Article
Immunology
Pierre M. Bataille, Cecile-Audrey Durel, Dominique Chauveau, Arnaud Panes, Eric Simon Thervet, Benjamin Terrier
Summary: A study conducted in France revealed that despite advances in therapeutic management, the mortality rates of GPA and MPA patients remain high and stable, highlighting the need for further improvement in management.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Rheumatology
Jan Henrik Schirmer, Beatriz Sanchez-Alamo, Bernhard Hellmich, David Jayne, Sara Monti, Raashid Ahmed Luqmani, Gunnar Tomasson
Summary: This systematic literature review provides evidence on the treatment of antineutrophil cytoplasm antibody-associated vasculitis (AAV) and suggests that cyclophosphamide and rituximab have similar efficacy for remission induction, but rituximab is more effective in relapsing disease. Faster tapering glucocorticoid protocols result in similar remission rates but lower rates of serious infections. Avacopan shows potential for rapid tapering and replacing glucocorticoids. Use of rituximab for maintenance of remission is associated with lower relapse rates compared with azathioprine. Prolonged maintenance treatment reduces relapse rates for both azathioprine and rituximab.
Review
Medicine, General & Internal
Salem Almaani, Lynn A. Fussner, Sergey Brodsky, Alexa S. Meara, David Jayne
Summary: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of small vessel vasculitides characterized by granulomatous and neutrophilic tissue inflammation, often associated with the production of antibodies that target neutrophil antigens. AAV involves multiple organ systems clinically, including the lungs, kidneys, skin, and nervous system. The prognosis of AAV has significantly improved due to advances in understanding its pathogenesis and treatment options.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Augusto Pereira, Javier F. Magrina, Paul M. Magtibay, Beatriz G. Stamps, Elena Munoz-Nunez, Tirso Perez-Medina
Summary: This study conducted a systematic review of the literature on patients with GPA and gynecological involvement. It found that GPA could affect various parts of the genital tract, with the most common site being the uterine cervix. The main symptom was bleeding, but exclusive gynecologic symptomatology was rare. Medical treatment was effective for GPA.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Dario Roccatello, Savino Sciascia, Stefano Murgia, Giacomo Quattrocchio, Michela Ferro, Emanuele De Simone, Carla Naretto, Antonella Barreca, Andrea Sammartino, Daniela Rossi, Roberta Fenoglio
Summary: The study assessed the safety and efficacy of an intensified B-cell depletion therapy (IBCDT) in severely affected AAV patients. The results showed that IBCDT had the same efficacy as the conventional therapy with CYC plus AZA, while reducing the drug-related side effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Maxime Samson, Herve Devilliers, Sara Thietart, Pierre Charles, Christian Pagnoux, Pascal Cohen, Alexandre Karras, Luc Mouthon, Benjamin Terrier, Xavier Puechal, Loic Guillevin
Summary: The study aimed to develop a score for assessing the likelihood of relapse in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Long-term follow-up data from patients with GPA and MPA included in five randomized controlled trials were pooled. Variables associated with relapse were identified and used to build a score, which was validated in an independent cohort.
Review
Pediatrics
Preawkalaya Suksai, Suphawe Wasuanankun, Vitit Lekhavat, Ornatcha Sirimongkolchaiyakul, Sirikarn Tangcheewinsirikul
Summary: Microscopic polyangiitis (MPA) is a systemic necrotizing vasculitis primarily associated with kidney and lung involvement. However, neurological manifestations, particularly in the central nervous system (CNS), are rarely observed. This case report highlights an unusual manifestation of MPA in a 13-year-old girl, emphasizing the importance of raising awareness of this orphaned disease among healthcare professionals.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Soko Kawashima, Mitsumasa Kishimoto, Tomoya Hibino, Hearyoung Lee, Yuriko Sato, Yoshinori Komagata, Shinya Kaname
Summary: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic disease that can occur after COVID-19 infection. The immune response triggered by the infection may lead to more severe symptoms, highlighting the importance of vaccination and education on standard precautions.
Article
Medicine, General & Internal
James Hesford, Andrew R. L. Medford, Harsha Gunawardena
Summary: This case highlights the multisystem nature of granulomatosis with polyangiitis (GPA) with unusual dural and large vessel aortic and pulmonary trunk involvement.
Article
Urology & Nephrology
Marta Calatroni, Filippo Consonni, Marco Allinovi, Alessandra Bettiol, Natasha Jawa, Susanna Fiasella, Dritan Curi, Sarah Abu-Rumeileh, Leonardo Tomei, Laura Fortunato, Elena Gelain, Davide Gianfreda, Elena Oliva, Guido Jeannin, Chiara Salviani, Giacomo Emmi, Monica Bodria, Renato Sinico, Gabriella Moroni, Giuseppe A. Ramirez, Enrica Bozzolo, Enrico Tombetti, Sara Monti, Claudia Bracaglia, Giulia Marucci, Serena Pastore, Pasquale Esposito, Maria Catanoso, Barbara Crapella, Giovanni Montini, Rosa Roperto, Marco Materassi, Giovanni Rossi, Salvatore Badalamenti, Rae Yeung, Paola Romagnani, Gian Marco Ghiggeri, Damien Noone, Augusto Vaglio
Summary: In children with ANCA-associated kidney vasculitis, microscopic polyangiitis and granulomatosis with polyangiitis are the most common types. Patients often present with rapidly progressive GN and nephrotic-range proteinuria. Those with sclerotic histology on kidney biopsy have shorter kidney survival and poorer prognosis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Rheumatology
Naomi A. Amudala, Sara Boukhlal, Brittany Sheridan, Carol A. Langford, Abdallah Geara, Peter A. Merkel, Divi Cornec
Summary: Obinutuzumab appears to be a safe and efficacious therapy for patients with ANCA-associated vasculitis who have had refractory disease or a history of anaphylaxis to rituximab. Prospective studies comparing rituximab to obinutuzumab in ANCA-associated vasculitis patients are warranted.
Article
Immunology
Desiree Tampe, Peter Korsten, Philipp Stroebel, Samy Hakroush, Bjoern Tampe
Summary: This study systematically analyzed sex differences in patients with AAV and biopsy-proven ANCA GN, finding that female patients presented at an older age with more joint involvement and exhibited specific sex differences in laboratory parameters and histopathological findings. There were fewer associations between clinical, laboratory parameters, and histopathological findings in females compared to males, indicating the importance of considering sex differences in AAV, particularly ANCA GN.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Adel Molnar, Peter Studinger, Nora Ledo
Summary: The heterogeneity of ANCA-associated vasculitis poses challenges for diagnosis and management, despite the increasing incidence of the disease. Prompt diagnosis and early treatment initiation are crucial for favorable patient and renal outcomes. A better understanding of the pathogenesis leads to more targeted and less toxic treatments.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Shota Obata, Sumi Hidaka, Mizuki Yamano, Mitsuru Yanai, Kunihiro Ishioka, Shuzo Kobayashi
Summary: COVID-19 vaccines may increase the risk of immune-mediated diseases, as shown in a case of ANCA-associated vasculitis following vaccination with the BNT162b2 vaccine. The causal relationship between the vaccine and vasculitis is uncertain, but environmental and genetic factors may have played a role in the development of the disease, with the vaccine potentially triggering a chain reaction.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Immunology
Mitsuhiro Akiyama, Satoshi Takanashi, Tsutomu Takeuchi, Yuko Kaneko
Summary: Salivary gland involvement in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is rare and can present with unilateral swelling, with majority of patients diagnosed with granulomatosis with polyangiitis. Early recognition of this unusual presentation is crucial for accurate diagnosis and management.
AUTOIMMUNITY REVIEWS
(2021)
Article
Emergency Medicine
Despoina Tramma, Maria Gogou, Vasilios Lambropoulos
Summary: The differential diagnosis of scrotal pain in childhood can be a challenge for primary care physicians. This case study reports a 5-year-old boy with acute left scrotal pain, revealing a Morgagni hydatid in the left testis through ultrasound screening and X-rays. The presence of microcalcifications in the cyst wall and stroma on X-rays indicated chronic inflammation, which was confirmed by histological examination. No similar use of X-rays has been previously described in the literature. A brief discussion on Morgagni hydatid in childhood is included.
PEDIATRIC EMERGENCY CARE
(2021)
Review
Pediatrics
Chrysoula Kosmeri, Rigas Kalaitzidis, Ekaterini Siomou
JOURNAL OF PEDIATRIC UROLOGY
(2019)
Letter
Obstetrics & Gynecology
Foteini Balomenou, Ekaterini Siomou, Georgios Kolios, Eleni Bairaktari, Meropi Tzoufi, Vasileios Giapros
EARLY HUMAN DEVELOPMENT
(2020)
Letter
Pediatrics
Ekaterini Siomou, Vasileios Giapros, Zoe Papadopoulou, Maria Pavlou, Kleanthi Sapka, Maria Syrrou
INDIAN JOURNAL OF PEDIATRICS
(2021)
Review
Pediatrics
Sophia Tsabouri, Alexandros Makis, Chrysoula Kosmeri, Ekaterini Siomou
PEDIATRIC CLINICS OF NORTH AMERICA
(2021)
Article
Pediatrics
Stella Stabouli, Konstantinos Kollios, Thomaitsa Nika, Katerina Chrysaidou, Despoina Tramma, Vasilios Kotsis
PEDIATRIC NEPHROLOGY
(2020)
Article
Pediatrics
Ekaterini Siomou, Vasileios Giapros, Anastasios Serbis, George Makrydimas, Frederica Papadopoulou
PEDIATRIC RADIOLOGY
(2020)
Letter
Pediatrics
Despoina Tramma, Despoina Samourkasidou
Article
Medicine, Research & Experimental
Anastasios Serbis, Vasileios Giapros, Assimina Galli-Tsinopoulou, Ekaterini Siomou
METABOLIC SYNDROME AND RELATED DISORDERS
(2020)
Review
Oncology
Chrysoula Kosmeri, Epameinondas Koumpis, Sophia Tsabouri, Ekaterini Siomou, Alexandros Makis
PEDIATRIC BLOOD & CANCER
(2020)
Editorial Material
Pediatrics
Anna Zisi, Chrysoula Kosmeri, Ioanna Siatara, Anastasia Giantsouli, Vasileios Xydis, Ekaterini Siomou
PEDIATRIC NEPHROLOGY
(2021)
Editorial Material
Pediatrics
Anna Zisi, Chrysoula Kosmeri, Ioanna Siatara, Anastasia Giantsouli, Vasileios Xydis, Ekaterini Siomou
PEDIATRIC NEPHROLOGY
(2021)
Letter
Pediatrics
Eleni M. Domouzoglou, Sophia Tsabouri, Antonios P. Vlahos, Christos Kittas, Konstantina Gartzonika, Ekaterini Siomou, Alexandros Makis
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Behavioral Sciences
Margarita Papassava, Ekaterini Siomou, Iliada Nakou, Vasileios Cholevas, Anna Challa, Meropi Tzoufi
Summary: In children with epilepsy, long-term polytherapy may result in lower bone turnover rates, but after a year of vitamin D intake, bone biochemical markers improved.
EPILEPSY & BEHAVIOR
(2021)
Article
Medicine, General & Internal
Evgeniya Babatseva, Ilias Chatziioannidis, Alexia-Angeliki Tagaraki, Despoina Tramma, Kalliopi Dampala, Efthymia Chatzitoliou, Efthymia Papacharalambous, Georgios Mitsiakos, Christos Tsakalidis, Paraskevi Karagianni, Maria Lithoxopoulou, Kleanthis Anastasiadis, Vasiliki Soubasi
CLINICAL CASE REPORTS
(2020)