Review
Pharmacology & Pharmacy
Wenlin Liu, Lili Li, Xuemei Zhang, Haonan Dong, Miaomiao Lu
Summary: Veverimer is effective in increasing bicarbonate levels and improving physical function in CKD patients with metabolic acidosis, compared to placebo, with similar safety profiles. Further research is needed to compare long-term veverimer use with traditional alkali therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Joao Victor Salgado, Miguel Angelo Goes, Natalino Salgado Filho
Summary: The global nephrology community acknowledges the increasing burden of kidney disease and emphasizes on early diagnosis, understanding of disease progression, and development of new therapeutic interventions. FGF21 is considered a key regulator of lipid, glucose, and energy metabolism, as well as stress responses. While promising results have been shown with FGF21 analogs in metabolic disease, its exact role in kidney function remains poorly understood.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Urology & Nephrology
Sebastian Hultin, Chris Hood, Katrina L. Campbell, Nigel D. Toussaint, David W. Johnson, Sunil V. Badve
Summary: Sodium bicarbonate therapy may slow the progression of chronic kidney disease and reduce the risk of end-stage kidney failure, but its effects on proteinuria, systolic blood pressure, all-cause death, and edema remain uncertain.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Urology & Nephrology
Marcin Adamczak, Stanislaw Surma
Summary: Metabolic acidosis in CKD patients is common and can contribute to disease progression and various complications, worsening patient prognosis. Currently, sodium bicarbonate is the main treatment for metabolic acidosis. The role of the new drug veverimer in metabolic acidosis therapy requires further study.
Article
Transplantation
Vandana S. Mathur, Elizabeth Li, Donald E. Wesson
Summary: Veverimer effectively treats metabolic acidosis in patients with diabetes and CKD, significantly improving their quality of life and physical function.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Navdeep Tangri, Vandana Mathur, Nancy Reaven, Susan E. Funk, Donald E. Wesson
Summary: Metabolic acidosis is associated with chronic kidney disease (CKD) progression and mortality. The incidence of metabolic acidosis is higher in Asian, Black, and Hispanic individuals, but residing in higher education zip codes mitigates this risk. Metabolic acidosis is independently associated with adverse outcomes in CKD patients across all racial/ethnic groups.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Review
Nutrition & Dietetics
Annalisa Noce, Giulia Marrone, Georgia Wilson Jones, Manuela Di Lauro, Anna Pietroboni Zaitseva, Linda Ramadori, Roberto Celotto, Anna Paola Mitterhofer, Nicola Di Daniele
Summary: Metabolic acidosis is a severe complication of chronic kidney disease, and dietary-nutritional treatments can effectively control it, with different dietary regimens having their own advantages and limitations.
Article
Urology & Nephrology
Antonia Zhu, Reid H. Whitlock, Thomas W. Ferguson, Mohammad Nour-Mohammadi, Paul Komenda, Claudio Rigatto, David Collister, Clara Bohm, Nancy L. Reaven, Susan E. Funk, Navdeep Tangri
Summary: Metabolic acidosis is associated with a higher risk of acute kidney injury in patients with chronic kidney disease. AKI should be considered as an outcome in studies of treatments for patients with metabolic acidosis.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Transplantation
Vandana S. Mathur, David A. Bushinsky, Lesley Inker, Gerrit Klaerner, Elizabeth Li, Dawn Parsell, Vlado Perkovic, Yuri Stasiv, Michael Walker, Donald E. Wesson, David C. Wheeler, Navdeep Tangri
Summary: The VALOR-CKD trial aims to evaluate the impact of veverimer on the progression of kidney disease in patients with metabolic acidosis and CKD. The trial has recruited a large population of high-risk CKD patients to study the development of kidney disease and loss of kidney function. It will assess the efficacy of veverimer as a treatment option.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Hyo Jin Kim, Hyunjin Ryu, Eunjeong Kang, Minjung Kang, Miyeun Han, Sang Heon Song, Joongyub Lee, Ji Yong Jung, Kyu-Beck Lee, Suah Sung, Eun Young Seong, Curie Ahn, Kook-Hwan Oh
Summary: Metabolic acidosis was significantly associated with increased renal events and a rapid decline in renal function in Korean predialysis CKD patients.
FRONTIERS IN MEDICINE
(2021)
Article
Veterinary Sciences
Ilaria Lippi, Francesca Perondi, Eleonora Gori, Alessio Pierini, Lucrezia Bernicchi, Veronica Marchetti
Summary: Serum bicarbonate deficiency is common in dogs with acute and chronic kidney disease. This study investigated its frequency and severity and found that it was more frequent and severe in dogs with AKI and ACKD compared to CKD. It was also associated with the severity of azotaemia and calcium phosphate disorders.
VETERINARY SCIENCES
(2023)
Article
Urology & Nephrology
Navdeep Tangri, Nancy L. Reaven, Susan E. Funk, Thomas W. Ferguson, David Collister, Vandana Mathur
Summary: In this large U.S. community-based cohort study, metabolic acidosis was found to be a significant, independent risk factor for the composite adverse outcome of CKD progression, renal replacement therapy, and all-cause mortality (DD40) in patients with stage 35 CKD.
Article
Urology & Nephrology
Navdeep Tangri, Vandana Mathur, Nancy L. Reaven, Susan E. Funk, Reid H. Whitlock, Donald E. Wesson, David A. Bushinsky
Summary: This study evaluated the association between serum bicarbonate level and kidney stone development in patients with chronic kidney disease (CKD). It found that metabolic acidosis was associated with a higher incidence of kidney stones and shorter time to stone formation in patients with CKD. Future studies may investigate the role of correcting metabolic acidosis to prevent stone formation.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Vandana Mathur, Nancy L. Reaven, Susan E. Funk, Reid Whitlock, Thomas W. Ferguson, David Collister, Navdeep Tangri
Summary: This study quantified the independent association between metabolic acidosis and adverse muscle, bone, and functional outcomes in a large US community-based cohort. The results showed that the presence and severity of metabolic acidosis were significant independent risk factors for failure to thrive, protein-calorie malnutrition, and fall or fracture in patients with stage 3-5 CKD.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Medicine, General & Internal
Zakia Rafique, Muhammad Haseeb Tariq, Arif-ullah Khan, Muhammad Junaid Farrukh, Nida Khan, Ahmed Mujadid Burki, Khalid Mehmood
Summary: This study aimed to assess the clinical outcomes of bicarbonate therapy in critically ill renally compromised patients with metabolic acidosis. The results showed that bicarbonate therapy did not reduce the mortality rate in these patients. Disease-related complications, such as hypoxia, cardiac failure, and multiple organ failure were associated with a higher mortality rate, while concomitant administration of sodium chloride and bicarbonate therapy was linked to a lower mortality rate without significant impact on sodium loading or weight gain.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)