Review
Environmental Sciences
Jutti Levita, Gofarana Wilar, Ika Wahyuni, Lidya Cahyo Bawono, Tiara Ramadaini, Rohani Rohani, Ajeng Diantini
Summary: Intoxication of vitamin D is not commonly seen in pediatrics. This review provides insights into the clinical toxicology of vitamin D in pediatrics, including the mechanism, case reports, and management of vitamin D poisoning.
Article
Nutrition & Dietetics
Seunghye Lee, Hye Jin Chung, Sehyun Jung, Ha Nee Jang, Se-Ho Chang, Hyun-Jung Kim, Min-Chul Cho
Summary: Appropriate management of vitamin D deficiency and hyperparathyroidism is essential in preventing metabolic bone disorder and cardiovascular diseases in chronic kidney disease. The study found that the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (VMR) can serve as a useful biomarker for evaluating metabolic bone disorder in CKD patients. The study concluded that 24,25-dihydroxyvitamin D and VMR have the potential to be reliable vitamin D biomarkers in CKD patients.
Review
Nutrition & Dietetics
Marta Zieminska, Beata Sieklucka, Krystyna Pawlak
Summary: Vitamin K and vitamin D deficiency in chronic kidney disease can lead to impaired bone health and increased risk of fractures. Currently, there is no consensus on the optimal supplementation approach for these vitamins in CKD patients.
Article
Cardiac & Cardiovascular Systems
Simon Hsu, Leila R. Zelnick, Nisha Bansal, Julia Brown, Michelle Denburg, Harold I. Feldman, Charles Ginsberg, Andrew N. Hoofnagle, Tamara Isakova, Mary B. Leonard, Benjamin Lidgard, Cassianne Robinson-Cohen, Myles Wolf, Dawei Xie, Bryan R. Kestenbaum, Ian H. de Boer, CRIC Study Investigators
Summary: The study investigated the associations of the vitamin D metabolite ratio (VDMR), 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH](2)D) with cardiovascular disease (CVD) in chronic kidney disease patients. The results showed that lower VDMR and 1,25(OH)(2)D were associated with incident CVD, while only 25(OH)D was associated with left ventricular mass index. However, none of these metabolites were found to be associated with incident CVD in chronic kidney disease after adjustment for relevant factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Nutrition & Dietetics
Mario Flores-Aldana, Marta Rivera-Pasquel, Armando Garcia-Guerra, Jesus Giovanni Perez-Cortes, Juan E. Barcena-Echegollen
Summary: This study aimed to assess the effect of vitamin D supplementation at different doses on serum 25(OH)D concentrations in preschool children. After three months, there was a significant increase in serum concentrations of 25(OH)D and a decrease in the prevalence of vitamin D deficiency. No adverse effects were observed.
Review
Nutrition & Dietetics
Vincent Brandenburg, Markus Ketteler
Summary: This review examines the developments of vitamin D therapies in CKD patients and discusses the association between vitamin D deficiency and sHPT as well as its impact on important clinical outcomes in CKD patients. However, vitamin D therapy also comes with the risk of side effects, so it is necessary to address core issues regarding PTH target levels, optimal vitamin D levels, and the effectiveness of sHPT treatment in CKD patients.
Article
Medical Laboratory Technology
G. Priyadarshini, Sreejith Parameswaran, Jayaprakash Sahoo, Sandhiya Selvarajan, Medha Rajappa
Summary: The study found that 75% of CKD patients in South India had normal levels of vitamin D, with 15% being deficient and 10% severely deficient. Most patients had a history of taking vitamin D and calcium supplements before coming to the institute, which may explain this paradoxical finding.
CLINICA CHIMICA ACTA
(2021)
Review
Nutrition & Dietetics
Rakesh Balachandar, Raghu Pullakhandam, Bharati Kulkarni, Harshpal Singh Sachdev
Summary: This study found that cholecalciferol was more effective than ergocalciferol in improving vitamin D status and regulating PTH levels, regardless of participant demographics, dosage, and vehicle of supplementation.
Review
Nutrition & Dietetics
Giuseppe Cianciolo, Maria Cappuccilli, Francesco Tondolo, Lorenzo Gasperoni, Fulvia Zappulo, Simona Barbuto, Francesca Iacovella, Diletta Conte, Irene Capelli, Gaetano La Manna
Summary: The text highlights the common issue of poor vitamin D status in patients with chronic kidney disease, attributing it to various factors such as uremic malnutrition, dietary restrictions, and proteinuria. Furthermore, it points out the lack of large-scale interventional studies on the non-calcemic activities of vitamin D in the literature.
Review
Nutrition & Dietetics
Wen-Fang Chiang, Po-Jen Hsiao, Jenq-Shyong Chan
Summary: This article reviews the immune system alterations and risks of COVID-19 infections in chronic kidney disease (CKD) patients, as well as the role of vitamin D in the pathogenesis of COVID-19. Previous studies have shown that vitamin D deficiency can affect the outcomes of COVID-19, and supplementing vitamin D during treatment may be protective against COVID-19.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Eva Pal, Zoltan Ungvari, Zoltan Benyo, Szabolcs Varbiro
Summary: Deficiency in vitamin D affects a significant portion of the Western population and plays a crucial role in cardiovascular health. This deficiency leads to adverse vascular remodeling, endothelial dysfunction, vascular inflammation, and increased risk for cardiovascular and cerebrovascular diseases. Understanding the complex role of vitamin D deficiency is important for intervention and prevention among cardiologists, dietitians, and geriatricians.
Review
Urology & Nephrology
Marc G. Vervloet, Simon Hsu, Ian H. de Boer
Summary: The efficacy of vitamin D supplements in patients with chronic kidney disease is controversial. Observational studies have shown that higher circulating concentrations of 25hydroxyvitamin D are associated with improved health outcomes. However, recent large clinical trials have contradicted these findings.
KIDNEY INTERNATIONAL
(2023)
Article
Food Science & Technology
Sarina Salemi, Ahmad Saedisomeolia, Fateme Azimi, Sareh Zolfigol, Ezeddin Mohajerani, Mehrdad Mohammadi, Mehdi Yaseri
Summary: This study determined that sliced mushrooms irradiated with UV-B lamps had significantly higher vitamin D2 content. An internal temperature of 27 degrees C was found to be optimal for vitamin D production, and increasing the distance from the UV source reduced the production of vitamin D.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Endocrinology & Metabolism
Marco Zaffanello, Angelo Pietrobelli, Luana Nosetti, Giorgio Piacentini, Giuliana Ferrante, Michele Piazza, Alessandra Guzzo, Franco Antoniazzi
Summary: The study found a correlation between the search volume of vitamin D and its adverse biological effects (hypercalcemia, renal failure, kidney stones, bone density). Interest in kidney stones increased more rapidly than other search terms. The highest concentration of interest in vitamin D was in North America, Europe, India, and Australia, while interest in ergocalciferol was higher in Central and South America, Spain, and Thailand.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Cardiac & Cardiovascular Systems
Debasish Banerjee, Nihil Chitalia, Irina Chis Ster, Evan Appelbaum, Ravi Thadhani, Juan Carlos Kaski, David Goldsmith
Summary: A study on vitamin D supplementation in stable, non-diabetic CKD patients showed no beneficial effects on left ventricular mass.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)