Article
Immunology
Angelique E. Boutzoukas, Daniel A. Freedman, Christine Koterba, Garrett W. Hunt, Kathy Mack, Jennifer Cass, Vedat O. Yildiz, Emily de los Reyes, Jaime Twanow, Melissa G. Chung, Christopher P. Ouellette
Summary: La Crosse virus (LACV) is the most common neuroinvasive arboviral infection in children in the United States, but there is limited data on predictors of disease severity and neurologic outcomes. This study found that altered mental status and seizures at presentation were independent predictors of severe disease, and epileptiform discharges on electroencephalogram were associated with long-term epilepsy diagnosis. Long-term neurobehavioral issues were also found to be frequent among children with LACV-ND.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Cameron Cook, Annastashia Blesi, Samantha Brozak, Suzanne Lenhart, Hanna Reed, Cassandra Urquhart, Abelardo Moncayo, Rebecca Trout Fryxell
Summary: This study explores the transmission pathways and infection risks of La Crosse virus in Appalachia, using ordinary differential equation models to describe the relationship between insect population dynamics and environmental variables. The findings suggest that considering environmental factors such as daily temperature and accumulated precipitation can more accurately predict transmission risks, highlighting the importance of incorporating these variables into control strategies.
Article
Virology
Bradley S. Hollidge, Mary-Virginia Salzano, John M. Ibrahim, Jonathan W. Fraser, Valentina Wagner, Nicole E. Leitner, Susan R. Weiss, Friedemann Weber, Francisco Gonzalez-Scarano, Samantha S. Soldan
Summary: La Crosse virus (LACV) is a common pathogen in the United States that causes encephalitis and meningitis. The Gc glycoprotein of LACV plays a crucial role in the neuropathogenesis of encephalitis. The fusion peptide is identified as a determinant of neuroinvasion, but not neurovirulence. Targeting mutations in the fusion peptide could be a potential strategy for live-attenuated virus vaccines.
Article
Multidisciplinary Sciences
Benoit Arragain, Quentin Durieux Trouilleton, Florence Baudin, Jan Provaznik, Nayara Azevedo, Stephen Cusack, Guy Schoehn, Helene Malet
Summary: This study elucidates the structure and mechanisms of action of the La Crosse virus polymerase through cryo-electron microscopy, providing valuable insights for the future design of antiviral drugs against this virus.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Sara A. Thannickal, Sophie N. Spector, Kenneth A. Stapleford
Summary: Arthropod-borne viruses, including the La Crosse virus, pose a global public health threat. This study reveals that La Crosse virus uses a cholesterol-dependent entry mechanism similar to chikungunya virus and identifies specific amino acid residues in the Gc ij loop that are important for virus infectivity and replication. The findings contribute to understanding the mechanisms of La Crosse virus infection and provide potential targets for broad-spectrum antiviral drugs.
JOURNAL OF VIROLOGY
(2023)
Article
Virology
Maria A. Cruz, Griffith D. Parks
Summary: The study found significant differences between insect cell-derived LACV and human cell-derived virus, with insect cell-derived LACV depending on serum factors to enhance infectivity while human cell-derived LACV does not exhibit increased infectivity in serum. These findings highlight the importance of understanding the differential composition of insect versus animal cell-derived LACV for potential new antiviral approaches.
Article
Microbiology
Sarah N. Wilson, Krisangel Lopez, Sheryl Coutermash-Ott, Dawn Auguste, Danielle L. Porier, Philip M. Armstrong, Theodore G. Andreadis, Gillian Eastwood, Albert J. Auguste
Summary: This study compared four viral strains from different lineages and found that a representative strain from lineage I was the most lethal, with other strains showing excessive mortality in the suckling mouse neurovirulence model. The study also showed that within lineage III, viruses vary in pathogenesis with contemporaneous strains exhibiting reduced neuroinvasiveness compared to an ancestral strain from the same U.S. state (Connecticut). These findings highlight the importance of strain selection for assessing vaccine and therapeutic efficacies.
Article
Immunology
Rahul Basu, Vinod Nair, Clayton W. Winkler, Tyson A. Woods, Iain D. C. Fraser, Karin E. Peterson
Summary: The study found that BCECs isolated from adult and weanling mice have differential viral load, infectivity, and susceptibility to LACV. These age-related differences in susceptibility may strongly influence LACV-induced BBB leakage and neurovascular damage allowing virus invasion of the CNS and the development of neurological disease.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Physics, Multidisciplinary
Arsham Ghavasieh, Sebastiano Bontorin, Oriol Artime, Nina Verstraete, Manlio De Domenico
Summary: This study characterized the interactions between viral and human proteins using statistical physics techniques, revealing that COVID-19 exhibits properties typical of systemic diseases. The authors investigated the influence of SARS-CoV-2 viral proteins on the function of human cells through protein-protein interaction networks, providing a deeper understanding of COVID-19 and potential applications in drug repurposing. The comparison of molecular similarities between SARS-CoV-2 and other viruses allowed for predictions of potential effects of the novel coronavirus and identified unexpected similarities with viruses from distant families, indicating COVID-19 is a systemic disease with effects on multiple organs and sub-systems in the human body.
COMMUNICATIONS PHYSICS
(2021)
Article
Clinical Neurology
Hyoshin Son, Jun-Sang Sunwoo, Sang Kun Lee, Kon Chu, Soon-Tae Lee
Summary: This study investigated the clinical outcomes of laboratory-confirmed Japanese encephalitis (JE) patients who received combination treatment or supportive management. The results showed that combination therapy of immunoglobulin, ribavirin, and interferon-alpha 2b was tolerable and led to partial recovery in some patients, although adverse events were reported. Supportive management alone did not show significant improvement in patients with JE. Further studies with larger sample sizes are needed to evaluate the efficacy of combination therapy.
JOURNAL OF CLINICAL NEUROLOGY
(2021)
Article
Microbiology
Wan-Da Tang, Hai-Lin Tang, Hao-Ran Peng, Rui-Wen Ren, Ping Zhao, Lan-Juan Zhao
Summary: TBEV, a major zoonotic pathogen, causes severe encephalitis without specific antiviral drugs. Ribavirin shows antiviral effect against TBEV, inhibiting virus replication and protecting infected cells. Ribavirin could be a safe and effective antiviral drug against TBEV.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Entomology
Christie S. Darby, Kyah M. Featherston, Jingyi Lin, Alexander W. E. Franz
Summary: The vertical transmission potential of La Crosse virus (LACV) was investigated in two mosquito species, Ae. albopictus and Ae. aegypti. Productive midgut infection was essential for ovary infection in both species, although infection levels varied. LACV was found to be transmitted vertically from mothers to offspring at lower rates than typically described for transovarial transmission (TOT). The patterns of infection in the ovaries suggested transovum transmission rather than TOT in both mosquito species, although TOT potential was observed in Ae. albopictus.
Article
Public, Environmental & Occupational Health
Grace M. Vahey, Nicole P. Lindsey, J. Erin Staples, Susan L. Hills
Summary: La Crosse virus is a mosquito-transmitted virus that mainly affects children and causes encephalitis and meningitis. The virus is most commonly reported in the Great Lakes, mid-Atlantic, and southeastern regions of the United States. Surveillance data may underestimate the true incidence of LACV disease.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Parasitology
Eliza A. H. Little, Michael L. Hutchinson, Keith J. Price, Alyssa Marini, John J. Shepard, Goudarz Molaei
Summary: This study investigated the distribution, abundance, host interactions, and West Nile virus infection prevalence of Aedes albopictus and Aedes japonicus in Pennsylvania. The findings suggest that these mosquito species are extensively distributed, abundant, and frequently interact with mammalian hosts, potentially contributing to the transmission of arboviruses.
PARASITES & VECTORS
(2022)
Article
Infectious Diseases
Corey Allen Day, Agricola Odoi, Rebecca Tiffany Fryxell
Summary: The mosquito-borne La Crosse virus (LACV) is the leading cause of pediatric neuroinvasive disease in the United States. The study found a stable distribution of LACV neuroinvasive disease clusters from 2003 to 2021, with three persistent clusters in Appalachia and one intermittent cluster in the upper Midwest. Socioeconomic and demographic factors, such as race and household income, were associated with increased disease risk.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Anesthesiology
Nicholas West, J. Mark Ansermino, Roxane R. Carr, Karen Leung, Guohai Zhou, Gillian R. Lauder
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2015)
Review
Pharmacology & Pharmacy
Jennifer G. Kendrick, Roxane R. Carr, Mary H. H. Ensom
CLINICAL THERAPEUTICS
(2015)
Review
Pediatrics
Daniel Rainkie, Mary H. H. Ensom, Roxane Carr
Article
Education, Scientific Disciplines
Patricia Gerber, Roxane Carr
AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
(2013)
Article
Pharmacology & Pharmacy
Marc M. Perreault, Zoe Thiboutot, Lisa D. Burry, Louise Rose, Salmaan Kanji, Jaclyn M. LeBlanc, Roxane R. Carr, David R. Williamson
ANNALS OF PHARMACOTHERAPY
(2012)
Article
Medicine, General & Internal
Jeremy P. Daniels, Kate Hunc, D. Douglas Cochrane, Roxane Carr, Nicola T. Shaw, Annemarie Taylor, Susan Heathcote, Rollin Brant, Joanne Lim, J. Mark Ansermino
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2012)
Article
Pharmacology & Pharmacy
M. Seear, D. Gandhi, R. Carr, A. Dayal, D. Raghavan, N. Sharma
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2011)
Article
Pediatrics
Jennifer G. Kendrick, Mary H. H. Ensom, Andrew Steer, Colin T. White, Eddie Kwan, Roxane R. Carr
Article
Pediatrics
Iona Berger, Kathryn Haubrich, Mary H. H. Ensom, Roxane Carr
PEDIATRIC TRANSPLANTATION
(2019)
Editorial Material
Pediatrics
Paige H. Dean, Roxane Carr, Chris Jensen, Caron Strahlendorf
Summary: The role of a Drug Access Navigator (DAN) aims to expedite the process of patients obtaining drugs through various programs, especially in complex settings such as paediatrics. Introducing a DAN at BC Children's Hospital is expected to improve drug access efficiency in the pediatric population.
PAEDIATRICS & CHILD HEALTH
(2021)
Article
Allergy
Clara Levivien, Jennifer Kendrick, Roxane Carr
Summary: The study successfully assessed the validity, feasibility, and reliability of the Pediatric Asthma kNowleDge and mAnagement (PANDA) questionnaires through expert reviews and testing, confirming their effectiveness for use in research and practical applications.
Article
Oncology
Jennifer Kendrick, Lisa Jacques, Bjorn Baadjes, Roxane Carr
Summary: This study suggests that Lactated Ringers can be used instead of sodium bicarbonate for intravenous hydration during high-dose methotrexate, with similar rates of delayed clearance and adverse events.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jennifer Kendrick, Arielle Beauchesne, Yunji Valerie Lee, Sue Corrigan, Roxane Carr
Summary: The study found that conflict is common in the pharmacy preceptor-learner relationship, with preceptors and learners having different perspectives on the causes and outcomes of conflict. However, most individuals stated that they still felt comfortable working together after a conflict. Conflicts were typically caused by issues such as the learner's professionalism, knowledge/skills, communication, differing expectations, and teaching styles. Preceptors were more likely to take the initiative to resolve conflicts, with verbal communication being the preferred method for resolution by both parties.
CANADIAN JOURNAL OF HOSPITAL PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Donna Leung, Mary H. H. Ensom, Roxane Carr
CANADIAN JOURNAL OF HOSPITAL PHARMACY
(2019)
Article
Cardiac & Cardiovascular Systems
Carolina Escudero, Roxane Carr, Shubhayan Sanatani
PROGRESS IN PEDIATRIC CARDIOLOGY
(2013)