Article
Biochemistry & Molecular Biology
Yiying Zhu, Zhangxun Zhao, Minggao Xue, Dan Wang, Guifeng Su, Xiaoman Ju, Qihong Yang, Shaohua Zhang, Dongmei Fan, Huifang Zhu, Min Yu, Yan Li, Lingmei Kong, Hongyu Zhou
Summary: Activation of the NKG2D receptor can enhance the sensitivity of leukemia cells to NK cell cytotoxicity, and this can be achieved through the use of drugs such as Ciclopirox Olamine (CPX). CPX can increase the expression of NKG2D ligands (NKG2DLs) on leukemia cells, thereby enhancing the efficacy of NK cell-mediated immunotherapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Elisabetta Vulpis, Luisa Loconte, Chiara Cassone, Fabrizio Antonangeli, Giulio Caracciolo, Laura Masuelli, Francesca Fazio, Maria Teresa Petrucci, Cinzia Fionda, Alessandra Soriani, Cristina Cerboni, Marco Cippitelli, Angela Santoni, Alessandra Zingoni
Summary: Natural Killer (NK) cells are innate cytotoxic lymphoid cells that play a crucial role in cancer immunosurveillance. The secretion of NKG2D ligands (NKG2DLs) through extracellular vesicles (EVs) is a mechanism used by cancer cells to evade NKG2D-mediated immunosurveillance. This study investigates the spreading of NKG2DLs through EV-mediated cross-dressing on multiple myeloma (MM) cells and the potential therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Abrar Ul Haq Khan, Melinda Blimkie, Doo Seok Yang, Mandy Serran, Tyler Pack, Jin Wu, Ji-Young Kang, Holly Laakso, Seung-Hwan Lee, Yevgeniya Le
Summary: LDR significantly influenced the proportion, proliferation, activation, and function of immune cells, particularly NK and T cells, but had no noticeable impact on mammary cancer development. The study also demonstrated the modulation of the cross-talk between NKG2D receptor and its ligands by LDR exposure at different time points.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Laura Strobel, Kilian Vomstein, Christiana Kyvelidou, Susanne Hofer-Tollinger, Katharina Feil, Ruben-Jeremias Kuon, Susanne Ebner, Jakob Troppmair, Bettina Toth
Summary: In this study, we found that compared to sRPL patients, sCtrls had higher numbers of CD56(+) and CD56(dim)CD16(bright) cells. Furthermore, sRPL patients had lower numbers of CD56(dim)CD16(bright)NKG2D(+) and CD56(dim)CD16(bright)NKp46(+) compared to sCtrls.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Kiera L. Clayton, Geetha Mylvaganam, Alonso Villasmil-Ocando, Heather Stuart, Marcela Maus, Mohammad Rashidian, Hidde L. Ploegh, Bruce D. Walker
Summary: NK cells target HIV-infected CD4(+) T cells and use ADCC to eliminate the infected targets. However, HIV-infected macrophages resist NK cell killing and skew the response towards cytokine production instead of cytolytic contents. This evasion of cytolytic function by HIV-infected macrophages highlights the importance of eliminating them in HIV cure efforts.
CELL HOST & MICROBE
(2021)
Review
Cell Biology
Jagoda Siemaszko, Aleksandra Marzec-Przyszlak, Katarzyna Bogunia-Kubik
Summary: Natural Killer (NK) cells are natural cytotoxic cells of the innate immune system that can recognize and attack transformed or infected cells through their NKG2D receptor, which has significant immunological functions and clinical relevance.
Article
Cell Biology
Elisabetta Vulpis, Luisa Loconte, Agnese Peri, Rosa Molfetta, Giulio Caracciolo, Laura Masuelli, Luana Tomaipitinca, Giovanna Peruzzi, Sara Petillo, Maria Teresa Petrucci, Francesca Fazio, Lucilla Simonelli, Cinzia Fionda, Alessandra Soriani, Cristina Cerboni, Marco Cippitelli, Rossella Paolini, Giovanni Bernardini, Gabriella Palmieri, Angela Santoni, Alessandra Zingoni
Summary: This study investigated the immunomodulatory properties of the NKG2D ligand MICA*008 associated with different populations of extracellular vesicles (sEVs and mEVs). The results showed that MICA*008 is present on both vesicle populations, and NKG2D is involved in the uptake of vesicles expressing its cognate ligand. MICA*008-expressing sEVs and mEVs can activate NK cells, but prolonged stimulation leads to NKG2D downmodulation and impaired NKG2D-mediated functions. Additionally, MICA*008 can be transferred by vesicles to NK cells, causing fratricide. The accumulation of NKG2D ligands associated with vesicles in the tumor microenvironment may suppress NK cell activity.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Oncology
Nayoung Kim, Mi Yeon Kim, Woo Seon Choi, Eunbi Yi, Hyo Jung Lee, Hun Sik Kim
Summary: GSK-3 alpha primarily restrains the expression of activating receptor ligands on target cells, reducing their susceptibility to NK cells, suggesting a potential strategy to enhance tumor cell susceptibility to NK cells.
Article
Neurosciences
Alessandro Mormino, Germana Cocozza, Giulia Fontemaggi, Sergio Valente, Vincenzo Esposito, Antonio Santoro, Giovanni Bernardini, Angela Santoni, Francesco Fazi, Antonello Mai, Cristina Limatola, Stefano Garofalo
Summary: HDAC8 plays a key role in glioma growth and tumor microenvironment by regulating immune response. Inhibition of HDAC8 reduces tumor volume and controls glioma migration by increasing the acetylation of alpha-tubulin. Additionally, HDAC8 modulates the immunogenicity of the tumor microenvironment by regulating gene transcription of NKG2D ligands.
Article
Immunology
Maria Giovanna Desimio, Andrea Finocchi, Gigliola Di Matteo, Silvia Di Cesare, Carmela Giancotta, Francesca Conti, Luciana Chessa, Maria Piane, Davide Montin, Marta Dellepiane, Paolo Rossi, Caterina Cancrini, Margherita Doria
Summary: NK cells in A-T patients show reduced NKG2D expression, possibly contributing to increased susceptibility. The abnormal expression of NKG2D in A-T patients may be associated with disease progression.
CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Johannes M. Jung, Wilhelm Ching, Martin E. Baumdick, Helga Hofmann-Sieber, Jens B. Bosse, Tobias Koyro, Kimberly J. Moeller, Lucy Wegner, Annika Niehrs, Kristina Russu, Mareike Ohms, Wenli Zhang, Anja Ehrhardt, Kevin Duisters, Eric Spierings, Angelique Hoelzemer, Christian Koerner, Suze A. Jansen, Sven Peine, Ingo Koenigs, Marc Luetgehetmann, Daniel Perez, Konrad Reinshagen, Caroline A. Lindemans, Marcus Altfeld, Mirjam Belderbos, Thomas Dobner, Madeleine J. Bunders
Summary: The study reveals that up-regulated HLA-F enhances NK cell killing of infected cells during HAdV infection, while HAdV5 infection leads to significant down-regulation of HLA-A and HLA-B to evade CD8(+) T cell attack. In a pediatric allo-HSCT cohort, children receiving KIR3DS1(+)/HLA-Bw4(+) donor cells show reduced risk of severe HAdV disease and faster viral clearance.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Fangming Wang, Xuejiao Dong, Jing Wang, Feiya Yang, Donghua Liu, Jianlin Ma, Shuai Liu, Dehua Chang, Nianzeng Xing
Summary: The study shows that large-scale ex vivo expanded NK cells exhibit significant cytotoxicity against prostate cancer and demonstrate excellent therapeutic efficacy in a preclinical mouse model of castration-resistant prostate cancer.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Reem Alkhayer, Viviane Ponath, Miriam Frech, Till Adhikary, Johannes Graumann, Andreas Neubauer, Elke Pogge von Strandmann
Summary: This study identifies the transcription factor KLF4 as associated with the MICA promoter, and demonstrates that pharmacological activation of KLF4 leads to increased expression of MICA in AML cells. The small compound APTO253, which activates KLF4, also inhibits MYC expression and causes DNA damage in AML cells. The induction of MICA expression renders AML cells more susceptible to NK cell-mediated killing, suggesting a potential therapeutic approach for targeting AML cells.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Gastroenterology & Hepatology
Carolina Hernandez, Karen Toledo-Stuardo, Paulina Garcia-Gonzalez, Macarena Garrido-Tapia, Karina Kramm, Jose Alejandro Rodriguez-Siza, Marcela Hermoso, Carolina H. Ribeiro, Maria Carmen Molina
Summary: Stimulation of human gastric adenocarcinoma cells with H. pylori promotes the expression of NKG2DL, leading to an immune response that may contribute to either gastric tissue damage or tumor immune evasion. The upregulation of MICA and ULBP4 on the surface of stimulated cells enables NK cell cytotoxic activation, suggesting a potential role in anti-tumor immunity.
Article
Microbiology
Einat Seidel, Liat Dassa, Corinna Schuler, Esther Oiknine-Djian, Dana G. Wolf, Vu Thuy Khanh Le-Trilling, Ofer Mandelboim
Summary: The study reveals that the uncharacterized HCMV protein UL147A interferes with the immune response by downregulating the expression of the immune ligand MICA*008, hindering the elimination of HCMV-infected cells. This finding advances the understanding of complex HCMV immune evasion mechanisms and may facilitate the development of antiviral drugs and vaccines.
Article
Immunology
Jeong Hwa Kim, Jae Kwon Lee
INTERNATIONAL IMMUNOPHARMACOLOGY
(2015)
Article
Food Science & Technology
Jeong Hwa Kim, Sang Min Kim, Kwang Hyun Cha, Il-Kyoon Mok, Song Yi Koo, Cheol-Ho Pan, Jae Kwon Lee
APPLIED BIOLOGICAL CHEMISTRY
(2016)
Article
Chemistry, Applied
Il-Kyoon Mok, Jae Kwon Lee, Jeong Hwa Kim, Cheol-Ho Pan, Sang Min Kim
Article
Chemistry, Medicinal
Jeong Hwa Kim, Su-Yeon Oh, Sang-Bae Han, Golam Mezbah Uddin, Chul Young Kim, Jae Kwon Lee
ARCHIVES OF PHARMACAL RESEARCH
(2015)
Article
Integrative & Complementary Medicine
Rangachari Balamurugan, Jeong Hwa Kim, Mi-na Jo, Chenglian Xue, Jin Kyu Park, Jae Kwon Lee
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2019)
Article
Entomology
Jae Kwon Lee, Jeong Hwa Kim, Mina Jo, Balamurugan Rangachari, Jin Kyu Park
JOURNAL OF APICULTURAL SCIENCE
(2018)
Article
Entomology
Jeong Hwa Kim, Jin Kyu Park, Jae Kwon Lee
JOURNAL OF APICULTURAL SCIENCE
(2016)