Article
Gastroenterology & Hepatology
Jing Zeng, Feng Shen, Zi-Yuan Zou, Rui-Xu Yang, Qian Jin, Jing Yang, Guang-Yu Chen, Jian-Gao Fan
Summary: This study suggests that maternal obesity may increase the risk of overweight/obesity and fatty liver in offspring, and the presence of gestational diabetes mellitus (GDM) also increases the risk of overweight/obesity in offspring. Weight management and glycemic control before and during pregnancy need to be emphasized in the primary prevention of pediatric obesity and fatty liver.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, Research & Experimental
Qi Liu, Wei Xia, Xin Xiong, Ju-Xiao Li, Ying Li, Shun-Qing Xu, Yuan-Yuan Li
Summary: This study found that gestational diabetes mellitus (GDM) and excessive gestational weight gain (GWG) have different effects on offspring growth in early childhood. Excessive GWG is positively associated with the risk of offspring overweight/obesity, while the status of GDM is not significantly associated with the risk. The interactive effect of these risk factors may vary by sex.
CURRENT MEDICAL SCIENCE
(2022)
Review
Nutrition & Dietetics
Shan Wu, Jiani Jin, Kai-Lun Hu, Yiqing Wu, Dan Zhang
Summary: This study aimed to evaluate the optimal intervention strategy to prevent gestational diabetes mellitus (GDM) and restrict gestational weight gain (GWG) among overweight/obese pregnant women. The results showed that PA and diet + PA interventions had a trend of preventing GDM, and interventions of diet, PA, and diet + PA were significant factors to restrict GWG. Overall, a combination of diet and physical activity intervention seemed to be the superior choice for both GDM prevention and excessive GWG.
Review
Endocrinology & Metabolism
Sara Farhat, Mahboobeh Hemmatabadi, Hanieh-Sadat Ejtahed, Nooshin Shirzad, Bagher Larijani
Summary: Gestational diabetes mellitus (GDM) is associated with alterations in the microbiome of pregnant women and their offspring. Despite inconsistencies in study results, significant changes were observed in the gut, oral, vaginal microbiome of women with GDM and their offspring, suggesting the need for further research to address confounding factors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ming Gao, Shu Cao, Ninghua Li, Jinnan Liu, Yuanjun Lyu, Jing Li, Xilin Yang
Summary: The meta-analysis found that offspring of women with gestational diabetes mellitus (GDM) were at an increased risk for overweight as they aged, with the risk gradually rising. However, lifestyle interventions for GDM did not reduce the elevated overweight risk. These findings emphasize the importance of adopting an active and healthy lifestyle in this high-risk group.
Article
Genetics & Heredity
Bachuki Shashikadze, Florian Flenkenthaler, Jan B. Stoeckl, Libera Valla, Simone Renner, Elisabeth Kemter, Eckhard Wolf, Thomas Froehlich
Summary: Maternal diabetes can have a significant impact on the health of offspring, potentially leading to increased birth weight and metabolic disorders in later life, making early diagnosis and prevention challenging. Omics technologies allow comprehensive investigation of the effects of maternal diabetes on offspring and may help identify diagnostic biomarkers and support the development of preventive and therapeutic strategies.
Article
Endocrinology & Metabolism
Catherine Kim, Kylie K. Harrall, Deborah H. Glueck, Belinda L. Needham, Dana Dabelea
Summary: This study found that children exposed to GDM experience greater extrinsic EAA, which is associated with lower insulin sensitivity and greater insulin secretion. These associations persisted even after further adjustment for measures of maternal and child adiposity.
Article
Psychology, Multidisciplinary
Jing He, Kaili Hu, Cui Xing, Binghua Wang, Tieying Zeng, Hui Wang
Summary: This qualitative study aimed to understand the puerperium experience and lifestyle of women with overweight/obesity and gestational diabetes mellitus (GDM). The study found that unhealthy lifestyles, misconceptions about food, conflicts between physical activity and confinement behavior, lack of social and family support, and low awareness of disease risk are common among these women. The researchers emphasized the importance of continuous preventive care from pregnancy to postpartum and promoting long-term health in high-risk populations with a history of GDM associated with overweight/obesity.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Obstetrics & Gynecology
Xiao-guang Yin, Peng Wang, Mei-ting Zhou, De-qin Li, Rui-xue Tao, Fang-biao Tao, Yang Wang, Peng Zhu
Summary: The timing of gestational diabetes mellitus (GDM) diagnosis and gestational weight gains (GWG) during pregnancy are associated with the growth trajectory of children from perinatal to early childhood. GDM diagnosed before 26 weeks increases the risk of fetal overgrowth and higher birth weight, as well as higher BMI peak within 48 months. Maternal early GDM diagnosis and excessive gestational weight gains have additive impacts on offspring overgrowth, with higher levels of hsCRP observed in the early EGWG group.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Multidisciplinary Sciences
Sanna Mustaniemi, Elina Keikkala, Eero Kajantie, Markku Nurhonen, Antti Jylha, Laure Morin-Papunen, Hanna Ohman, Tuija Mannisto, Hannele Laivuori, Johan Eriksson, Reijo Laaksonen, Marja Vaarasmaki
Summary: This study suggests that the concentrations of four ceramides in early pregnancy are associated with the development of gestational diabetes. The highest quartiles of ceramide concentrations, along with high levels of triglycerides and LDL, are independent predictors of GDM.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Brenda Eskenazi, Stephen Rauch, Enrico Iurlaro, Robert B. Gunier, Albertina Rego, Michael G. Gravett, Paolo Ivo Cavoretto, Philippe Deruelle, Perla K. Garcia-May, Mohak Mhatre, Mustapha Ado Usman, Mohamed Elbahnasawy, Saturday Etuk, Raffaele Napolitano, Sonia Deantoni, Becky Liu, Federico Prefumo, Valeria Savasi, Patricia F. Marques, Eric Baafi, Ghulam Zainab, Ricardo Nieto, Berta Serrano, Muhammad Baffah Aminu, Jorge Arturo Cardona-Perez, Rachel Craik, Adele Winsey, Gabriela Tavchioska, Babagana Bako, Daniel Oros, Caroline Benski, Hadiza Galadanci, Monica Savorani, Manuela Oberto, Loic Sentilhes, Milagros Risso, Ken Takahashi, Carmen Vecciarelli, Satoru Ikenoue, Anil K. Pandey, Constanza P. Soto Conti, Irene Cetin, Vincent Bizor Nachinab, Ernawati Ernawati, Eduardo A. Duro, Alexey Kholin, Michelle L. Firlit, Sarah Rae Easter, Joanna Sichitiu, Yetunde John-Akinola, Roberto Casale, Hellas Cena, Josephine Agyeman-Duah, Paola Roggero, Ana Langer, Zulfiqar A. Bhutta, Stephen H. Kennedy, Jose Villar, Aris T. Papageorghiou
Summary: This study found that diabetes mellitus and overweight or obesity are risk factors for COVID-19 in pregnancy, and gestational diabetes mellitus is associated with the disease, especially among women requiring insulin. Therefore, women with these comorbidities should be vaccinated.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Endocrinology & Metabolism
Li-Rong He, Li Yu, Yong Guo
Summary: There has been a decrease in birth weight and prevalence of large for gestational age (LGA) among offspring of women with gestational diabetes mellitus (GDM) in southern China. However, the risk of LGA remains stable at a relatively high level for GDM women over the past 10 years.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ying Jiang, Hong Zhu, Zi Chen, Yi-Chen Yu, Xiao-Han Guo, Yuan Chen, Meng-Meng Yang, Bang-Wu Chen, Matthew Sagnelli, Dong Xu, Bai-Hui Zhao, Qiong Luo
Summary: The study aimed to evaluate the impact of gestational diabetes mellitus (GDM) exposure in the second half of pregnancy on hepatic glucose intolerance. By creating a GDM mouse model, the researchers found that the first generation of GDM offspring exhibited impaired glucose tolerance and insulin resistance, predominantly in males. The downregulation of the imprinted genes IGF2 and H19, as well as their abnormal methylation, were identified as potential molecular mechanisms underlying these effects. The study also suggested that intrauterine hyperinsulinemia may contribute to these genetic alterations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Shiau, Leishen Wang, Huikun Liu, Yinan Zheng, Alex Drong, Brian T. Joyce, Jun Wang, Weiqin Li, Junhong Leng, Yun Shen, Ru Gao, Gang Hu, Lifang Hou, Andrea A. Baccarelli
Summary: In the Tianjin GDM Observational Study, offspring of women with GDM showed accelerated epigenetic age compared to control participants, independent of other maternal factors. Epigenetic age in offspring was associated with cardiometabolic risk factors, suggesting that GDM and GDM-associated factors may have long-term effects on offspring epigenetic age and contribute to health outcomes.
Article
Nutrition & Dietetics
Ninghua Li, Jing Li, Hui Wang, Yijuan Qiao, Weiqin Li, Ming Gao, Enqing Liu, Zhijie Yu, Gang Hu, Zhongze Fang, Junhong Leng, Xilin Yang
Summary: This study found that high serum levels of methionine and cystine, as well as low serum levels of taurine in early pregnancy, were significantly associated with an increased risk of gestational diabetes mellitus (GDM). Maternal high cystine and low taurine were also associated with an increased risk of persistent obesity growth pattern (POGP) in offspring, largely independent of GDM.
Article
Pediatrics
Fredrik Norstrom, Fredinah Namatovu, Annelie Carlsson, Lotta Hogberg, Anneli Ivarsson, Anna Myleus
Summary: The study found no significant associations between parents' education level and occupation with coeliac disease prevalence, suggesting that parental socioeconomic status is not a reliable indicator for identifying children at higher risk of coeliac disease.
Article
Endocrinology & Metabolism
Johnny Ludvigsson, Indusmita Routray, Tore Vigard, Ragnar Hanas, Bjorn Rathsman, Annelie Carlsson, Stefan Sarnblad, Anna-Karin Albin, Carl-Goran Arvidsson, Ulf Samuelsson, Rosaura Casas
Summary: The study showed that combination therapy with glutamic acid decarboxylase (GAD-alum), Etanercept, and vitamin D was feasible and tolerable in children and adolescents with newly diagnosed type 1 diabetes (T1D), but had no beneficial effects on the autoimmune process or beta cell function.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Endocrinology & Metabolism
Mara Cerqueiro Bybrant, Elin Uden, Filippa Frederiksen, Anna L. Gustafsson, Carl-Goran Arvidsson, Anna-Lena Fureman, Gun Forsander, Helena Elding Larsson, Sten A. Ivarsson, Marie Lindgren, Johnny Ludvigsson, Claude Marcus, Auste Pundziute Lycka, Martina Persson, Ulf Samuelsson, Stefan Sarnblad, Karin Akesson, Eva Ortqvist, Annelie Carlsson
Summary: Children with type 1 diabetes who have tissue transglutaminase antibodies greater than or equal to 10 times the upper limit of normal are highly likely to have celiac disease, indicating a strong relationship between the two conditions.
PEDIATRIC DIABETES
(2021)
Article
Endocrinology & Metabolism
Nina Lindell, Marie Bladh, Annelie Carlsson, Ann Josefsson, Karin Aakesson, Ulf Samuelsson
Summary: The study investigated the relationship between size for gestational age and the risk of developing type 1 diabetes in Swedish children. Findings showed that being born LGA increased the risk of type 1 diabetes, while being born SGA decreased the risk.
Article
Gastroenterology & Hepatology
Fredrik Norstrom, Anna Myleus, Katrina Nordyke, Annelie Carlsson, Lotta Hogberg, Olof Sandstrom, Lars Stenhammar, Anneli Ivarsson, Lars Lindholm
Summary: Research indicates that conducting mass screening for coeliac disease can effectively lower diagnosis delay, and is cost-effective at a threshold of 50,000 Euro per gained QALY.
BMC GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Lue Ping Zhao, George K. Papadopoulos, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding Larsson, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Daniel E. Geraghty, Ake Lernmark
Summary: Using deep learning of DQ residue sequences, critical residues and motifs associated with T1D were uncovered on HLA-DQ molecules, including susceptibility and resistance associations. These residues, located on alpha and beta chains, play significant roles in the risk and protection against T1D.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Lue Ping Zhao, George K. Papadopoulos, Terry P. Lybrand, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding Larsson, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Stephen S. Rich, Ake Lernmark
Summary: The study identified three amino acid residues of HLA-DRB1 (beta 71, beta 74, beta 86) predictive of T1D risk, with the KAG motif being most strongly associated with increased risk. Other motifs were also found to be linked with T1D risk or protection.
Article
Pediatrics
Olof Sandstrom, Fredrik Norstrom, Annelie Carlsson, Lotta Hogberg, Maria van der Palz, Lars Stenhammar, Charlotta Webb, Anneli Ivarsson, Anna Myleus
Summary: The study found a high risk of conversion to coeliac disease among those with potential disease within 5 years, while individuals with a negative serological screening had a very low risk of being clinically diagnosed during the follow-up period.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Nutrition & Dietetics
Hanna Soederstrom, Julia Rehn, Matti Cervin, Cathrine Ahlstermark, Mara Cerqueiro Bybrant, Annelie Carlsson
Summary: Children with both type 1 diabetes (T1D) and celiac disease (CD) have lower compliance to a gluten-free diet compared to children with CD only. Results suggest that intensified dietary support may be necessary for children with both T1D and CD, particularly for older children and those with poor metabolic control.
Article
Parasitology
Johan Hoglund, Anneli Carlsson, Katarina Gustafsson
Summary: This study assessed the occurrence of a periparturient rise in winter and spring lambing ewes, investigating nematode egg excretion patterns. Results showed that winter lambing ewes had significantly lower FEC compared to spring lambing ewes, indicating that factors other than lambing influenced the rise in nematode egg count. This suggests that pasture contamination is less from winter lambing ewes compared to spring lambing ewes.
VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS
(2021)
Article
Pediatrics
Emma Hedlund, Johnny Ludvigsson, Helena Elding Larsson, Gun Forsander, Sten Ivarsson, Claude Marcus, Ulf Samuelsson, Martina Persson, Annelie Carlsson
Summary: This study used population-based data in Sweden to investigate the association between month of birth and incidence of type 1 diabetes. The results showed that there was no significant correlation between month of birth and the risk of type 1 diabetes in the entire cohort. However, boys diagnosed before the age of 5 were more likely to be born in May.
Letter
Dermatology
Pelle G. Lindqvist, Elisabeth Epstein, Mona Landin-Olsson
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Pediatrics
Mara Cerqueiro Bybrant, Elsa Palmkvist, Hanna Soderstrom, Marie Lindgren, Hans Hildebrand, Fredrik Norstrom, Annelie Carlsson
Summary: This study investigated whether there was a difference in the prevalence of coeliac disease in children with type 1 diabetes born during and after the Swedish coeliac epidemic. The study found no significant difference in the prevalence of coeliac disease among children with type 1 diabetes between the two cohorts.
Article
Endocrinology & Metabolism
Marie Lindgren, Elsa Palmkvist, Fredrik Norstrom, Mara Cerqueiro Bybrant, Anna Myleus, Ulf Samuelsson, Johnny Ludvigsson, Annelie Carlsson
Summary: In Sweden, there was a fourfold increase in the incidence of celiac disease in young children between 1985 and 1996. It was believed that the timing and amount of gluten introduced during infancy could explain this epidemic. A national register study compared the cumulative incidence of type 1 diabetes in two birth cohorts, and found that children born after the epidemic had a higher incidence of type 1 diabetes compared to those born during the epidemic.
ACTA DIABETOLOGICA
(2023)
Article
Medicine, Research & Experimental
Hanna Soderstrom, Matti Cervin, Jonatan Dereke, Magnus Hillman, Iren Tiberg, Fredrik Norstrom, Annelie Carlsson
Summary: The study found that children with newly diagnosed T1D showed better glycemic control after following a GFD, suggesting a positive effect of GFD on blood sugar control. However, the GFD group reported poorer quality of life. The findings should be interpreted with caution due to the small sample size and possible confounding effects.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)
