Article
Multidisciplinary Sciences
Afshin Nikzad, Mohammad Akbarpour, Michael A. Rees, Alvin E. Roth
Summary: The proposal suggests organizing kidney exchange chains between middle-income and high-income countries to address financial barriers to transplantation in the former and the difficulty in finding matches for patients in the latter. Financing for such chains would involve utilizing savings from US health care payers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Urology & Nephrology
Gianluigi Ardissino, Donata Cresseri, Francesca Tel, Antenore Giussani, Stefania Salardi, Martina Sgarbanti, Bice Strumbo, Sara Testa, Valentina Capone, Samantha Griffini, Elena Grovetti, Massimo Cugno, Mirco Belingheri, Chiara Tamburello, Evangeline Millicent Rodrigues, Michela Perrone, Massimo Cardillo, Grazia Corti, Dario Consonni, Lucrezia Furian, Silvana Tedeschi, Piergiorgio Messa, Claudio Beretta
Summary: This study presents experience with KTx in aHUS patients, showing that prophylactic use of Eculizumab can significantly reduce relapse rates. Tailored timing of Eculizumab doses based on classical complement pathway activity for each patient has also shown positive results.
JOURNAL OF NEPHROLOGY
(2021)
Article
Immunology
Xianzhang Luo, Ji Zhang, Sijuan Zou, Xinqiang Wang, Gen Chen, Zhen Li, Kaiyan Li, Mengqing Wang, Zhishui Chen, Changshen Ming, Xiaohua Zhu, Nianqiao Gong
Summary: The combination of bone fragment co-transplantation and bone marrow aspirate infusion (BF-BM) in living kidney transplantation (LKT) was found to benefit recipients by improving kidney recovery and regulating the immune response. The study showed that BF-BM had positive effects on kidney function and immune regulation over a 5-year follow-up period.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Manuela Yepes-Calderon, Daan Kremer, Adrian Post, Camilo G. G. Sotomayor, Ulrike Seidel, Patricia Huebbe, Tim J. J. Knobbe, Kai Lueersen, Michele F. F. Eisenga, Eva Corpeleijn, Martin H. H. De Borst, Gerjan J. J. Navis, Gerald Rimbach, Stephan J. L. Bakker
Summary: A study found that kidney transplant recipients have an increased risk of cardiovascular mortality. It also revealed an association between post-transplantation copper status and the risk of cardiovascular mortality, with a potential effect modification by sex. Among male recipients, higher plasma copper concentration was independently associated with a higher risk of cardiovascular mortality, while this association was absent among female recipients.
Article
Immunology
Evaldo Favi, Paolo Molinari, Carlo Alfieri, Giuseppe Castellano, Mariano Ferraresso, Donata Cresseri
Summary: The use of eculizumab in kidney transplantation has reduced the incidence of relapsing aHUS, but the management of aHUS transplant candidates with anti-CFH antibodies is still debated. We present a case of a successful kidney transplant in a patient with elevated anti-CFH antibodies, using eculizumab and obinutuzumab. The patient had a good outcome with undetectable anti-CFH antibodies, B-cell depletion, and no signs of aHUS activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ping Li, Yanru Wu, Huizhi Wu, Qiuhong Xiong, Na Zhao, Guangxin Chen, Changxin Wu, Han Xiao
Summary: This study identified a mutation in the FH gene that is associated with uterine leiomyomas and investigated its pathogenicity. The FH mutation exhibited lower enzyme activity and higher fumarate levels, possibly due to impaired homotetramer formation. Additionally, the mutation led to increased cell proliferation and extracellular acidification, as well as inhibited autophagy. These findings provide important insights for accurate genetic counseling and clinical diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Hongfeng Huang, Qixia Shen, Jingyi Zhou, Xiuyan Yang, Qiuqin Cai, Jia Shen, Shi Feng, Wenqing Xie, Hong Jiang, Jianghua Chen
Summary: The clinical experience demonstrates the efficacy of non-myeloablative conditioning protocol in inducing tolerance in HLA identical patients, and complete chimerism may be a risk factor for GVHD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hitoshi Iwamoto, Masaaki Okihara, Isao Akashi, Yu Kihara, Osamu Konno, Shigeyuki Kawachi, Makoto Sunamura, Masahiro Sugimoto
Summary: Kidney biopsy is commonly used to diagnose kidney transplant dysfunction. In this study, capillary electrophoresis-mass spectrometry was used to analyze the biofluids of transplant recipients. Metabolomics analyses revealed significant differences in the metabolomic profiles of the different groups, particularly in arginine biosynthesis and purine metabolism in plasma samples. Different types of kidney disorders also showed distinct metabolomic profiles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Sanober Sadiq, Anatoly Urisman, Onur Cil
Summary: Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by various factors. Eculizumab, an anti-C5 monoclonal antibody, is effective in treating aHUS caused by genetic defects. However, its use in non-genetic forms of aHUS and when to discontinue treatment are still controversial.
FRONTIERS IN MEDICINE
(2023)
Article
Medical Laboratory Technology
Konrad Buscher, Rebecca Rixen, Paula Schuetz, Birte Huechtmann, Veerle Van Marck, Barbara Heitplatz, Ulrich Jehn, Daniela A. Braun, Gert Gabrieels, Hermann Pavenstaedt, Stefan Reuter
Summary: This study analyzed the systemic immune response in kidney transplanted patients and identified circulating immune modules that are associated with kidney function and transplant rejection, providing insights for developing translational biomarkers.
TRANSLATIONAL RESEARCH
(2023)
Article
Immunology
Matthias Schaier, Christian Morath, Lei Wang, Christian Kleist, Gerhard Opelz, Thuong Hien Tran, Sabine Scherer, Lien Pham, Naruemol Ekpoom, Caner Suesal, Gerald Ponath, Florian Kaelble, Claudius Speer, Louise Benning, Christian Nusshag, Christoph F. Mahler, Luiza Pego da Silva, Claudia Sommerer, Angela Hueckelhoven-Krauss, David Czock, Arianeb Mehrabi, Constantin Schwab, Ruediger Waldherr, Paul Schnitzler, Uta Merle, Vedat Schwenger, Markus Krautter, Stephan Kemmner, Michael Fischereder, Manfred Stangl, Ingeborg A. Hauser, Anna-Isabelle Kaelsch, Bernhard K. Kraemer, Georg A. Boehmig, Carsten Mueller-Tidow, Jochen Reiser, Martin Zeier, Michael Schmitt, Peter Terness, Anita Schmitt, Volker Daniel
Summary: Administration of modified immune cells (MIC) before kidney transplantation led to improved clinical outcomes, including stable kidney graft function, absence of donor-specific human leukocyte antigen antibodies (DSA) or acute rejections, and reduced opportunistic infections compared to standard immunosuppressive therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Stathis Tsiakas, Smaragdi Marinaki, Sophia Lionaki, John Boletis
Summary: Therapeutic plasma exchange (TPE) is used as an adjunctive intervention for severe renal involvement or lung hemorrhage in patients with ANCA-associated vasculitis (AAV). However, the efficacy of TPE in severe AAV remains controversial in the vasculitis medical community, as the largest clinical trial to date failed to demonstrate a clear benefit.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Stijn C. van de Laar, Matthew L. Robb, Rachel Hogg, Lisa Burnapp, Vassilios E. Papalois, Frank J. M. F. Dor
Summary: The study found that LDKT performed within the UKLKSS had longer cold ischaemia time, higher incidence of delayed graft function, and lower graft function compared to the non-KEP group, but excellent 5-year graft survival similar to non-KEP was observed.
Article
Immunology
Luying Guo, Jia Shen, Wenhua Lei, Pengpeng Yan, Meifang Wang, Qin Zhou, Huiping Wang, Jianyong Wu, Jianghua Chen, Rending Wang
Summary: Recent studies have shown the role of plasma donor-derived cell-free DNA (ddcfDNA) as a non-invasive biomarker for allograft injury after kidney transplantation. This study investigates the impact of Banff lesions and inflammatory infiltrates on ddcfDNA levels in kidney transplant recipients, aiming to explore the intrinsic factors associated with ddcfDNA elevation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Margarita Lopez-Trascasa, Angel Alonso-Melgar, Marta Melgosa-Hijosa, Laura Espinosa-Roman, Maria Dolores Lledin-Barbancho, Eugenia Garcia-Fernandez, Santiago Rodriguez de Cordoba, Pilar Sanchez-Corral
Summary: Pathogenic gain-of-function mutations in complement Factor B were found to be the cause of atypical HUS in 2007. A four-month-old boy diagnosed with hypocomplementemic aHUS in 2000 suffered severe complications and end-stage renal disease by the age of 3, eventually undergoing a combined liver and kidney transplantation in 2009. After experiencing post-transplant complications, including B-cell non-Hodgkin lymphoma and liver rejection, the patient currently maintains normal kidney and liver functions 12 years post-surgery, suggesting that CLKT was an acceptable therapeutic option.
FRONTIERS IN IMMUNOLOGY
(2021)