Article
Orthopedics
Z. Qu, F. Yang, Y. Yan, J. Huang, J. Zhao, J. Hong, S. Li, G. Jiang, W. Wang, S. Yan
Summary: This study indicated an inverse causal relationship between serum PTH concentrations and development of OA, especially knee OA, but no evidence of the causal effect of serum 25(OH)D levels on OA was found. Further investigation is needed to explore potential mechanisms by which serum PTH affects OA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Nutrition & Dietetics
Ning Xie, Jiale Xie, Ziwei Wang, Qiuai Shu, Haitao Shi, Jinhai Wang, Na Liu, Feng Xu, Jian Wu
Summary: This study utilized a two-sample Mendelian randomization (MR) analysis to explore the causal effects among calcium, vitamin D (Vit-D), parathyroid hormone (PTH), and irritable bowel syndrome (IBS). The results did not find any causal relationship between serum calcium, Vit-D levels, and the risk of IBS. However, there was an association between genetic predisposition to IBS and decreased levels of PTH.
Article
Medicine, General & Internal
Hussein Abdullah Rajab
Summary: This study found that patients with 25-hydroxyvitamin D (25OHD) levels below 15 ng/mL were more likely to experience symptoms, and there was a correlation between vitamin D level and changes in parathyroid hormone (PTH) and alkaline phosphatase (ALP).
Article
Nutrition & Dietetics
Ola Hysaj, Patricia Marques-Gallego, Aline Richard, Magdeldin Elgizouli, Alexandra Nieters, Katharina C. Quack Lotscher, Sabine Rohrmann
Summary: This study assessed parathyroid hormone concentrations in pregnant women during early and late pregnancy, finding an inverse correlation between serum 25(OH)D and PTH levels. Statistically significant determinants of PTH concentrations included 25(OH)D levels, season, parity, and partner's education in early pregnancy, while late pregnancy was affected by 25(OH)D levels and country of origin. These factors seem to primarily impact PTH through 25(OH)D, but may also have other mechanisms of influence.
Article
Biochemistry & Molecular Biology
Rivak Punchoo, Greta Dreyer, Tahir S. Pillay
Summary: Preclinical studies have shown that vitamin D metabolites have anticancer effects by inducing apoptosis, inhibiting cell proliferation, and causing cell cycle arrest. In cervical cancer cells, there is an autocrine vitamin D metabolizing system (VDMS) that includes a vitamin D receptor, vitamin D catabolic enzyme (CYP24A1), and an activating enzyme (CYP27B1) for 25-hydroxycholecalciferol (25(OH)D3). This study demonstrates that physiological and supraphysiological doses of 25(OH)D3 inhibit cell growth and induce apoptosis in cervical cancer cells, potentially providing a promising therapeutic option.
Article
Medicine, General & Internal
Aurelie Ladang, Olivier Rousselle, Loreen Huyghebaert, Anne-Catherine Bekaert, Stephanie Kovacs, Caroline Le Goff, Etienne Cavalier
Summary: This study reports PTH levels and BALP levels in a large cohort of 1200 children according to their vitamin D status. The results highlight the inverse relationship between vitamin D deficiency and PTH levels in children, emphasizing the need for a well characterized pediatric population to establish reference ranges for PTH.
ACTA CLINICA BELGICA
(2022)
Article
Endocrinology & Metabolism
David Gillis, Ari Hefter, Shalom Edri, David Strich
Summary: The aim of this study was to determine the optimal pediatric levels of 25-hydroxy-vitamin D (25OHD) for bone health. The study analyzed a large dataset of 49,935 25OHD tests from children sampled between 2009 and 2019. Significant correlations were found between 25OHD levels and parathyroid hormone (PTH) and calcium, indicating that increasing 25OHD levels up to at least 100 nmol/l can improve bone mineralization.
HORMONE AND METABOLIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Hope A. Weiler, Wen Hsuan Fu, Maryam Razaghi, Nathalie Gharibeh, Catherine A. Vanstone
Summary: This study found an association between vitamin D deficiency and elevated parathyroid hormone levels in newborn infants. The global consensus recommendation on vitamin D deficiency (<25 nmol/L) aligns better with the threshold at which parathyroid hormone is elevated compared to the definition set by the National Academy of Medicine (<30 nmol/L).
Article
Veterinary Sciences
Dennis E. Jewell, Kiran S. Panickar
Summary: The optimum concentration of vitamin D for dogs is still debated, but a minimum concentration of 100 ng/mL (250 nM) of circulating vitamin D has been suggested for optimal health. The relationship between dietary intake of vitamin D-3 and circulating 25(OH) D in adult dogs has not been well studied. The safe upper limit of vitamin D in dog foods for adult maintenance is 3,200 IU/kg on a dry matter basis, but this guideline was not based on studies of adult maintenance requirements. Understanding the relationship between dietary vitamin D and circulating vitamin D is important for promoting health in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Pediatrics
Teodoro Dura-Trave, Fidel Gallinas-Victoriano, Maria Malumbres-Chacon, Lotfi Ahmed-Mohamed, Maria Jesus Chueca-Guindulain, Sara Berrade-Zubiri
Summary: The study revealed that vitamin D deficiency and high levels of PTH were more common in children with severe obesity, with lower seasonal variations in 25(OH)D levels compared to the control group.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Jacklyn N. Hellwege, Xiangzhu Zhu, Xiang Huang, Martha J. Shrubsole, Lei Fan, Bingshan Li, Reid Ness, Douglas L. Seidner, Edward L. Giovannucci, Todd L. Edwards, Qi Dai
Summary: Optimal 25(OH)D levels are associated with a significantly reduced risk of colorectal cancer, particularly among women. Individuals with BPRVID are at higher risks of incident adenoma and colorectal cancer compared to those with HPRVID, especially among women. Treatment strategies should be tailored based on individuals' different response types.
CLINICAL NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Qing Hao, Yun Qin, Wanjun Zhao, Lingyun Zhang, Han Luo
Summary: The study suggests that supplying calcitriol based on a 70% RDP cutoff may be a wise practice in thyroidectomy patients, helping to stratify high-risk patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Rakesh Balachandar, Raghu Pullakhandam, Bharati Kulkarni, Harshpal Singh Sachdev
Summary: This study found that cholecalciferol was more effective than ergocalciferol in improving vitamin D status and regulating PTH levels, regardless of participant demographics, dosage, and vehicle of supplementation.
Article
Biochemistry & Molecular Biology
Caroline A. Mcwhorter, Molly J. Mead, Megan D. Rodgers, Myla D. Ebeling, Judy R. Shary, Mathew J. Gregoski, Danforth A. Newton, John E. Baatz, Bruce W. Hollis, Martin Hewison, Carol L. Wagner
Summary: Pregnancy leads to increased synthesis of vitamin D binding protein (DBP) and higher concentrations of total vitamin D and metabolites. The ratio of free 25-hydroxyvitamin D (25(OH)D) to parathyroid hormone (PTH) appears to be a better predictor of pregnancy complications, such as gestational diabetes, compared to total 25(OH)D/PTH. Further research is needed to validate and explore this association.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Katharina Otani, Kazuki Kanno, Taisuke Akutsu, Hironori Ohdaira, Yutaka Suzuki, Mitsuyoshi Urashima
Summary: This study used machine learning method MARS to explore the threshold levels of serum 25-hydroxyvitamin D and found that vitamin D supplementation improved bone health and 5-year relapse-free survival in patients with low baseline levels, but not in those with high baseline levels.