Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 31, Issue 12, Pages 1284-1285Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e3182737410
Keywords
Down syndrome; influenza A vaccination; H1N1
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We determined the response of 48 Down syndrome children to 2 doses of influenza A/H1N1 vaccination. Ninety-two percent of the children reached the previously defined protective level (hemagglutination-inhibition titer >= 1:40), but only 27% of the children reached the level of >= 1:110 which was recently described to predict the conventional 50% clinical protection rate in children. Further studies, and potentially adaptations of the schedule, are needed.
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