This study confirms protein displacement as the main mechanism for the dolutegravir/valproic acid drug-drug interaction, although additional mechanisms might be involved too. If dolutegravir is taken with food, this drug-drug interaction is probably not clinically relevant.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Natalia A. A. Shnayder, Violetta V. V. Grechkina, Vera V. V. Trefilova, Ilya S. S. Efremov, Evgenia A. A. Dontceva, Ekaterina A. A. Narodova, Marina M. M. Petrova, Irina A. A. Soloveva, Liia E. E. Tepnadze, Polina A. A. Reznichenko, Mustafa Al-Zamil, Gulnara I. I. Altynbekova, Anna I. I. Strelnik, Regina F. F. Nasyrova
Summary: Valproic acid and its salts are widely used psychotropic drugs in neurology and psychiatry, but long-term use increases the risk of adverse drug reactions, including metabolic syndrome. This review examines the use of blood and urinary biomarkers for the prevention and diagnosis of valproate-induced metabolic syndrome, suggesting the development of a personalized multidisciplinary strategy.
Article
Pediatrics
Ting Li, Zhihong Lu, Jingjing Wang, Junyi Chen, Haidong Fu, Jianhua Mao
Summary: Fanconi syndrome is a primary renal manifestation of mitochondrial cytopathies caused by mtDNA mutation, with growth retardation being a major clinical presentation. This case report demonstrates a patient carrying the common 4977-bp mtDNA deletion and showing improvement after treatment with oral coenzyme Q10 and levocarnitine. It highlights the importance of early detection and management of renal tubular abnormalities associated with mitochondrial disorders.
Article
Cell Biology
Jiaying Li, Xiaoxiao Shi, Zhixin Chen, Jiatong Xu, Ruohuan Zhao, Yuhao Liu, Yubing Wen, Limeng Chen
Summary: Renal tubular epithelial cells are high energy-consuming cells that depend mainly on mitochondrial energy supply. ALDH2 activation alleviates mitochondrial dysfunction in AKI by enhancing PGC-1 alpha-mediated mitochondrial biogenesis. ALDH2 may serve as a potential therapeutic target to prevent AKI progression.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Eyal Karzbrun, Aimal H. Khankhel, Heitor C. Megale, Stella M. K. Glasauer, Yofiel Wyle, George Britton, Aryeh Warmflash, Kenneth S. Kosik, Eric D. Siggia, Boris Shraiman, Sebastian J. Streichan
Summary: Understanding human organ formation is a challenging scientific task with important medical implications. A chip-based culture system has been developed to recreate neural tube folding from human stem cells, revealing the crucial roles played by neural and non-neural ectoderm in the folding process. The mechanisms of folding involve apical contraction of neural ectoderm and basal adhesion mediated by non-neural ectoderm, with neural tissue width determining neural tube shape. This approach offers a new avenue for studying human organ morphogenesis in both health and disease.
Article
Cell & Tissue Engineering
Alain Aguirre-Vazquez, Fabiola Castorena-Torres, Beatriz Silva-Ramirez, Katia Penuelas-Urquides, Maria Elena Camacho-Moll, Luis A. Salazar-Olivo, Ivan Velasco, Mario Bermudez de Leon
Summary: The small molecules HYD and VPA have been found to affect the expression of pluripotency genes in adult and neonatal human fibroblasts. HYD upregulates the expression of OCT4 and NANOG genes, while VPA upregulates NANOG expression in adult fibroblasts and c-MYC expression in neonatal fibroblasts. The combination of HYD and VPA cancels the upregulation of OCT4 and NANOG genes induced by HYD and reinforces the effects of VPA on c-MYC expression.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Nutrition & Dietetics
Anusara Aranarochana, Soraya Kaewngam, Tanaporn Anosri, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat
Summary: The study found that hesperidin can reduce the VPA-induced down-regulation of hippocampal neurogenesis, leading to memory impairments. After co-administration, the cell numbers in the hippocampus returned to normal levels, alleviating memory loss.
Article
Pharmacology & Pharmacy
Ivana Kacirova, Milan Grundmann, Hana Brozmanova
Summary: The study found significant correlations between milk/maternal serum concentration ratio and infant/maternal serum concentration ratio. Valproic acid concentrations in milk and infant serum did not reach the lower limit of the reference range for the general epileptic population, indicating that routine monitoring of serum concentrations of breastfed infants is not necessary.
Article
Neurosciences
Kazuhiko Sawada, Shiori Kamiya, Ichio Aoki
Summary: This study investigated the effects of developmental exposure to VPA in ferret infants. The results showed that VPA exposure can promote the proliferation of DG progenitors in ferrets, supplying excessive progenitors for hippocampal adult neurogenesis.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Francesca Giordano, Alessandro Paoli, Martina Forastiero, Stefania Marsico, Francesca De Amicis, Mariangela Marrelli, Giuseppina Daniela Naimo, Loredana Mauro, Maria Luisa Panno
Summary: This study tested the effects of Valproic Acid on breast cancer cells and found that it can inhibit cell proliferation, induce cell cycle arrest, and modulate mitochondrial function and apoptosis markers. The drug also increased the production of Reactive Oxygen Species (ROS) in the cells. These findings indicate that Valproic Acid has potential as a therapeutic agent for breast cancer treatment, but further research is needed to fully understand its efficacy and potential combination with other chemotherapy drugs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Neurosciences
Chuchu Qi, Andi Chen, Honghui Mao, Erling Hu, Junye Ge, Guaiguai Ma, Keke Ren, Qian Xue, Wenting Wang, Shengxi Wu
Summary: This study explored the role of environmental factors, specifically medication during pregnancy, in the development of autism spectrum disorder (ASD). The researchers found that exposure to valproic acid (VPA) during pregnancy led to changes in excitatory and inhibitory synaptic function and contributed to ASD-like behaviors. They also discovered that treatment with exogenous brain-derived neurotrophic factor (BDNF) rescued synaptic functions and improved social defects in the mouse model.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Pediatrics
Anna Luiza Braga Albuquerque, Rafael dos Santos Borges, Ana Flavia Conegundes, Erika Emmylaine dos Santos, Frederico Moreira Man Fu, Clara Tavares Araujo, Pedro Alves Soares Vaz de Castro, Ana Cristina Simoes e Silva
Summary: Fanconi-Debre-de Toni syndrome is a disease that affects the function of the proximal convoluted tubule in the kidney. It can be inherited or secondary to systemic disorders. In children, it is often associated with energy supply disorders, and early diagnosis and treatment can improve prognosis and quality of life.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Yuanyuan Di, Zhongqi Li, Jin Li, Qiangqiang Cheng, Qi Zheng, Chenyang Zhai, Mengsi Kang, Chunling Wei, Jijun Lan, Juan Fan, Wei Ren, Yingfang Tian
Summary: Maternal vitamin supplementation, specifically high dose folic acid, has been shown to prevent delays in growth and development, as well as deficits in social communication and repetitive behaviors associated with ASD. This may be achieved through restoring dendritic spine density and rectifying the over-expression of synaptic proteins related to excitatory neurons and the lower expression of inhibitory ones.
Article
Endocrinology & Metabolism
Erika Ogawa, Masaru Shimura, Takuya Fushimi, Makiko Tajika, Keiko Ichimoto, Ayako Matsunaga, Tomoko Tsuruoka, Mika Ishige, Tatsuo Fuchigami, Taro Yamazaki, Masato Mori, Masakazu Kohda, Yoshihito Kishita, Yasushi Okazaki, Shori Takahashi, Akira Ohtake, Kei Murayama
JOURNAL OF INHERITED METABOLIC DISEASE
(2017)
Letter
Oncology
Maiko Hirai, Hiroshi Yagasaki, Junya Fujimura, Masami Inoue, Katsuyoshi Shimozawa, Hirotsugu Okuma, Motoaki Chin, Shori Takahashi
LEUKEMIA & LYMPHOMA
(2018)
Article
Emergency Medicine
Yuki Kasuga, Tatsuo Fuchigami, Ayumi Fukuda, Satoko Takahashi, Takemi Murai, Ryuuta Yonezawa, Michio Miyashita, Ryutaro Kohira, Yukihiko Fujita, Shori Takahashi
PEDIATRIC EMERGENCY CARE
(2017)
Article
Emergency Medicine
Rie Ichikawa, Yukihiro Maeda, Akiko Shibuya, Yoshimasa Umesato, Yoshiaki Kondo, Takeshi Maeda, Atsuo Yoshino, Shori Takahashi
PEDIATRIC EMERGENCY CARE
(2018)
Article
Pediatrics
Koichi Kamei, Kenji Ishikura, Mayumi Sako, Kunihiko Aya, Ryojiro Tanaka, Kandai Nozu, Hiroshi Kaito, Koichi Nakanishi, Yoshiyuki Ohtomo, Kenichiro Miura, Shori Takahashi, Tetsuji Morimoto, Wataru Kubota, Shuichi Ito, Hidefumi Nakamura, Kazumoto Iijima
PEDIATRIC NEPHROLOGY
(2017)
Article
Pediatrics
Chika Takano, Mika Ishige, Erika Ogawa, Hiromi Usui, Reiko Kagawa, Go Tajima, Ryoji Fujiki, Toshiyuki Fukao, Koichi Mizuta, Tatsuo Fuchigami, Shori Takahashi
PEDIATRIC TRANSPLANTATION
(2017)
Article
Clinical Neurology
Katsunori Shijo, Nobuhiro Moro, Mari Sasano, Mitsuru Watanabe, Hiroshi Yagasaki, Shori Takahashi, Taku Homma, Atsuo Yoshino
Article
Clinical Neurology
Yukari Miyakawa, Tatsuo Fuchigami, Masako Aoki, Yusuke Mine, Junichi Suzuki, Tatsuhiko Urakami, Shori Takahashi
BRAIN & DEVELOPMENT
(2018)
Article
Infectious Diseases
Chika Takano, Mitsuko Seki, Hiroaki Shiihara, Shihoko Komine-Aizawa, Kazumichi Kuroda, Shori Takahashi, Hiroshi Ushijima, Satoshi Hayakawa
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2018)
Article
Pediatrics
Masataka Kato, Mamoru Ayusawa, Hirofumi Watanabe, Akiko Komori, Yuriko Abe, Takahiro Nakamura, Hiroshi Kamiyama, Shori Takahashi
PEDIATRICS INTERNATIONAL
(2018)
Article
Medicine, General & Internal
Kimitaka Nakazaki, Erika Ogawa, Mika Ishige, Nobuyuki Ishige, Tatsuo Fuchigami, Shori Takahashi
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Pediatrics
Ayako Seimiya, Tomoo Okada, Nobuhiko Nagano, Shigeharu Hosono, Shigeru Takahashi, Shori Takahashi
PEDIATRICS INTERNATIONAL
(2019)
Article
Peripheral Vascular Disease
Satoshi Umemura, Hisatomi Arima, Shuji Arima, Kei Asayama, Yasuaki Dohi, Yoshitaka Hirooka, Takeshi Horio, Satoshi Hoshide, Shunya Ikeda, Toshihiko Ishimitsu, Masaaki Ito, Sadayoshi Ito, Yoshio Iwashima, Hisashi Kai, Kei Kamide, Yoshihiko Kanno, Naoki Kashihara, Yuhei Kawano, Toru Kikuchi, Kazuo Kitamura, Takanari Kitazono, Katsuhiko Kohara, Masataka Kudo, Hiroo Kumagai, Kiyoshi Matsumura, Hideo Matsuura, Katsuyuki Miura, Masashi Mukoyama, Satoko Nakamura, Takayoshi Ohkubo, Yusuke Ohya, Takafumi Okura, Hiromi Rakugi, Shigeyuki Saitoh, Hirotaka Shibata, Tatsuo Shimosawa, Hiromichi Suzuki, Shori Takahashi, Kouichi Tamura, Hirofumi Tomiyama, Takuya Tsuchihashi, Shinichiro Ueda, Yoshinari Uehara, Hidenori Urata, Nobuhito Hirawa
HYPERTENSION RESEARCH
(2019)
Correction
Pediatrics
Shori Takahashi, Yasuyuki Noguchi, Teruo Kitagawa
PEDIATRICS INTERNATIONAL
(2019)
Review
Cardiac & Cardiovascular Systems
Nobutaka Noto, Akiko Komori, Mamoru Ayusawa, Shori Takahashi
CARDIOVASCULAR DIAGNOSIS AND THERAPY
(2018)
Article
Clinical Neurology
Ani Gok, Seha Kamil Saygili, Sebuh Kurugoglu, Sema Saltik, Nur Canpolat
Summary: This study examines the occurrence of nephrolithiasis in children with type 1 SMA and identifies hypercalciuria and high urine specific gravity as common risk factors. The study suggests that children with SMA type 1 may have an increased risk of nephrolithiasis compared to the general population.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Glenn S. Rivera, Jesse A. Stokum, Janet Dean, Cristina L. Sadowsky, Allan J. Belzberg, Matthew J. Elrick
Summary: This study evaluated the surgical efficacy of nerve transfer surgery in patients with acute flaccid myelitis (AFM) and found that preoperative clinical and neurophysiological data play a valuable role in preoperative planning and patient selection. The postoperative outcomes demonstrated that nerve transfer surgery is an effective strategy to restore strength.
PEDIATRIC NEUROLOGY
(2024)
Review
Clinical Neurology
Tristan T. Sands, Jennifer N. Gelinas
Summary: This review explores the concept of epileptic encephalopathy (EE) in pediatric epilepsy, discussing the potential impact of epileptic activity on normal brain development and mechanisms underlying cognitive and behavioral impairments. The findings highlight the threat of epileptic activity to normal brain physiology and development.
PEDIATRIC NEUROLOGY
(2024)
Editorial Material
Clinical Neurology
Grace Gombolay, Melissa A. Walker
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Salman Rashid, Monisha Goyal, Kathryn Lalor, Khaled Al-Robaidi, Vivek Shukla, Fazlur Rahman, Manimaran Ramani
Summary: This study investigated the seizure risk in asymptomatic preterm infants with high-grade intraventricular hemorrhage who underwent long-term video electroencephalographic monitoring. The findings showed that approximately 16% of these infants had seizures, and those with seizures were younger and more likely to be remonitored.
PEDIATRIC NEUROLOGY
(2024)
Letter
Clinical Neurology
Bernadeta Zabielska, Natalia Rzewuska, Sergiusz Jozwiak
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Kelly C. Burk, Maki Kaneko, Catherine Quindipan, My H. Vu, Maritza Feliz Cepin, Jonathan D. Santoro, Michele Van Hirtum-Das, Deborah Holder, Gordana Raca
Summary: This study compared the diagnostic yields of chromosomal microarray (CMA) and epilepsy-genes sequencing (EGS) for genetic epilepsy etiologies. It found that EGS had a significantly higher diagnostic yield than CMA, especially for patients with infantile seizure onset and additional neurological findings.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Ursula Thome, Larissa A. Batista, Renata P. Rocha, Vera C. Terra, Ana Paula A. Hamad, Americo C. Sakamoto, Antonio C. Santos, Marcelo Santos, Helio R. Machado
Summary: Rasmussen encephalitis (RE) is a characterized by pharmacoresistant epilepsy and progressive neurological deficits. Surgical disconnection of the affected hemisphere is considered the treatment of choice, although the precise etiology is still unknown. This study reports the clinical, electrographic, and neuroimaging features of children and adolescents who underwent hemispheric surgery (HS) for the treatment of RE.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Michal Tzadok, Rotem Gur-Pollack, Hadar Florh, Yael Michaeli, Tal Gilboa, Mirit Lezinger, Eli Heyman, Veronika Chernuha, Irina Gudis, Andreea Nissenkorn, Tally Lerman-Sagie, Bruria Ben Zeev, Shimrit Uliel-Sibony
Summary: Purified CBD is well-tolerated and effective in reducing seizure frequency in children and young adults with drug-resistant epilepsy.
PEDIATRIC NEUROLOGY
(2024)
Editorial Material
Clinical Neurology
Zimeng Ye, Sufang Lin, Xia Zhao, Mathew Wallis, Xinyi Gao, Li Sun, Jiarui Wu, Jing Duan, Yi Yao, Lin Li, Li Chen, Dezhi Cao, Zhanqi Hu, Victor W. Zhang, Samuel F. Berkovic, Ingrid E. Scheffer, Jianxiang Liao, Michael S. Hildebrand
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Nicolas J. Abreu, Madeline Chiujdea, Shanshan Liu, Bo Zhang, Sarah J. Spence
Summary: This study found a low completion rate of chromosomal microarray (CMA) testing for patients with autism spectrum disorder (ASD). Provider recommendation and more follow-up visits were associated with CMA completion. Age, intellectual disability or global developmental delay, first-degree relative with ASD, and public insurance were all related to CMA completion. Parental concern and cost/insurance coverage were the most frequently documented barriers.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Wafa Bouchaala, Sirine Laroussi, Yosra Mzid, Imen Maaloul, Olfa Jallouli, Salma Zouari, Sihem Ben Nsir, Zeineb Mnif, Fatma Kammoun, Chahnez Triki
Summary: Moyamoya angiopathy is a rare but serious cerebrovascular disease in children, which may result in arterial ischemic stroke. The clinical and radiological presentations can vary and are often overlooked. Early diagnosis and treatment are crucial.
PEDIATRIC NEUROLOGY
(2024)
Letter
Clinical Neurology
Eline M. C. Hamilton, Pinar Topaloglu, Jigyasha Sinha, Francesco Nicita, Genevieve Bernard, S. Ali Fatemi, Marjo S. van der Knaap
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Muhamad Azamin Anuar, Muhammad'Adil Zainal Abidin, Soo Hong Tan, Cai Fong Yeap, Nor Azni Yahaya
Summary: This study conducted in Malaysia found that most infants with epilepsy can achieve seizure remission. However, poor seizure control and developmental delay are associated with abnormal EEG background and neuroimaging abnormalities.
PEDIATRIC NEUROLOGY
(2024)