Article
Endocrinology & Metabolism
Jiao Zuo, Ahmed A. Hasan, Carl-Friedrich Hocher, Philipp Kalk, Burkhard Kleuser, Bernhard K. Kraemer, Berthold Hocher
Summary: This study investigated the relationship between 25(OH)D and 1,25(OH)2D with PTH. The results showed a negative correlation between all forms of PTH and 25(OH)D, while there was no significant correlation between 1,25(OH)2D and PTH. This finding suggests an inhibitory effect of 25(OH)D on the synthesis of all forms of PTH in the chief cells of the parathyroid gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Cell Biology
Robert H. Mak, Uwe Querfeld, Alex Gonzalez, Sujana Gunta, Wai W. Cheung
Summary: The supplementation of 25(OH)D-3 in CKD mice showed metabolic advantages by attenuating adipose tissue browning and muscle wasting, in contrast to the repletion of 1,25(OH)(2)D-3.
Article
Biochemistry & Molecular Biology
Caroline A. Mcwhorter, Molly J. Mead, Megan D. Rodgers, Myla D. Ebeling, Judy R. Shary, Mathew J. Gregoski, Danforth A. Newton, John E. Baatz, Bruce W. Hollis, Martin Hewison, Carol L. Wagner
Summary: Pregnancy leads to increased synthesis of vitamin D binding protein (DBP) and higher concentrations of total vitamin D and metabolites. The ratio of free 25-hydroxyvitamin D (25(OH)D) to parathyroid hormone (PTH) appears to be a better predictor of pregnancy complications, such as gestational diabetes, compared to total 25(OH)D/PTH. Further research is needed to validate and explore this association.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Nutrition & Dietetics
Rakesh Balachandar, Raghu Pullakhandam, Bharati Kulkarni, Harshpal Singh Sachdev
Summary: This study found that cholecalciferol was more effective than ergocalciferol in improving vitamin D status and regulating PTH levels, regardless of participant demographics, dosage, and vehicle of supplementation.
Article
Neurosciences
Zhizhong Zhang, Shuai Yuan, Susanna C. Larsson, Mengmeng Wang, Xinfeng Liu
Summary: Elevated serum calcium, 25-hydroxyvitamin D, and parathyroid hormone levels were found to be associated with an increased risk of aneurysmal subarachnoid hemorrhage (SAH) in this Mendelian randomization study. The study used genetic variants to predict these hormone levels and found that higher genetically predicted S-Ca and S-PTH levels were associated with an increased risk of aneurysmal SAH. However, there was no association between genetically predicted S-25OHD concentration and aneurysmal SAH.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Maryam Barzin, Amir Ebadinejad, Farnaz Vahidi, Alireza Khalaj, Maryam Mahdavi, Majid Valizadeh, Farhad Hosseinpanah
Summary: Vitamin D metabolism is altered in obese individuals, and surgery-induced weight loss can increase the threshold of vitamin D and suppress the secretion of parathyroid hormone.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Limin Yang, Miori Sato, Mayako Saito-Abe, Minaho Nishizato, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada, Yukihiro Ohya
Summary: The study found no association between early-life 25-hydroxyvitamin D levels and the risk of developing childhood atopic dermatitis (AD).
Article
Orthopedics
Z. Qu, F. Yang, Y. Yan, J. Huang, J. Zhao, J. Hong, S. Li, G. Jiang, W. Wang, S. Yan
Summary: This study indicated an inverse causal relationship between serum PTH concentrations and development of OA, especially knee OA, but no evidence of the causal effect of serum 25(OH)D levels on OA was found. Further investigation is needed to explore potential mechanisms by which serum PTH affects OA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Pediatrics
Chayatat Ruangkit, Sukrit Suwannachat, Pornchanok Wantanakorn, Napapailin Sethaphanich, Surapat Assawawiroonhakarn, Oraporn Dumrongwongsiri
Summary: Most exclusively breastfed Thai infants at 6 months old have serum vitamin D levels below sufficiency level. However, supplementing with vitamin D (400 IU/day) improves their vitamin D status and prevents deficiency.
Article
Nutrition & Dietetics
Bridget A. Baxter, Michaela G. Ryan, Stephanie M. LaVergne, Sophia Stromberg, Kailey Berry, Madison Tipton, Nicole Natter, Nikiah Nudell, Kim McFann, Julie Dunn, Tracy L. Webb, Michael Armstrong, Nichole Reisdorph, Elizabeth P. Ryan
Summary: This study investigates the association between vitamin D deficiency and COVID-19 severity among survivors. The findings show a correlation between vitamin D deficiency and severe cases, as well as the presence of post-acute sequelae of COVID-19 (PASC) among survivors. Gender and BMI are also found to be related to vitamin D levels, but not to the presence of PASC.
Review
Nutrition & Dietetics
Vincent Brandenburg, Markus Ketteler
Summary: This review examines the developments of vitamin D therapies in CKD patients and discusses the association between vitamin D deficiency and sHPT as well as its impact on important clinical outcomes in CKD patients. However, vitamin D therapy also comes with the risk of side effects, so it is necessary to address core issues regarding PTH target levels, optimal vitamin D levels, and the effectiveness of sHPT treatment in CKD patients.
Article
Medical Laboratory Technology
Francesco Vierucci, Lara Fusani, Alessandro Saba, Tania Minucciani, Maria Paola Belluomini, Raffaele Domenici, Gian Luca Bracco, Angelina Vaccaro, Giovanni Federico
Summary: This study assessed the relationship between assumed risk factors for maternal vitamin D deficiency and levels of cord blood 25(OH)D-3 and C-3-epimer. The results showed that vitamin D deficiency was common in newborns, especially those born to mothers who did not receive vitamin D supplementation and had poor sun exposure.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Robert C. Tuckey, Chloe Y. S. Cheng, Lei Li, Yuhan Jiang
Summary: Our study found that 25-hydroxyvitamin D3 (25(OH)D3) can exist in the human circulation in the sulfated form, and can be metabolized by vitamin D-metabolizing cytochromes P450 (CYPs). Specifically, CYP27A1 can convert vitamin D3 sulfate to 25(OH)D3 3-sulfate, while CYP11A1 can convert vitamin D3 sulfate to 20(OH)D3 3-sulfate, but at a lower rate.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Andrea Hanel, Cor Veldhuizen, Carsten Carlberg
Summary: This study compared the modulation of the transcriptome of human peripheral blood mononuclear cells (PBMCs) by the vitamin D metabolites 25-hydroxyvitamin D-3 (25(OH)D-3), 25(OH)D-2, and 1 alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3). The findings showed that 25(OH)D-3 and 25(OH)D-2 were equally potent in modulating the transcriptome of PBMCs at supra-physiological concentrations, possibly by directly activating the vitamin D receptor.
FRONTIERS IN NUTRITION
(2022)
Article
Urology & Nephrology
Il-Soo Ha, Hui K. Yap, Reyner L. Munarriz, Pedro H. Zambrano, Joseph T. Flynn, Ilmay Bilge, Maria Szczepanska, Wai-Ming Lai, Zenaida L. Antonio, Ashima Gulati, Nakysa Hooman, Koen Van Hoeck, Lina M. S. Higuita, Enrico Verrina, Guenter Klaus, Michel Fischbach, Mohammed A. Riyami, Lja Sahpazova, Anja Sander, Bradley A. Warady, Franz Schaefer
KIDNEY INTERNATIONAL
(2015)
Article
Medicine, Research & Experimental
Whitney Besse, Ke Dong, Jungmin Choi, Sohan Punia, Sorin V. Fedeles, Murim Choi, Anna-Rachel Gallagher, Emily B. Huang, Ashima Gulati, James Knight, Shrikant Mane, Esa Tahvanainen, Pia Tahvanainen, Simone Sanna-Cherchi, Richard P. Lifton, Terry Watnick, York P. Pei, Vicente E. Torres, Stefan Somlo
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Correction
Medicine, Research & Experimental
Whitney Besse, Ke Dong, Jungmin Choi, Sohan Punia, Sorin V. Fedeles, Murim Choi, Anna-Rachel Gallagher, Emily B. Huang, Ashima Gulati, James Knight, Shrikant Mane, Esa Tahvanainen, Pia Tahvanainen, Simone Sanna-Cherchi, Richard P. Lifton, Terry Watnick, York P. Pei, Vicente E. Torres, Stefan Somlo
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Review
Pediatrics
Ashima Gulati, Stefan Somlo
PEDIATRIC NEPHROLOGY
(2018)
Article
Urology & Nephrology
Ashima Gulati, Allen E. Bale, Daniel J. Dykas, Margaret J. Bia, Gabriel M. Danovitch, Gilbert W. Moeckel, Stefan Somlo, Neera K. Dahl
AMERICAN JOURNAL OF KIDNEY DISEASES
(2018)
Letter
Medicine, General & Internal
Ashima Gulati, Kyongtae T. Bae, Stefan Somlo, Terry Watnick
ANNALS OF INTERNAL MEDICINE
(2018)
Article
Urology & Nephrology
Mariken P. Gruppen, Antonia H. Bouts, Marijke C. Jansen-van der Weide, Maruschka P. Merkus, Aleksandra Zurowska, Michal Maternik, Laura Massella, Francesco Emma, Patrick Niaudet, Elisabeth A. M. Cornelissen, Thierry Schurmans, Ann Raes, Johan van de Walle, Mieke van Dyck, Ashima Gulati, Arvind Bagga, Jean-Claude Davin
KIDNEY INTERNATIONAL
(2018)
Article
Urology & Nephrology
Aditi Sinha, Ashima Gulati, Savita Saini, Caroline Blanc, Aarti Gupta, Bahadur Singh Gurjar, Himanshi Saini, Shambhuprasad T. Kotresh, Uma Ali, Divya Bhatia, Alpana Ohri, Manish Kumar, Indira Agarwal, Sanjeev Gulati, Kanav Anand, M. Vijayakumar, Rajiv Sinha, Sidharth Sethi, Maud Salmona, Anna George, Vineeta Bal, Geetika Singh, Amit K. Dinda, Pankaj Hari, Satyajit Rath, Marie-Agnes Dragon-Durey, Arvind Bagga
KIDNEY INTERNATIONAL
(2014)
Article
Transplantation
Aditi Sinha, Divya Bhatia, Ashima Gulati, Meenakshi Rawat, Amit K. Dinda, Pankaj Hari, Arvind Bagga
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2015)
Letter
Urology & Nephrology
Ashima Gulati, Neera Dahl
AMERICAN JOURNAL OF KIDNEY DISEASES
(2019)
Review
Pediatrics
Ashima Gulati, Neera Dahl, Alda Tufro
PEDIATRIC NEPHROLOGY
(2020)
Article
Urology & Nephrology
Whitney Besse, Alex R. Chang, Jonathan Z. Luo, William J. Triffo, Bryn S. Moore, Ashima Gulati, Dustin N. Hartzel, Shrikant Mane, Vicente E. Torres, Stefan Somlo, Tooraj Mirshahi
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Urology & Nephrology
Qi Li, Ashima Gulati, Mathieu Lemaire, Timothy Nottoli, Allen Bale, Alda Tufro
Summary: A rare MYO9A loss of function mutation has been identified as a possible contributor to familial FSGS/proteinuria, involving the regulation of RhoA activity.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Ashima Gulati, Angel M. Sevillano, Manuel Praga, Eduardo Gutierrez, Ignacio Alba, Neera K. Dahl, Whitney Besse, Jungmin Choi, Stefan Somlo
KIDNEY INTERNATIONAL REPORTS
(2020)
Meeting Abstract
Pediatrics
Aditi Sinha, Divya Bhatia, Pankaj Hari, Ashima Gulati, Arvind Bagga
PEDIATRIC NEPHROLOGY
(2013)