Article
Immunology
Ramin Mazhari, Eizo Takashima, Rhea J. Longley, Shazia Ruybal-Pesantez, Michael T. White, Bernard N. Kanoi, Hikaru Nagaoka, Benson Kiniboro, Peter Siba, Takafumi Tsuboi, Ivo Mueller
Summary: As progress is made towards eliminating malaria, the challenge of Plasmodium vivax becomes more apparent. In regions where both P. vivax and Plasmodium falciparum are co-endemic, the proportion of P. vivax cases has increased as transmission declines. The lack of advanced vaccines for P. vivax and limited potential candidates highlight the need for novel tools for accelerated elimination. In this study, researchers aimed to identify promising P. vivax proteins for a subunit vaccination approach by screening protein constructs and confirming previous results, as well as discovering four novel candidates with predicted protective efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Suelen Queiroz Diniz, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Dhelio Batista Pereira, Mauro Shugiro Tada, Luis Carlos Crocco Afonso, Markus Kohlhoff, Carlos Leomar Zani, Ricardo Tostes Gazzinelli, Fabiano Oliveira, Lis Ribeiro Antonelli
Summary: This study reveals that monocytes in patients with malaria produce high levels of inflammatory cytokines and also have a regulatory role through specific receptors, suggesting a dual role of monocytes in malaria.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Tobias Mourier, Denise Anete Madureira de Alvarenga, Abhinav Kaushik, Anielle de Pina-Costa, Olga Douvropoulou, Qingtian Guan, Francisco J. Guzman-Vega, Sarah Forrester, Filipe Vieira Santos de Abreu, Cesare Bianco Junior, Julio Cesar de Souza Junior, Silvia Bahadian Moreira, Zelinda Maria Braga Hirano, Alcides Pissinatti, Maria de Fatima Ferreira-da-Cruz, Ricardo Lourenco de Oliveira, Stefan T. Arold, Daniel C. Jeffares, Patricia Brasil, Cristiana Ferreira Alves de Brito, Richard Culleton, Claudio Tadeu Daniel-Ribeiro, Arnab Pain
Summary: Plasmodium simium, a malaria parasite of non-human primates, likely originated in South America from Plasmodium vivax and has recently acquired the ability to infect humans. Genetic analysis suggests that specific gene deletions in P. simium, especially in the Duffy-binding protein 1 (DBP1), may play a role in its ability to invade human red blood cells, leading to recent zoonotic infections.
Article
Biotechnology & Applied Microbiology
Jack Adderley, Christian Doerig
Summary: This study fills gaps in the kinomes of Plasmodium falciparum and Plasmodium vivax, highlighting their similarities and differences for target selection. It also identifies kinases that are not suitable targets for drug discovery due to their high similarity with human counterparts.
Editorial Material
Infectious Diseases
Fang Huang, Li Zhang, Zhi-Gui Xia
Summary: This article highlights China's practices and experience in targeting vivax malaria control and elimination, including radical cure strategies, comprehensive but adaptive strategies, mass drug administration, and case-/focus-centered surveillance and response systems. After nearly 70 years of effort, China was certified as a malaria-free country in June 2021.
INFECTIOUS DISEASES OF POVERTY
(2023)
Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biology
Joao L. Silva-Filho, Joao C. K. Dos-Santos, Carla Judice, Dario Beraldi, Kannan Venugopal, Diogenes Lima, Helder Nakaya, Erich De Paula, Stefanie C. P. Lopes, Marcus V. G. Lacerda, Matthias Marti, Fabio T. M. Costa
Summary: In patients with vivax malaria, there is a correlation between peripheral and total parasite biomass and host response, with high heterogeneity in clinical features, parasite burden, and host signatures. Patients can be categorized into Vivax(low) and Vivax(high) clusters based on differences in total parasite biomass, rather than peripheral parasitaemia, showing distinct alterations in various parameters related to host homeostasis.
Article
Immunology
Maelle Le Goff, Eric Kendjo, Marc Thellier, Renaud Piarroux, Pierre Yves Boelle, Stephane Jaureguiberry
Summary: This study analyzed the impact of chemoprophylaxis on the outcomes of Plasmodium vivax and Plasmodium ovale infections in civilian travelers. It found that travelers using blood-stage drugs were at a higher risk of delayed-onset illness. This calls for new chemoprophylaxis acting on liver stages.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Gisele Tatiane Soares da Veiga, Matheus Ribeiro Moriggi, Jean Franciesco Vettorazzi, Marcelo Mueller-Santos, Letusa Albrecht
Summary: Malaria is a devastating infectious disease caused by Plasmodium parasites, and finding an effective vaccine is a major challenge. Plasmodium vivax, the second most prevalent species, has been neglected for decades, leading to a lack of knowledge and vaccine development. The main difficulties in developing a P. vivax vaccine are its high genetic diversity and complex life cycle. This review presents the main findings of vivax malaria vaccines to date to support future investigations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Surafel K. Tebeje, Wakweya Chali, Elifaged Hailemeskel, Jordache Ramjith, Abrham Gashaw, Temesgen Ashine, Desalegn Nebret, Endashaw Esayas, Tadele Emiru, Tizita Tsegaye, Karina Teelen, Kjerstin Lanke, Eizo Takashima, Takafumi Tsuboi, Nichole D. Salinas, Niraj H. Tolia, David Narum, Chris Drakeley, Benoit Witkowski, Amelie Vantaux, Matthijs M. Jore, William J. R. Stone, Ivo S. Hansen, Fitsum G. Tadesse, Teun Bousema
Summary: This study investigated the association between antibody prevalence and the infectivity of Plasmodium vivax to mosquitoes. The results showed that antibodies against Pvs47, Pvs230, and Pvs25 were significantly associated with a reduction in mosquito infection rates. Further research can help establish causality and contribute to our understanding of P. vivax transmission and vaccine development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Luis Carlos Salazar Alvarez, Omaira Vera Lizcano, Dayanne Kamylla Alves da Silva Barros, Djane Clarys Baia-da-Silva, Wuelton Marcelo Monteiro, Paulo Filemon Paolluci Pimenta, Marcus Vinicius Guimaraes de Lacerda, Fabio Trindade Maranhao Costa, Stefanie Costa Pinto Lopes
Summary: In a Plasmodium vivax infection, gametocytes show increased distribution in bone marrow aspirant, indicating the organ's role as a parasite reservoir. Ex vivo assays demonstrate gametocyte adherence to bone marrow endothelial cells, with ICAM1 as a significant receptor and CD36 showing high adhesion rate without significance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Edwin Kamau, Jason W. Bennett, Anjali Yadava
Summary: Safety data on Plasmodium vivax controlled human malaria infection (PvCHMI) is limited due to the small number of studies conducted. However, mosquito bite-induced PvCHMI was found to be safe, with most infections being detected before clinical symptoms appeared. Sensitive molecular methods were effective in diagnosing infections early on, indicating their potential to alleviate clinical symptoms.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Marly M. Melo, Monica R. F. Costa, Franklin S. Santana Filho, Jose Diego Brito-Sousa, Anne C. G. Almeida, Wuelton M. Monteiro, Gisely C. Melo, Jose Luiz Fernandes Vieira, Maria das Gracas Costa Alecrim
Summary: This study described the pharmacokinetic parameters of chloroquine in whole blood of adult patients with P. vivax malaria from the western Brazilian Amazon basin and compared the area under the curve (AUC) with the parasitological outcome at day 28. The results showed that the pharmacokinetic parameters were similar in both groups, suggesting the lack of influence of early reappearance of parasites on chloroquine pharmacokinetics.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Immunology
Sonalika Kar, Abhinav Sinha
Summary: The neglected but highly prevalent Plasmodium vivax in South-east Asia and South America poses a great challenge for long-term in-vitro culturing and functional assays, hindering the development of new drugs and vaccines. The leading vaccine candidate antigen PvDBP, despite completing clinical trial Phase 1 successfully, faces challenges such as its highly polymorphic nature and strain-specific immunity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Kayla Sylvester, Steven P. Maher, Dora Posfai, Michael K. Tran, McKenna C. Crawford, Amelie Vantaux, Benoit Witkowski, Dennis E. Kyle, Emily R. Derbyshire
Summary: This study utilizes high-resolution microscopy to characterize temporal changes of the TVN in Plasmodium vivax liver stage, revealing its presence in dormant hypnozoites and association with host nuclei. The unexpected association of the host water channel protein AQP3 with TVN-derived vesicles is demonstrated, suggesting a potential function of AQP3 during this stage. These findings enhance understanding of host-parasite interactions in both dormant and replicating P. vivax liver stage forms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Editorial Material
Pediatrics
Jennifer H. Huang, Sunil Saharan, Amy McCammond, Seshadri Balaji
JOURNAL OF PEDIATRICS
(2015)
Letter
Pediatrics
S. Saharan, B. Jose, R. Seth, V. K. Iyer, S. K. Kabra
Letter
Pediatrics
K. Allegaert, I. Casteels, D. Tibboel
Article
Cardiac & Cardiovascular Systems
Sunil Saharan, Arthur T. Legg, Laurie B. Armsby, M. Mujeeb Zubair, Richard D. Reed, Stephen M. Langley
ANNALS OF THORACIC SURGERY
(2014)
Article
Immunology
Avanish K. Varshney, Rama Chaudhry, Sunil Saharan, Sushil Kumar Kabra, Benu Dhawan, Lalit Dar, Pawan Malhotra
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
(2009)
Article
Pediatrics
Utkarsh Kohli, Sunil Saharan, Rakesh Lodha, S. K. Kabra
INDIAN JOURNAL OF PEDIATRICS
(2008)
Article
Pediatrics
Sunil Saharan, Rakesh Lodha, Ramesh Agarwal, Ashok K. Deorari, Vinod K. Paul
INDIAN JOURNAL OF PEDIATRICS
(2008)
Article
Pediatrics
Sunil Saharan, Rakesh Lodha, Sushil K. Kabra
INDIAN JOURNAL OF PEDIATRICS
(2010)
Article
Pediatrics
Sunil Saharan, Rakesh Lodha, Sushil K. Kabra
INDIAN JOURNAL OF PEDIATRICS
(2011)
Article
Pediatrics
Sunil Saharan, Rakesh Lodha, Sushil Kumar Kabra
INDIAN JOURNAL OF PEDIATRICS
(2010)
Article
Cardiac & Cardiovascular Systems
M. Mujeeb Zubair, David K. Bailly, Gurion Lantz, Rachel E. Sunstrom, Sunil Saharan, Lynn K. Boshkov, Paul Sochacki, A. Roger Hohimer, Michael R. Lasarev, Stephen M. Langley
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2015)
Article
Cardiac & Cardiovascular Systems
Sunil Saharan, Seshadri Balaji
ANNALS OF PEDIATRIC CARDIOLOGY
(2015)
