SINGLE-DOSE PHARMACOKINETICS AND TOLERABILITY OF DAPTOMYCIN 8 TO 10 MG/KG IN CHILDREN AGED 2 TO 6 YEARS WITH SUSPECTED OR PROVED GRAM-POSITIVE INFECTIONS

A pharmacokinetic analysis was performed for single intravenous doses of daptomycin 8 or 10 mg/kg in subjects aged 2 to 6 years. Proportional increases in maximum plasma concentration (68.4 mu g/mL, 79.2 mu g/mL) and area under the curve (429.1 mu g.h/mL, 549.7 mu g.h/mL) were observed for each dose cohort, respectively. Half-life, clearance, and distribution volume were similar between groups. Both doses were well tolerated.