Article
Hematology
Simon Baylis, Rahul Costa-Pinto, Sarah Hodgson, Rinaldo Bellomo, Ian Baldwin
Summary: In this case, the combination of CRRT and hemoperfusion led to a significant reduction in CBZ levels, removing close to 35 mg/h of the drug and achieving a 50% reduction in CBZ level from 16 mg/L to 8 mg/L over 3 hours.
BLOOD PURIFICATION
(2022)
Article
Critical Care Medicine
Paul Koeglberger, Sebastian J. Klein, Georg Franz Lehner, Romuald Bellmann, Andreas Peer, Daniel Schwaerzler, Michael Joannidis
Summary: This study evaluated the effectiveness of switching from high to low bicarbonate replacement fluid in alkalotic critically ill patients undergoing CVVH with RCA. The switch led to a significant decrease in serum HCO3- concentration and base excess, which remained stable up to 72 hours later.
ANNALS OF INTENSIVE CARE
(2021)
Review
Pediatrics
Christopher Markham, Caroline Williams, Cory Miller, Dorothy K. Grange, T. Keefe Davis, Kenneth E. Remy
Summary: This study assessed the feasibility of using hemofiltration for ammonia clearance in low body weight infants with an inborn error of metabolism and found that continuous renal replacement therapy was more effective than scavenger therapy alone. Therefore, CRRT is technically feasible in low weight infants with severe hyperammonemia secondary to an inborn error of metabolism.
FRONTIERS IN PEDIATRICS
(2021)
Article
Critical Care Medicine
Jon Lillie, Alison Pienaar, Jenny Budd, Simone Speggiorin, Anne Gordon, Paul James, Jo Perkins, Benedict Griffiths, Miriam Fine-Goulden, Conal Austin, Caner Salih, Nicola Agnew, Andrew G. Nyman
Summary: This study reported on the use of VV extracorporeal membrane oxygenation in neonates and children under 10 kg, accessing the jugular and returning to the femoral vein. The procedure was technically successful and post-decannulation follow-up showed no clinical implications.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Article
Urology & Nephrology
Willem Boer, Mathias Van Tornout, Margot Vander Laenen, Kim Engelen, Ingrid Meex, Philippe Jorens
Summary: The study found that CathPR led to a significant decrease in PfiCA and an increase in PfCC, affecting calcium clearance, especially with the increase in citrate concentration. In citrate CVVH, CathPR in dysfunctional catheters should be limited in duration and monitored closely.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Medicine, General & Internal
Jing Huang, Fengping Qiu, Huiqi Zhang, Xiangli Shen, Xia Lin
Summary: This study retrospectively analyzed the clinical data of 73 patients with multiple myeloma (MM) complicated with acute kidney injury (AKI). It was found that continuous veno-venous hemofiltration (CVVH) combined with hemoperfusion was more effective than simple chemotherapy. The observation group had a significantly higher total efficacy, lower renal function indexes, and lower levels of serum globulin and erythrocyte sedimentation rate (ESR) compared to the control group. The results suggest that combining CVVH and hemoperfusion improves treatment efficacy, promotes renal function recovery, and improves serum globulin and ESR levels.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Hematology
Ibrahim Deger, Muhittin celik, Ibrahim Tas, Serhat Samanci
Summary: This study discusses the experience of urgent renal replacement therapy in newborns with Maple syrup urine disease. The study found that CVVHDF is more effective than PD in rapidly reducing elevated leucine levels, but complications were observed in the CVVHDF group.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Hematology
Zhengzhi Mao, Yanyan Zhong
Summary: This study investigated the prognostic factors in patients with refractory heart failure undergoing continuous veno-venous hemofiltration (CVVH). The results showed that CVVH improved renal function and regulated blood pressure and vital signs in patients with refractory HF. Age, APACHE II score, disease duration, and hypotension were identified as risk factors affecting the prognosis.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Immunology
Andrew S. Jarrell, Jessica R. Crow, Sara E. Strout, Rachel M. Kruer, Lindsey P. Toman, Maria Dioverti-Prono, Laura Lees, Robin K. Avery, Mark A. Marzinke
Summary: Valganciclovir 450 mg enterally every 24 hours achieved ganciclovir trough concentrations >= 0.60 mu g/mL in most patients on CVVHD, similar to those reported with intravenous ganciclovir for prophylaxis in this population. Neutropenia did not occur in the study period. Thrombocytopenia was common and likely multifactorial.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Elles J. Reimerink, Daan W. Huntjens, Lindsey G. Pelkmans, Jan-Willem H. J. Geerts, Eric J. F. Franssen
Summary: This case report describes a potentially lethal caffeine intoxication in a patient who ingested 10 g of caffeine. Due to insufficient response to continuous labetalol infusion, the patient underwent continuous veno-venous haemodialysis (CVVHD) for 15 hours, resulting in successful treatment and subsequent discharge. This is the first report to demonstrate the use of CVVHD as a haemodialysis modality for caffeine intoxication and its effect on caffeine clearance. Early recognition of caffeine intoxication is crucial to consider haemodialysis in cases of potentially lethal intoxication.
Article
Gastroenterology & Hepatology
Satish Chandra Yadav, Bingqiang Zhang
Summary: This study compared the effects of conventional treatment and continuous veno-venous haemofiltration (CVVH) on the prevention of pseudocyst and walled-off necrosis in severe acute pancreatitis (SAP) patients. The results showed that CVVH patients had a significantly greater decrease in various markers, and no local pancreatic complications, indicating that early CVVH may be able to effectively prevent the formation of pseudocyst and walled-off necrosis in SAP patients.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2022)
Article
Pediatrics
Jinglin Xu, Lingyu Fang, Jiangbin Chen, Xinhua Chen, Hansong Yang, Weifeng Zhang, Lianqiang Wu, Dongmei Chen
Summary: This study aimed to describe the clinical characteristics, effects, short-term outcomes, and predictors of death in critically ill neonates who received continuous kidney replacement therapy (CKRT). The study found that the mortality rate was 35.9% among critically ill neonates who received CKRT, with neonatal sepsis being the most common primary diagnosis. Complications and CKRT-related adverse events were observed, with thrombocytopenia being the most common complication. CKRT initiation resulted in improvements in certain clinical parameters. Neonatal critical illness score was identified as an independent risk factor for death in this population.
PEDIATRIC NEPHROLOGY
(2023)
Article
Cell Biology
Andreas Margraf, Chang Liu, Mira Kullmar, Melanie Meersch, Jan Rossaint, Alexander Zarbock
Summary: Acute kidney injury significantly affects leukocyte function during CVVH treatment, impairing selectin-mediated slow rolling and chemokine-induced arrest. Systemic heparin and local citrate anticoagulants have no differential effect on leukocyte recruitment steps.
Article
Engineering, Biomedical
Beibei Jin, Da Cao, Ning Yang, Ling Wang, Ruifang Li, Xiumei Liu, Ping Gong
Summary: This study found that early high-dose continuous venous-venous hemofiltration (CVVH) can alleviate the alterations in CD4(+) T lymphocyte subsets in septic patients combined with acute kidney injury. This may be one of the factors associated with improved sepsis severity.
Article
Urology & Nephrology
Fang Wang, Min Zhang, Xu Li, Xiankun Sun, Xuanchen He, Mingjing Guan, Zhiwen Chen, Li Lin, Xue Tang, Ling Zhang
Summary: This study aimed to evaluate the effect of three dilution modes (pre-dilution, post-dilution, and pre- to post-dilution) on circuit lifespan during continuous veno-venous hemodiafiltration (CVVHDF). The results showed that the pre- to post-dilution mode significantly prolonged circuit lifespan compared with the pre-dilution and post-dilution modes, but there were no significant differences in terms of changes in serum creatinine and blood urea nitrogen levels, admission day, and 28-day all-cause mortality.
SEMINARS IN DIALYSIS
(2023)