Article
Pharmacology & Pharmacy
Manuel Rey-Funes, Daniela S. Contartese, Rafael Pelaez, Josune Garcia-Sanmartin, Judit Narro-Iniguez, Manuel Solino, Juan Carlos Fernandez, Anibal Sarotto, Nicolas S. Ciranna, Juan Jose Lopez-Costa, Veronica B. Dorfman, Ignacio M. Larrayoz, C. Fabian Loidl, Alfredo Martinez
Summary: Hypothermia has a protective effect on the retina in rat models of perinatal asphyxia, correcting abnormalities in electroretinogram and reducing retinal cell apoptosis. Expression of cold-shock proteins is upregulated in hypothermia treated groups, suggesting a potential mechanism for preventing vision disabling sequelae related to asphyxia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Manuel Rey-Funes, Juan Carlos Fernandez, Rafael Pelaez, Manuel Solino, Daniela S. Contartese, Nicolas S. Ciranna, Ronan Nakamura, Anibal Sarotto, Veronica B. Dorfman, Jose M. Zapico, Ana Ramos, Beatriz de Pascual-Teresa, Juan Jose Lopez-Costa, Ignacio M. Larrayoz, Alfredo Martinez, Cesar Fabian Loidl
Summary: The study found that zr17-2 had similar effects to hypothermia in treating asphyctic rats, improving parameters of electroretinography, reducing apoptotic cell numbers, and correcting morphological parameters of the retina. Injection of this small molecule did not have toxicity in the absence of asphyxia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pediatrics
Chiara Maddaloni, Domenico Umberto De Rose, Marco Perulli, Ludovica Martini, Iliana Bersani, Francesca Campi, Immacolata Savarese, Andrea Dotta, Maria Paola Ronchetti, Cinzia Auriti
Summary: This study compared the levels of presepsin in plasma and urine between newborn infants with perinatal asphyxia and controls. The results showed that the levels of presepsin in blood and urine were consistent in neonates with perinatal asphyxia at any time point. Additionally, perinatal asphyxia was found to increase the levels of serum CRP and procalcitonin.
Article
Pediatrics
Kasper J. Kyng, Sigrid Kerrn-Jespersen, Kristine Bennedsgaard, Torjus Skajaa, Michael Pedersen, Ida E. Holm, Tine B. Henriksen
Summary: The study indicated that RIPC could reduce brain lactate/N-acetylaspartate ratios at 72 hours after HI, but had no effect on diffusion-weighted imaging, neuropathology scores, neurological recovery, or mortality. RIPC may have a selective metabolic effect by ameliorating lactate accumulation without improving other short-term outcomes.
PEDIATRIC RESEARCH
(2021)
Article
Endocrinology & Metabolism
James DS. Aridas, Tamara Yawno, Amy E. Sutherland, Ilias Nitsos, Flora Y. Wong, Rod W. Hunt, Michael Ditchfield, Michael C. Fahey, Atul Malhotra, Euan M. Wallace, Alistair J. Gunn, Graham Jenkin, Suzanne L. Miller
Summary: This study found that combined use of TH and MLT for neonatal encephalopathy in newborn lambs provides significantly greater neuroprotection than either treatment alone.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Andrei Munteanu, Aniko-Maria Manea, Cristian Marius Jinca, Marioara Boia
Summary: Perinatal hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal death or long-term disability. Inflammation plays a crucial role in mediating brain damage caused by HIE. The predictive value of peak lactate dehydrogenase (LDH), C-reactive protein (CRP), procalcitonin (PCT) and the evolution of leukocytes, neutrophils and lymphocytes in the first 96 hours after birth for the grade of encephalopathy and neurodevelopmental outcome in newborns with HIE is being extensively researched.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Multidisciplinary Sciences
Kim V. Annink, Linda S. de Vries, Floris Groenendaal, Rian M. J. C. Eijsermans, Manouk Mocking, Monique M. J. van Schooneveld, Jeroen Dudink, Henrica L. M. van Straaten, Manon J. N. L. Benders, Maarten Lequin, Niek E. van der Aa
Summary: In children with HIE, neurocognitive and memory problems are common at school-age, regardless of therapeutic hypothermia. Hippocampal volumes and MB atrophy are linked to various aspects of cognitive function, and normal MB and larger hippocampi are associated with higher global fractional anisotropy. Injury to the MB and hippocampi may serve as early biomarkers for neurocognitive and memory issues in children with HIE.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Sudhin Thayyil, Paolo Montaldo, Vaisakh Krishnan, Phoebe Ivain, Stuti Pant, Peter J. Lally, Prathik Bandiya, Naveen Benkappa, Chinnathambi N. Kamalaratnam, Rema Chandramohan, Swati Manerkar, Jayshree Mondkar, Ismat Jahan, Sadeka C. Moni, Mohammod Shahidullah, Ranmali Rodrigo, Samanmali Sumanasena, Radhika Sujatha, Constance Burgod, Reema Garegrat, Munirah Mazlan, Ismita Chettri, Sathyanathan Babu Peter, Anagha R. Joshi, Ravi Swamy, Kling Chong, Ronit R. Pressler, Paul Bassett, Seetha Shankaran
Summary: This study investigated the association between place of birth and the efficacy of whole-body hypothermia for protection against brain injury in neonates with hypoxic-ischemic encephalopathy. The findings showed that whole-body hypothermia did not reduce brain injury in neonates born in South Asia, regardless of their place of birth. Therefore, the use of whole-body hypothermia for hypoxic-ischemic encephalopathy in low- and middle-income countries is not supported.
Review
Hematology
Marina Tsaousi, Zoi Iliodromiti, Nicoletta Iacovidou, Eleni Karapati, Alma Sulaj, Andreas G. Tsantes, Chrysa Petropoulou, Theodora Boutsikou, Argirios E. Tsantes, Rozeta Sokou
Summary: Birth asphyxia can lead to multiorgan dysfunction, including coagulation disorders. Standard coagulation tests provide a rough estimation of the bleeding or thrombotic risk in hypoxic neonates, while viscoelastic methods seem to be more precise. Further research is needed to determine the most appropriate coagulation assays for diagnosis and management of coagulation derangement in neonates with perinatal hypoxia.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Pediatrics
Vishnu-Priya Akula, Achyuth Sriram, Sherian Xu, Eileen Walsh, Krisa Van Meurs, Matthew Cranshaw, Michael Kuzniwiecz
Summary: Mild neonatal encephalopathy may lead to adverse short- and long-term outcomes, including developmental disorders and motor and speech delay. The group with mild encephalopathy had significantly higher rates of adverse outcomes compared to the unexposed group.
PEDIATRIC RESEARCH
(2023)
Review
Pediatrics
Marina-Stefania Stroe, Lieselotte Van Bockstal, Allan Valenzuela, Miriam Ayuso, Karen Leys, Pieter Annaert, Sebastien Carpentier, Anne Smits, Karel Allegaert, Adrian Zeltner, Antonius Mulder, Chris Van Ginneken, Steven Van Cruchten
Summary: Animal models provide valuable information on human disease mechanisms and (patho)physiological factors affecting drug development. Nonclinical data is critical for understanding pediatric disease conditions and developing new drug therapies. This study aimed to develop a neonatal Gottingen Minipig model for investigating the impact of systemic hypoxia and therapeutic hypothermia on drug disposition in perinatal asphyxia.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Kylie A. Corry, Olivia R. White, AnnaMarie E. Shearlock, Daniel H. Moralejo, Janessa B. Law, Jessica M. Snyder, Sandra E. Juul, Thomas R. Wood
Summary: In a ferret model of inflammation-sensitized hypoxic-ischemic brain injury, uridine monophosphate and therapeutic hypothermia did not provide meaningful neuroprotection, with uridine monophosphate appearing to worsen outcomes. In contrast, erythropoietin showed significant neuroprotection in this model, although not complete.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Banu Aydin, Nurullah Okumus, Mehmet Burak Ozkan, Aysegul Zenciroglu, Dilek Dilli, Serdar Beken
Summary: Therapeutic hypothermia seems to help restore renal blood flow and kidney functions during the neonatal adaptive period with its neuroprotective properties.
PEDIATRIC NEPHROLOGY
(2023)
Article
Obstetrics & Gynecology
Toshiyuki Imanishi, Masaki Shimizu, Wakako Sumiya, Chika Kanno, Masayuki Kanno, Masami Kanno, Ken Kawabata
Summary: This study evaluated abnormal MRI findings in neonates with mild hypoxic-ischemic encephalopathy and found that a discontinuous amplitude-integrated electroencephalography pattern is associated with abnormal MRI results.
JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Joanna R. G. Vijverberg, Enrico Lopriore, Arjan B. te Pas, Monique Rijken, Erik W. van Zwet, Francisca T. de Bruine, Sylke J. Steggerda
Summary: Therapeutic hypothermia in neonates with perinatal asphyxia may increase the risk of PPHN, but it is usually reversible and does not lead to an overall increase in adverse outcomes. However, in individual cases, deterioration of PPHN occurs rapidly.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Critical Care Medicine
Aybuke Yazici, Gulsum Kadioglu Simsek, Serhan Elbayiyev, Fuat Emre Canpolat, Hayriye Gozde Kanmaz Kutman
Summary: This study aimed to evaluate the impact of asphyxia and therapeutic hypothermia on thyroid function in neonates with hypoxic ischemic encephalopathy. The results suggest that therapeutic hypothermia may cause alterations in thyroid function tests, and repeat TSH screening after hypothermia may be necessary.
THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
(2023)
Article
Clinical Neurology
Burak Ceran, Hayriye Gozde Kanmaz Kutman, Rana Beyoglu, Gulsum Kadioglu Simsek, Sarkhan Elbayiyev, Fuat Emre Canpolat
Summary: The study aimed to investigate the ONSD measurements and cerebral blood flows in neonates with HIE. The results showed that the RI and PI of the middle cerebral artery were significantly lower in the HIE group compared to the control group. Ultrasonographic ONSD measurements showed high compatibility with MRI measurements.
CHILDS NERVOUS SYSTEM
(2023)
Article
Obstetrics & Gynecology
Sarkhan Elbayiyev, Gulsum Kadioglu Simsek, Omer Ertekin, Sehribanu Isik, Hayriye Gozde Kanmaz Kutman, Fuat Emre Canpolat
Summary: Therapeutic hypothermia treatment has an effect on inflammatory markers CRP and IL-6 in infants with HIE, leading to an increase in CRP and decrease in IL-6 and white blood cell count. The influence of hypoxia and hypothermia should be considered when evaluating acute phase reactants.
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
(2022)
Correction
Obstetrics & Gynecology
Sarkhan Elbayiyev, Gulsum Kadioglu Simsek, Omer Ertekin, Sehribanu Isik, Hayriye Gozde Kanmaz Kutman, Fuat Emre Canpolat
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
(2022)
Article
Pathology
Duygu Tugrul Ersak, Ozgur Kara, Kadriye Yakut, Aytekin Tokmak, Cem Yasar Sanhal, Aykan Yucel, Dilek Sahin
Summary: This study found that platelet indices, including MPV and PLR, were lower and PDW was higher in patients with placental abruption (PA) in its early stages, suggesting that these parameters might be useful for the diagnosis of PA.
FETAL AND PEDIATRIC PATHOLOGY
(2023)
Article
Obstetrics & Gynecology
Atakan Tanacan, Deniz Oluklu, Bergen Laleli Koc, Selcan Sinaci, Dilek Menekse Beser, Derya Uyan Hendem, Muradiye Yildirim, Bedri Sakcak, Berhan Besimoglu, Duygu Tugrul Ersak, Betul Akgun Aktas, Esra Gulen Yildiz, Serpil Unlu, Ozgur Kara, Evrim Alyamac Dizdar, Fuat Emre Canpolat, Ihsan Ates, Ozlem Moraloglu Tekin, Dilek Sahin
Summary: The aim of this study was to investigate the association between the systemic immune-inflammation index (SII) and the systemic immune-response index (SIRI) with adverse perinatal outcomes in pregnant women with COVID-19. The results showed that both SII and SIRI were significantly higher in complicated cases. The researchers also identified optimal cutoff values for SII and SIRI in predicting the severity of COVID-19, pregnancy complications, NICU admission, and maternal mortality.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Pediatrics
Huseyin Ustun, Mehmet Yekta Oncel, Melike Kefeli, Melek Akar, Defne Enguer
Summary: The present study aimed to evaluate the feasibility and reliability of a smartphone application for monitoring bilirubin levels in preterm infants. The results showed that using the BiliScan smartphone application had a certain correlation with other traditional monitoring methods in preterm infants, but the correlation was lower compared to term infants. Therefore, the results should be interpreted with caution in preterm infants.
KLINISCHE PADIATRIE
(2023)
Article
Clinical Neurology
Gokce Tanyeri Toker, Yusuf Cagdas Kumbul, Ali Emre Cetinkol, Hale Aslan, Pinar Baba, Mehmet Yekta Oncel
Summary: The objective of this study was to investigate the association between COVID-19 during pregnancy and congenital hearing loss. A retrospective cohort study was conducted on 60,223 newborns, and it was found that the gestational COVID-19 group had a higher incidence of hearing loss compared to the control group. However, no significant difference was observed in the third screening test conducted within the first 30 days of life. Therefore, gestational COVID-19 may not be a risk factor for permanent congenital hearing loss.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Pathology
Duygu Tugrul Ersak, Hakki Serbetci, Bergen Laleli Koc, Ozgur Kara, Seyma Butun Turk, Guelsuem Kadioglu Simsek, Fuat Emre Canpolat, Oezlem Moraloglu Tekin, Dilek Sahin
Summary: In this study, we evaluated the association between placental pathologies and adverse preterm births. We found that fetal vascular lesions, inflammatory responses other than histological chorioamnionitis (HCA), and placentas with combined maternal vascular malperfusion (MVM) and HCA were excluded. Out of the 772 placentas evaluated, those with MVM only had a higher risk of early neonatal sepsis, retinopathy of prematurity, necrotizing enterocolitis, and neonatal death compared to those with HCA only. The frequency of bronchopulmonary dysplasia (BPD) was significantly higher in the HCA-only group compared to the MVM-only group, and HCA was identified as an independent risk factor for BPD.
FETAL AND PEDIATRIC PATHOLOGY
(2023)
Article
Pediatrics
Hayriye Gozde Kanmaz Kutman, Gulsum Kadioglu Simsek, Burak Ceran, Esra Beser, Fuat Emre Canpolat
Summary: The study aimed to assess troponin I, CK-MB, and IS as markers for disease severity and predictors of mortality in HIE patients. The results showed that troponin I and IS could be successfully used as markers for disease severity and good predictors of mortality in HIE patients.
Review
Pediatrics
Istemi Han Celik, Aslinur Ozkaya Parlakay, Fuat Emre Canpolat
Summary: COVID-19 in pregnancy has negative outcomes for both mother and fetus, including vertical transmission and in-utero infection. The management of neonates born from infected mothers has changed as knowledge about the virus progressed. Data now supports returning to pre-pandemic practices for prenatal, delivery room, and postnatal care.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, General & Internal
Melek Akar, Gulsah Cetin, Mine Inal Akkaya, Mehmet Helvaci, Nihal Olgac Dundar, Firat Ergin, Ozgun Uygur, Sinem Akbay, Nail Ozdemir, Meltem Koyuncu Arslan, Mehmet Yekta Oncel
Summary: This study aimed to evaluate the neurodevelopmental outcomes of neonates with myelomeningocele (MMC) operated in the postnatal period. The study compared the neurodevelopmental outcomes of MMC patients with healthy term newborns using the Bayley Scales of Infant and Toddler Development-Third Edition (BSID III) at 12-18 months. The study found that MMC patients requiring ventriculoperitoneal shunt had significantly worse neurodevelopmental prognosis in the postnatal period, and patients who underwent surgery within 72 hours had better neurodevelopmental outcomes.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Burak Ceran, Gulsum Kadioglu Simsek, Esra Beser, Cuneyt Tayman, Fuat Emre Canpolat, Hayriye Goezde Kanmaz Kutman
Summary: This study aimed to investigate the clinical utility of serum 132-M levels in predicting broncho-pulmonary dysplasia (BPD) in preterm infants. The results showed that infants in the BPD group had significantly higher levels of 132-M compared to the non-BPD group, and there was a weak correlation between serum 132-M levels and BPD. Therefore, monitoring 132-M levels in high-risk preterm infants who may develop BPD could provide additional benefit in predicting BPD occurrence.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
Article
Pediatrics
Sevinc Odabasi Gunes, Erhan Calisici, Mutluay Arslan, Onur Akin, Belma Saygili Karagol
Summary: Neonatal diabetes mellitus is a common genetic disease that needs to be considered when epileptic seizures occur in early life. Patients with ABCC8 mutations may present with neurodevelopmental changes and epileptic seizures, in addition to the typical features.
JOURNAL OF PEDIATRIC GENETICS
(2023)
Meeting Abstract
Pediatrics
Nagihan Ciftci Pinar, Umut Selda Bayrakci, Serife Suna Oguz
PEDIATRIC NEPHROLOGY
(2022)