Article
Infectious Diseases
Jun Ni, Liusha Zhou, Hua Wang, Jin Yu, Mengli Tong, Dongrong Yu
Summary: This study investigates the clinical characteristics of enterococcus-associated peritonitis in peritoneal dialysis (PD) patients. The study included patients with PD-associated enterococcal peritonitis (Group E) treated between January 2010 and September 2020. Cohort-control groups were formed with matched patients with streptococcus peritonitis (Group S) and coagulase-negative staphylococcus peritonitis (Group CNS). The analysis shows that enterococcus peritonitis is a rare and severe complication of PD, with high rates of treatment failure and poor prognosis compared to CNS and streptococcus-related infections.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Urology & Nephrology
Jeffrey Perl, Douglas S. Fuller, Neil Boudville, Alan S. Kliger, Douglas E. Schaubel, Isaac Teitelbaum, Bradley A. Warady, Alicia M. Neu, Priti R. Patel, Beth Piraino, Martin Schreiber, Ronald L. Pisoni
Summary: Optimizing the prevention of peritonitis in the United States requires standardization of definitions, data elements, and outcomes, as well as describing variations across facilities to identify potential prevention strategies. Collaborative efforts and knowledge translation pathways are crucial for reducing peritonitis incidence and disseminating best practices.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Transplantation
Valentine Forte, Sophie Novelli, Mohamad Zaidan, Renaud Snanoudj, Christian Verger, Severine Beaudreuil
Summary: Polymicrobial peritonitis in peritoneal dialysis is associated with poor outcomes, especially when caused by enteric pathogens. The study analyzed data from the French Language Peritoneal Dialysis Registry and found that mono- and polymicrobial peritonitis have distinct microbiology and patient characteristics. The presence of enteric pathogens in monomicrobial peritonitis was associated with higher risks of death and transition to hemodialysis.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Yi-Hsin Chou, Yung-Tai Chen, Jinn-Yang Chen, Der-Cherng Tarng, Chih-Ching Lin, Szu-Yuan Li
Summary: This study found that a high baseline peritoneal membrane transport rate is an independent risk factor for peritonitis in PD patients.
Article
Medicine, General & Internal
Rong Dai, Chuyi Peng, Tian Sang, Meng Cheng, Yiping Wang, Lei Zhang
Summary: The aim of this study was to construct and validate a risk prediction model for peritoneal dialysis-associated peritonitis (PDAP). The results showed that neutrophil-to-lymphocyte ratio, serum albumin, uric acid, high sensitivity C-reactive protein, and diabetes mellitus were independent predictors of PDAP after peritoneal dialysis catheterization. The column line graph model developed based on these factors had good discrimination and calibration ability, and helped to predict the risk of PDAP after peritoneal dialysis catheterization.
FRONTIERS IN MEDICINE
(2023)
Review
Physiology
Hong-yong Su, Jia-jie Yang, Rong Zou, Ning An, Xiao-cui Chen, Chen Yang, Hai-juan Yang, Cui-wei Yao, Hua-feng Liu
Summary: Peritoneal dialysis (PD) is widely used for end-stage renal disease (ESRD) patients. Peritoneal fibrosis (PF) is a common complication of PD that leads to peritoneal injury. Autophagy, the process of self-eating, has been shown to be involved in PF progression in human peritoneal mesothelial cells (HPMCs). However, the roles and mechanisms of autophagy in PF progression remain unclear.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Transplantation
Mitsuhiro Tawada, Yasuhiko Ito, Masataka Banshodani, Masahiro Yamashita, Sadanori Shintaku, Ting Sun, Yasuhiro Suzuki, Hiroshi Kinashi, Yoko Kubo, Masahiko Ando, Makoto Yamaguchi, Takayuki Katsuno, Masashi Mizuno, Hideki Kawanishi
Summary: The study found that patients in the conventional PD solution group had less angiogenesis but more severe vasculopathy, while those in the pH-neutral solution group had milder vasculopathy. The L/V ratio was significantly associated with the relapse rate of EPS.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Sosuke Fukui, Masashi Mizuno, Mitsuhiro Tawada, Yasuhiro Suzuki, Hiroshi Kojima, Yoshihisa Matsukawa, Masaki Imai, Hangsoo Kim, Hiroshi Kinashi, Makoto Mizutani, Kenichi Minoshima, Shoichi Maruyama, Yasuhiko Ito
Summary: This study investigated the expression of membrane complement regulators and tissue injuries in peritoneal dialysis-related peritonitis. The results showed that peritonitis led to severe peritoneal injuries and decreased expression of membrane complement regulators. Fungal and Pseudomonas aeruginosa peritonitis were associated with more severe injuries compared to Gram-positive bacterial peritonitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Melissa S. Cheetham, Junhui Zhao, Keith McCullough, Douglas S. Fuller, Yeoungjee Cho, Rathika Krishnasamy, Neil Boudville, Ana E. Figueiredo, Yasuhiko Ito, Talerngsak Kanjanabuch, Jeffrey Perl, Beth M. Piraino, Ronald L. Pisoni, Cheuk C. Szeto, Isaac Teitelbaum, Graham Woodrow, David W. Johnson
Summary: This study investigated the impact of training practices on the outcomes of patients receiving peritoneal dialysis. The results showed no significant association between training characteristics and the risk of peritonitis.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Simon Wai Yin So, Lu Chen, Alex Yuk Hei Woo, Derek Man Him Ng, Jennifer Ka Wah Wong, Kai Ming Chow, Naomi Runnegar, David W. Johnson, Philip Kam-Tao Li
Summary: This article provides a comprehensive review of recent stability and compatibility studies pertaining to a wide range of antibiotics admixed in various PD solutions, offering important data support for the treatment of peritoneal dialysis-related peritonitis.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Medicine, General & Internal
Grazia Maria Virzi, Sabrina Milan Manani, Davide Marturano, Anna Clementi, Silvia Lerco, Ilaria Tantillo, Anna Giuliani, Giovanni Giorgio Battaglia, Claudio Ronco, Monica Zanella
Summary: This study investigated the connection between eryptosis and inflammatory damage in PD patients with PD-related peritonitis. The results showed that eryptosis was significantly higher in PD patients with peritonitis and had positive correlations with CRP, IL-1 beta, and IL-6. In vitro exposure to higher concentrations of cytokines also resulted in increased eryptosis. These findings suggest that upregulated inflammatory markers and immune system dysregulation may contribute to systemic eryptosis during PD-related peritonitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Eric W. Young, Junhui Zhao, Ronald L. Pisoni, Beth M. Piraino, Jenny I. Shen, Neil Boudville, Martin J. Schreiber, Isaac Teitelbaum, Jeffrey Perl, Keith McCullough
Summary: This study measured the occurrence rate of peritoneal dialysis associated peritonitis using Medicare claims data and identified its clinical risk factors. The results showed that the peritonitis rate declined over time and was lower among older patients. A claims-based approach offers a promising framework for the study of peritoneal dialysis associated peritonitis.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Hematology
Ayse Seda Pinarbasi, Mehtap Akbalik Kara
Summary: This study investigated the causes and frequency of peritonitis in children undergoing peritoneal dialysis (PD). The results showed that although factors such as parents' education level and dialysis modality may influence peritonitis episodes, statistically significant associations were not observed.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Urology & Nephrology
Tianlei Chen, Wenying Chao, Yun Zou, Jia Di, Xin Zhou, Yin Zong, Mengyu Zhang, Min Yang
Summary: The study aimed to investigate the relationship between conscientiousness score and prognosis in peritoneal dialysis (PD) patients. The results showed that conscientiousness score was associated with prognostic indicators in PD patients, with higher conscientiousness scores associated with better prognosis.
Article
Urology & Nephrology
Jenny Shen, Yeoungjee Cho, Karine E. Manera, Fiona Brown, Jie Dong, Muthana Al Sahlawi, Rafael G. Acevedo, Htay Htay, Yasuhiko Ito, Talerngsak Kanjanabuch, Sharon J. Nessim, Grace Ngaruiya, Beth Piraino, Cheuk-Chun Szeto, Isaac Teitelbaum, Noa Amir, Jonathan C. Craig, Amanda Baumgart, Andrea M. Gonzalez, Nicole Scholes-Robertson, Andrea K. Viecelli, Martin Wilkie, Allison Tong, Jeffrey Perl
Summary: This article introduces a consensus workshop on the core outcome measure for PD-related peritonitis. Through discussions, it is determined that the measure should include both symptom-based and laboratory-based criteria, and the importance of accuracy, feasibility, and patient understandability is emphasized.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Worapot Treamtrakanpon, Talerngsak Kanjanabuch, Tanawin Nopsopon, Piyatida Chuengsaman, Phongsak Dandecha, Sarinya Boongird, Kamol Khositrangsikun, Laddaporn Wongluechai, Sajja Tatiyanupanwong, Pongpratch Puapatanakul, Nattachai Srisawat, Somchai Eiam-Ong, David W. Johnson, Suchai Sritippayawan, Surasak Kantachuvesiri
Summary: The national survey in Thailand showed that acute peritoneal dialysis for acute kidney injury is underutilized, with major constraints including competency in PD catheter insertion, timely support for catheter insertion, and deficits in knowledge and competency among the medical supporting team.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Review
Urology & Nephrology
Emma Elphick, Matthew Holmes, Matthew Tabinor, Yeoungjee Cho, Thu Nguyen, Tess Harris, Angela Yee Moon Wang, Arsh K. Jain, Daniela Ponce, Josephine S. F. Chow, Annie-Claire Nadeau-Fredette, Adrian Liew, Neil Boudville, Allison Tong, David W. Johnson, Simon J. Davies, Jeffrey Perl, Karine E. Manera, Mark Lambie
Summary: The study found substantial heterogeneity in how PD technique survival is defined and measured in different studies of patients receiving peritoneal dialysis, leading to considerable variability in reported rates. Standardised measures are needed to improve comparability in PD studies.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Urology & Nephrology
Andrea K. Viecelli, Emily Duncanson, Paul N. Bennett, Matilda D'Antoine, Kathryn Dansie, William Handke, Allison Tong, Suetonia Palmer, Shilpanjali Jesudason, Stephen McDonald, Rachael L. Morton
Summary: Monitoring electronic patient-reported outcome measures (e-PROMs) with feedback to clinicians is feasible and supported by patients and clinicians for improving quality of life in hemodialysis patients. However, there are challenges in terms of patient engagement, technical barriers, and delayed symptom feedback during implementation.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Urology & Nephrology
Ashik Hayat, David W. Johnson, Carmel M. Hawley, Lauren R. Jaffrey, Usman Mahmood, Sarah Saw Yu Mon, Yeoungjee Cho
Summary: This study aimed to compare the associations, microbiologic profiles, and outcomes between pre-training peritonitis (PTP) and post-training peritonitis in patients with kidney failure. The results showed that PTP was closely associated with prior exit-site infection, often had culture-negative peritonitis, and was associated with worse outcomes of hemodialysis transfer or death.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Health Policy & Services
Dharmenaan Palamuthusingam, Elaine M. Pascoe, Carmel M. Hawley, David W. Johnson, Gishan Ratnayake, Stephen McDonald, Neil Boudville, Matthew Jose, Magid Fahim
Summary: This study assessed the concordance between comorbidities recorded in the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry and those in state-based hospital admission datasets. The results showed that the accuracy of diabetes mellitus recording was the highest, while the accuracy of cerebrovascular disease recording was the lowest.
HEALTH INFORMATION MANAGEMENT JOURNAL
(2023)
Article
Pediatrics
Chandana Guha, Rabia Khalid, Anita van Zwieten, Anna Francis, Carmel M. Hawley, Allison Jaure, Armando Teixeira-Pinto, Alistair R. Mallard, Amelie Bernier-Jean, David W. Johnson, Deirdre Hahn, Donna Reidlinger, Elaine M. Pascoe, Elizabeth G. Ryan, Fiona Mackie, Hugh J. McCarthy, Jonathan C. Craig, Julie Varghese, Charani Kiriwandeniya, Kirsten Howard, Nicholas G. Larkins, Luke Macauley, Amanda Walker, Martin Howell, Michelle Irving, Patrina H. Y. Caldwell, Reginald Woodleigh, Shilpanjali Jesudason, Simon A. Carter, Sean E. Kennedy, Stephen Alexander, Steven McTaggart, Germaine Wong
Summary: This study aims to evaluate the effectiveness of a patient navigator program in children with chronic kidney disease. A total of 162 patients were enrolled and randomized into immediate intervention and waitlisted groups. The results of the study will be completed by October 2022.
PEDIATRIC NEPHROLOGY
(2023)
Review
Urology & Nephrology
Ashik Hayat, Rachael C. Walker, Andrea K. Viecelli, Karine E. Manera, Allison Jaure, Rathika Krishnasamy, Elaine M. Pascoe, Yeoungjee Cho, David W. Johnson
Summary: This study assessed the range and consistency of gastrointestinal (GI) outcomes reported in contemporary peritoneal dialysis (PD) trials. It found that only 19% of PD trials reported GI outcomes, with nausea, diarrhea, vomiting, constipation, and abdominal pain being the most frequently reported outcomes. The majority of GI outcomes were patient-reported adverse events with no defined metrics.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Orthopedics
Ian A. Harris, Michelle F. Lorimer, Christopher E. Davies, Dominic Keuskamp, Kathryn B. Dansie, Peter L. Lewis, Stephen E. Graves, Stephen P. McDonald
Summary: This study compared the rate of revision surgery and mortality following THA between patients who have kidney failure receiving long term dialysis or who had a kidney transplant and those who did not have kidney failure. The results showed that patients on dialysis had a higher risk of mortality after THA compared to those with a functioning kidney transplant or no kidney failure, but there was no early excess mortality due to the surgery.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Urology & Nephrology
Ashik Hayat, Yeoungjee Cho, Carmel M. Hawley, Htay Htay, Rathika Krishnasamy, Elaine Pascoe, Isaac Teitelbaum, Marliene Varnfield, David W. Johnson
Summary: Comparing with full-dose PD start, incremental PD start shows similar declines in RKF and UV.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
B. Logan, A. K. Viecelli, D. W. Johnson, E. M. Aquino, J. Bailey, T. A. Comans, L. C. Gray, C. M. Hawley, L. E. Hickey, M. Janda, A. Jaure, M. D. Jose, E. Kalaw, C. Kiriwandeniya, M. Matsuyama, G. Mihala, K. H. Nguyen, E. Pascoe, J. D. Pole, K. R. Polkinghorne, D. Pond, R. Raj, D. M. Reidlinger, N. Scholes-Robertson, J. Varghese, G. Wong, R. E. Hubbard
Summary: This study aims to evaluate the clinical utility and cost-effectiveness of comprehensive geriatric assessment (CGA) for frail older people living with chronic kidney disease (CKD). The study compares the attainment of self-identified goals between participants receiving CGA and those receiving standard care. The study will help improve the survival and quality of life of patients with CKD.
Article
Urology & Nephrology
Yeoungjee Cho, Kai-Ming Chow, Philip Kam-Tao Li, Naomi Runnegar, David W. Johnson
Summary: Peritoneal dialysis is an important treatment option for patients with kidney failure, providing various benefits such as enhanced participation in daily activities, flexibility in schedules, cost savings, and improved quality of life. However, the utilization of peritoneal dialysis has remained static or declining in certain regions due to concerns about PD-related infections. This review aims to provide an overview of the definition, epidemiology, risk factors, prevention, and treatment of PD-related infections based on current evidence.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Urology & Nephrology
Stephen P. Mcdonald, Katie Cundale, Kelli J. Owen, Matilda D'Antoine, Jaquelyne T. Hughes
Summary: Indigenous people in Australia are disadvantaged in accessing kidney transplantation. The National Indigenous Kidney Transplant Taskforce was established to address this issue by providing support to clinicians, implementing and evaluating innovative practices, and developing strategies to overcome barriers in the care system.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Urology & Nephrology
Yu-Hui Zhang, Xiao Xu, Hai-Chen Pi, Zhi-Kai Yang, David W. Johnson, Jie Dong
Summary: This study aimed to examine the effects of vitamin D supplementation on the risk of PD-related peritonitis. The results showed that oral natural vitamin D supplementation can increase serum 25(OH)D levels in PD patients, without affecting the occurrence or outcome of peritonitis. The study suggests that conducting this type of randomized controlled trial is feasible and safe.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Biology
Ken-Soon Tan, Stephen McDonald, Wendy Hoy
Summary: This study compared the performance of a clinical diagnosis to biopsy-proven diagnosis of diabetic kidney disease (DKD) and found that a clinical diagnosis has high sensitivity but low specificity, indicating the possibility of overdiagnosis.
Letter
Urology & Nephrology
Richard Le Leu, Paul N. Bennett, Kathryn Dansie, Lisa Shanahan, Anna Chur-Hansen, Kathryn L. Collins, Anne L. J. Burke, Fiona Donnelly, Emily Duncanson, Anthony Meade, Stephen McDonald, Shilpanjali Jesudason
JOURNAL OF NEPHROLOGY
(2023)