Endothelin antagonists in hypertension and kidney disease

Enhanced endothelin-1 system activity with overweight and obesity

(2011) Brian R. Weil et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Prevention of post-cardiopulmonary bypass acute kidney injury by endothelin A receptor blockade*

(2011) Nishith N. Patel et al.   CRITICAL CARE MEDICINE

Distinct Actions of Endothelin A-Selective Versus Combined Endothelin A/B Receptor Antagonists in Early Diabetic Kidney Disease

(2011) M. A. Saleh et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Addition of Atrasentan to Renin-Angiotensin System Blockade Reduces Albuminuria in Diabetic Nephropathy

(2011) D. E. Kohan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Impaired Stimulatory Effect of ETB Receptor on D3 Receptor in Immortalized Renal Proximal Tubule Cells of Spontaneously Hypertensive Rats

(2011) Ye Zhang et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Endothelin Receptor A Antagonism Attenuates Renal Medullary Blood Flow Impairment in Endotoxemic Pigs

(2011) Johan Fenhammar et al.   PLoS One

Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt dietThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.

(2010) Erika I. Boesen et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

At the heart of tissue: endothelin system and end-organ damage

(2010) Marc Iglarz et al.   CLINICAL SCIENCE

Endothelin-1 gene regulation

(2010) Lisa R. Stow et al.   FASEB JOURNAL

Endothelin-1 Increases Collagen Accumulation in Renal Mesangial Cells by Stimulating a Chemokine and Cytokine Autocrine Signaling Loop

(2010) Michael S. Simonson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SNP-by-fitness and SNP-by-BMI interactions from seven candidate genes and incident hypertension after 20 years of follow-up: the CARDIA Fitness Study

(2010) M A Sarzynski et al.   JOURNAL OF HUMAN HYPERTENSION

Avosentan for Overt Diabetic Nephropathy

(2010) J. F.E. Mann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endothelin type A and B receptors in the control of afferent and efferent arterioles in mice

(2010) Janice Schildroth et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endothelin as a Clinical Target in the Treatment of Systemic Hypertension

(2009) Vinoy S. Prasad et al.   Cardiology in Review

Effects of Endothelin Receptor Antagonism Relate to the Degree of Renin-Angiotensin System Blockade in Chronic Proteinuric Kidney Disease

(2009) Neeraj Dhaun et al.   HYPERTENSION

Blood Pressure–Independent Reduction in Proteinuria and Arterial Stiffness After Acute Endothelin-A Receptor Antagonism in Chronic Kidney Disease

(2009) Neeraj Dhaun et al.   HYPERTENSION

Avosentan Reduces Albumin Excretion in Diabetics with Macroalbuminuria

(2009) R. R. Wenzel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial

(2009) Michael A Weber et al.   LANCET

Short-term angiotensin-1 receptor antagonism in type 2 diabetic Goto–Kakizaki rats normalizes endothelin-1-induced mesenteric artery contraction

(2009) Takayuki Matsumoto et al.   PEPTIDES

Endothelin receptor blockade in the management of pulmonary arterial hypertension: Selective and dual antagonism

(2009) Terence K. Trow et al.   RESPIRATORY MEDICINE

Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ETA receptors and ERK

(2008) T Kobayashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy and Safety of Atrasentan in Patients With Cardiovascular Risk and Early Atherosclerosis

(2008) Eugenia Raichlin et al.   HYPERTENSION

Role of angiotensin II, endothelin-1 and L-type calcium channel in the development of glomerular, tubulointerstitial and perivascular fibrosis

(2008) Teresa M Seccia et al.   JOURNAL OF HYPERTENSION

Chymase-Dependent Conversion of Big Endothelin-1 in the Mouse in Vivo

(2008) E. Simard et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats

(2008) Senol Gulmen et al.   JOURNAL OF SURGICAL RESEARCH

Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase–glycogen synthase kinase-3β signaling in endothelial cells

(2007) Zeran Yang et al.   LIFE SCIENCES