Article
Immunology
Satoshi Kamidani, Shikha Garg, Melissa A. Rolfes, Angela P. Campbell, Charisse N. Cummings, Julia C. Haston, Kyle P. Openo, Emily Fawcett, Shua J. Chai, Rachel Herlihy, Kimberly Yousey-Hindes, Maya L. Monroe, Sue Kim, Ruth Lynfield, Chad Smelser, Alison Muse, Christina B. Felsen, Laurie Billing, Ann Thomas, H. Keipp Talbot, William Schaffner, Ilene Risk, Evan J. Anderson
Summary: This study provides important population-based data on influenza-associated hospitalizations in US children. It highlights the higher rates of hospitalization and death among younger children, but also emphasizes the increased risk of severe outcomes among older children.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Alfredo Cruz-Lagunas, Tatiana Sofia Rodriguez-Reyna, Gustavo Ramirez-Martinez, Montserrat Sandoval-Vega, Diana Lizzeth Hernandez-Garcia, Eduardo M. Choreno-Parra, Yalbi I. Balderas-Martinez, Mariana Esther Martinez-Sanchez, Eduardo Marquez-Garcia, Edda Sciutto, Jose Moreno-Rodriguez, Jose Omar Barreto-Rodriguez, Hazel Vazquez-Rojas, Gustavo Ivan Centeno-Saenz, Nestor Alvarado-Pena, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, David Galeana-Cadena, Gabriela Hernandez, Criselda Mendoza-Milla, Andrea Dominguez, Julio Granados, Lula Mena-Hernandez, Luis Angel Perez-Buenfil, Guillermo Dominguez-Cheritt, Carlos Cabello-Gutierrez, Cesar Luna-Rivero, Jorge Salas-Hernandez, Patricio Santillan-Doherty, Justino Regalado, Angelica Hernandez-Martinez, Lorena Orozco, Federico Avila-Moreno, Ethel A. Garcia-Latorre, Carmen M. Hernandez-Cardenas, Shabaana A. Khader, Albert Zlotnik, Joaquin Zuniga
Summary: By comparing patients with COVID-19 and pandemic influenza A(H1N1), it was found that influenza patients had more severe respiratory symptoms, while COVID-19 patients more often experienced dry cough and gastrointestinal symptoms. The immune responses also differed between the two diseases, with pandemic influenza A(H1N1) characterized by higher levels of certain cytokines and COVID-19 displaying a distinct immune profile with increased Th1 and Th2 cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
W. Jon Windsor, Molly M. Lamb, Samuel R. Dominguez, Rakesh D. Mistry, Suchitra Rao
Summary: This study retrospectively analyzed data from 931 children and found that RSV, hMPV, and HRV/EV infections were associated with a higher risk of hospitalization, while RSV, parainfluenza, and atypical bacterial pathogen infections were associated with a longer duration of illness. Compared to other respiratory pathogens, RSV, hMPV, and atypical bacterial pathogen infections were more severe and had longer durations, while coinfection was not associated with increased illness severity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Gustavo Ramirez-Martinez, Montserrat Sandoval-Vega, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, Cesar Luna-Rivero, Erika Mariana Hernandez-Montiel, Luis Alejandro Fernandez-Lopez, Maria Fernanda Cabrera-Cornejo, Eduardo Misael Choreno-Parra, Alfredo Cruz-Lagunas, Andrea Dominguez, Eduardo Marquez-Garcia, Carlos Cabello-Gutierrez, Francina Valezka Bolanos-Morales, Lourdes Mena-Hernandez, Diego Delgado-Zaldivar, Daniel Rebolledo-Garcia, Parmenides Guadarrama-Ortiz, Nora E. Regino-Zamarripa, Criselda Mendoza-Milla, Ethel A. Garcia-Latorre, Tatiana Sofia Rodiguez-Reyna, Diana Cervantes-Rosete, Carmen M. Hernandez-Cardenas, Shabaana A. Khader, Albert Zlotnik, Joaquin Zuniga
Summary: The study found that serum levels of CXCL17 were increased only in patients with pandemic influenza A(H1N1), and its expression in lung tissue had specific patterns, while no similar observations were made in COVID-19 and TB patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Gregory Queromes, Emilie Frobert, Elena Burtseva, Anca Draganescu, Paravaiz A. Koul, Andrey Komissarov, V. Alberto Laguna-Torres, Jason Leblanc, F-Xavier Lopez-Labrador, Snezana Medic, Alla Mironenko, Nancy A. Otieno, Guillermo M. Ruiz-Palacios, M. Tanriover, Laurence Josset, Bruno Lina
Summary: The Global Influenza Hospital Surveillance Network (GIHSN) confirms its ability to provide valuable information on influenza infection dynamics in hospital settings through standardized data collection and analysis.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Geriatrics & Gerontology
Filippo Luca Fimognari, Diana Lelli, Francesco Landi, Raffaele Antonelli Incalzi
Summary: This study investigated the relationship between age and appropriateness of emergency department visits, and the mismatching between clinical severity in the emergency department and hospitalizations. The results showed that the appropriateness of emergency department visits increased with age, while the mismatching between clinical severity and hospitalizations decreased with age.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Immunology
Petra Mooij, Daniella Mortier, Aafke Aartse, Alexandre B. Murad, Ricardo Correia, Antonio Roldao, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman
Summary: Influenza-naive cynomolgus macaques were immunized with virus-like particles (VLPs) displaying different hemagglutinin (HA) antigens from seasonal H1N1 strains. Subsequent infection with pandemic H1N1 (H1N1pdm09) resulted in increased immune response against intermediate antigenic variants but not against all H1N1 vaccine strains.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Daiva Radzisauskiene, Monika Vitkauskaite, Karolina Zvinyte, Ruta Mameniskiene
Summary: The study described a case series of influenza A-associated neurological complications, with a low incidence rate of influenza-associated neurological complications in hospitalized patients in 2019 at 1.9%. The findings suggest that during influenza epidemics, patients with unexplained neurological symptoms resembling aseptic and septic meningitis/encephalitis should be tested for influenza virus.
BRAIN AND BEHAVIOR
(2021)
Article
Immunology
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Summary: Despite the use of vaccines and anti-viral drugs, influenza A virus still poses a significant epidemic risk to global public health. Through single-cell transcriptome analyses, we have identified the high heterogeneity of susceptibility to viral infection and biological responses in different subsets of CD4(+) T and CD8(+) T cells. Effector memory CD8(+) T cells (CD8(+) T-EM) were found to be the most susceptible subset to pandemic influenza A virus infection among primary human T cells. Non-productive infection was established in CD8(+) T-EM and naive CD8(+) T cells, indicating the mechanisms of intracellular antiviral activities in human T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Medicine, General & Internal
Ying-Ju Chen, Chun-Yu Chen, En-Pei Lee, Wun-Yan Huang, Han-Ping Wu
Summary: This study compared the epidemiology and clinical characteristics of pediatric emergency department (PED) visits before and after the COVID-19 outbreak. The results showed a significant decline in PED visits during the pandemic, with a shift in the most common diseases from infectious diseases to digestive system diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Management
Emilio Gutierrez, Adrian Rubli
Summary: This study examines the impact of hospital congestion on in-hospital mortality using data from a large public hospital system in Mexico, leveraged the shock in hospitalizations induced by the 2009 H1N1 pandemic, and found that congestion led to an increase in non-ARI in-hospital mortality. The effects were nonlinear in the size of the local outbreak, and supply-side policies such as improving patient assignment and strategically increasing hospital capacity could mitigate some of the negative impacts.
MANAGEMENT SCIENCE
(2021)
Article
Virology
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanne Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy
Summary: Research demonstrates that utilizing combinations of conserved antigens of influenza A virus, such as NP and various forms of M2e, can generate broad immune protection in mice, reducing lung viral burden and weight loss.
Article
Public, Environmental & Occupational Health
Florence Cote, Guy Boivin, Vilayvong Loungnarath, Annie Ruest, Julie Bestman-Smith, Julie Carbonneau, Marie-Eve Hamelin, Marie-Claude Roy
Summary: This study describes 10 COVID-19 patients with severe symptoms who were treated with tocilizumab and dexamethasone. The duration of isolation, which exceeded 21 days for 7 patients, was correlated with the Ct values of nucleic acid amplification tests, clinical condition, and viral culture results.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Infectious Diseases
Joan Robinson, Tammie Dewan, Shaun K. Morris, Ari Bitnun, Peter Gill, Tala El Tal, Ronald M. Laxer, E. Ann Yeh, Carmen Yea, Rolando Ulloa-Gutierrez, Helena Brenes-Chacon, Adriana Yock-Corrales, Gabriela Ivankovich-Escoto, Alejandra Soriano-Fallas, Marcela Hernandez-de Mezerville, Jesse Papenburg, Marie-Astrid Lefebvre, Alireza Nateghian, Behzad Haghighi Aski, Ali Manafi, Rachel Dwilow, Jared Bullard, Suzette Cooke, Lea Restivo, Alison Lopez, Manish Sadarangani, Ashley Roberts, Nicole Le Saux, Jennifer Bowes, Rupeena Purewal, Janell Lautermilch, Jacqueline K. Wong, Dominique Piche, Karina A. Top, Cheryl Foo, Luc Panetta, Joanna Merckx, Michelle Barton
Summary: This study describes the clinical course and outcomes in children with technology dependence (TD) hospitalized with SARS-CoV-2 infection. The results show that children with TD have an increased risk of COVID-19 hospitalization, but all patients were discharged home in the absence of end-stage chronic conditions.
Article
Clinical Neurology
Carmen Yea, Michelle Barton, Ari Bitnun, Shaun K. Morris, Tala El Tal, Rolando Ulloa-Gutierrez, Helena Brenes-Chacon, Adriana Yock-Corrales, Gabriela Ivankovich-Escoto, Alejandra Soriano-Fallas, Marcela Hernandez-de Mezerville, Peter Gill, Alireza Nateghian, Behzad Haghighi Aski, Ali Anari Manafi, Rachel Dwilow, Jared Bullard, Jesse Papenburg, Rosie Scuccimarri, Marie-Astrid Lefebvre, Suzette Cooke, Tammie Dewan, Lea Restivo, Alison Lopez, Manish Sadarangani, Ashley Roberts, Jacqueline Wong, Nicole Le Saux, Jennifer Bowes, Rupeena Purewal, Janell Lautermilch, Cheryl Foo, Joanna Merckx, Joan Robinson, E. Ann Yeh
Summary: This multicenter observational study aimed to describe the characteristics and prevalence of neurological involvement in hospitalized pediatric patients with SARS-CoV-2. The results showed that approximately 21% of hospitalized children had neurological signs/symptoms, with headache, encephalopathy, and seizures being the most reported. Factors associated with neurological involvement included ICU admission, satisfaction of MIS-C criteria, fever during hospitalization, and gastrointestinal involvement.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Editorial Material
Medicine, General & Internal
Maude Paquette, Christian Renaud, Jesse Papenburg
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2023)
Article
Immunology
Yvette N. N. Lowensteyn, Joukje E. E. Willemsen, Natalie I. I. Mazur, Nienke M. M. Scheltema, Nynke C. J. van Haastregt, Amber A. A. ten Buuren, Ichelle van Roessel, Dunja Scheepmaker, Harish Nair, Peter M. M. van de Ven, Louis J. J. Bont
Summary: This study provides the first global case series of children dying with nosocomial RSV infection. Infant-targeted immunization strategies in the future could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in low- and lower-middle-income countries (LMICs), the reported number of these deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pediatrics
Aidan Pucchio, Maya Heled Akiva, Helena Evangeliou, Jesse Papenburg, Marina Salvadori
Summary: This article presents a pediatric case of severe rhabdomyolysis following COVID-19 mRNA vaccination. The patient experienced muscle pain and dark urine after vaccination, and was diagnosed with rhabdomyolysis. With treatment, the patient recovered well.
PEDIATRIC NEPHROLOGY
(2023)
Letter
Pediatrics
Marina I. Salvadori, Aidan Pucchio, Maya Heled Akiva, Helena Evangeliou, Jesse Papenburg
PEDIATRIC NEPHROLOGY
(2023)
Editorial Material
Medicine, General & Internal
Maude Paquette, Christian Renaud, Jesse Papenburg
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2023)
Article
Infectious Diseases
Kate Zinszer, Katia Charland, Laura Pierce, Adrien Saucier, Britt McKinnon, Marie-eve Hamelin, Islem Cheriet, Margot Barbosa Da Torre, Julie Carbonneau, Cat Tuong Nguyen, Gaston De Serres, Jesse Papenburg, Guy Boivin, Caroline Quach
Summary: This study aimed to assess the seroprevalence, seroconversion, and seroreversion of infection-induced SARS-CoV-2 antibodies in children and adolescents in Montreal, Canada. The results showed an increasing trend in infection rates among children during the study period, with higher rates observed in females, racial or ethnic minorities, and low-income households. The likelihood of remaining seropositive at 6 months and 1 year after infection was 68% and 42% respectively. Serological studies are important for estimating infection prevalence and understanding the dynamics of antibody levels after infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Deidre Wilkins, Annefleur C. Langedijk, Robert Jan Lebbink, Christopher Morehouse, Michael E. Abram, Bahar Ahani, Anastasia A. Aksyuk, Eugenio Baraldi, Tyler Brady, Albert Tian Chen, Hsin Chi, Eun Hwa Choi, Robert Cohen, Daria M. Danilenko, Vancheswaran Gopalakrishnan, Anne Greenough, Terho Heikkinen, Mitsuaki Hosoya, Christian Keller, Elizabeth J. Kelly, Leyla Kragten-Tabatabaie, Federico Martinon-Torres, Abiel Homero Mascarenas de los Santos, Marta C. Nunes, Maria Angelica Palomino, Jesse Papenburg, Jeffrey M. Pernica, Peter Richmond, Renato Stein, Kevin M. Tuffy, Charl Verwey, Mark T. Esser, David E. Tabor, Louis J. Bont, INFORM RSV Study Grp
Summary: This study evaluated the geotemporal distribution of RSV A and RSV B between 2015 and 2021 and functionally characterized the nirsevimab binding-site substitutions during this period. The results showed that the nirsevimab binding site remained highly conserved, with only a few rare mutations affecting nirsevimab neutralization emerging between 2016 and 2021. The genetic diversity of RSV fusion protein was lower compared to influenza hemagglutinin and SARS-CoV-2 spike proteins.
LANCET INFECTIOUS DISEASES
(2023)
Letter
Medicine, General & Internal
William J. Muller, Shabir A. Madhi, Beatriz Seoane Nunez, Manuel Baca Cots, Miroslava Bosheva, Ron Dagan, Laura L. Hammitt, Conrado J. Llapur, Jose M. Novoa, Xavier Saez Llorens, Amy Grenham, Elizabeth J. Kelly, Vaishali S. Mankad, Manish Shroff, Therese Takas, Amanda Leach, Tonya Villafana
Summary: Nirsevimab, a monoclonal antibody, effectively prevents hospitalization and severe lower respiratory tract infection in term and late-preterm infants caused by respiratory syncytial virus (RSV).
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Emily Boucher, Christian Cao, Sean D'Mello, Nathan Duarte, Claire Donnici, Natalie Duarte, Graham Bennett, Anil SeroTracker Consortium, Anil Adisesh, Rahul Arora, David Kodama, Niklas Bobrovitz
Summary: This study synthesised and described SARS-CoV-2 seroprevalence studies by occupation before the widespread vaccine roll-out. The results showed significant differences in seroprevalence between occupations, but most studies had small sample sizes and high risk of bias. More high-quality studies are needed to improve our understanding of the occupational risk of SARS-CoV-2.
Article
Public, Environmental & Occupational Health
Abdulla Alfraij, Ahmed Abdelmoniem, Mohamed Elseadawy, Mohammad Surour, Mohamed Basuni, Jesse Papenburg, Mohammad Alghounaim
Summary: This study aimed to evaluate the impact of telehealth antimicrobial stewardship program (ASP) on the rate of antimicrobial use in pediatric intensive care units (PICU), and found that it significantly decreased antimicrobial use.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Microbiology
Amel Saim-Mamoun, Julie Carbonneau, Chantal Rheaume, Yacine Abed, Guy Boivin
Summary: Baloxavir, the latest antiviral drug approved against seasonal influenza A and B viruses, shows low resistance against the PA-I38T substitution. This study evaluates the impact of this substitution on the fitness of contemporary influenza B viruses. The results indicate that influenza B viruses with the PA-I38T mutation may retain a significant level of fitness, emphasizing the importance of monitoring the emergence of such variant.
Article
Infectious Diseases
Tilmann Schober, Shaun K. Morris, Julie A. Bettinger, Christina Bancej, Catherine Burton, Cheryl Foo, Scott A. Halperin, Taj Jadavji, Kescha Kazmi, Jacqueline Modler, Manish Sadarangani, Jesse Papenburg
Summary: This study evaluated immunocompromising conditions and subgroups of immunocompromise as risk factors for severe outcomes among children admitted for influenza. The results showed that immunocompromised children had a decreased risk of ICU admission, mechanical ventilation, and mortality. Therefore, immunocompromised children require special attention and protection.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)